FMRI detects activation of the visual association cortex during laser AP of the foot in humans

[Guest guest]

Hi All,

 

See this:

 

Siedentopf CM, Golaszewski SM, Mottaghy FM, Ruff CC, Felber

S, Schlager A. Functional magnetic resonance imaging detects

activation of the visual association cortex during laser AP of the

foot in humans.Neurosci Lett. 2002 Jul 12;327(1):53-6. Dept of

Radiology II, University Hospital of Innsbruck, Innsbruck, Austria.

The aim of this study was to investigate the effect of laser AP on

cerebral activation. Using functional magnetic imaging (fMRI)

cortical activations during laser AP at the left foot (Bladder 67) and

dummy AP, were compared employing a block design in ten

healthy male volunteers. All experiments were done on a 1.5 Tesla

magnetic resonance scanner equipped with a circular polarized

head coil. During laser AP, we found activation in the cuneus

corresponding to Brodmann Area (BA) 18 and the medial occipital

gyrus (BA 19) of the ipsilateral visual cortex. Placebo stimulation

did not show any activation. We could demonstrate that laser AP

of a specific acupoint, empirically related to ophthalmic disorders,

leads to activation of visual brain areas, whereas placebo AP does

not. These results indicate that fMRI has the potential to elucidate

effects of AP on brain activity. Publication Types: Clinical Trial

Controlled Clinical Trial MeSH Terms: Acupuncture* Adolescent

Adult Foot Human Lasers Magnetic Resonance Imaging* Male

Support, Non-U.S. Gov't Visual Cortex/physiology* PMID:

12098499 [PubMed - indexed for MEDLINE]

 

Best regards,

 

Email: <

 

WORK : Teagasc, c/o 1 Esker Lawns, Lucan, Dublin, Ireland

Mobile: 353-; [in the Republic: 0]

 

HOME : 1 Esker Lawns, Lucan, Dublin, Ireland

Tel : 353-; [in the Republic: 0]

WWW : http://homepage.eircom.net/~progers/searchap.htm

 

Chinese Proverb: " Man who says it can't be done, should not interrupt man doing

it "

[Guest guest]

The study below was really exciting because it confirmed the very first study

ever done for acupuncture using fMRI by UC Irvine's Dr. Z.H. Cho in 1997. That

study employed needles rather than lasers. - Matt Bauer

-

aCUPUNCTURE ; pa-l ; pVA-L

Cc: traditional_Chinese_Medicine ;

 

Friday, December 10, 2004 7:41 AM

FMRI detects activation of the visual association cortex during

laser AP of the foot in humans

 

 

Hi All,

 

See this:

 

Siedentopf CM, Golaszewski SM, Mottaghy FM, Ruff CC, Felber

S, Schlager A. Functional magnetic resonance imaging detects

activation of the visual association cortex during laser AP of the

foot in humans.Neurosci Lett. 2002 Jul 12;327(1):53-6. Dept of

Radiology II, University Hospital of Innsbruck, Innsbruck, Austria.

The aim of this study was to investigate the effect of laser AP on

cerebral activation. Using functional magnetic imaging (fMRI)

cortical activations during laser AP at the left foot (Bladder 67) and

dummy AP, were compared employing a block design in ten

healthy male volunteers. All experiments were done on a 1.5 Tesla

magnetic resonance scanner equipped with a circular polarized

head coil. During laser AP, we found activation in the cuneus

corresponding to Brodmann Area (BA) 18 and the medial occipital

gyrus (BA 19) of the ipsilateral visual cortex. Placebo stimulation

did not show any activation. We could demonstrate that laser AP

of a specific acupoint, empirically related to ophthalmic disorders,

leads to activation of visual brain areas, whereas placebo AP does

not. These results indicate that fMRI has the potential to elucidate

effects of AP on brain activity. Publication Types: Clinical Trial

Controlled Clinical Trial MeSH Terms: Acupuncture* Adolescent

Adult Foot Human Lasers Magnetic Resonance Imaging* Male

Support, Non-U.S. Gov't Visual Cortex/physiology* PMID:

12098499 [PubMed - indexed for MEDLINE]

 

Best regards,

Email: <

 

WORK : Teagasc, c/o 1 Esker Lawns, Lucan, Dublin, Ireland

Mobile: 353-; [in the Republic: 0]

 

HOME : 1 Esker Lawns, Lucan, Dublin, Ireland

Tel : 353-; [in the Republic: 0]

WWW : http://homepage.eircom.net/~progers/searchap.htm

 

Chinese Proverb: " Man who says it can't be done, should not interrupt man

doing it "

 

 

http://babel.altavista.com/

 

and adjust

accordingly.

 

If you , it takes a few days for the messages to stop being

delivered.

 

 

 

[Guest guest]

Hi All, & Matt,

 

Matt Bauer wrote:

> The study below was really exciting because it confirmed the very

> first study ever done for acupuncture using fMRI by UC Irvine's

> Dr. Z.H. Cho in 1997. That study employed needles rather than

> lasers. - Matt Bauer

 

Medline had 55 hits for the profile:

(acupunc* OR electroacu* OR acupo*) AND (FMRI OR " functional magnetic "

OR RMI)

 

From Medline abstracts, Cho et al published their first paper by on fMRI and AP

in 1998. However, a Japanese group (Higuchi et al), published on the topic in

1977:

 

Higuchi T, Fukunaga M, Umeda M, Ebisu T, Tanaka C, Naruse S, Ueda S.

[Functional brain mapping in motor task and somatosensory stimulation using

echo planar MRI - Article in Japanese] Nippon Rinsho. 1997 Jul;55(7):1688-93.

Department of Neurosurgery, Kyoto Prefectural University of Medicine.

Functional brain mapping was performed with a 1.5T clinical MRI apparatus.

Single shot gradient echo echo-planar imaging (EPI) sequence was employed.

Normal volunteers were studied with the task of grasping hand or opposition of

fingers at the frequency of 3 Hz, median nerve electro-stimulation, pure

somatosensory stimulation by roller for AP. Apparent signal increase was

observed at contralateral sensorimotor cortex with motor task. Signal changes

delayed about 5 seconds compared with the start and the cessation of the

task, which may suggest that regional changes of CBF and blood oxygen level

in capillary and/or in venule lag behind electrical excitation. It was hard to

detect the activated area with median nerve electro-stimulation. On the other

hand, roller stimulation provoked distinct activated areas at contralateral

sensorimotor cortex. The activated areas caused by the roller stimulation and

the motor task coincided entirely, which suggests the possibility of the

intermixed localization of primary areas of motor and somatosensory. It was

also clearly demonstrated that the activated area was broader with quick (3 Hz)

and complicated motor task (finger opposition) than with slow (1Hz) and simple

motor task (hand grasping). PMID: 9233010 [PubMed - indexed for MEDLINE]

 

Cho ZH, Chung SC, Jones JP, Park JB, Park HJ, Lee HJ, Wong EK, Min BI.

New findings of the correlation between acupoints and corresponding brain

cortices using functional MRI. Proc Natl Acad Sci U S A. 1998 Mar

3;95(5):2670-3. Department of Radiological Sciences, Psychiatry, and Human

Behavior, University of California, Irvine, CA 92697, USA. zcho A

preliminary study of the correlation between AP points (acupoints) for the

treatment of eye disorders suggested by ancient Oriental literature and the

corresponding brain localization for vision described by Western medicine was

performed by using functional MRI (fMRI). The vision-related acupoint (VA1) is

located in the lateral aspect of the foot, and when AP stimulation is performed

there, activation of occipital lobes is seen by fMRI. Stimulation of the eye by

directly using light results in similar activation in the occipital lobes by

fMRI.

The experiment was conducted by using conventional checkerboard 8-Hz light-

flash stimulation of the eye and observation of the time-course data. This was

followed by stimulation of the VA1 by using the same time-course paradigm as

visual light stimulation. Results obtained with 12 volunteers yielded very clean

data and very close correlations between visual and AP stimulation. We have

also stimulated nonacupoints 2 to 5 cm away from the vision-related acupoints

on the foot as a control, and activation in the occipital lobes was not

observed.

The results obtained demonstrate the correlation between activation of specific

areas of brain cortices and corresponding acupoint stimulation predicted by

ancient AP literature. PMID: 9482945 [PubMed - indexed for MEDLINE]

 

Also, see this one, to be in print in 2005:

 

Newberg AB, Lariccia PJ, Lee BY, Farrar JT, Lee L, Alavi A.Cerebral blood flow

effects of pain and AP: a preliminary single-photon emission computed

tomography imaging study. J Neuroimaging. 2005 Jan;15(1):43-9. Division of

Nuclear Medicine, Hospital of the University of Pennsylvania, 110 Donner

Building, 3400 Spruce Street, Philadelphia, PA 19104.

newberg BACKGROUND: The purpose of this study was to

investigate the cerebral blood flow changes associated with the analgesic effect

of AP in patients with chronic pain. METHODS: Seven patients presenting with

a chronic pain syndrome and 5 healthy controls were included. All single-

photon emission com puted tomography (SPECT) scans were acquired with a

uniform protocol. The patient group was injected with the radioisotope

hexamethyl propyleneamine oxime (HMPAO) while experienc ing their usual

level of pain. A baseline scan was acquired approximately 20 minutes after

administration of the HMPAO. The patient then underwent AP therapy with

needles placed in points specifically selected to relieve pain. When the pain

improved, as determined by a 10-digit score for pain assessment, the patient

was reinjected with HMPAO and imaged 20 minutes later for the AP scan. The

refer ence group also had a baseline and AP scan, although the AP itself was

performed using a stan dardized set of needle points. RESULTS: The reference

group par ticipants were found to have significant increases in the thalamic and

prefrontal cortex activity on the AP scan compared to the baseline. The

baseline scans of the pain patients showed significant asymmetric uptake in

the thalami compared to controls. This asymmetry reversed or normalized after

the AP therapy. Significant correlations were observed between the change of

activity in the prefrontal cortex and ipsilateral sensorimotor area.

CONCLUSION: The results from these cases show that HMPAO-SPECT is

capable of detecting changes in cerebral blood flow associated with pain and

that AP analgesia is associated with changes in the activity of the frontal

lobes,

brain stem, and thalami. PMID: 15574573 [PubMed - in process]

 

 

Best regards,

 

Email: <

 

WORK : Teagasc, c/o 1 Esker Lawns, Lucan, Dublin, Ireland

Mobile: 353-; [in the Republic: 0]

 

HOME : 1 Esker Lawns, Lucan, Dublin, Ireland

Tel : 353-; [in the Republic: 0]

WWW : http://homepage.eircom.net/~progers/searchap.htm

 

Chinese Proverb: " Man who says it can't be done, should not interrupt man doing

it "