New Herbal Abstracts

[Guest guest]

Phil -

 

Ray Rubio here. I am a professor at Emperor's College here in Los

Angeles and I am in the midst of putting together a research project

utilizing Chinese Herbal Medicine. I was wondering if I could pick your

brain about a couple of things. Can you reply to me off list when you

have a second? (rtoo)

 

Thanks in advance,

 

Ray.

 

On Nov 5, 2004, at 4:16 AM, wrote:

 

>

> Hi All,

>

> See these.

>

> Phil

>

> Chiasson, H.; Vincent, C.; Bostanian, N. J. Insecticidal

> properties of a Chenopodium-based botanical Journal of

> Economic Entomology 97 (4), August 2004; 1378-1383.

> Codena Inc, 426 Chemin Patriotes, Quebec City, PQ, J0H 2G0,

> Canada The emulsifiable concentrate UDA-245 based on an

> essential oil extract from Chenopodium ambrosioides variety near

> ambrosioides, a North American herbaceous plant, was compared

> with commercially available pesticides for their effectiveness to

> control green peach aphid, Myzus persicae (Sulzer) (Homoptera:

> Aphididae), western flower thrips, Frankliniella occidentalis

> (Pergande) (Thysanoptera: Thripidae), and greenhouse whitefly,

> Trialeurodes vaporariorium (Westwood) (Homoptera: Aleyrodidae).

> Side effects on the whitefly parasitoid Encarsia formosa Gahan

> (Hymenoptera: Aphelinidae) also were determined. With green

> peach aphid, UDA-245 at 0.5% concentration was significantly

> more effective than the control (water) treatment in a laboratory

> bioassay and significantly more effective than neem oil and the

> control treatment and as effective as insecticidal soap in a

> greenhouse assay. With the western flower thrips, UDA-245 at

> 0.5% was significantly more effective than neem oil, insecticidal

> soap and the control treatment in a laboratory bioassay, whereas

> in a greenhouse assay, UDA-245 at 1.0% was the only treatment

> that maintained control of the western flower thrips 2 wk after the

> last treatment period. UDA-245 at 0.5% (laboratory bioassay) was

> significantly more effective in managing greenhouse whitefly than

> neem oil, endosulfan, and the control treatment and as effective as

> insecticidal soap. Insecticidal soap proved to be toxic to the

> parasitoid E. formosa (71.9% mortality ), whereas UDA-245 at

> 0.5% was not significantly more toxic than the control (11.2 and

> 4.6% mortality , respectively). Our results suggest that a

> greenhouse integrated pest management (IPM) program using a

> botanical such as UDA-245 could effectively control infestations of

> major pests present while having a negligible effect on biological

> control agents.

>

> Chiasson, H.; Bostanian, N. J.; Vincent, C. Acaricidal properties

> of a Chenopodium-based botanical. Journal of Economic

> Entomology 97 (4), Aug 2004; 1373-1377. Codena Inc, 426

> Chemin Patriotes, St Charles Sur Richelieu, PQ, J0H 2G0,

> Canada. The emulsifiable concentrate UDA-245 (25% EC

> (vol:vol)), based on all essential oil extract from Chenopodium

> ambrosioides variety ambrosioides, a North American herbaceous

> plant, was compared with commercially available pesticides for

> their effectiveness to control the adult stage and egg hatch of the

> twospotted spider mite, Tetranychus urticae Koch (Acari:

> Tetranychidae) and the European red mite, Panonychus ulmi

> (Koch) (Acari: Tetranychidae). After a laboratory bioassay with

> adult twospotted spider mites, a 0.5% concentration of UDA-245

> was more effective than 0.7% (AI) of neem oil (Neem Rose

> Defense). After a similar bioassay with the European red mite, a

> 0.5% concentration UDA-245 was as effective as 0.006% (AI) of

> abamectin (Avid). UDA-245 at 0.5% significantly reduced egg hatch

> of the twospotted spider mite, 5 and 9 d after treatment and of the

> European red mite 6 d after treatment Egg hatch was significantly

> lower using 0.006% (AI) of abamectin. 0.7% of neem oil, and 1.0%

> insecticidal soap than UDA-245. Residual tests indicated that UDA-

> 245 may be persistent in the environment only for a few hours.

> Only 23% mortality was noted when mites were introduced on

> bean leaves 1 h after treatment with a 2% concentration of UDA-

> 245. At the recommended dose of 0.5%, UDA-245 was not

> considered phytotoxic for most plants tested, i.e., lettuce, roses,

> and tomatoes. Results suggest that a greenhouse integrated pest

> management program using UDA-245 could effectively and

> selectively control mite infestations, by treating " hot spots " with

> negligible effect on biological control agents when treating before

> introduction or when natural enemies are absent.

>

> Wang, Cheng; Zhang, Jin-Xia; Shen, Xiao-Ling; Wan, Chi-Keung;

> Tse, Anfernee Kai-Wing; Fong, Wang-Fun Reversal of P-

> glycoprotein-mediated multidrug resistance by Alisol B 23-acetate.

> Biochemical Pharmacology 68 (5); Sep 1, 2004, 843-855.

> bhwffong Dept Biol and ChemBioact Prod Res Grp,

> City Univ Hong Kong, Kowloon, Hong Kong, China. Herbal drugs

> were screened for their activity in reversing multidrug resistance

> (MDR) in P-glycoprotein (P-gp) over-expressing cancer cells.

> Through bio-assay guided fractionation an active compound was

> isolated from Rhizoma Alismatis, the underground part of Alisma

> orientale and the chemical structure of the isolate compound was

> confirmed by HPLC, LC-MS and NMR as Alisol B 23-acetate

> (ABA). ABA restored the sensitivity of MDR cell lines HepG2-DR

> and K562-DR to anti-tumor agents that have different modes of

> action but are all P-gp substrates. It restored the activity of

> vinblastine, a P-gp substrate, in causing G2/M arrest in MDR cells.

> In a dose-dependent manner, ABA increased doxorubicin

> accumulation and slowed down the efflux of rhodamin-123 from

> MDR cells. ABA inhibited the photoaffinity labeling of P-gp by

> (125I)iodoarylazidoprazosin and stimulated the ATPase activity of

> P-gp in a concentration-dependent manner, suggesting that it could

> be a transporter substrate for P-gp. In addition, ABA was also a

> partial non-competitive inhibitor of P-gp when verapamil was used

> as a substrate. Our results suggest that ABA may be a potential

> MDR reversal agent and could serve as a lead compound in the

> development of novel drugs. Copyright 2004 Elsevier Inc. All rights

> reserved.

>

> Patil, S.; Narayanan, S.; Eibl, G.; Jolly, C. I. Evaluation of

> antimitotic activity of Rotula aquatica (Lour): A traditional herb used

> in treatment of cancer. Indian Journal of Experimental Biology 42

> (9); Sep 2004; 893-899. s.patil Dept Pharmacognosy

> and Phytochem, KM Kundnani Coll Pharm, 47 RG Thadani Marg,

> Bombay, Maharashtra, 400018, India. Rotula aquatica was

> extensively used by vaidyas ( Ayurvedic practioners) in holistic

> treatment of cancer. In the present study, an attempt has been

> made to evaluate the antimitotic activity of R. aquatica. Preliminary

> antimitotic screening was done using Allium cepa root tip assay.

> The mitotic index of the root tips markedly decreased with

> increasing concentration of the aqueous extract. The different

> fractions obtained by successive extraction of R. aquatica using

> solvents of increasing polarity were also evaluated for their

> antimitotic activity. Tannins were isolated which showed a better

> activity than the non-tannin fraction. Experiments were also carried

> out with incorporation of folic acid in the aqueous extract. Folic

> acid inhibited the antimitotic activity of aqueous extract of R.

> aquatica in a dose dependent manner. The results obtained were

> compared with methotrexate- a known drug available in market as

> anti-cancer agent. The studies were extended to human cells using

> 3 pancreatic cancer cell lines, viz: HPAF-II, BxPC-3, and CAPAN-

> 2. Extract of R. aquatica was found to be extremely effective in the

> prevention of cell proliferation of the pancreatic cancer cell lines.

> The phytochemical evaluation revealed presence of polyphenols

> (tannins) and steroids. A HPTLC fingerprinting was developed and

> studied. Two compounds were isolated and subjected to spectral

> studies like UV, IR and mass spectrums. The empirical formula

> was derived by considering this data with elemental analysis of the

> compounds.

>

> Lal, A. Arun Sam; Kumar, T.; Murthy, P. Balakrishna; Pillai, K.

> Sadasivan Hypolipidemic effect of Coriandrum sativum L. in triton-

> induced hyperlipidemic rats. Indian Journal of Experimental Biology

> 42 (9) Sep 2004; 909-912. fippat Dept

> Toxicol, IIBAT, Padappai, 601301, India. In the biphasic model of

> triton-induced hyperlipidemia, C. sativum at a dose of lg/kg body

> weight reduced cholesterol and triglycerides levels in both

> synthesis and excretory phases in rats, and the results were

> comparable with that of Liponil, a commercially available herbal

> hypolipidemic drug. The results suggest that coriander decreases

> the uptake and enhances the breakdown of lipids. From the study

> it can be assumed that coriander has the potential to be

> popularized as a household herbal remedy with preventive and

> curative effect against hyperlipidemia.

>

> Sheu, Shuenn-Jyi; Shen, Chung Guang Herbal pharmaceutical

> compositions for prophylaxis and/or treatment of cardiovascular

> diseases and the method of preparing the same Official Gazette

> of the United States Patent and Trademark Office Patents VOL.

> 1286 (3) Sep. 21, 2004 PATENT NUMBER- US 6793944

> PATENT DATE- September 21, 2004 PATENT CLASS- 424-725

> PATENT ASSIGNEE(S)- Shen; Chung Guang, Foster City, CA,

> USA; Sun Ten Pharmaceutical Co., Ltd., Taipei, Taiwan

> http://www.uspto.gov/web/menu/patdata.html The present

> invention provides an herbal pharmaceutical composition

> comprising the root of scutellaria, the rhizome of coptis, the root

> and rhizome of rhubarb, and the dry powders of the root of ginseng

> (or American ginseng) or the rhizome of ginger. The herbal

> pharmaceutical composition is effective in preventing patients from

> developing or treating patients with cardiovascular diseases, which

> include, but are not limited to, hypertension, coronary heart

> disease, cerebrovascular disease, peripheral vascular disease,

> heart failure , rheumatic heart disease, congenital heart disease,

> and cardiomyopathies. The present invention also provides

> methods for preparing and using the herbal pharmaceutical

> composition.

>

>

>

> Best regards,

>

> Email: <

[Guest guest]

Ray Rubio wrote:

>

> Phil -

>

> Ray Rubio here. I am a professor at Emperor's College here in Los

 

Hi Dr. Ray!

 

Off list? Don't you think your brain pickings to be of general interest

to the whole profession? I do.

 

Regards,

 

Pete