Recent AP Abstracts

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Lee, Jae-Dong; Kim, Su-Young; Kim, Tae-Woo; Lee, Sang-Hoon;

Yang, Hyung-In; Lee, Doo-Ik; Lee, Yun-Ho | 2004 | Anti-

inflammatory effect of bee venom on type II collagen-induced

arthritis. | American Journal of 32 (3), 361-367. |

Coll Oriental MedDept AP and Moxibust, Kyunghee Univ, Hoigi

Dong 1, Seoul, 130701, South Korea; ljdacu | Bee

venom (BV) has been used to relieve pain and reduce inflammation

in traditional Oriental medicine, especially in chronic inflammatory

diseases such as rheumatoid arthritis (RA). We previously reported

that the BV injection into a traditional AP point (ST36) reduced

arthritis-associated edema and nociceptive responses in Freund's

adjuvant-induced arthritis in rats (Kwon et al., 2001). This study

was designed to evaluate the anti-inflammatory and anti-cytokine

effect of BV on a murine type-II collagen-induced arthritis (CIA)

model. Male mice were immunized by spontaneous injection of 100

mug of an emulsion of bovine type-II collagen and complete

Freund's adjuvant (CIA), with a booster injection after 2 weeks. In

the experimental group, 0.1 ml BV was injected at AP point (ST36)

near both knees twice a week for a total of 5 times. In the control

group, normal saline was injected at the same frequencies. These

injections began 5 weeks after the first collagen injection. Starting

the 3rd week after the first collagen injection, we examined limb

swelling and severity of arthritis twice a week. At 8 weeks, mice

were sacrificed and synovial tissue was examined with the light

microscope and serum cytokines (IL-1beta and TNF-alpha) were

measured by ELISA. The incidence of arthritis, the mean arthritis

index and the number of arthritic limbs were significantly lower in

the treatment compared to the control group (63% versus 75%,

3.4% versus 8.5%, 23% versus 75%, respectively). Among the

serum proinflammatory cytokines, the production of TNF-alpha in

the BV group was suppressed compared to the control group (59+/-

4.5 versus 99.5+/-6.5, p<0.05), but IL-1beta was not suppressed.

The examination of the histopathology of the joints of murine CIA

showed decreased inflammation signs and less lymphocyte

infiltration after BV AP therapy. AP therapy with BV suppressed

the development of arthritis and caused inhibition of the immune

responses in type-II collagen-induced arthritis.

 

Lee, Sang-Eun; Song, Kun-Ho; Liu, Jianzhu; Kwon, Hyun-Ju;

Youn, Sang-Bo; Lee, Young-Won; Cho, Sung-Hwan; Kim, Duck-

Hwan | 2004 | The effectiveness of auriculoacupoint treatment for

artificially induced acute hepatic injury in dogs | American Journal

of 32 (3), 445-451. | Coll Vet MedLabs Vet

Internal Med, Chungnam Natl Univ, 220 Gung Dong, Taejon,

305764, South Korea; dhkim | This study was to

investigate effects of Ear AP treatment on carbon tetrachloride

(CCl4)-induced acute liver injury in 10 dogs (4 females and 6

males). Dogs were divided into two groups: the control group (4

dogs), not stimulated after induction of hepatic injury and the

experimental group (6 dogs), stimulated with Ear AP and

massaged at the affected liver region of internal ear after induction

of hepatic injury. Serum enzyme activities and histopathological

findings were examined after the application of Ear AP. Compared

to the control group, serum alanine aminotransferase (ALT) and

aspartate aminotransferase (AST) activities in the experimental

group were significantly decreased at the 4th day (p<0.05) and at

the 5th day (p<0.05), respectively. Histopathological findings of the

experimental group showed decrease of necrotic region and size of

lipid droplets compared to the control group. Ear AP treatment had

a therapeutic effect on the recovery of liver injury induced by CCl4

in dogs.

 

Tsay, Shiow-Luan; Cho, Yi-Ching; Chen, Mei-li | 2004 |

Acupressure and transcutaneous electrical acupoint stimulation in

improving fatigue, sleep quality and depression in hemodialysis

patients. | American Journal of 32 (3), 407-416. |

Grad Inst Nursing, Natl Taipei Coll Nursing, 365 Ming Te Rd,Pei

Tou 112, Taipei, Taiwan; sltsay | The purpose of this

study was to test the effectiveness of acupressure and

Transcutaneous Electrical Acupoint Stimulation (TEAS) on fatigue,

sleep quality and depression in patients who were receiving routine

hemodialysis treatment The study was a randomized controlled

trial; qualified patients were randomly assigned to acupressure,

TEAS or control groups. Patients in the acupressure and TEAS

groups received 15 minutes of treatment 3 times a week for 1

month, whereas patients in the control group only received routine

unit care. A total of 106 patients participated. Methods of

measurement included the revised Piper Fatigue Scale (PFS), the

Pittsburgh Sleep Quality Index and the Beck Depression Inventory.

Data were collected at baseline, during the intervention and post-

treatment. The results indicated that patients in the acupressure

and TEAS groups had significantly lower levels of fatigue, a better

sleep quality and less depressed moods compared with patients in

the control group based upon the adjusted baseline differences.

However, there were no differences between acupressure and

TEAS groups in outcome measures. This study provides an

alternative method for health care providers in managing dialysis

patients with symptoms of fatigue, poor sleep or depression.

 

Zhang, Wenping; Kanehara, Masayuki; Ishida, Torao; Guo, Yi;

Wang, Xiuyun; Li, Guilan; Zhang, Bingli; Kondo, Hiroyo; Tachi,

Saori | 2004 | Preventive and therapeutic effects of AP on bone

mass in osteopenic ovariectomized rats. | American Journal of

32 (3), 427-443. | Inst Tradit Chinese Med,

Suzuka Univ Med Sci, 1275-3 Kishioka, Suzuka, Mie, 5100226,

Japan; ishida-t | This study was designed to (1)

test the preventive and therapeutic effects of AP on osteopenia in

ovariectomized (OVX) rats, and (2) assess whether treatment of

different AP points causes different effects on tibiae, femora or

lumbar spines. 35 female Sprague-Dawley rats were divided into

four groups: Sham (sham-operated, non-AP); Model (OVX, non-

AP); AP-A (OVX, bilateral needling of points ST36 and SP06); and

AP-B (OVX, bilateral needling of BL20 and BL23). Operations were

performed at 8 weeks of age, I week later the study was started

and continued for 16 weeks. Ovariectomy resulted in decreased

bone mineral density (BMD) compared to the sham group over

time, and AP-A tended to have higher BMD than the other OVX

groups, especially for tibiae. In addition, the bone ash weight of the

AP groups tended to be heavier than the model group.

Deoxypyridinoline, the urinary marker of bone resorption, also

appeared to be decreased in both AP groups. Similarly,

microarchitecture and bone morphometry of lumbar vertebrae and

tibiae, such as bone volume, trabecular thickness, trabecular

number, mineralizing surface, bone formation rate, mineral

apposition rate, number of nodes and number of node-terminus

struts, also showed the same improvement in the AP groups as

compared to the model control group. AP may prevent the

development of osteopenia in rats induced by ovariectomy.

Needling of ST36 and SP06 seems more effective than needling of

BL20 and BL23 in bone anabolic regulation.

 

 

 

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