Modified toxic vaccines - United States Patent 4709017

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Modified toxic vaccines

 

Document Type and Number:

United States Patent 4709017

Link to this page:

http://www.freepatentsonline.com/4709017.html

 

Abstract:

Diphtheria toxin, fragment A, which has been modified by the deletion of Glu-148 or the substitutions of Glu-148 with Asp is catalytically inactive and immunologically cross-reactive with naturally occurring diphtheria toxin, fragment A. The modified diphtheria toxin is compounded with a pharmacologically suitable vehicle to form a vaccine that is innoculated into a mammal to generate immunological protection against diphtheria toxin. The modified diphtheria toxin is produced by a cell that includes a vector having DNA encoding the non-toxic protein and regulatory DNA capable of effecting its expression.

 

http://www.freepatentsonline.com/4709017.html