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RAISING GLUTATHIONE USING CYSTEINE

Enhancement of glutathione levels through cysteine supplementation

has proven and important health benefi ts.

But consumers have questions about the best available source of

cysteine. Immunotec provides the answer.

IN SEARCH OF THE BEST STRATEGY

FOR CYSTEINE SUPPLEMENTATION

By Dr. Wulf Dröge, Senior Vice-President, Research and Development

A series of clinical studies and complementary laboratory experiments

has shown that

aging is associated with a progressive decrease in plasma cysteine

and intracellular

glutathione concentrations. This decrease leads to (and can be viewed

as a manifestation

of) age-related oxidative stress. Cysteine and glutathione

concentrations are particularly

low during the night and early morning hours, i.e. during periods of

starvation.

Several clinical studies have also shown that cysteine

supplementation on top of the regular

diet ameliorates several aging-related processes and improves amongst

other parameters

skeletal muscle functions and infl ammatory cytokine levels. Most of

these studies have

been performed with N-acetylcysteine (NAC). This was the best choice

for this purpose

because the free amino acid cysteine is not very stable and cysteine-

rich proteins such as

IMMUNOCAL® contain various different amino acids and would not have

been helpful in

studies designed to identify cysteine as the most important amino

acid in this context.

The search for the best strategy to supply additional amounts of

cysteine to the average

consumer is now raising a very different and practical question. Not

surprisingly the

answer is different.

Let us compare NAC with IMMUNOCAL®. NAC has some adverse effects

which are not shared by IMMUNOCAL® and which render

NAC unattractive as a source of cysteine over long periods of time.

In addition, there are studies to suggest that dietary cysteine from

any source is converted within the blood into its less accessible

derivative cystine and within the liver into its breakdown product

sulfate

unless it is rapidly cleared from the blood by protein synthesis in

skeletal muscle and other tissues. The undenatured whey protein

IMMUNOCAL® provides all protein-forming amino acids and is known to

stimulate rapid protein synthesis within less than 2 hours.

This process allows the body to store cysteine until it is recovered

by regulated protein breakdown during periods of starvation,

i.e. during the night and early morning hours. IMMUNOCAL® is clearly

superior to NAC in stimulating this process of cysteine storage.

Dr. Wulf Dröge, Ph.D. –

A world-renowned research scientist, Dr. Dröge has devoted more than

forty

years to basic and clinical research that form the basis for the

design of safe,

effective new Immunotec products.

• Published over 260 times in peer-reviewed publications

• Postdoctoral fellowships at the Max Planck Institute

and Harvard University

• Professor, Faculty of biology, University of Heidelberg and Head of

the

department of Immunochem., German Cancer Research Center.

• Continues to write articles and teach at McGill University

& Research

Development

Bulletin

IMMUNOCAL®.

Accept no substitutes.

Immunotec®

CYSTEINE, N-ACETYLCYSTEINE (NAC), AND IMMUNOCAL®

By Dr. Jimmy Gutman, Medical Consultant

Research over the past quarter century has shown that the limiting

factor for our body's ability to make

glutathione, is the availability of cysteine in our diet. There are

several options, let's look at cysteine

itself, N-acetylcysteine (NAC) and IMMUNOCAL®.

The amino acid cysteine can be found in supplement form in pills and

powders. Unfortunately just

eating cysteine has not proved to be an effective way to raise

glutathione. Cysteine alone is quickly

oxidized in the digestive system and does not make it to the cells in

an appreciable quantity. Cysteine

must be in a form that can survive the trip through the gut, into the

bloodstream and across the

cell membrane.

NAC is a form of cysteine that has been chemically modified to be

able to make this long journey from

your mouth to your cells. NAC is used as a drug to raise glutathione

in critical medical situations such

as acetaminophen overdose. It is also the drug most commonly used in

research studies investigating

glutathione augmentation.

NAC suffers from two drawbacks. It is effective in raising

glutathione only for a short few hours, which is why doctors must

give it to

patients throughout the entire day. Individuals who take NAC pills

experience a peak in glutathione and then levels may crash,

occasionally

below baseline values. The other complication of NAC is that side

effects such as nausea, vomiting and diarrhea are common.

After years of investigation, Dr. Gustavo Bounous developed what we

know as

IMMUNOCAL®. This is a protein supplement that has the ability to

deliver cysteine to

our cells. It can be viewed as a " cysteine delivery vehicle " . Being a

complicated natural

protein, the transformation of cysteine into glutathione starts

quickly, but continues

over many hours as our digestion and metabolism do their job. Side

effects from

IMMUNOCAL® are very rare.

It must be kept in mind that the amount of cysteine in IMMUNOCAL® is

not as

important as the form of cysteine. For example, if you were to boil

IMMUNOCAL®,

the amount of cysteine would remain the same, but the ability to

raise glutathione

would be destroyed, because the cysteine would no longer be in a

deliverable form for

the cell to properly utilize.

The advantages of IMMUNOCAL® over cysteine and NAC are clear once the

physiology

is understood. Glutathione molecule and structure

 

 

give a look about it. It really does what it talks about plus it has

over 13 patents and is in the red and blue book of medical sorces,

and has no side effects.

 

www.immunotec.com/ebs

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Try reading the book The Hydrogen Peroxide Miracle with the disease. My cousin

has the same disorder and that was the only thing that I found to help her.

-------------- Original message ----------------------

Mary <hoffke02

> will this appky to sarcoidosis?

 

 

 

 

will this appky to sarcoidosis?

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