Body clock 'control switch' found

[Guest guest]

Body clock 'control switch' found

http://news.bbc.co.uk/1/hi/health/7140017.stm

 

 

 

 

 

 

 

We are governed by an internal 24-hour clockResearchers say they have identified the chemical switch that controls the genetic mechanism regulating people's internal body clocks. Although the process involves complex genes, the whole mechanism is controlled by a single amino acid - a building block of protein - they say. It is hoped the discovery may lead to more effective drugs to treat sleep disorders and related ailments. The University of California study appears in the journal Nature.

 

 

 

 

 

 

 

People's sleep problems tend to be very individual, but we currently have a one-size-fits-all approach

 

Dr Neil StanleyNorwich University Hospital

Lead researcher Professor Paolo Sassone-Corsi said: "Because the triggering action is so specific, it appears to be a perfect target for compounds that could regulate this activity. "It is always amazing to see how molecular control is so precise in biology." Sensitive mechanism The body's internal clock, a highly sensitive mechanism able to anticipate changes in the environment, regulates a host of body functions, from sleep patterns to metabolism and behaviour. It is estimated that it regulates up to 15% of all human genes. Disruption of these rhythms can profoundly influence human health and has been linked to insomnia, depression, heart disease, cancer and neurodegenerative disorders. The gene CLOCK and its partner BMAL1 control the body's internal clock. The latest study found that a single amino acid in a protein produced by BMAL1 undergoes a modification that triggers the genetic chain of events involved with setting the body's rhythms. The researchers found that if this modification is impaired in any way, the switching mechanism can be thrown off, undermining the whole system. They are currently testing antibodies that can target the activity of this amino acid. Dr Neil Stanley, a sleep expert at Norwich University Hospital, said 89 different types of sleep disorder had so far been classified, but all sleep medications - hypnotics - currently targeted the same neurotransmitter called GABA. "People's sleep problems tend to be very individual, but we currently have a one-size-fits-all approach - our armamentarium is not exactly huge," he said. "A new target may allow us to develop more specific treatments and to offer patients more personalised care."

[Guest guest]

THERAPEUTIC GRADE 'A' ESSENTIAL OIL OF LAVENDER, APPLIED TO THE BOTTOM OF

OUR FEET HAS DONE WONDERS FOR SLEEP DISORDERS........I WOULD FURTHER

CONTEND THAT IF ANYONE WITH A SLEEP DISORDER WOULD GET INTO THE BATH TUB

WITH MIRACLE ll AND CLEAN OUT THEIR TOXIC BURDEN, ALL MANNER OF " THINGS "

WOULD GO AWAY!!!!! KRAIG

Kraig Carroll

Environmental Damage Repair

 

 

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[Guest guest]

I always use lavender

if I can’t sleep or am suffereing a lot of stress…

I put it in the bath

and have a relaxing bath with lavender and candle light…

And if that didn’t

work fully, I mix up a body rub with a base oil and lavender and put it all

over myself and then go to sleep…

I haven’t had a

time when that hasn’t worked…

Alice J

 

 

 

 

 

 

On Behalf Of The Havens

Friday, 14 December 2007

12:30 am

To:

 

 

Re:Body clock 'control switch' found

 

 

 

 

 

THERAPEUTIC

GRADE 'A' ESSENTIAL OIL OF LAVENDER, APPLIED TO THE BOTTOM OF

OUR FEET HAS DONE WONDERS FOR SLEEP DISORDERS........I WOULD FURTHER

CONTEND THAT IF ANYONE WITH A SLEEP DISORDER WOULD GET INTO THE BATH TUB

WITH MIRACLE ll AND CLEAN OUT THEIR TOXIC BURDEN, ALL MANNER OF

" THINGS "

WOULD GO AWAY!!!!! KRAIG

Kraig Carroll

Environmental Damage Repair