Piperine

June 20, 2005

I have been doing some reading lately with respect to increasing

bioavailability of Hawthorn, co-q10, curcumin, vit-c...ect. In my

reading I have learned of piperine. This substance appears to be VERY

powerfull indeed. Its use is a big no-no when taking many medications

and suppliments.

http://www.delano.com/Articles/piperine-multiplies.html

" Piperine inhibits a number of enzymes responsible for metabolizing

drugs and nutritional substances; it stimulates the activity of amino-

acid transporters in the intestinal lining; it inhibits p-

glycoprotein, the `pump' protein that removes substances from cells;

and it decreases the intestinal production of glucuronic acid,

thereby permitting more of the substances to enter the body in active

form. Consequently, some of these substances are able to reach,

enter, and remain within their target cells for longer periods of

time than would otherwise be the case. Of course, this can be a mixed

blessing — if one is using a drug for which the therapeutic level is

not substantially lower than the toxic level, piperine

supplementation might raise the bioavailability of the drug until its

intracellular concentration exceeds the toxic threshold. On the other

hand, piperine supplementation can sometimes turn a marginally

effective therapeutic substance into a highly effective one simply by

increasing its bioavailability and intracellular residency time. A

good example of this latter phenomenon is the use of piperine to

increase the bioavailability of curcumin, a supplement with broad

activity against cancers, inflammation and infections. A 20 mg dose

of piperine can increase curcumin's bioavailability twentyfold. "

Has anyone here on the list ever used it? I am just learning about

all this and your input would be very helpfull. I am recovering from

a heart attack at the age of 36, I am currently getting great results

with what I am doing and feeling great but am trying to reverse much

of the damage I did to my body for years.

Steve

June 23, 2005

__________________

Thank-you Steve,

....for making me aware of this drug

....and for those of us who are taking medication for heart, blood pressure, seizures,

sleep, headache, muscle discomfort, asthma, and narcotic pain killers need to be aware

of all the harmful side effects if taking these prescriptions with PIPERINE.

(Steve, check to see if your medication is included on the list below...mine is)

....Be Blessed in the right use of Knowledge...

....JOYintheMorning...

__________________________

Interactions With:

Prescription Medicine:

The following heart or blood pressure medicine:Acebutolol (Sectral®); Atenolol (Tenormin®); Betaxolol (Kerlone®); Bisoprolol (Zebeta®); Carteolol (Cartrol®); Esmolol (Brevibloc®); Labetalol (Normodyne®, Trandate®); Metoprolol (Lopressor®, Toprol XL®); Nadolol (Corgard®); Penbutolol (Levatol®); Pindolol (Visken®); Propranolol (Inderal®); Sotalol (Betapace®); Timolol (Betimol®, Blocadren®

Harmful Effect:

Taking PIPERINE and these heart or blood pressure medicines together may increase the chance of side effects including feeling tired, chest pain, limb swelling, insomnia (difficult to sleep), depression, constipation, upset stomach, irregular heart beats, and skipped heart beats.

This interaction has been reported when PIPERINE and PROPRANOLOL were taken together and might also occur with other drugs in this class listed above.

Proof:

This interaction has been reported in people (1).

What To Do:

Talk to your doctor before taking PIPERINE and the above heart or blood pressure medicine together. Taking PIPERINE and these medicines together may be harmful. If you are already taking PIPERINE and one of the above heart or blood pressure medicines together and are feeling tired, have chest pain, limb swelling, trouble sleeping, depression, constipation, upset stomach, irregular heart beats, or skipped heart beats, call your doctor right away.

The following medicines for seizures: Ethotoin (Peganone®); Fosphenytoin (Cerebyx®); Mephenytoin (Mesantoin®); Phenytoin (Dilantin®, Diphenylan Sodium®)

Harmful Effect:

Taking PIPERINE and seizure medicines together may increase the chance of side effects including dizziness, itchiness, low blood pressure, and increased heat rate.

This interaction has been reported when PIPERINE and PHENYTOIN were taken together and might also occur with other drugs in this class listed above.

Proof:

This interaction has been reported in people (2).

What To Do:

Talk to your doctor before taking PIPERINE and seizure medicines together. Taking PIPERINE and seizure medicines together may be harmful. If you are already taking PIPERINE and seizure medicines together and have dizziness, itchiness, low blood pressure, or increased heat rate, call your doctor right away.

The following medicines used for sleep, headache, seizures, or muscle relaxants:

Amobarbital (Amytal®); Aprobarbital (Alurate®); Butabarbital (Butalan®); Butalbital (Amaphen®, Esgic®, Fioricet®, Fiorinal®, Fiortal®, Phrenilin®, Sedapap®); Mephobarbital (Mebaral®); Methohexital (Brevital® Sodium); Pentobarbital (Nembutal®); Phenobarbital (Barbita®, Luminal®); Secobarbital (Seconal®); Thiopental (Pentothal® Sodium)

Harmful Effect:

Taking PIPERINE and medicines used for sleep, headache, seizures, or muscle relaxants together may increase the chance of side effects including dizziness, lightheadedness, feeling tired, upset stomach, throwing-up, and constipation.

This interaction has been reported when PIPERINE and PHENOBARBITAL were taken together and might also occur with other drugs in this class listed above.

Proof:

This interaction has been reported in animals but how it affects people is not clear (3).

What To Do:

Talk to your doctor before taking PIPERINE and medicines used for sleep, headache, seizures, or muscle relaxants together. Taking PIPERINE and these medicines together may be harmful. If you are already taking PIPERINE and any of the medicines listed above together and have dizziness, lightheadedness, tiredness, upset stomach, throwing-up or constipation, call your doctor right away.

The following asthma medicines: Theophylline (Aerolate®, Bronkodyl®, Slo-Phyllin®, Slo-Bid, Theobid®, Theochron®, Theo-Dur®, Theolair, Uni-Dur®, Uniphyl®)

Harmful Effect:

Taking PIPERINE and THEOPHYLLINE together may increase the chance of side effects including, increased heart rate, nervousness, upset stomach, and throwing up.

This interaction has been reported when PIPERINE and THEOPHYLLINE were taken together and might also occur with other drugs in this class listed above.

Proof:

This interaction has been reported in people (1).

What To Do:

Talk to your doctor before taking PIPERINE and THEOPHYLLINE together. Taking PIPERINE and THEOPHYLLINE together may be harmful. If you are already taking PIPERINE and THEOPHYLLINE together and have an increased heart rate, nervousness, upset stomach, or are throwing up, call your doctor right away.

The following narcotic pain killers: Morphine (Astramorph®, Duramorph®, Infumorph®, Kadian®, MS Contin®, MSIR®, OMS®, Oramorph SR®, RMS®, Roxanol®)

Harmful Effect:

Taking PIPERINE and narcotic pain killers together may increase the chance of side effects including difficulty breathing, low blood pressure, constipation, dizziness, muscle weakness, confusion, trembling, problems with vision, upset stomach, and throwing up.

Proof:

This interaction has not been studied and is not proven. But it is possible that this interaction can occur based upon the information available about herbs and drugs (3).

What To Do:

Talk to your doctor before taking PIPERINE and narcotic pain killers together. Taking PIPERINE and narcotic pain killers together may be harmful. If you are already taking PIPERINE and narcotic pain killers together and have difficulty breathing, low blood pressure, constipation, dizziness, muscle weakness, confusion, trembling, problems with vision, upset stomach, or are throwing up, call your doctor right away.

Nonprescription (Over-The-Counter) Medicine:

At the time this document was written, no interactions between PIPERINE and nonprescription (over-the-counter) medicine were found.

Dietary Supplements:

At the time this document was written, no interactions between PIPERINE and dietary supplements were found.

Food:

At the time this document was written, no interactions between PIPERINE and food were found.

Alcohol:

At the time this document was written, no interactions between PIPERINE and alcohol were found.

Tobacco:

At the time this document was written, no interactions between PIPERINE and tobacco were found.

__________________________

Steve stevenmi1000 wrote:

I have been doing some reading lately with respect to increasing bioavailability of Hawthorn, co-q10, curcumin, vit-c...ect. In my reading I have learned of piperine. This substance appears to be VERY powerfull indeed. Its use is a big no-no when taking many medications and suppliments.http://www.delano.com/Articles/piperine-multiplies.html"Piperine inhibits a number of enzymes responsible for metabolizing drugs and nutritional substances; it stimulates the activity of amino-acid transporters in the intestinal lining; it inhibits p-glycoprotein, the `pump' protein that removes substances from cells; and it decreases the intestinal production of glucuronic acid, thereby permitting more of the substances to enter the body in active form. Consequently, some of

these substances are able to reach, enter, and remain within their target cells for longer periods of time than would otherwise be the case. Of course, this can be a mixed blessing — if one is using a drug for which the therapeutic level is not substantially lower than the toxic level, piperine supplementation might raise the bioavailability of the drug until its intracellular concentration exceeds the toxic threshold. On the other hand, piperine supplementation can sometimes turn a marginally effective therapeutic substance into a highly effective one simply by increasing its bioavailability and intracellular residency time. A good example of this latter phenomenon is the use of piperine to increase the bioavailability of curcumin, a supplement with broad activity against cancers, inflammation and infections. A 20 mg dose of piperine can increase curcumin's bioavailability twentyfold." Has anyone here on the list ever

used it? I am just learning about all this and your input would be very helpfull. I am recovering from a heart attack at the age of 36, I am currently getting great results with what I am doing and feeling great but am trying to reverse much of the damage I did to my body for years.SteveFederal Law requires that we warn you of the following: 1. Natural methods can sometimes backfire. 2. If you are pregnant, consult your physician before using any natural remedy. 3. The Constitution guarantees you the right to be your own physician and toprescribe for your own health. We are not medical doctors although MDs are welcome to post here as long as they behave themselves. Any opinions put forth by the list members are exactly that, and any person following the advice of anyone posting here does so at their own risk. It is up to you to educate yourself. By

accepting advice or products from list members, you are agreeing to be fully responsible for your own health, and hold the List Owner and members free of any liability. Dr. Ian ShillingtonDoctor of NaturopathyDr.IanShillington

June 23, 2005

Joy...

Yes, My lipid lowering meds(working on getting off these too...)

Piperine is sold as Bioprine....unfortunate that it interacts with so many common meds...Seems it could help alot of people when used with caution..it IS in my curcumin source. I personally dont know that it has or has not effected anything....but i feel well...and have gotten off all my meds except for Vytorin for my blood fat and niacin for raising my HDL...

Stevejoy wilson <joy2yrwrld wrote:

__________________

Thank-you Steve,

....for making me aware of this drug

....and for those of us who are taking medication for heart, blood pressure, seizures,

sleep, headache, muscle discomfort, asthma, and narcotic pain killers need to be aware

of all the harmful side effects if taking these prescriptions with PIPERINE.

(Steve, check to see if your medication is included on the list below...mine is)

....Be Blessed in the right use of Knowledge...

....JOYintheMorning...

__________________________

Interactions With:

Prescription Medicine:

The following heart or blood pressure medicine:Acebutolol (Sectral®); Atenolol (Tenormin®); Betaxolol (Kerlone®); Bisoprolol (Zebeta®); Carteolol (Cartrol®); Esmolol (Brevibloc®); Labetalol (Normodyne®, Trandate®); Metoprolol (Lopressor®, Toprol XL®); Nadolol (Corgard®); Penbutolol (Levatol®); Pindolol (Visken®); Propranolol (Inderal®); Sotalol (Betapace®); Timolol (Betimol®, Blocadren®

Harmful Effect:

Taking PIPERINE and these heart or blood pressure medicines together may increase the chance of side effects including feeling tired, chest pain, limb swelling, insomnia (difficult to sleep), depression, constipation, upset stomach, irregular heart beats, and skipped heart beats.

This interaction has been reported when PIPERINE and PROPRANOLOL were taken together and might also occur with other drugs in this class listed above.

Proof:

This interaction has been reported in people (1).

What To Do:

Talk to your doctor before taking PIPERINE and the above heart or blood pressure medicine together. Taking PIPERINE and these medicines together may be harmful. If you are already taking PIPERINE and one of the above heart or blood pressure medicines together and are feeling tired, have chest pain, limb swelling, trouble sleeping, depression, constipation, upset stomach, irregular heart beats, or skipped heart beats, call your doctor right away.

The following medicines for seizures: Ethotoin (Peganone®); Fosphenytoin (Cerebyx®); Mephenytoin (Mesantoin®); Phenytoin (Dilantin®, Diphenylan Sodium®)

Harmful Effect:

Taking PIPERINE and seizure medicines together may increase the chance of side effects including dizziness, itchiness, low blood pressure, and increased heat rate.

This interaction has been reported when PIPERINE and PHENYTOIN were taken together and might also occur with other drugs in this class listed above.

Proof:

This interaction has been reported in people (2).

What To Do:

Talk to your doctor before taking PIPERINE and seizure medicines together. Taking PIPERINE and seizure medicines together may be harmful. If you are already taking PIPERINE and seizure medicines together and have dizziness, itchiness, low blood pressure, or increased heat rate, call your doctor right away.

The following medicines used for sleep, headache, seizures, or muscle relaxants:

Amobarbital (Amytal®); Aprobarbital (Alurate®); Butabarbital (Butalan®); Butalbital (Amaphen®, Esgic®, Fioricet®, Fiorinal®, Fiortal®, Phrenilin®, Sedapap®); Mephobarbital (Mebaral®); Methohexital (Brevital® Sodium); Pentobarbital (Nembutal®); Phenobarbital (Barbita®, Luminal®); Secobarbital (Seconal®); Thiopental (Pentothal® Sodium)

Harmful Effect:

Taking PIPERINE and medicines used for sleep, headache, seizures, or muscle relaxants together may increase the chance of side effects including dizziness, lightheadedness, feeling tired, upset stomach, throwing-up, and constipation.

This interaction has been reported when PIPERINE and PHENOBARBITAL were taken together and might also occur with other drugs in this class listed above.

Proof:

This interaction has been reported in animals but how it affects people is not clear (3).

What To Do:

Talk to your doctor before taking PIPERINE and medicines used for sleep, headache, seizures, or muscle relaxants together. Taking PIPERINE and these medicines together may be harmful. If you are already taking PIPERINE and any of the medicines listed above together and have dizziness, lightheadedness, tiredness, upset stomach, throwing-up or constipation, call your doctor right away.

The following asthma medicines: Theophylline (Aerolate®, Bronkodyl®, Slo-Phyllin®, Slo-Bid, Theobid®, Theochron®, Theo-Dur®, Theolair, Uni-Dur®, Uniphyl®)

Harmful Effect:

Taking PIPERINE and THEOPHYLLINE together may increase the chance of side effects including, increased heart rate, nervousness, upset stomach, and throwing up.

This interaction has been reported when PIPERINE and THEOPHYLLINE were taken together and might also occur with other drugs in this class listed above.

Proof:

This interaction has been reported in people (1).

What To Do:

Talk to your doctor before taking PIPERINE and THEOPHYLLINE together. Taking PIPERINE and THEOPHYLLINE together may be harmful. If you are already taking PIPERINE and THEOPHYLLINE together and have an increased heart rate, nervousness, upset stomach, or are throwing up, call your doctor right away.

The following narcotic pain killers: Morphine (Astramorph®, Duramorph®, Infumorph®, Kadian®, MS Contin®, MSIR®, OMS®, Oramorph SR®, RMS®, Roxanol®)

Harmful Effect:

Taking PIPERINE and narcotic pain killers together may increase the chance of side effects including difficulty breathing, low blood pressure, constipation, dizziness, muscle weakness, confusion, trembling, problems with vision, upset stomach, and throwing up.

Proof:

This interaction has not been studied and is not proven. But it is possible that this interaction can occur based upon the information available about herbs and drugs (3).

What To Do:

Talk to your doctor before taking PIPERINE and narcotic pain killers together. Taking PIPERINE and narcotic pain killers together may be harmful. If you are already taking PIPERINE and narcotic pain killers together and have difficulty breathing, low blood pressure, constipation, dizziness, muscle weakness, confusion, trembling, problems with vision, upset stomach, or are throwing up, call your doctor right away.

Nonprescription (Over-The-Counter) Medicine:

At the time this document was written, no interactions between PIPERINE and nonprescription (over-the-counter) medicine were found.

Dietary Supplements:

At the time this document was written, no interactions between PIPERINE and dietary supplements were found.

Food:

At the time this document was written, no interactions between PIPERINE and food were found.

Alcohol:

At the time this document was written, no interactions between PIPERINE and alcohol were found.

Tobacco:

At the time this document was written, no interactions between PIPERINE and tobacco were found.

__________________________

Steve stevenmi1000 wrote:

I have been doing some reading lately with respect to increasing bioavailability of Hawthorn, co-q10, curcumin, vit-c...ect. In my reading I have learned of piperine. This substance appears to be VERY powerfull indeed. Its use is a big no-no when taking many medications and suppliments.http://www.delano.com/Articles/piperine-multiplies.html"Piperine inhibits a number of enzymes responsible for metabolizing drugs and nutritional substances; it stimulates the activity of amino-acid transporters in the intestinal lining; it inhibits p-glycoprotein, the `pump' protein that removes substances from cells; and it decreases the intestinal production of glucuronic acid, thereby permitting more of the substances to enter the body in active form. Consequently, some of

these substances are able to reach, enter, and remain within their target cells for longer periods of time than would otherwise be the case. Of course, this can be a mixed blessing — if one is using a drug for which the therapeutic level is not substantially lower than the toxic level, piperine supplementation might raise the bioavailability of the drug until its intracellular concentration exceeds the toxic threshold. On the other hand, piperine supplementation can sometimes turn a marginally effective therapeutic substance into a highly effective one simply by increasing its bioavailability and intracellular residency time. A good example of this latter phenomenon is the use of piperine to increase the bioavailability of curcumin, a supplement with broad activity against cancers, inflammation and infections. A 20 mg dose of piperine can increase curcumin's bioavailability twentyfold." Has anyone here on the list ever

used it? I am just learning about all this and your input would be very helpfull. I am recovering from a heart attack at the age of 36, I am currently getting great results with what I am doing and feeling great but am trying to reverse much of the damage I did to my body for years.SteveFederal Law requires that we warn you of the following: 1. Natural methods can sometimes backfire. 2. If you are pregnant, consult your physician before using any natural remedy. 3. The Constitution guarantees you the right to be your own physician and toprescribe for your own health. We are not medical doctors although MDs are welcome to post here as long as they behave themselves. Any opinions put forth by the list members are exactly that, and any person following the advice of anyone posting here does so at their own risk. It is up to you to educate yourself. By

accepting advice or products from list members, you are agreeing to be fully responsible for your own health, and hold the List Owner and members free of any liability. Dr. Ian ShillingtonDoctor of NaturopathyDr.IanShillington Federal Law requires that we warn you of the following: 1. Natural methods can sometimes backfire. 2. If you are pregnant, consult your physician before using any natural remedy. 3. The Constitution guarantees you the right to be your own physician and toprescribe for your own health. We are not medical doctors although MDs are welcome to post here as long as they behave themselves. Any opinions put forth by the list members are exactly that, and any person following the advice of anyone posting here does so at their own risk. It is up to you to educate yourself. By accepting advice or products from list members, you are

agreeing to be fully responsible for your own health, and hold the List Owner and members free of any liability. Dr. Ian ShillingtonDoctor of NaturopathyDr.IanShillington

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