RES: Restless Legs Syndrome in Patients with Irritable Bowel Syndrome: Response

[Guest guest]

Tue, 16 Oct 2007 10:33:17 -0400

" Bernice A. Melsky " <bernice.melsky1

 

 

Restless Legs Syndrome in Patients with Irritable Bowel Syndrome:

Response to Small Intestinal Bacterial Overgrowth Therapy.

 

Dig Dis Sci. 2007 Oct 13; [Epub ahead of print]

 

Weinstock LB, Fern SE, Duntley SP.

 

Washington University School of Medicine, 11525 Olde Cabin Road, St.

Louis, MO, 63141, USA, lw.

 

PMID: 17934858

 

 

Background: Small intestinal bacterial overgrowth (SIBO) occurs in

irritable bowel syndrome (IBS) and fibromyalgia. Since restless legs

syndrome (RLS) occurs with fibromyalgia, a link between IBS, SIBO,

and RLS was studied.

 

Methods: BS patients with abnormal lactulose breath tests received

rifaximin 1,200 mg day(-1) for 10 days, followed by tegaserod 3 mg,

long-term, and 1 month of zinc 220 mg day(-1) and once-daily

probiotic (N = 11) or rifaximin monotherapy (N = 2). IBS symptom

improvement was assessed after rifaximin. RLS symptoms, IBS symptoms,

and overall IBS global improvement were assessed at last

posttreatment visit: 8/10 patients were followed long-term (mean, 139

days; range, 54-450 days).

 

Results: Ten of 13 patients exhibited >/=80% improvement from

baseline in RLS symptoms. Five maintained complete resolution of RLS

symptoms. Global gastrointestinal symptom improvement was great (n =

6), moderate (n = 5), or mild (n = 2).

 

Conclusion: This study suggests that SIBO associated with IBS may be

a factor in some RLS patients and SIBO therapy provides long-term RLS

improvement.

 

 

 

------------

Send posts to CO-CURE

Un at http://www.co-cure.org/unsub.htm

Select list topic options at http://www.co-cure.org/topics.htm

------------

Co-Cure's purpose is to provide information from across the spectrum of

opinion concerning medical, research and political aspects of ME/CFS and/or

FMS. We take no position on the validity of any specific scientific or

political opinion expressed in Co-Cure posts, and we urge readers to

research the various opinions available before assuming any one

interpretation is definitive. The Co-Cure website <www.co-cure.org> has a

link to our complete archive of posts as well as articles of central

importance to the issues of our community.