Prostate

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Green Tea Polyphenols may decrease the risk of developing prostate

cancer and may be useful therapeutically

 

 

In a study mice lacking immune system function were implanted

with androgen receptor positive human prostate cancer. They were then

given either Green Tea Polyphenols, Black Tea Extract, or EGCG (the

major constituent in Green Tea) or Theaflavins (the major constituent

in Black Tea). It was found that all four preparations significantly

inhibited the growth of prostate cancer tumors, significantly reduced

PSA levels, significantly improved the killing of prostate cancer

cells, significantly inhibited levels of Bcl-2 protein, a gene that

blocks the destruction of cancerous tumors, and significantly

improved levels of Bax protein, a gene that both inhibits Bcl-2 and

causes the destruction of cancerous tumor cells. The preparations

also inhibited VEGF levels, a protein that allows the spread of

prostate cancer.

 

It was also found that giving Green Tea Polyphenols to a mouse who

already had established prostate cancer caused significant tumor

regression. The study was performed at the University of Wisconsin-

Madison, and is published in the journal Carcinogenesis.

Jerome Mittelman, DDS, FAPM

jmittelman

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