A Cardiologist Looks at CoQ10

[Guest guest]

A Cardiologist Looks at CoQ10

http://www.spacedoc.net/cardiologist_CoQ10.html

 

Dr. Peter Langsjoen, a leading cardiologist in the use of CoQ10 in the

treatment of heart problems in the United States, owns one of three specialized

machines in the world for measuring this vitamin-like substance.

 

Langsjoen, board certified in internal medicine and cardiovascular diseases,

says coenzyme Q10 is a vitamin-like substance produced in adequate amounts in

young people but produced much less in older folks.

 

The University of Texas at Austin 1975 graduate in chemistry with honors,

also says coenzyme Q10 is essential for the production of energy in all cells,

" and because the heart muscle uses more energy than any other type of tissue it

requires a huge amount of coenzyme Q10 for normal function. "

 

Other important roles for CoQ10 are for cell wall integrity and

anti-oxidation. When the synthesis of CoQ10 is reduced for any reason the side

effects on

the body are profound. Impairment of cell membranes from CoQ10 lack plays a

major role in hepatitis, myopathy, neuropathy and rhabdomyolysis.

 

Lack of effective anti-oxidation from CoQ10 lack exposes our mitochondria to

to the full effects of oxidation, contributing to a variety of mitochondrial

mutations. Interference with CoQ10’s vital role in energy production results

in

chronic fatigue and congestive heart failure.

 

With recent developments, resulting in a faster absorbing CoQ10, Langsjoen

started a clinical trial in 2005 for severe heart failure patients, seeing

dramatic results in the first volunteers. He said as Americans grow older, CoQ10

is

produced less by the body. " We have known since the 1970s that patients with

heart failure have low levels of coenzyme Q10 both in their blood and heart

muscle. We also have known that supplemental coenzyme Q10 improves heart muscle

function in patients with congestive heart failure, " he said.

 

" It is very important to point out that supplemental coenzyme Q10 will not

benefit heart muscle function unless the blood levels of CoQ10 are high enough

to enter into heart muscle and thereby improve its function. "

 

The implication here is that “token dosing†of CoQ10 rarely helps. The dose

must be therapeutic, a level that may vary from person to person.

 

Dr. Langsjoen’s father, Per H. Langsjoen, was a cardiologist who pioneered

clinical research with Co Q10 in the United States and performed the first human

double blind controlled heart failure study with CoQ10. He and his son

practiced and performed research trials together up until his father's death in

1993.

 

“We now have here at our office in Tyler an extremely accurate high pressure

liquid chromatography laboratory for measuring coenzyme Q10 in both blood and

heart muscle, " he said. " We are now able to very accurately measure the

quality of different coenzyme Q10 supplements and are able to much better treat

patients with congestive heart failure, " he added. Only two other laboratories

of

this type are in the world, one in Japan and the other in Italy.

 

Dr. Langsjoen has proved beyond a doubt both the close association of CoQ10

levels with congestive heart failure and the profound inhibition of blood CoQ10

level secondary to statin use. This effect is inevitable with statins because

they cause mevalonate inhibition, a pathway that serves not only cholesterol

synthesis but also that of CoQ10, dolichols and other substances vital to the

body.

 

In other countries, including Canada, CoQ10 supplementation is strongly

recommended when statins are used but not in the U.S

 

Duane Graveline MD MPH

Former USAF Flight Surgeon

Former NASA Astronaut

Retired Family Doctor

 

 

 

 

 

[Guest guest]

Once more, we have a directive that when taking Q10 to aid the heart, only

levels high enough for it to enter the heart, must be achieved if the heart is

to be helped. But we're not told what this dose range is? I understand that we

can't pinpoint an amount. But there is certainly a range, and the range must be

finite. The piece may as well not have been written, if we're not told the dose

levels that are required to create assistance to the heart muscle. Dr.

Langsjoen, tells us that Q10 has value. We already know that. What we don't

know is what is meant by " high enough " doses to do the job, and Dr. Langsjoen

dosen't tell us; at any rate, not in this piece, provided here.

jp

[Guest guest]

so if the heart requires a huge amount of CoQ10 for " normal "

function,

> and statin drugs deplete the body of 40% of CoQ10,

> any doctor prescribing statins without requiring a patient

> to take a large (expensive) quantity of CoQ10

> is basically killing you.

 

 

.

 

 

 

[Guest guest]

Although it is an individual thing it is generally accepted than 100mg of

CoQ10 or higher is needed for any effect.

 

Jane

[Guest guest]

100mg to 200mg per day is sufficient. However there are COQ10

formulations around that are synthetic and not very bioavailable so less

effective if at all. Try and get the liquid nanodispersion which

clinical trials have shown to be the most bioavailable COQ10. We supply

it if you have problems finding it.

[Guest guest]

Generally speaking the lowest beneficial level of intake of CoQ10 is 30mg/day

but 100mg/day is generally reckoned to be a good level - and 400mg/day along

with a range of other vitamins and minerals - known as the Stockholm protocol -

has been shown to be curative in one study on breast cancer patients.

 

Jonathan

 

John Polifronio <counterpnt wrote:

Once more, we have a directive that when taking Q10 to aid the heart,

only levels high enough for it to enter the heart, must be achieved if the heart

is to be helped. But we're not told what this dose range is?

 

 

 

Jonathan Chamberlain

 

www.fightingcancer.com

[Guest guest]

I suffer edema without it.

Takes 300mg a day for me.

 

Kirk

 

jonathan chamberlain <jonomark33 wrote:

Generally speaking the lowest beneficial level of intake of CoQ10 is 30mg/day

but 100mg/day is generally reckoned to be a good level - and 400mg/day along

with a range of other vitamins and minerals - known as the Stockholm protocol -

has been shown to be curative in one study on breast cancer patients.

 

Jonathan

 

John Polifronio wrote:

Once more, we have a directive that when taking Q10 to aid the heart, only

levels high enough for it to enter the heart, must be achieved if the heart is

to be helped. But we're not told what this dose range is?

 

Jonathan Chamberlain

 

www.fightingcancer.com

[Guest guest]

, " John Polifronio "

<counterpnt wrote:

>

> Once more, we have a directive that when taking Q10 to aid the

heart, only levels high enough for it to enter the heart, must be

achieved if the heart is to be helped. But we're not told what this

dose range is? I understand that we can't pinpoint an amount. But

there is certainly a range, and the range must be finite. The piece

may as well not have been written, if we're not told the dose levels

that are required to create assistance to the heart muscle. Dr.

Langsjoen, tells us that Q10 has value. We already know that. What

we don't know is what is meant by " high enough " doses to do the job,

and Dr. Langsjoen dosen't tell us; at any rate, not in this

pieceprovided here.

> jp

>

 

Based on bioavailability studies, the best preparations appear to be

soft-gelatin capsules that contain CoQ10 in an oil base or in a

soluble form.In order to further enhance absorption, CoQ10 should be

taken with food also.

 

While the usual dosage recommendation for CoQ10 is 50 to 150 mg/day,

there are a lot of variables to consider when trying to determine

whether this amount is really ideal.

First of all, it appears that the ultimate judge of whether CoQ10 is

going to be effective is whether or not CoQ10 blood levels rise

above2.5 mcg/ml and are maintained at this level for a prolonged

period.

 

Since the normal 'blood level' for CoQ10 is roughly 1 mcg/ml, it is

often rather difficult to achieve this therapeutic blood level

especially if

using poorly absorbed forms of CoQ10.

 

Here are my recommendations for getting the most out of CoQ10.

 

Use a loading dosage of four capsules with a meal. This loading

dosage will provide 200 mg CoQ10 and 1600 IU vitamin E. I would

recommend that it be in a soft gelatin capsule and that you take 300

mg of CoQ10 as a loading dosage and be sure that the meal includes

at least one

tablespoon of oil ( olive oil, flaxseed oil, etc.).

 

After the loading dosage, I would recommend taking two

capsules for one week followed by a maintenance dosage of one

capsuledaily thereafter for people weighing up to 250 pounds; and

two capsules per day for people over 250 pounds.

 

In order to enhance the absorption and utilization of CoQ10,some

manufacturers dissolve CoQ10 in its purest form- natural vitamin E

(Vitamin E; 100% natural d-alpha tocopheryl acetate).The result is

that the CoQ10 is biologically enhanced due to

increased absorption, utilization, and function.

 

By providing the CoQ10 dissolved in the vitamin E, absorption is not

only enhanced, but also the likelihood that the CoQ10 will remain in

its " active " form.CoQ10 is present in the blood in both oxidized

(inactive) and reduced(active) form.

 

During times of increased oxidative stress or low vitamin E levels,

more CoQ10 will be converted to its oxidized (inactive form).

Thus, by providing high levels of pure vitamin E the biological

activity and function of CoQ10 is enhanced.In addition, the CoQ10

actually " enhances " vitamin E activity as

well.

 

Warm regards,

JoAnn

[Guest guest]

Please let me know where I can obtain the " liquid nanodispersion " Q10 you speak

of, including doses and prices.

thank you

john poilfronio