Statins & Glyconutrients

[Guest guest]

Statins & Glyconutrients

http://www.spacedoc.net/statins_glyconutrients.html

 

For the past five years I have been talking about the importance of the

mevalonate pathway and the inevitable problems to come from inhibition of this

vital biochemical complex especially at its very beginning.

 

Think of the mevalonate pathway as a tree with multiple branches and then

think of the effect of our statins drugs as “girding†this tree at the base,

in

our misguided efforts to block cholesterol.

 

Our pharmaceutical industry threw caution to the wind 15 years ago when our

national priority to lower cholesterol so fogged our minds that we (medical,

pharmaceutical and the food industry) focused just on the cholesterol branch of

the mevalonate pathway and completely disregarded the important consequences

of collateral damage to the other main branches of our tree from our statin

drugs.

 

The predictable result of all this has been our bizarre spectrum of statin

associated side effects ranging from cognitive, to myotoxic, neurotoxic,

neurodegenerative and even behavioral.

 

When our powerful statins cut our cholesterol 50%, our CoQ10 is also likely

to be cut a similar amount and therein lay the problem, for CoQ10 has vital

roles in energy production, cell wall integrity and mitochondrial

anti-oxidation,

all of which leads to the enormous variety of symptoms and problems we now

are seeing.

 

And what about another major branch of the mevalonate tree, that of dolichol?

Recently I have learned much about the vital role of dolichols and it is time

to share it with you. I have been talking of the consequences of statin

associated dolichol inhibition for years now, calling attention to the

importance

of this substance in neuropeptide formation and our feelings of thought,

sensation and emotion. More recently, I have pointed at dolichol inhibition as a

possible cause of our statin associated behavioral side effects, such as

irritability, hostility and depression, while wondering how, with so few

proteins,

such amazing subtlety of emotion could be created.

 

Now, however, I have learned that along with peptide assembly within the

endoplasmic reticulum of every cell is the process of sacharride attachment. It

is

here in the heart of every cell that our sacharrides (sugars) are attached to

proteins to give a far broader range of diversity and information transfer

than protein alone. This process is called glycosylation and it demands a ready

supply of dolichol.

 

No longer do we consider our sugars as just simple fuel. The effects of these

eight vital sugars on the resulting peptide structure being created in the

endoplasmic reticulum and companion piece, the Golgi apparatus, is just short of

miraculous. And this attachment of sugars, this glycosylation, is completely

dependent on dolichol’s orchestration. Throw in a statin and what do you have

–

an inevitable inhibition of dolichol (roughly comparable to the degree of

cholesterol inhibition). The resulting effect upon our body of this dolichol

theft is completely unpredictable for this is at the very center of cell

communication and immunodefense.

 

Dolichols may well be fully as important as CoQ10 in this unfortunate game of

statin roulette that Big Pharma has placed us in. Statin damage is often

additive to pre-existing impairment of glycolysis from aging, disease and poor

nutrition. Glyconutrients, now increasingly available as a source of these vital

sugars, may offer hope to thousands of statin damaged victims to help the body

repair the effects of impaired glycolysis. It is much too early to talk of

proof of effect for studies are only now in the planning stage. However, based

upon my six years of research, I have an intuitive feeling of success and

anxiously look forward to the results.

 

Duane Graveline MD MPH

Former USAF Flight Surgeon

Former NASA Astronaut

Retired Family Doctor

 

 

 

 

 

[Guest guest]

Bottom line, which I find missing in ALL of Dr. Graveline's

articles,

> is that all physicians (including himself) should stop

administering

> statin drugs since they are so damaging to the body.

> Josephine

>