Grape seed proanthocyanidin extract demonstrates better antioxidant acti

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Grape seed proanthocyanidin extract demonstrates better antioxidant

activity JoAnn Guest

Apr 06, 2007 14:10 PDT

 

Grape seed proanthocyanidin extract demonstrates better antioxidant

activity than other free radical scavengers

 

http://www.herbs.org/current/grapeproanth.html

 

Proanthocyanidins are naturally occurring polyphenolic bioflavonoids

in

many fruits and vegetables. They have been reported to have

antiviral,

antibacterial, anti-inflammatory and antiallergic activities. These

compounds may also protect against oxidative damage of tissue by

free

radicals. One source of these antioxidants is grape seed

proanthocyanidin extract (GSPE). In this laboratory study, GSPE

demonstrated significant antioxidant activity in liver and brain

tissue,

compared to controls. GSPE was shown to decrease chemically-induced

DNA

damage, lipid peroxidation, and production of oxygen free radicals.

It

also provided better protection against oxidative damage than the

same

doses of other antioxidants, including vitamin C, vitamin E

succinate,

and b-carotene. From the results of these in vivo studies, GSPE

appears

to be better at scavenging free radicals and preventing oxidative

damage

to brain and liver tissue than other antioxidants. Results also show

that GSPE is available to target tissues and, therefore, can be

useful

in vivo in inhibiting oxidative damage to brain and liver tissue.

 

 

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Bagchi D, Garg D, Krohn R, et al. Protective effects of grape seed

proanthocyanidins and selected antioxidants against TPA-induced

hepatic

and brain lipid peroxidation and DNA fragmentation, and peritoneal

macrophage activation in mice. Gen Pharmac 1998; 30(5):771-776.

 

 

JoAnn Guest

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www.geocities.com/mrsjoguest/Diets