Fwd: [Biofuel] 90-day GM maize rat feeding study now available as PDF

[Guest guest]

Keith Addison <keith wrote:

" Substantial equivalence " , hm.

 

Compliments of Thomas Wittman of GE_NEWS.

 

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http://www.springerlink.com/content/02648wu132m07804/

New Analysis of a Rat Feeding Study with a Genetically Modified Maize

Reveals Signs of Hepatorenal Toxicity

Journal Archives of Environmental Contamination and Toxicology

Publisher Springer New York

ISSN 0090-4341 (Print) 1432-0703 (Online)

DOI 10.1007/s00244-006-0149-5

SpringerLink Date Wednesday, March 14, 2007

 

Gilles-Eric Seralini1, 2 , Dominique Cellier1, 3 and Joel Spiroux de Vendomois1

 

(1) Committee for Independent Information and Research on Genetic

Engineering CRIIGEN, Paris, France

(2) Laboratory of Biochemistry, Institute of Biology, University of

Caen, Caen, France

(3) Laboratory LITIS, University of Rouen, Mont-Saint-Aignan, France

 

Received: 18 July 2006 Accepted: 20 November 2006 Published online:

13 March 2007

 

Abstract: Health risk assessment of genetically modified organisms

(GMOs) cultivated for food or feed is under debate throughout the

world, and very little data have been published on mid- or long-term

toxicological studies with mammals. One of these studies performed

under the responsibility of Monsanto Company with a transgenic corn

MON863 has been subjected to questions from regulatory reviewers in

Europe, where it was finally approved in 2005. This necessitated a

new assessment of kidney pathological findings, and the results

remained controversial. An Appeal Court action in Germany (Munster)

allowed public access in June 2005 to all the crude data from this

90-day rat-feeding study. We independently re-analyzed these data.

Appropriate statistics were added, such as a multivariate analysis of

the growth curves, and for biochemical parameters comparisons between

GMO-treated rats and the controls fed with an equivalent normal diet,

and separately with six reference diets with different compositions.

We observed that after the consumption of MON863, rats showed slight

but dose-related significant variations in growth for both sexes,

resulting in 3.3% decrease in weight for males and 3.7% increase for

females. Chemistry measurements reveal signs of hepatorenal toxicity,

marked also by differential sensitivities in males and females.

Triglycerides increased by 24.0% in females (either at week 14, dose

11% or at week 5, dose 33%, respectively); urine phosphorus and

sodium excretions diminished in males by 31.5% (week 14, dose 33%)

for the most important results significantly linked to the treatment

in comparison to seven diets tested. Longer experiments are essential

in order to indicate the real nature and extent of the possible

pathology; with the present data it cannot be concluded that GM corn

MON863 is a safe product.

 

Gilles-Eric Seralini

Email: criigen

 

 

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