Mineral Water as a Source of Dietary Calcium: Acute Effects on Parathyroid func

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Mineral Water as a Source of Dietary Calcium: Acute Effects on

Parathyroid function and Bone Resorption

JoAnn Guest

Jan 18, 2007 08:18 PST

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Mineral Water as a Source of Dietary Calcium: Acute Effects on

Parathyroid Function and Bone Resorption in Young Men

 

Author:

 

Guillemant J, Le H-T, Accarie C, Tézenas du Montcel S, Delabroise A-

M,

Arnaud MJ, Guillemant S

 

Source:

 

Am J Clin Nutr. 2000;71:999-1002.

http://www.enzy.com/abstracts/display.asp?id=1897

Abstract:

 

BACKGROUND: Calcium is a major component of mineralized tissues and

is

required for normal growth and maintenance of bone. Epidemiologic

studies showed that a large percentage of the population fails to

meet

the currently recommended guidelines for optimal calcium intake.

 

OBJECTIVE: The present study was designed to determine whether

high-calcium mineral water is an efficient additional source of

dietary

calcium.

 

 

DESIGN: Twelve healthy young men (mean ± SD age: 21.1 ± 1.2 y)

ingested

in a randomized order either 0.5 L of a mineral water containing 344

mg

Ca/L or 0.5 L of a mineral water with a very low concentration of

calcium (< 10 mg/L) as a control. Blood samples were drawn before

and 1,

2, 3, and 4 h after intake of the water. Urine was collected for 2 h

before and every 2 h for 4 h after ingestion of the water. Serum

concentrations of intact parathyroid hormone (iPTH) and serum

concentrations and urinary excretion of a recently developed

biochemical

marker of bone resorption, type 1 collagen cross-linked C-

telopeptide

(CTx), were measured.

 

 

RESULTS: Serum iPTH was significantly (P < 0.002) lower after

ingestion

of high-calcium water than after ingestion of the control. There was

a

significant (P = 0.01) progressive decrease in urinary CTx after

ingestion of the high-calcium water, whereas after ingestion of

low-calcium water the changes were modest and not significant. The

fall

in serum CTx concentrations was 34.7% 3 h after ingestion of

high-calcium water, compared with 17.6% with the control. The

decreases

in serum CTx concentrations were significantly (P < 0.05) lower 1,

2, 3,

and 4 h after ingestion of high-calcium water than after ingestion

of

the control.

 

 

CONCLUSION: The present study showed that one oral intake of water

containing a very moderate dose of calcium (172 mg) acutely

inhibited

iPTH secretion and bone resorption.

 

 

 

JoAnn Guest

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