A Case-Control Study of Gastric Cancer and Diet in Italy

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A Case-Control Study of Gastric Cancer and Diet in Italy

JoAnn Guest

Jan 07, 2007 09:42 PST

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A Case-Control Study of Gastric Cancer and Diet in Italy

http://www.enzy.com/abstracts/display.asp?id=454

 

Author:

 

Buiatti E, Palli D, Decarli A, Amadori D, Avellini C, Bianchi S,

Biserni

R, Cipriani F, Cocco P, Giacosa A, Marubini E, Puntoni R, Vindigni

C,

Fraumeni Jr J, Blot W

 

Source:

 

Int. J. Cancer. 1989; 44:611-616.

 

Abstract:

 

A case-study was conducted in high- and low-risk areas of Italy to

evaluate reasons for the striking geographic variation in gastric

cancer (GC) mortality within the country. Personal interviews with 1,016

histologically confirmed GC cases and 1,159 population controls of similar age

and sex revealed that the patients were more often of lower social class and

resident in rural areas and more frequently reported a familial history of

gastric (but not other) cancer.

 

After adusting for these effects, case-control differences were found for

several dietary variables, assessed by asking about the usual frequency of

consumption of 146 food items and beverages.

 

A significant trend of increasing GC risk was found with increasing consumption

of traditional soups, meat and a combination of cold cuts and seasoned cheeses.

 

The habit of adding salt and the preference for salty foods were

associated with elevated GC risk, while more frequently storing

foods in the refrigerator, the availability of a freezer and use of frozen foods

lowered risk.

 

Reduced GC risk associated with increasing intake of

raw vegetables, fresh fruit and citrus fruits. Lowered risk was also related to

consumption of spices, olive oil and garlic.

 

Neither cigarette

smoking nor alcoholic beverage drinking were significantly related

to GC risk. The case-control differences tended to be consistent across

geographic areas, despite marked regional variations in intake levels of certain

foods.

 

The high-risk areas tended to show higher consumption

of food associated with elevated risk (traditional soups, cold cuts)

and lower consumption of foods associated with reduced risks (raw

vegetables, citrus fruits, garlic).

 

Our findings indicate that dietary

factors contribute to the regional variation of stomach cancer

occurrence in Italy, and offer clues for further etiologic and

prevention research.

 

 

JoAnn Guest

mrsjo-

www.geocities.com/mrsjoguest/Diets