Endogenous retroviruses as potential hazards for vaccines.

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Endogenous retroviruses as potential hazards for vaccines.

_Biologicals._ (javascript:AL_get(this,%20'jour',%20'Biologicals.') 2010

Apr 7. [Epub ahead of print]

 

Endogenous retroviruses as potential hazards for vaccines.

_Miyazawa T_

(http://www.ncbi.nlm.nih.gov/pubmed?term= " Miyazawa%20T " [Author]) .

Laboratory of Signal Transduction, Department of Cell Biology, Institute

for Virus Research, Kyoto University, 53 Shogoin-Kawaracho, Sakyo-ku, Kyoto

606-8507, Japan.

 

Abstract

Retroviruses are classified as exogenous or endogenous according to their

mode of transmission. Generally, endogenous retroviruses (ERVs) are not

pathogenic in their original hosts; however, some ERVs induce diseases. In

humans, a novel gammaretrovirus was discovered in patients with prostate

cancer or chronic fatigue syndrome. This virus was closely related to

xenotropic

murine leukemia virus (X-MLV) and designated as xenotropic murine leukemia

virus-related virus (XMRV). The origin and transmission route of XMRV are

still unknown at present; however, XMRV may be derived from ERVs of rodents

because X-MLVs are ERVs of inbred and wild mice. Many live attenuated

vaccines for animals are manufactured by using cell lines from animals, which

are known to produce infectious ERVs; however, the risks of infection by

ERVs from xenospecies through vaccination have been ignored. This brief review

gives an overview of ERVs in cats, the potential risks of ERV infection by

vaccination, the biological characteristics of RD-114 virus (a feline

ERV), which possibly contaminates vaccines for companion animals, and the

methods for detection of infectious RD-114 virus. 2010 The

International Association for Biologicals. Published by Elsevier Ltd. All

rights

reserved.

PMID: 20378372 [PubMed - as supplied by publisher]