Inhibitory effects of (-)-Epigallocatechin-3-gallate from green tea on the,growt

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Inhibitory effects of (-)-Epigallocatechin-3-gallate

from green tea on the,growth of Babesia parasites.

 

Parasitology. 2009 Dec 22;:1-7 [Epub ahead of print]

 

Inhibitory effects of (-)-Epigallocatechin-3-gallate from green

tea on the growth of Babesia parasites.

 

Aboulaila M, Yokoyama N, Igarashi I.

 

National Research Center for Protozoan Diseases, Obihiro

University of Agriculture and Veterinary Medicine, Inada-Cho,

Obihiro, Hokkaido 080-8555, Japan.

 

SUMMARY(-)-Epigallocatechin-3-gallate (EGCG) is the major tea

catechin and accounts for 50-80% of the total catechin in green

tea.

(-)-Epigallocatechin-3-gallate has antioxidant,

anti-inflammatory, anti-microbial, anti-cancer, and

anti-trypanocidal activities. This report describes the

inhibitory effect of (-)-Epigallocatechin-3-gallate on the in

vitro growth of bovine Babesia parasites and the in vivo growth

of the mouse-adapted rodent babesia B. microti. The in vitro

growth of the Babesia species was significantly (P<0.05)

inhibited in the presence of micromolar concentrations of EGCG

(IC50 values=18 and 25 muM for B. bovis, and B. bigemina,

respectively). The parasites showed no re-growth at 25 muM for B.

bovis and B.

bigemina in the subsequent viability test. The drug significantly

(P<0.05) inhibited the growth of B. microti at doses of 5 and 10

mg/kg body weight, and the parasites completely cleared on day 14

and 16 post-inoculation in the 5 and 10 mg/kg treated groups,

respectively.

 

These findings highlight the potentiality of

(-)-Epigallocatechin-3-gallate as a chemotherapeutic drug for the

treatment of babesiosis.

 

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PMID: 20025823 [PubMed - as supplied by publisher]