Comprehensive, Randomized Double Blind Study -Oats Safe for Celiacs

[Guest guest]

Comprehensive, Randomized Double Blind Study Finds Oats Safe for

Children with Celiac Disease

 

 

Gut. 2004 May;53(5):649-654

 

A multi-center Swedish study involving eight separate pediatric

clinics looked at 116 children with newly diagnosed celiac disease.

The group

was randomized into two groups, and one group was given a standard

gluten-free

diet, while the other was given a standard gluten-free diet that

also included

oats.

 

The study period was one year, small bowel biopsies were performed

at the

beginning and end of the study, and serum IgA antigliadin,

antiendomysium, and

antitissue transglutaminase antibodies were monitored at 0, 3, 6,

and 12 months.

The median

intake of oats for the oat-eating group was 15g per day.

 

By the end of the study all patients were in clinical remission for

celiac disease. Neither group differed significantly from one

another with regard to serology markers or small bowel mucosal

architecture

(including numbers of intraepithelial lymphocytes). Out of the

original 116 children 93 finished the study, and significantly more

younger

patients withdrew from it than older patients.

 

The researchers conclude:

 

" This is the first randomized double blind study showing that the

addition of moderate amounts of oats to a gluten-free diet does not

prevent clinical or small bowel mucosal healing, or humoral

immunological downregulation in coeliac children.

 

This is in accordance with the findings of studies in adult coeliacs

and indicates that oats, added to the otherwise gluten-free diet,

can be accepted and tolerated by the majority of children with

celiac disease. "

 

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Posted: Wed Sep 28, 2005 5:19 pm

-

Joseph Murray's Lecture at the September 5-7, 1996 Conference in

Tampere, Finland

 

 

From an oral report by Dr. Murray; transcribed for the list by Ann

Whelan, editor of the bi-monthly newsletter " Gluten-Free Living " . To

, write to P.O. Box 105, Hastings-on-Hudson, NY 10706. Dr.

Joseph Murray, one of the leading USA physicians in the diagnosis of

celiac disease (CD) and dermatitis herpetiformis (DH).

 

Dr. Murray (murray.-) of the Mayo Clinic Rochester, MN,

is a gastroenterologist who specializes in treating Celiac disease:

THE DAILY REPORT:

 

The big story today from Finland is oats. There were two talks and

several

posters presented about the topic.

 

In the first talk, Dr. Risto Julkunen spoke about the Finnish five-

year follow-up study in which oats were given to a population of

well-controlled celiacs. They ingested an average of 34 grams, which

is slightly over one ounce, daily for up to five years.

 

The oats used in the study were specially grown and tested to be

free of wheat, barley and rye. The researchers claim there was no

difference in

those allowed the oats and those who were not.

 

There was a second study presented from Dublin, and reported by Dr.

Conleth Feighery. This 12-week study looked at a small group of

patients with healed CD to start with, who were given 50 grams of

oats a day.

 

Again, the oats were carefully screened and tested to make sure

there was no contamination.

 

After 12 weeks, no effect was seen on biopsy or through antibody

tests.

The researchers also took 2 of the 12 participants and did what they

called a " micro challenge " of 500 milligrams of gluten a day. Both

patients got reactions, so the researchers felt that at least two of

the participants were sensitive celiacs -- and they still did not

respond to the oats.

 

A poster from Italy showed biopsies taken from celiacs that had been

studied in the culture plate in the presence of oats, which did show

some effect on the biopsies. In other words, tissue from biopsies

from patients with treated CD were put in a plate and grown in the

presence of oat protein, and the oat protein had an effect on the

biopsies.

 

This sounded odd, so I made sure I'd really understood what Joe

reported and paraphrased:

 

In other words, they're seeing no reaction from

oats within the body in some studies but this one showed a reaction

outside the body?

" Yes, " Joe said, " this of course is puzzling. "

 

Continuing on the oats issue, a series of short studies from several

places also showed what the Finns had shown in the body, i.e., no

problem in the short term.

 

Dr. Murray's summary on Oats:

 

Over the short term, in well-controlled, healed celiacs who are

compliant in every other way, it may be safe for them to take oats

that have been tested to be free of contamination of other grains.

 

He also mentioned that there were studies showing that contamination

of

commercial oats may be common in several European countries.

 

 

---

Oats Safe For Gluten Intolerant

---

 

NEW YORK (Reuters) -- People who unable to digest gluten must

strictly avoid foods that contain the protein, including wheat, rye,

and barley.

 

 

Now a new study suggests that they may be able to safely eat another

type of grain -- oats. Past studies had suggested that oats could be

toxic to such patients and they were told to avoid them, according

to the report in the December 25 issue of The New England Journal of

Medicine.

 

The inability to digest gluten is known as celiac disease, an inborn

disorder that causes abdominal distention, vomiting, diarrhea,

muscle wasting, and lethargy. Patients can also develop dermatitis

herpetiformis -- blister-like lesions on the elbows, buttocks and

knees.

 

The only treatment is strict avoidance of certain foods.

 

" It takes an average of two years after gluten is withdrawn from the

diet before the rash is completely controlled, although the rash

invariably recurs within 12 weeks after the reintroduction of

gluten, " reported senior investigator Dr. Lionel Fry, of St. Mary's

Hospital

in London, England.

 

The new study included 10 men and women who had been on a strict

gluten-free diet for an average of 16 years. For 12 weeks, the

patients ate a moderate amount of oats -- an average of 63 grams per

day --that

were not contaminated with any other type of grain.

 

None of the patients had any adverse effects, according to blood

tests, as well as intestinal and skin biopsies. They also did not

develop a rash

or gastrointestinal problems.

 

" We found that the ingestion of moderate amounts of oats had no

deleterious effects on the skin or intestine of patients with

dermatitis herpetiformis, " the authors wrote. Oats may have appeared

to be toxic

in the past because they may have been contaminated with other

grains.

 

" Conventional oats are frequently contaminated with wheat during

growth (by crop rotation) or the milling process, and it is

important that oats

supplied to patients be free of such contamination, " they concluded.

 

SOURCE: The New England Journal of Medicine (1997;337:1884-1887)

 

JoAnn Guest

mrsjo-

www.geocities.com/mrsjoguest/Diets

[Guest guest]

Oats contain a lot of carbohydrate, which feed bowel

dysbiosis/pathogenic organisms and they use it faster than probiotic

organisms do.

 

So, although the oats may be safe for celiacs, every parent should be

aware that candida is fed by it; candida presents a similar molecule,

resulting in the same reaction.

 

In other words candida aggravates and mimics symptoms of gluten

intolerance, and it's fed by carbs. This is of particular importance

in children and adults who wish to prevent the outcome of colitis,

Crohn's and surgery.

 

Anyone on a relatively high carbohydrate diet should ensure they get

enough inulin in their diet to feed the control mechanism, represented

by the natural probiotic organisms in the intestine and colon. Not by

eating probiotics either, by feeding the existing culture.

 

For more information on probiotic and prebiotics, join the candidiasis

, (NOT the candidasupport group, which suffers from serious

dogma issues due to moderator Bee Wilder's adherence to minimizing

probiotic fermentation in the gut).

 

Duncan Crow