Pantethine and reducing cholesterol

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Pantethine

 

Pantethine is a form of pantothenic acid (vitamin B5)

that has been shown to lower cholesterol.

Specifically, it reduces levels of LDL and total

cholesterol, raises HDL, and is the most effective

supplement for lowering triglyceride levels.

Pantethine works by improving fat metabolism and by

slowing down production of cholesterol in the liver.

 

Pantethine is often recommended for diabetics.

 

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Pantethine and pantothenic acid, 400 to 900 mg each

per day. The use of pantethine to reduce total

cholesterol, LDL cholesterol, and triglyceride level,

while raising the good HDL cholesterol at the same

time, is well documented. Bertolini et al treated a

series of 65 adults suffering from

hypercholesterolemia alone or associated with

hypertriglyceridemia (types IIa and IIb of

Fredrickson's classification). Pantethine 1200 mg

daily for adults was used for 3 years. In adult

population with type IIa hyperlipoproteinemia, the

study showed a 25% decrease in total cholesterol, a

39% decrease in LDL-cholesterol, a 34% decrease in

Apo-B, and a modest increase in HDL-cholesterol were

observed. In adult patients with type IIb

hyperlipoproteinemia, total cholesterol was reduced by

19.8%, LDL-cholesterol by 37%, triglycerides by 31%,

and Apo-B by 6%. In this subgroup, a 23% increase of

HDL-cholesterol and a 15% increase in apolipoprotein

A-I were also observed. In another double-blind

placebo-controlled study, 29 people with high

cholesterol and triglycerides were followed for 8

weeks. The dosage used was 300 mg 3 times daily, for a

total daily dose of 900 mg. In this study, subjects

taking pantethine experienced a 30% reduction in blood

triglycerides, a 13.5% reduction in LDL ( " bad " )

cholesterol, and a 10% rise in HDL ( " good " )

cholesterol. Typically, a daily dose of 900 mg

pantethine has been shown to reduce triglyceride by

20-30%, total cholesterol by 10-20%, LDL cholesterol

by 10-20%, and a rise in HDL cholesterol by 10-20% in

many studies.

 

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Pantothenic acid supplementation has been proven

effective in addressing hyperlipidemia, as its

derivatives— including pantethine—lowered total

cholesterol and triglycerides in obese mice, 141 and

600 mg/d of pantethine severely reduced fatty liver in

16 hypertriglyceridemic patients.142 A University of

Minnesota trial further showed 600 mg/d to 900 mg/d of

pantethine (as Pantesin®, from Daiichi Pharmaceutical)

improved levels of LDL, VLDL and triglycerides and

increased HDL.143

 

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