Guest guest Posted June 26, 2006 Report Share Posted June 26, 2006 Zinaxin - promoting joint health with complete safety. JoAnn Guest Jun 25, 2006 19:09 PDT Zinaxin - promoting joint health with complete safety. What is Zinaxin? Centuries ago the Chinese discovered a natural remedy for relieving joint discomfort without any of the dangerous side effects of modern anti-inflammatory drugs like Celebrex and Ibuprofen. Today that ancient remedy has arrived in the U.S. in the form of an all-natural dietary supplement, Zinaxin™. Zinaxin™ is based on extracts of a rare, bitter ginger root harvested at only certain times of the year in a remote region of China. Rigorously tested around the world, Zinaxin™ has been the subject of three clinical trials and massive scientific testing abroad involving over a thousand subjects, all of which " have confirmed that those Chinese ancestors were right, " said Zinaxin's inventor Dr. Morton Weidner, a Danish biochemist with a Ph.D. in pharmacology and a chemical engineer. Zinaxin™, which contains the same ginger extracts that the ancient Chinese found effective, has been shown in all the studies to help in promoting joint health with complete safety. Now all Americans can discover what hundreds of thousands of people around the world have discovered, from ordinary people in Australia and Europe to Olympic champions like Carl Lewis, a strong believer in Zinaxin™'s effectiveness. Contrary to popular belief, Dr. John Taylor, noted rheumatologist and arthritis expert affiliated with the Cleveland Clinic believes that unhealthy joints are more than just a problem linked with aging. " Joint health is a problem that affects more than 80 million people a year in the U.S., including a large percentage of young, active adults, " Taylor said. Dr. Taylor has used Zinaxin™ on more than 500 of his patients, with nearly 80 percent of them reporting significant improvement in their conditions. How can Ginger be of use to someone with serious arthritis pain? NSAIDs are a valuable treatment in many rheumatic disorders as well as growing in use for acute and non-inflammatory conditions due to their pain killing effect. However, prolonged use of NSAIDs does expose patients to unpleasant side effects. Many of the clinical effects of NSAIDs are a result of inhibition of pain promoting prostaglandins. However, NSAID-induced inhibition of GI mucosal PG synthesis is thought to be a major mechanism responsible for the GI toxicity of these therapeutic agents. Inflamations start when the immune cells start one or more of several cascade reactions that yield inflamatory mediators. Ginger inhibits, in part the 5-lipogenase enzyme and its inflammatory cascade reaction. Ginger also partly blocks the COX enzymes, but unlike the synthetic NSAIDS, ginger does not fully block COX-1 and does not create gastric bleeding or stomach upset. Ginger has been found to lessen stomach acid and to lessen ulcer form stomach irritants Studies have shown that Zinaxin does not cause gastric irritation. Furthermore, various studies indicate that Zinaxin has no irritant or ulcerogenic effects in-vivo. Ginger acts to maintain a healthy balance of inflammatory mediators Ginger (Zingiber officinale) is mostly known to us in the West as a spice and a flavor. In China, however, it has been used for thousands of years for medicinal purposes, such as nausea, stomachache, rheumatism and toothache. Modern research has found ginger to be a powerful anti-oxidant and to have strong anti- inflammatory effects. The pharmacologically active components of the ginger root are thought to be aromatic ketones known as gingerols. These have been shown in experimental studies to inhibit both the cyclooxygenase and lipoxygenase pathways and the production of prostaglandins, thromboxane and leukotrienes (Kiuchi F et al., 1992; Srivastava KC, 1986; Flynn DL et al., 1986), just as the NSAIDs do. No significant side effects have been reported. Ginger oil is obtained by steam distillation of dried ginger root. In an experimental study on rats (Sharma JN et al., 1997), arthritis was induced in the knee and paw by injection of bacilli, leading to inflammation. One group of rats was also given ginger oil by mouth for 28 days starting the day before the injection. The rats given ginger oil had less than half the knee and paw inflammation compared to the controls. Ginger reduces runaway inflammation through its antioxidant activity The oxidative " explosion " results in, amongst other things, free radicals which play a role in tissue destruction and the inflammatory process. Results show that Zinaxin apart from its pain relieving effect, also counteracts the aggravation caused by the oxidative burst. This oxidative explosion in granulocytes plays a role in the inflammatory process. The inhibitory effect of Zinaxin on the oxidative burst is much stronger than large doses of Ibuprofen which has no significant effect. Pharmacokinetic studies indicate that Zinaxin is absorbed much faster and reaches a higher level in the blood than control extracts. This higher level is maintained for a longer period of time (2.2 times higher absorption). STUDY CONFIRMS USE OF GINGER EXTRACT FOR ARTHRITIS OF THE KNEE 25 September 2002 A highly purified extract of ginger has been shown to reduce knee pain in patients with osteoarthritis in a US study. The ginger extract, which is available in Australia as Zinaxin JointCare, contains extract from 2 species of ginger which were selected for their anti-inflammatory properties after testing more than 100 varieties of ginger plants. http://www.mydr.com.au/default.asp?article=3788 The US study (Arthritis & Rheumatism 2001: 44: 2531-38) evaluated results from 247 patients with osteoarthritis of the knee who had moderate to severe pain. The study is one of the few published on the use of ginger in arthritis. Patients in the trial took one capsule of ginger complex in the morning and one in the evening. How effective was the ginger extract? After 6 weeks of treatment, a higher percentage of people (63 per cent) were classified as responders for improvement of knee pain on standing in the ginger extract group than in the group given placebo (dummy tablets). Pain on standing was the main variable used to measure efficacy in this study and is a standard measure of pain in medical studies. Pain on standing is measured using a visual scale. People are shown the scale and asked to mark the level of their pain on the scale. This difference between the ginger-treated group and the dummy tablet group was statistically significant, meaning that there was a low probability that the result occurred by chance. Is it safe? Ginger has been used for at least 2500 years in China, India and Tibet as an anti-inflammatory for arthritic pain apparently without cause for concern. The US Food and Drug Administration lists ginger as `generally regarded as safe'. In the US study the only significant difference in adverse events between the ginger-treated group and the group on dummy tablets was that gastrointestinal effects such as burping, bad taste in the mouth, stomach upset and heartburn were more common in the people taking the ginger complex. Warnings have been sounded about a possible effect of ginger on bleeding times and certainly some ginger products in Australia above a certain concentration have to carry a warning that people on blood- thinning medications, called anticoagulants, and people at risk of bleeding should talk to their doctor before taking them. Zinaxin JointCare does not carry such a warning. Biotechnology Zinaxin JointCare capsules use a unique biotechnology called LipoCap to protect and encapsulate the ginger complex so that it arrives intact in the bloodstream and can be delivered to the joints for maximum benefit. myDr, 2002 Reviewed : 28/4/2005 http://www.tqsi.com/pmasupport/pmatools/Zinaxin.pdf --- REVOLUTIONARY NEW TREATMENT FOR ARTHRITIS NOW AVAILABLE IN CANADA: CLINICAL TRIALS DEMONSTRATE GINGER EXTRACT COMBINATION COMBATS ARTHRITIS IN TWO OUT OF THREE PATIENTS May 24, 2002 From a press release TORONTO - A combination of ginger extracts has been proven highly effective in the treatment of arthritis. In a recent clinical trial conducted by the University of Miami, a natural ginger combination extract called Zinaxin® EV.EXT® 77 was shown to reduce osteoarthritis pain and stiffness in the knee joints of more than 65% of patients studied. This standardized combination extract has been widely used by arthritis patients around the world and is now available in Canada from Jamieson Laboratories under the Arthrimin brand. The double-blind, multi-centred, placebo-controlled trial was conducted by leading rheumatologist and professor, Dr. Roy D. Altman. The trial was designed to study the effectiveness and side effects of this standardized form of ginger. From the study, Dr. Altman concluded the ginger combination extract provided positive benefits without the harsh side effects of current prescription treatments for osteoarthritis. " I've been asked on several occasions whether I give Zinaxin to my patients. Certainly I do, " said Dr. Altman, Chief of Rheumatology at Miami University Hospital. " There is a safety edge involved with using ginger over a COX-2 drug. " In the clinical trial, Zinaxin® EV.EXT® 77 was evaluated on its own and not compared to prescription anti-inflammatories. However, following the study Dr. Altman undertook a comparison of the efficacy data from studies on COX-2 inhibitors versus Zinaxin® EV.EXT® 77, which demonstrated very similar results. " At the end of the six weeks, the benefit of the anti-inflammatory drug seemed to be identical with that of Zinaxin, " said Altman. There are some serious issues facing many of the four million Canadians suffering from arthritis, such as the high expense and harsh side effects from current prescription medications. The side effect profile of current treatments includes stomach bleeding, high blood pressure, increased risk of renal failure and increased risk of stroke. Zinaxin® EV.EXT® 77 was proven effective for the relief of arthritis symptoms without the serious side effects attributed to many currently available prescription products, such as COX-2 inhibitors. It is all naturaland available without a prescription. www.jamiesonvitamins.com. JoAnn Guest mrsjo- www.geocities.com/mrsjoguest/Diets Quote Link to comment Share on other sites More sharing options...
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