Guest guest Posted May 10, 2006 Report Share Posted May 10, 2006 Steve Martin, Ph D, is a California immunologist who runs www.grouppekurosawa.com. Those of us who have followed Steve would agree he is a first-rate scientist, with an open mind and big heart. HIV is his no. 1 priority, along with many other disease. Steve's latest Quote Folks, the following is a copy of an email sent to all the HIV Mice. Most of these people are not members of the DG. Lets hope this one finally works. NEW HIV THOUGHTS There is good news on the HIV front. I believe Adam, our first and only really successful Mouse, and I have finally figured out how and why his immune system returned to normal. Adam is the only HIV infected person in the world who has ever seen his immune system return to normal. The immune systems of people on HIV drugs are grossly defective. Adam's immune system is close to perfect and he never took an HIV drug. But he did take EGCG polyphenols. Unfortunately, other people who adopted similar protocols saw their CD4 T cell counts continue to decline over time. Clearly, something else was going on, but for the life of me I couldn't figure out what it was. We have tracked Adam's immune success to two factors. First, Adam used a 70% EGCG prep made by a company called Dr. Hoffmann's. This prep is NOT decaffeinated. According to Tom Lahey of Lutimax Nutraceuticals, decaffeination removes theanine as well as caffeine from the tea compounds. Thank God Tom knew this. Most other people have used a decaffeinated form of EGCG made by Food Science called Green Tea-70. This prep does not stimulate the immune system. Theanine is a natural amino acid found only in tea plants. Its breakdown product stimulates a population of gamma delta T cells that are now known to control virtually the entire immune system. The activation of these cells stimulates the release of massive amounts of anti-viral immune hormones such as TNF and gamma interferon. HIV infection causes a deficiency in this subpopulation of T cells while theanine activates these cells. So far, so good. However, these gamma delta cells must be mature in order to be activated by theanine products. The maturation process is induced by alpha or beta interferon. The alpha/beta interferon response against the HIV virus is well known to be grossly deficient. This means the maturation of these critical gamma delta T cells will remain defective. It also means that theanine, under these conditions, isn't going to do anything. Second, Adam used 800 mgs of ibuprofen daily for three months PRIOR to going on the EGCG. The use of high doses of ibuprofen was part of my original HIV protocol, long removed from the Web site. Ibuprofen blocks the Cox-2 enzyme which produces the prostaglandin PGE2. PGE2 stimulates cyclic AMP accumulation. Cyclic AMP is extremely immunosuppressive. Cyclic AMP inhibits the synthesis of IL-2, TNF, the zeta chain of the T cell receptor, AND the synthesis of both alpha and beta interferon. It also stimulates HIV synthesis. And this is just a short list. Since both the viral proteins p24 and gp120 stimulate PGE2 production, I used cheap ibuprofen to inhibit Cox-2 activity. I did not know that Adam was taking ibuprofen in large doses for three months prior to starting the EGCG protocol. One month after starting the EGCG, he had a blood test. It appeared that in a month's time, the EGCG and the melatonin he was also taking returned his immune system to almost normal status. I was ecstatic. Unfortunately, these results were never duplicated by anyone else. In three months time, Adam had stopped the progression of his disease and blocked the HIV induced immunosuppression by the use of ibuprofen. As the PGE2 induced cyclic AMP accumulation subsided, the immune system gained strength. Alpha and beta interferon, in the absence of cyclic AMP, were no doubt synthesized again, thereby blocking HIV synthesis and inducing the maturation of that critical population of gamma delta T cells. The theanine present in his EGCG prep further activated the immune response against the virus. Blocking cyclic AMP accumulation, either due to Cox-2 inhibition, or by the use of general beta1/beta2 anti-hypertensive drugs, is absolutely critical to block HIV induced immunosuppression. In Adam's case, psychological stress wasn't much of an issue. He is very religious, he has a great family and support group and he absolutely believed that I was going to cure his HIV. He is lucky. Psychological stress is well known to enhance HIV infections, and it does so by increasing the release of epinephrine and norepinephrine, cyclic AMP inducing hormones. Protocol. The current protocol is inexpensive and potentially VERY powerful. 1 gram of ibuprofen a day, 200 mgs 5 times a day. If you have stomach problems, take the OTC drug Prilosec with the ibuprofen. Prilosec is a proton pump inhibitor and it will prevent ibuprofen induced stomach ulceration. OR, take the generic prescription drug indomethasin. This is much more powerful than ibuprofen and is used to treat gout. Obviously, you need a doctor's prescription. It is cheap when purchased at Costco or Sams Clubs. If stress is an issue, I recommend, via my colleague Will LaValley, M.D., an old general beta1/beta2 blocker called pindolol. This drug ALSO blocks the synthesis of both epinephrine and norepinephrine. According to Will, it is prescribed off label as a treatment for anxiety. It is an inexpensive drug. 600 mgs of theanine a day. I recommend opening 3x 200 mgs caps and brewing a little theanine tea. Theanine is very water soluble and it tastes good. Make enough tea to last for the entire day. Take it to work in a glass bottle. Drink it constantly, a little at a time but not all at once. It will make you very sleepy if you take too much at once. Use more if you want. 400 mgs of CoQ10 in a gel cap, 200 mgs twice a day. CoQ10 increases the number of CD4 T cells in the body and it blocks the expression of the CR3 complement receptor. Activation of the CR3 receptor causes immunological tolerance which is known to exist in HIV infections. The last thing we need is for the immune system to ignore (to be tolerant to the presence of) the HIV virus. Melatonin 3-6 mgs at night. Melatonin is a known immune enhancer and it blocks excessive glucocorticoid (hydrocortisone) activity, which is also immunosuppressive. Lithium orotate is not necessary. Use glutamine and arginine as needed, but not in massive doses. Glutamate, a breakdown product of glutamine, is immunosuppressive. 6 grams of glutamine is fine unless your body is very depleted. Eat nuts to get your arginine. Anti-oxidants like alpha lipoic acid, n-acetylcysteine (NAC) and vitamin C are fine, but not in excessive doses. 400 mgs of ALA, 1 gram of NAC and 1 gram of vitamin C are fine. PLEASE keep me informed of any changes in your HIV status. It really infuriates me when people do not let me know how they are doing. Without feedback, I am just wasting my time working on these protocols. If you experience chills, fever and fatigue, it means the protocol is working. The immune system is becoming reactivated against the virus and it is releasing nasty fever causing immune hormones. Did you feel good when your immune system was trying to fight off the Flu virus? Pass this email along to everyone you know who has an HIV infection or who is interested in this disease. Start a viral email campaign. The technical details of the protocol will be spelled out in the New Blog. It should be up in a week. Get the word out and do it now. People do not have to die of this terrible viral infection. I would like to thank Adam and all the other HIV mice who had faith in me. I also want to thank our wonderful Webmaster, my sister, and my colleagues Will LaValley, M.D and Tom Lahey for their critical input. I would further like to thank all the good folks who paid for the scientific articles they sent me. Its difficult to start a scientific/medical revolution when you have no money. Let the revolution begin… God Bless Us One and All. Steve Martin End of quote Quote Link to comment Share on other sites More sharing options...
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