Antibiotics / Ear ringing / Nerve Damage

[Guest guest]

Great information. Thank-you for sharing that with us.

 

 

 

[Guest guest]

This is re tx for ear-ringing due to sp/kidney qi

vacuity and gallbladder heat. Trying to find a way to

communicate to an MD to please stop spuriously

prescribing antibiotics based on a five day old

positive test for bladder infection. The morning of

the test the patient had dark urine and no other s/s,

and previous days and following days she was back to

normal at clear urine, 4 x a day, medium volume.

Anybody have anything to add or comment on? Thanks!

ps - Frustrating to see how clearly antibiotics are

cold and serve to damage the ears (via the kidneys),

esp with long-term use. I've included a bit of

research a la Phil.

 

 

 

 

J Int Med Res. 2002 Jul-Aug;30(4):406-12.

 

Comparative cochlear toxicities of streptomycin,

gentamicin, amikacin and netilmicin in guinea-pigs.

 

Kalkandelen S, Selimoglu E, Erdogan F, Ucuncu H, Altas

E.

 

Department of Otolaryngology, Faculty of Medicine,

Erzurum, Turkey.

 

All the aminoglycoside antibiotics now in clinical use

are ototoxic. This study was designed to compare the

toxic effects of four aminoglycoside antibiotics,

streptomycin, gentamicin, amikacin and netilmicin,

administered to guinea-pigs systemically (at

respective doses of 125 mg/kg, 50 mg/kg, 150 mg/kg or

37.5 mg/kg, twice daily for 1 week) or topically via

the transtympanic route (0.25 ml/kg in 4% saline,

twice daily for 1 week). Chosen doses were 10-20 times

higher than the recommended human dosage. Cochlear

damage was observed in all animals that were given

systemic and local aminoglycosides. The severity of

the cochlear damage was in the order gentamicin,

amikacin, streptomycin, netilmicin, with gentamicin

being the most toxic. No statistically significant

difference between the severity of cochlear damage

resulting from the systemic and topical applications

was detected.

 

PMID: 12235923 [PubMed - indexed for MEDLINE]

 

 

 

 

 

Acta Otolaryngol. 2000 Aug;120(5):596-9. Related

Articles, Links

 

Topical aminoglycoside ototoxicity: attempting to

protect the cochlea.

 

Conlon BJ, Smith DW.

 

Hearing Research Laboratories, Division of

Otolaryngology-Head and Neck Surgery, Duke University

Medical Center, Durham, North Carolina, USA.

bconlon

 

Cochlear damage following topical application of

aminoglycoside antibiotics to the round window

membrane is a recognized phenomenon in both animal

experiments and clinical reports. The authors have

recently reported the ability of the free radical

scavenging agent, alpha lipoic acid, to protect

against the cochleo-toxic side effects of systemically

administered aminoglycoside antibiotics. This study

attempts to determine if the protective effect of this

free radical scavenging agent is also seen following

topical aminoglycoside application. Animals were

implanted with osmotic pumps which delivered 2.5

microl/h solution of either neomycin 5% or neomycin

plus alpha lipoic acid (50 mg/ml). Control animals

received normal saline solution. Drug solutions were

presented directly to the round window membrane over a

7-day period. Auditory sensitivity was monitored using

compound action potentials (CAPs) of the auditory

nerve recorded through an implanted chronic electrode

terminating at the round window. Sixteen animals were

entered into the study and randomized to one of the

above groups. All animals receiving neomycin solution,

with or without alpha lipoic acid, maintained normal

thresholds for the first 3 days of the treatment

period. Animals receiving neomycin solution alone

experienced profound and rapid deterioration in

auditory sensitivity, which was maximal by day 6.

Animals receiving neomycin plus alpha lipoic acid also

experienced significant cochlear damage; however, the

rate of deterioration was slower than that seen in the

group receiving neomycin alone. All control animals

receiving saline maintained good hearing thresholds

throughout the treatment period.

 

PMID: 11039868 [PubMed - indexed for MEDLINE]

 

 

 

 

 

Hear Res. 1998 Jan;115(1-2):217-23.

 

Loss of spiral ganglion cells as primary manifestation

of aminoglycoside ototoxicity.

 

Sone M, Schachern PA, Paparella MM.

 

Department of Otorhinolaryngology, Nagoya University

School of Medicine, Japan.

 

Although pulmonary infections caused by Pseudomonas

aeruginosa can hardly be eradicated in patients with

cystic fibrosis (CF, the most common genetic disease

among Caucasians), these patients are mainly treated

with intravenous and nebulized tobramycin. Long-term

treatment with tobramycin, however, may induce

ototoxic effects. We assessed the clinical histories

and postmortem temporal bones of six patients with CF

for signs of this ototoxicity. Four bones showed

typical manifestations of ototoxicity induced by

aminoglycosides (AGs): loss of hair cells in the lower

turns, and degeneration of ganglion cells. Six bones

revealed no loss or scattered loss of hair cells,

however, degeneration of the spiral ganglion cells was

observed. This suggests that degeneration of the

spiral ganglion may occur as a primary manifestation

in some cases of ototoxicity due to aminoglycosides.

Recent reports have shown that trophic factors

(neurotrophins and acidic fibroblast growth factor)

interacting with hair cells and the spiral ganglion

protect the inner ear from damage. It may be that

disturbances in supply of such trophic factors caused

degeneration of ganglion cells without loss of hair

cells in the cases we studied.

 

PMID: 9472750 [PubMed - indexed for MEDLINE]

 

 

 

 

 

 

 

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[Guest guest]

Hi Hugo & All,

 

If a specific antibiotic/other drug induces tinnitus, one might try oral

administration of an ISOPATHIC dilution of THAT specific agent.

 

In his book, Are Thoresen described some extraordinary results

with isopathy.

 

Hugo wrote:

> This is re tx for ear-ringing due to sp/kidney qi vacuity and

> gallbladder heat. Trying to find a way to communicate to an MD to

> please stop spuriously prescribing antibiotics based on a five day

> old positive test for bladder infection. The morning of the test

> the patient had dark urine and no other s/s, and previous days and

> following days she was back to normal at clear urine, 4 x a day,

> medium volume. Anybody have anything to add or comment on? Thanks!

> ps - Frustrating to see how clearly antibiotics are cold and serve

> to damage the ears (via the kidneys), esp with long-term use. I've

> included a bit of research a la Phil. : J Int Med Res. 2002

> Jul-Aug;30(4):406-12. Comparative cochlear toxicities of

> streptomycin, gentamicin, amikacin and netilmicin in guinea-pigs.

> Kalkandelen S, Selimoglu E, Erdogan F, Ucuncu H, Altas E.

> Department of Otolaryngology, Faculty of Medicine, Erzurum, Turkey.

> All the aminoglycoside antibiotics now in clinical use are

> ototoxic. This study was designed to compare the toxic effects of

> four aminoglycoside antibiotics, streptomycin, gentamicin, amikacin

> and netilmicin, administered to guinea-pigs systemically (at

> respective doses of 125 mg/kg, 50 mg/kg, 150 mg/kg or 37.5 mg/kg,

> twice daily for 1 week) or topically via the transtympanic route

> (0.25 ml/kg in 4% saline, twice daily for 1 week). Chosen doses

> were 10-20 times higher than the recommended human dosage. Cochlear

> damage was observed in all animals that were given systemic and

> local aminoglycosides. The severity of the cochlear damage was in

> the order gentamicin, amikacin, streptomycin, netilmicin, with

> gentamicin being the most toxic. No statistically significant

> difference between the severity of cochlear damage resulting from

> the systemic and topical applications was detected. PMID: 12235923

> [PubMed - indexed for MEDLINE]

 

 

 

 

 

 

 

 

 

Acta Otolaryngol. 2000 Aug;120(5):596-9. Related

Articles, Links

 

Topical aminoglycoside ototoxicity: attempting to

protect the cochlea.

 

Conlon BJ, Smith DW.

 

Hearing Research Laboratories, Division of

Otolaryngology-Head and Neck Surgery, Duke University

Medical Center, Durham, North Carolina, USA.

bconlon

 

Cochlear damage following topical application of

aminoglycoside antibiotics to the round window

membrane is a recognized phenomenon in both animal

experiments and clinical reports. The authors have

recently reported the ability of the free radical

scavenging agent, alpha lipoic acid, to protect

against the cochleo-toxic side effects of systemically

administered aminoglycoside antibiotics. This study

attempts to determine if the protective effect of this

free radical scavenging agent is also seen following

topical aminoglycoside application. Animals were

implanted with osmotic pumps which delivered 2.5

microl/h solution of either neomycin 5% or neomycin

plus alpha lipoic acid (50 mg/ml). Control animals

received normal saline solution. Drug solutions were

presented directly to the round window membrane over a

7-day period. Auditory sensitivity was monitored using

compound action potentials (CAPs) of the auditory

nerve recorded through an implanted chronic electrode

terminating at the round window. Sixteen animals were

entered into the study and randomized to one of the

above groups. All animals receiving neomycin solution,

with or without alpha lipoic acid, maintained normal

thresholds for the first 3 days of the treatment

period. Animals receiving neomycin solution alone

experienced profound and rapid deterioration in

auditory sensitivity, which was maximal by day 6.

Animals receiving neomycin plus alpha lipoic acid also

experienced significant cochlear damage; however, the

rate of deterioration was slower than that seen in the

group receiving neomycin alone. All control animals

receiving saline maintained good hearing thresholds

throughout the treatment period.

 

PMID: 11039868 [PubMed - indexed for MEDLINE]

 

 

 

 

 

Hear Res. 1998 Jan;115(1-2):217-23.

 

Loss of spiral ganglion cells as primary manifestation

of aminoglycoside ototoxicity.

 

Sone M, Schachern PA, Paparella MM.

 

Department of Otorhinolaryngology, Nagoya University

School of Medicine, Japan.

 

Although pulmonary infections caused by Pseudomonas

aeruginosa can hardly be eradicated in patients with

cystic fibrosis (CF, the most common genetic disease

among Caucasians), these patients are mainly treated

with intravenous and nebulized tobramycin. Long-term

treatment with tobramycin, however, may induce

ototoxic effects. We assessed the clinical histories

and postmortem temporal bones of six patients with CF

for signs of this ototoxicity. Four bones showed

typical manifestations of ototoxicity induced by

aminoglycosides (AGs): loss of hair cells in the lower

turns, and degeneration of ganglion cells. Six bones

revealed no loss or scattered loss of hair cells,

however, degeneration of the spiral ganglion cells was

observed. This suggests that degeneration of the

spiral ganglion may occur as a primary manifestation

in some cases of ototoxicity due to aminoglycosides.

Recent reports have shown that trophic factors

(neurotrophins and acidic fibroblast growth factor)

interacting with hair cells and the spiral ganglion

protect the inner ear from damage. It may be that

disturbances in supply of such trophic factors caused

degeneration of ganglion cells without loss of hair

cells in the cases we studied. PMID: 9472750 [PubMed - indexed

for MEDLINE]

 

 

Best regards,

 

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