Chinese Herb for glomerulonephritis

[Guest guest]

Hello

 

Does anyone have an idea what chinese herb we can use for

glomerulonephritis? I have a patient with the said condition and

despire being on steroid, his condition is deteriorating

 

Thanks a lot. This group has helped me a lot

[Guest guest]

Hi xyberdoc

 

> Does anyone have an idea what chinese herb we can use for

> glomerulonephritis? I have a patient with the said condition and

> despire being on steroid, his condition is deteriorating

 

Medline has many hits, covering many different herbs and

formulas, for herbal treatment of glomerulonephritis. Selection of

the best one may be a problem:

 

Bo S, Ju J, Chu D.|[Clinical study on Shenning Mixture in treating

IgA nephropathy] [Article in Chinese]| Zhongguo Zhong Xi Yi Jie He

Za Zhi. 2000 Oct;20(10):729-30. |Yuhuangding Hospital, Yantai

City, Shandong 264000.|OBJECTIVE: To study the clinical

therapeutic effect of Shenning Mixture (SNM) in treating IgA

nephropathy. METHODS: Patients were treated separately with

SNM or prednisone by randomized grouping. The criteria, including

clinical symptoms, signs, hematuria, albuminuria and immune

globulin were observed. RESULTS: The total effective rate and the

complete remission rate in the SNM group were 97.1% and 45.7%

respectively, while in the control group, they were 37.1% and 8.6%

respectively. Comparison of the two groups showed that the

therapeutic effect in the former was better than that in the latter

significantly, P < 0.01. The hematuria and albuminuria extenuated

and serum IgA lowered more significantly in the SNM group than

those in the control group (P < 0.05, P < 0.01). CONCLUSION:

SNM has obvious therapeutic effect on the hematuria and

albuminuria in treating IgA nephropathy.|Publication Types: Clinical

Trial Randomized Controlled Trial PMID: 11938804 [PubMed -

indexed for MEDLINE]

 

Chen XM, Cheng QL.|[Treatment of rapid progressive

glomerulonephritis (RPGN) with pulse methylprednisolone (MP)

and urokinase (UK): a renal rebiopsy study] [Article in Chinese]|

Zhonghua Nei Ke Za Zhi. 1993 Sep;32(9):607-9. |Department of

Nephrology, General Hospital of Chinese PLA, Beijing.|We have

performed a case controlled study on the morphological and

immunopathological alterations which can be induced by pulse MP

combined with UK in RPGN by means of before and post therapy

renal biopsies. The results showed renal function and histologic

patterns improved. The histopathological (endothelium and

mesangial cell proliferation, crescent and interstitial infiltration) and

immunopathological (deposition of IgG, C3, Collegen type III, IV,

Laminin and FN.) changes improved in all the patients after

treatment with pulse MP and UK. The results indicated that pulse

MP and UK therapy seems to be useful in treatment of RPGN in

early stage and renal rebiopsy could lead to a better understanding

of RPGN outcome.|PMID: 8112145 [PubMed - indexed for

MEDLINE]

 

Chu F, Wei M, Wang Q.|[Effect of inflammatory factor and yishen

huoxue xiezhuo decoction on growth of glomerular mesangial cells

in rats] [Article in Chinese]| Zhongguo Zhong Xi Yi Jie He Za Zhi.

2000 Feb;20(2):132-5. |Beijing Medical University, Beijing

(100083).|OBJECTIVE: To explore the part of inflammatory factors

(cytokines) and Yishen Huoxue Xiezhuo (YSHXXZ) Decoction on

the proliferation of extracorporeal cultured mesangial cells (MCs) in

rats. METHODS: The effects of lipopolysaccharide (LPS) and

interleukin-6 (IL-6) as stimulating factors, its action on the

proliferation of rat MCs were investigated by using the technique of

3H-TdR incorporation. Meanwhile, adopting serum pharmacology

assay, the medicated serum of rat, containing YSHXXZ decoction

was extracted and its effects on the growth of MCs were also

studied. RESULTS: LPS and IL-6, in a dose-dependent and time-

dependent manner, could markedly stimulate the MCS

proliferation, while this stimulatory effects could be strongly

antagonized by the serum containing YSHXXZ decoction.

CONCLUSION: Mesangial cell is the main target cell of the action

of YSHXXZ decoction, and the inhibition on MCs might be one of

the mechanisms of the YSHXXZ decoction in preventing the

progression of chronic glomerulonephritis.|PMID: 11783317

[PubMed - indexed for MEDLINE]

 

Guo D, Yu J.|[Clinical study on the effect of TCM treatment in

decreasing frequency of peritoneal dialysis] [Article in Chinese]|

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996 Feb;16(2):67-9. |First

Affiliated Hospital of Nanjing TCM University.|Traditional Chinese

herbal medicine was used in combination with peritoneal dialysis

(PD) in order to improve the renal function and reduce the

frequency of PD. The results indicated that, after 3 months of

PD+TCM, the serum BUN, creatinine and mean arterial pressure of

therapeutic group lowered and the hemoglobin elevated as

compared with those after 1 month of PD (P < 0.01), the difference

of above-mentioned criteria between PD+TCM group and less

frequent PD (LEPD) group was significant too, while there was no

obvious difference in comparison of the PD+TCM group with regular

PD group (P > 0.05). The effective rate and the edema cure rate of

TCM+PD group were superior to the LFPD group, but had no

evident difference as compared with the regular PD group. The

results revealed that PD combined with TCM treatment might

reduce the frequency of PD for the uremia patient deserved long-

term PD therapy.|Publication Types: Clinical Trial Randomized

Controlled Trial PMID: 8762415 [PubMed - indexed for MEDLINE]

 

Han MX, Wang YP.|[Effect of fushen decoction on thyroid hormone

in chronic glomerulonephritis of both spleen and kidney-yang

deficiency patients] [Article in Chinese]| Zhongguo Zhong Xi Yi Jie

He Za Zhi. 1993 Mar;13(3):155-7, 133. |Affiliated Hospital of Anhui

College of TCM, Hefei.|Changes of thyroid hormone level before and

after treatment in 45 patients with chronic glomerulo-nephritis were

observed. Of which, 23 cases were treated with Fushen Decoction

and the other with Shenyan Siwei tablet as control. The results

showed: (1) The level of serum T3 and T4 of 45 patients were

significantly reduced (P < 0.001-0.01). (2) The level of serum T3

and T4 were significantly negative correlated with the value of BUN

and Scr and the score of both Spleen and Kidney-Yang Deficiency

Syndrome (P < 0.01-0.05), but there existed no significant negative

correlation with urinary protein excretion in 24 hours (P > 0.05). (3)

After treatment with Fushen Decoction, the level of serum T3 and

T4 significantly increased (P < 0.01-0.05), but no significant

change was recorded in control group (P > 0.05). (4) Although the

level of serum T3 and T4 were raised, they were still lower than

those of normal people.|PMID: 8339034 [PubMed - indexed for

MEDLINE]

 

Hattori T, Fujitsuka N, Kurogi A, Shindo S.|[sairei-to may inhibit

the synthesis of endothelin-1 in nephritic glomeruli] [Article in

Japanese]| Nippon Jinzo Gakkai Shi. 1997 Mar;39(2):121-8.

|TSUMURA & Co. Central Laboratories, New Drug Research

Department 1.|In order to clarify the antinephritic mechanisms of

Sairei-to (TJ-114), its effects on the synthesis and expression of

endothelin-1 were evaluated in rats with anti-glomerular basement

membrane (GBM) nephritis. TJ-114 was administered orally once

daily from the 20th day after anti-GBM serum injection and was

continued throughout the experiment. TJ-114 prevented proteinuria

and histopathological changes in the glomeruli of nephritic rats. TJ-

114 inhibited elevation of the endothelin-1 concentration in the

supernatant from cultured glomeruli of nephritic rats and the

endothelin-1 positive area in the glomeruli. TJ-114 inhibited the

elevation of systolic blood pressure and the number of proliferating

cell nuclear antigen (PCNA)-positive cells per glomeruli. We also

found that the constitutive Kampo medicine in TJ-114, Gorei-san

(TJ-17), inhibited the synthesis and expression of endothelin-1. In

addition, the constitutive herbs TJ-17, alismatis rhizoma (Japanese

name " Takusha " ) and hoelen (Japanese name " Bukuryou " )

inhibited the synthesis and expression of endothelin-1. These

results indicate that the antinephritic actions of TJ-114 may be due

partially to the inhibition of endothelin-1 synthesis in the

glomeruli.|PMID: 9134828 [PubMed - indexed for MEDLINE]

 

Hattori T, Ito M, Nagamatsu T, Suzuki Y.|Studies on antinephritic

effect of TJ-8014, a new Japanese herbal medicine (3): Effects on

crescentic-type anti-GBM nephritis in rats.| Jpn J Pharmacol. 1990

Jan;52(1):131-40. |Department of Pharmacology, Faculty of

Pharmacy, Meijo University, Nagoya, Japan.|We investigated the

antinephritic effects of TJ-8014 (Syo-Saiko-To-Kyo-Shyokyo- Ka-

Ouren-Bukuryou), in comparison to dipyridamole, on crescentic-

type anti-GBM nephritis in rats. When administration of test drugs

was started from the heterologous phase (from the day after the

anti-GBM serum injection), TJ-8014 at 2.0 g/kg/day, p.o., markedly

inhibited the urinary protein excretion and elevations of plasma

cholesterol and urea nitrogen levels as well as glomerular

histopathological changes (i.e., crescent formation, adhesion and

fibrinoid necrosis) throughout the 40-day observation period. TJ-

8014 at 0.1 and 0.5 g/kg/day, p.o., and dipyridamole at 0.4 g/day,

p.o., inhibited only the histopathological changes. When treatment

was started from the autologous phase (from the 22nd day after the

anti-GBM serum injection) after the disease had been established,

only the high dose of 5.0 g/kg/day of TJ-8014, p.o., was effective in

improving the histopathological changes of the established

nephritis, as assessed on the 53rd day. The low doses of TJ-8014

and dipyridamole were ineffective. These results suggest that TJ-

8014 may be a useful Japanese herbal medicine against rapidly

progressive glomerulonephritis, which is characterized by severe

glomerular lesions with the extensive formation of crescents.

Furthermore, the mechanisms of action of this medicine will be

discussed.|PMID: 2308233 [PubMed - indexed for MEDLINE]

 

Hattori T, Ito M, Suzuki Y.|Studies on antinephritic effect of TJ-

8014, a new Japanese herbal medicine (4): Effects on accelerated

passive Heymann nephritis in rats.| Jpn J Pharmacol. 1990

Nov;54(3):265-75. |Department of Pharmacology, Faculty of

Pharmacy, Meijo University, Nagoya, Japan.|We investigated the

antinephritic effect of TJ-8014 (Syo-Saiko-To-Kyo-Shyokyo- Ka-

Ouren-Bukuryou), in comparison to dipyridamole, on accelerated

passive Heymann nephritis in rats. TJ-8014 (4.0 g/kg/day, p.o.)

given from the heterologous phase (from the day of injection of the

antiserum against Fx1A) markedly inhibited the urinary protein

excretion and the elevation of plasma cholesterol levels as well as

glomerular histopathological changes. When the treatment was

started from the autologous phase (from the 22nd day) after

proteinuria was fully developed, TJ-8014 also showed a beneficial

effect. Dipyridamole (0.4 g/kg/day, p.o.) had no effect when the

treatment was started either from the heterologous or autologous

phase. TJ-8014 decreased glomerular rat IgG and rat C3 deposits,

although it affected neither the plasma antibody titer against rabbit

gamma-globulin nor the plasma complement level. TJ-8014

markedly prevented the reduction of plasma and adrenal

corticosterone level as well as the reduction of renal blood flow of

rats with nephritis. These results suggest that TJ-8014 may be a

useful drug against idiopathic membranous nephropathy and the

beneficial effect of this drug may be caused by the elimination of

glomerular immune deposits and C3 through the increase in renal

blood flow related to the enhanced release of adrenal

corticosterone.|PMID: 1708836 [PubMed - indexed for MEDLINE]

 

Hattori T, Nishimura H, Makino B, Shindo S, Kawamura H.|[sairei-

to inhibits the production of endothelin-1 by nephritic glomeruli(2):

alisols, possible candidates as active compounds] [Article in

Japanese]| Nippon Jinzo Gakkai Shi. 1998 Feb;40(2):33-41. |New

Drug Research Department, TSUMURA & Co. Central

Laboratories, Ibaragi, Japan.|We have previously reported that

Sairei-to (TJ-114), a Japanese herbal medicine, prevented the

production of endothelin-1 in anti-GBM nephritic rats, and that

Alismatis Rhizoma (Takusha in Japanese), one of the twelve herbs

composing TJ-114, might be responsible for the action. In order to

further clarify the antinephritic components of TJ-114, we

investigated the effects of Takusha extracts on various parameters,

including endothelin-1 production of glomeruli in vitro and in vivo

using anti-GBM nephritic rats. MeOH-100% MeOH and MeOH-50%

MeOH fractions (31.3 microgram/ml or higher) strongly inhibited an

increase in endothelin-1 concentration in culture medium when

they were added to a culture of glomerular cells derived from

nephritic rats. In addition, oral administration of the MeOH-100%

MeOH fraction (30 mg/kg) ameliorated the proteinuria, increase in

systolic blood pressure and changes in histopathological

parameters in nephritic rats. Oral administration of the MeOH-

100% MeOH fraction inhibited increase in endothelin-1 expression

in the glomeruli of nephritic rats and in endothelin-1 production by a

culture of glomerular cells derived from the nephritic rats. Alisols A

and B, the main constituents of the MeOH-100% MeOH fraction,

inhibited in vitro endothelin-1 production by glomerular cells derived

from the nephritic rats. Oral administration of alisol B (30 mg/kg)

prevented the endothelin-1 expression by glomeruli and the

increase in endothelin-1 production by cultured nephritic glomerular

cells. Oral administration of alisol B also ameliorated the

proteinuria, the increase in systolic blood pressure and the

changes in histopathological parameters in the nephritic rats.

These results indicate that the antinephritic action of TJ-114,

resulting from the inhibition of endothelin-1 production, may be

attributed to the alisols in Takusha.|PMID: 9567069 [PubMed -

indexed for MEDLINE]

 

Hattori T, Shindo S, Hisada T, Fujitsuka N, Hibino T, Terazono Y,

Maruno M.|[Effects of Onpi-to (TJ-8117) on mesangial injury

induced by anti Thy-1 antibody] [Article in Japanese]| Nippon

Yakurigaku Zasshi. 1995 Feb;105(2):63-75. |Tsumura Central

Laboratories, Ibaraki, Japan.|We investigated the effect of Onpi-to

(TJ-8117) on the mesangial injury induced by anti-Thy-1 antibody.

TJ-8117 (400 mg/kg/day, p.o.) given from the 1st day (from the day

of injection of the anti-thymocyte serum) or 4th day (after

mesangial proliferation), markedly inhibited the mesangial

proliferation and hypercellularity in glomeruli. TJ-8117 prevented the

increase in the number of PCNA or ED-1 positive cells in glomeruli.

These results suggest that TJ-8117 is effective against glomerular

disease with mesangial injury.|PMID: 7737594 [PubMed - indexed

for MEDLINE]

 

Hattori T, Shindo S.|[Effects of sairei-to (TJ-114) on the expression

of adhesion molecule in anti-GBM nephritic rats] [Article in

Japanese]| Nippon Jinzo Gakkai Shi. 1995 Jul;37(7):373-83.

|Tsumura & Co. Tsumura Central Laboratories, New Drug Research

Department 1, Ibaragi, Japan.|In order to clarify the antinephritic

mechanisms of Sairei-to (TJ-114), the effects of TJ-114 on the

expression of adhesion molecules were evaluated in rats with anti-

GBM nephritis. TJ-114 was administered orally once a day from the

day (1st day) after anti-GBM serum injection throughout the

experiment. TJ-114 inhibited crescent formation in glomeruli at the

10th day compared to control rats with anti-GBM nephritis. The

ICAM-1- or VCAM-1-positive area in the glomeruli was increased in

the nephritic control rats at the 10th day. In contrast, TJ-114

prevented increase in the ICAM-1- or VCAM-1-positive area in the

glomeruli of nephritic rats. TJ-114 inhibited increase in the number

of LFA-1- or VLA-4-positive cells in the glomeruli. One of the

constituent components of TJ-114, Syo-saiko-to (TJ-9) at the dose

of 750 mg/kg, also significantly inhibited increase in the ICAM-1- or

VCAM-1-positive area in the glomeruli. Gorei-san (TJ-17), another

component of TJ-114, inhibited increase in the ELAM-1-positive

area and increase in the number of VLA-4-positive cells in the

glomeruli. Prednisolone markedly inhibited increase in the positive

area of those adhesion molecules and increase in the number of

ligand-molecule-positive cells in the glomeruli. These results

indicate that the antinephritic action of TJ-114 may be partially due

to inhibition of adhesion molecule expression in the

glomeruli.|PMID: 7543621 [PubMed - indexed for MEDLINE]

 

Hattori T, Yamada S, Furuta K, Nagamatsu T, Ito M, Suzuki

Y.|[studies on anti-nephritic effects of plant components (5).

Effects of pherodendrin on original and crescentic-type anti-GBM

nephritis in rats] [Article in Japanese]| Nippon Yakurigaku Zasshi.

1992 Jun;99(6):391-9. |Department of Pharmacology, Faculty of

Pharmacy, Meijo University, Nagoya, Japan.|Effects of

pherodendrin (OB-5) on anti-GBM nephritis were investigated. OB-5

(50 mg/kg/day, i.p.) prevented the urinary protein excretion in

original and crescentic-type anti-GBM nephritis in rats. In addition,

OB-5 also inhibited the elevation of serum creatinine, urea nitrogen

and cholesterol contents in both models of nephritis.

Histopathological observations indicated that OB-5 prevented the

hypercellularity, crescent formation, adhesion and fibrinoid necrosis

in the glomeruli of nephritic rats. OB-5 and cyclosporine A, a

positive control drug, prevented the increase in the number of OX-1,

CD8 and ED-1 positive cells in the glomeruli. These results

indicated that OB-5 may be effective in human glomerulonephritis,

and anti-nephritic mechanisms of OB-5 may be due to its inhibition

of the activation of macrophages or cytotoxic T cells.|PMID:

1398338 [PubMed - indexed for MEDLINE]

 

Hu Z, Tang L, Chen Y.|[Experimental study of influence of yiqi

huoxue (Nourish Qi Move Blood) serial recipes on basement

membrane in membranous nephritis in rabbits] [Article in Chinese]|

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999 Feb;19(2):96-9.

|Department of Nephrology, Longhua Hospital, Shanghai University

of TCM, Shanghai (200032).|OBJECTIVE: To clucidate the

mechanism of the therapeutic effect of Yiqi Huoxue (YQHX) serial

recipes on membranous nephritis. METHODS: Forty-nine New

Zealand male rabbits were made to menbranous nephritis model by

cation bovine serum albumin and divided into 5 groups, the group A

(treated by Qingre Moshen granule), B (treated by Bushen Moshen

granule), C (treated by steroid), D (the control group) and E (the

normal group). Twenty-four hours' urinary protein content of the

animals was determined every week, and plasma albumin, blood

lipid, renal function and prostaglandins were tested by the end of

experiment. And pathological changes of basement membrane

were observed by using light, electronic and immunofluorescent

microscopy with polyethylene imine stain. RESULTS: The 24 hours

urinary protein content, plasma albumin and blood lipid in the group

A and B were lower than those in the control group significantly, P

< 0.01 or 0.05, while those in the group C and the D were similar,

P > 0.05. In comparing the group A and B with the group C, the

difference was also significant, P < 0.05. Light, electronic and

immunofluorescent microscopic examination all showed that the

pathologic changes in the group A, B and C were lesser than that

of the control, the effect was in the order A > B > C.

CONCLUSION: YQHX serial recipes can reduce urinary protein

content, elevate plasma albumin level, restore the charge barrier

effect of and attenuate the immune complex deposition on the

basement membrane of glomeruli.|PMID: 11783306 [PubMed -

indexed for MEDLINE]

 

Hu ZY, Chen YP, Zha P.|[Analysis of the treatment with traditional

Chinese medicine in chronic glomerulonephritis based on

histopathologic type] [Article in Chinese]| Zhongguo Zhong Xi Yi Jie

He Za Zhi. 1992 Aug;12(8):455-7, 451. |Long Hua Hospital,

Shanghai College of TCM.|The histopathologic type of 189 cases of

chronic glomerulonephritis (GN) were confirmed by renal biopsies,

they were subdivided into 3 groups. 77 patients of Western

medicine (WM) group was treated by conventional WM (prednison

or CTX), and after treatment the total effective rate was 55.8%. The

TCM-WM group was treated by the same WM plus treatment

according to Syndrome Differentiation with Chinese medicinal

herbs, and the total effective rate was 86% in 50 patients. The TCM

group was treated by Chinese medicinal herbs, and the total

effective rate was 67.3% in 62 cases. There was very significant

difference (P < 0.01) between the WM and the TCM-WM group.

Among the patients of TCM-WM and TCM groups, 67% of 112

cases were manifested as Dampness-Heat Syndrome, so it

suggested that one of the important method for GN treatment is

clearing away Dampness-Heat. The effects of TCM-WM group is

much better than the WM group in treating mesangio-proliferative

GN and membranous GN. It was difficult for WM in treating IgA

nephropathy, membrano-proliferative GN and focal

glomerulosclerosis, but Chinese medicinal herbs were effective with

replenishing Qi and strengthening the Spleen, clearing away

Dampness-Heat, promoting blood circulation and relieving Stasis,

etc.|PMID: 1477498 [PubMed - indexed for MEDLINE]

 

Huang L, Shi P, Wang X.|[The effect of the extract from Radix

Paeoniae alba on IgA Glomerulonephritis in mice] [Article in

Chinese]| Zhong Yao Cai. 2003 Feb;26(2):109-11. |No. 451 Hospital

of PLA, Xi'an 710054.|OBJECTIVE: To observe the effect of the

extract from Radix Paeoniae Alba on IgA glomerulonephritis in

mice. METHODS: IgA glomerulonephritis was induced by injection

of dextran and sephadex-150. After administrating the extract, the

contents of urinary protein, BUN and Cr in serum were determined.

RESULTS: The extract could inhibit the decline of mouse weight,

and decrease urinary protein content and BUN content in serum.

While, the extract had no effect on Cr in serum. CONCLUSION:

The extract from Radix Paeoniae Alba had therapeutical effect on

IgA glomerulonephritis.|PMID: 12795222 [PubMed - indexed for

MEDLINE]

 

Jin YP, Yang XL, Wu H.|[Effect of baoyuantang on level of serum

lipid peroxide and vitamin E in chronic glomerulonephritis] [Article

in Chinese]| Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993

Mar;13(3):158-9, 161, 133. |2nd Affiliated Hospital of Hunan

Medical University, Changsha.|Serum lipid peroxide (LPO) and

vitamin E (VE) were determined in 18 patients with chronic

glomerulonephritis (CGN) before and after treatment with

Baoyuantang (BYT). It was found that before treatment the level of

serum LPO (4.89 +/- 1.85 mumol/L) was higher, while the content

of serum VE (4.27 +/- 1.84 micrograms/ml) was lower than those of

normal controls (3.36 +/- 0.59 mumol/L, P < 0.001; 7.03 +/- 0.69

microgram/ml, P < 0.05). After treatment with BYT, the level of

LPO lowered to 3.76 +/- 1.49 mumol/L, P < 0.05, as compared

with the value before treatment, while the content of VE was

increased to 5.33 +/- 2.45 micrograms/ml, but without statistical

significance. A negative correlation was found between LPO level

and VE content both before and after treatment (r = -0.495,P <

0.05; r = -0.522, P < 0.05). The results indicated chronic deficiency

of VE in association with an increase in the level of LPO in the

kidney in CGN patients and inhibition of LPO by BYT. After

treatment complete remission was observed in 5 cases, basic

remission in 3, and partial remission in 7.|PMID: 8339035 [PubMed

- indexed for MEDLINE]

 

Ju J, Guo Y, Liang Y, Sun S, Yang J, Yang S.|Clinical study on

treatment of chronic renal failure with shenshuailing.| J Tradit Chin

Med. 2001 Jun;21(2):93-5. |Yuhuangding Hospital, Yantai City

264000, Shandong Province.|The therapeutic effects of

Shenshuailing Kou Fu Ye (SKFY [symbol: see text], the Oral

Liquid for Renal Failure) and Shenshuailing Guan Chang Ye (SGCY

[symbol: see text], the Enema for Renal Failure) were evaluated in

treatment of chronic renal failure, with coateg aldehyde oxystarch

as the controls. The changes in the clinical symptoms, serum

creatinine, blood urea nitrogen and creatinine clearance rate were

observed. The total effective rate in the former was 90.46%, and the

latter 60.43%.|Publication Types: Clinical Trial Randomized

Controlled Trial PMID: 11498911 [PubMed - indexed for MEDLINE]

 

Kang Z, Bi Z, Ji W, Zhao C, Xie Y.|Observation of therapeutic effect

in 50 cases of chronic renal failure treated with rhubarb and

adjuvant drugs.| J Tradit Chin Med. 1993 Dec;13(4):249-52.

|Department of Internal Medicine, Union Hospital,

Beijing.|Treatment of chronic renal failure with rhubarb and adjuvant

drugs combined with other appropriate measures alleviates the

suffering of the patients and improves the quality of their survival.

Most patients can take care of themselves after treatment, and

some can engage in half-day work. The treatment prolongs the life

of the patient, and reduces medical expenses. It is of definite

social and economic benefit, and conforms with China's conditions.

Except for very severe cases whose blood creatinine exceeds 884

mumol/L, it can be given to all patients. It can also be used as a

transitional measure before more radical therapies may be

instituted.|PMID: 8139271 [PubMed - indexed for MEDLINE]

 

Kimura K, Nanba S, Tojo A, Matsuoka H, Sugimoto T.|Effects of

sairei-to on the relapse of steroid-dependent nephrotic syndrome.|

Am J Chin Med. 1990;18(1-2):45-50. |Second Department of

Internal Medicine, Faculty of Medicine, University of Tokyo,

Japan.|Sairei-To (Chai-Ling-Tang) was administered to four patients

with steroid-dependent relapsing nephrotic syndrome. It was

associated with prednisolone and immunosuppressive agents.

Histological diagnosis was minimal change in three patients and

mild focal glomerulonephritis in one patient. After the start of Sairei-

To administration the relapse was markedly suppressed in three

patients but not at all in the other. Although we could consider

Sairei-To effective for steroid-dependent nephrotic syndrome in the

present study, a larger study is necessary to confirm its

efficacy.|Publication Types: Case Reports PMID: 2239814

[PubMed - indexed for MEDLINE]

 

Kuo YC, Tsai WJ, Meng HC, Chen WP, Yang LY, Lin CY.|Immune

reponses in human mesangial cells regulated by emodin from

Polygonum hypoleucum Ohwi.| Life Sci. 2001 Feb 2;68(11):1271-

86. |Laboratory of Immunology, National Research Institute of

, Taipei, Taiwan.

Kuo9111|In the hope of identifying agents of

therapeutic value in glomerulonephritis from Chinese herbs, we

found that methanolic extracts of Polygonum hypoleucum Ohwi (P.

hypoleucum Ohwi) inhibit human mesangial cells proliferation

activated with interleukin-1beta (IL-1beta) and interleukin-6 (IL-6)

previously. This study was designed to identify bioactive

components from P. hypoleucum Ohwi and elucidate their action

mechanisms. We tested four anthraquinones emodin, emodin 1-O-

beta-D-glucoside (49A), physcion (62A), and physcion 1-O-beta-D-

glucoside (50A) purified from P. hypoleucum Ohwi for their effects

on human mesangial cell proliferation and cytokines production in

vitro. On a percentage basis, emodin had the highest suppressing

activity on the human mesangial cells proliferation activated by IL-

1beta and IL-6. The IC50 of emodin on human mesangial cells

proliferation were 17.9+/-1.2 microM. In contrast to 49A, 50A, and

62A, emodin also decreased IL-1beta, IL-6 and tumor necrosis

factor-alpha (TNF-alpha) production in human mesangial cells

activated with IL-1beta and IL-6. The IC50 of emodin on IL-1beta, IL-

6 and TNF-alpha production in activated human mesangial cells

were 16.6+/-1.8 microM, 8.2+/-1.3 microM, and 9.5+/-1.6 microM,

respectively. Moreover, IL-1beta and TNF-alpha mRNA expression

in activated human mesangial cells was impaired by emodin. The

intracellular free Ca2+ concentration ([Ca2+]i) in IL-1beta and IL-6

activated human mesangial cells was decreased by emodin. It is

unlikely that cytotoxicity was involved because no cell deaths were

observable. We hypothesize that the inhibitory mechanisms of

emodin on activated human mesangial cells proliferation may be

related to the impairments of gene expression and production of

cytokines and [Ca2+]i in the cells.|PMID: 11233994 [PubMed -

indexed for MEDLINE]

 

Li P, Fujio S.|Effects of chai ling tang on proteinuria in rat models.|

J Tradit Chin Med. 1995 Mar;15(1):48-52. |Graduate School, China

Academy of Traditional , Beijing.|Effects of Chai

Ling Tang (a decoction of medicinal herbs) on passive Heymann

nephritis (PHN) in rats, a model similar to human membranous

nephropathy, were examined. Four hundred mg/kg (body weight) of

Chai Ling Tang, or 240 mg/kg B.W. of Xiao Chai Hu Tang, or 130

mg/kg B.W. of Chai Hu (Radix Bupleuri), Ban Xia (Rhizoma

Pinelliae) and Sheng Jiang (Rhizoma Zingiberis Recens) were

intraperitoneally injected respectively into three groups of female

Wistar rats once a day starting from 5 days before intravenous

injection of anti-FxlA antibody to the end of the experiment.

Another group of rats intraperitoneally injected with phosphate

buffered saline (PBS) was used as the control. It was found that

the excretion of urinary protein was significantly suppressed in the

Chai Ling Tang treated group (52.2 +/- 46.9 mg/day) as compared

to that in the PBS control group (276.5 +/- 127.0 mg/day) 15 days

after anti-FxlA antibody injection (P < 0.01). The decrease of serum

albumin and total protein, and the increase of serum total

cholesterol were significantly inhibited in the Chai Ling Tang treated

group as compared to that in the control group (P < 0.05, P < 0.05

and P < 0.01 respectively). It is therefore concluded that proteinuria

in PHN can be significantly suppressed by Chai Ling Tang.|PMID:

7783463 [PubMed - indexed for MEDLINE]

 

Li P, Kawachi H, Morioka T, Orikasa M, Oite T, Shi ZS, Shimizu

F.|Suppressive effects of sairei-to on monoclonal antibody 1-22-3-

induced glomerulonephritis: analysis of effective components.|

Pathol Int. 1997 Jul;47(7):430-5. |Department of Cell Biology,

Niigata University School of Medicine, Japan.|The effects of

traditional Chinese medicine (Sairei-to) on experimental

glomerulonephritis induced in rats by monoclonal antibody (mAb) 1-

22-3 injection was examined. The level of proteinuria in the Sairei-to-

treated group was significantly lower than that in the PBS treated

group. This suppressive effect was caused by the major component

of Sairei-to, Syo-saiko-to but not by another component, Gorel-san.

The suppressive effect of Syo-saiko-to was identified in its

components (Bupleuri radix, Pinelliae tuber and Zingiberis

rhizoma), but not in the other combined components (Ginseng

radix and Zizyphi fructus). Further study revealed that the

suppressive effects of the combined components were mainly

derived from Bupleuri radix. It was demonstrated that the actual

active ingredient is probably Saikosaponin-d. Light microscopy

revealed that Sairei-to and its effective components suppressed the

proliferation of mesangial cells and mesangial matrix expansion.

Semiquantitative morphological studies of glomerular lesions on the

eighth day showed that Syo-saiko-to and its combined

components (Bupleuri radix, Zingiberis rhizoma and Pinelliae tuber)

suppressed mesangial matrix expansion significantly compared

with phosphate-buffered saline control groups (matrix score: 28.0

+/- 19.1 vs 102.3 +/- 14.1; 30.9 +/- 30.1 vs 102.3 +/- 14.1, P <

0.005, respectively). It was concluded that Saikosaponin-d, as well

as Bupleuri radix, Syo-saiko-to and Sairei-to can suppress

proteinuria and morphological changes in the rat glomerulonephritis

model induced by mAb 1-22-3.|PMID: 9234380 [PubMed - indexed

for MEDLINE]

 

Li QF, Ma QY, Zhu CF.|[Effect of combination of bushen jianpi

recipe and erythropoietin on serum tumor necrosis factor alpha in

patients with anemia] [Article in Chinese]| Zhongguo Zhong Xi Yi

Jie He Za Zhi. 2004 Feb;24(2):106-8. |Department of Nephrology,

Hangzhou Hospital of TCM, Hangzhou 310000.|OBJECTIVE: To

study the effect of treatment of renal anemia by combination of

Bushen Jianpi Recipe (BJR, a Chinese experience recipe for

supplementing Shen and supporting Pi) and low dosage

erythropoietin (EPO), and the influence of treatment on change of

serum tumor necrosis factor alpha (TNF-alpha) so as to explore the

possible mechanism of integrative Chinese and western medicine

(ICWM) in treating renal anemia. METHODS: Patients with renal

anemia were randomly divided into two groups, the ICWM group

and the control group, symptomatic and supporting treatment such

as dialysis, supplementing of ferrous, foliac acid and vitamin B12,

was given to both groups. Additionally, to the ICWM group, 50

IU/kg of EPO subcutaneous injection for twice every week, and oral

intake of BJR, one dose per day taken in two parts, were given,

and to the control group, EPO alone, 50 IU/kg by subcutaneous

injecting, 3 times per week, was given. The therapeutic course for

two groups was 3 months. Blood levels of hemoglobin (Hb),

hematocrit (Hct), TNF-alpha were measured before treatment and

the therapeutic effect was observed. RESULTS: After treatment,

the levels of Hb and Hct increased significantly in both groups (P <

0.01), comparison between the two groups in Hb and Hct after

being treated for 3 months showed significant difference (P < 0.05).

The serum level of TNF-alpha was markedly higher than normal

range in both groups before treatment, it significantly lowered after

treatment in the ICWM group (P < 0.05), but unchanged in the

control group. CONCLUSION: Combination of BJR and EPO could

significantly inhibit the production of TNF-alpha, this may be an

important factor for ICWM in effectively improving sensitivity to

EPO.|Publication Types: Clinical Trial Randomized Controlled Trial

PMID: 15015438 [PubMed - indexed for MEDLINE]

 

Lin CY, Ku FM, Kuo YC, Chen CF, Chen WP, Chen A, Shiao

MS.|Inhibition of activated human mesangial cell proliferation by the

natural product of Cordyceps sinensis (H1-A): an implication for

treatment of IgA mesangial nephropathy.| J Lab Clin Med. 1999

Jan;133(1):55-63. |Department of Pediatrics and Medical Research,

Veterans General Hospital-Taipei, Taiwan, Republic of

China.|Cordyceps sinensis (CS) is a parasitic fungus that has been

used as a Chinese medicine for a long time in the treatment of

nephritis. Today, the hypothesis about the pathogenesis of

immunoglobulin A nephropathy (IgAN) is that nephritogenic IgA

immune complexes (IgAIC) go to the kidney to stimulate resting

mesangial cells to release cytokines and growth factors. These

cytokines and growth factors cause mesangial cell proliferation and

release matrix, chemical mediators that lead to the glomerular

injury. However, nephritogenic IgAIC in humans is still unknown. To

solve this problem previously, we established an in vitro model that

showed that cultured human mesangial cells (HMC) stimulated

with interleukin-1 (IL-1) plus IL-6 can cause mesangial cell

proliferation, increasing production of chemical mediators and

superoxide anion. An in vivo model also proved that this culture

medium may lead to renal injury with hematuria and proteinuria.

Therefore, to fractionate the crude components that can be used in

the treatment of patients with IgAN, we cultured HMC, and then an

HMC activating model with HMC incubated with IL-1 and IL-6 was

established. We fractionated the crude methanolic extracts from

fruiting bodies of CS with the use of this in vitro inhibition of HMC

activation model as our assay method. In brief, the fruiting bodies

were extracted by silica gel column chromatography. One out of 6

column fractions, F-2, significantly inhibited the HMC activation by

IL-1 plus IL-6. The acute toxicity test with male Institute of Cancer

Research mice showed no liver toxicity or mutagenicity. Then we

established an IgAN animal model with R36A (Pneumococcal C-

polysaccharide purified from Streptococcus pneumoniae) as

antigen and anti-R36A IgA monoclonal antibody to form

nephritogenic IgA-IC, which can induce hematuria and proteinuria in

mice with IgA deposition in the mesangial area. The mice in the

IgAN model fed with 1% F-2 in diet had significant reduction of

hematuria and proteinuria together with histopathologic

improvement. Therefore this fraction was then purified by silica gel

column chromatography and high-performance liquid

chromatography, which got a purified compound H1-A, which can

suppress the activated HMC and alleviate IgAN (Berger's disease)

with clinical and histologic improvement. These results give us a

new regimen for the treatment of patients with IgAN in the

future.|PMID: 10385482 [PubMed - indexed for MEDLINE]

 

Liu F, Liu Y, Li J.|[Effects of danshen on solute transport by

peritoneal dialysis] [Article in Chinese]| Hunan Yi Ke Da Xue Xue

Bao. 1997;22(3):237-9. |Department of Nephrology, Second

Affiliated Hosiptal, Hunan Medical University, Changsha.|Danshen

injection was added in peritoneal dialysate with concentration of

6/1000. The D/P value of BUN, Cr and total protein and the D/Do

value of glucose and the drained volume were observed. The results

showed that the D/P value of BUN and Cr increased from the 2nd

day of Danshen addition; the D/Do value of glucose increased from

the 1st day of Danshen addition and then came to the original value

from the 2nd day of Danshen addition; the D/P value of protein

increased continuously from the 1st day of Danshen addition; the

drained volume had no change.|PMID: 9868123 [PubMed - indexed

for MEDLINE]

 

Liu X, Tao Y, Zhang X, Fan J, Li X.|[An experimental study

combined on traditional Chinese medicine with

immunosuppressant for treatment and prevention of tubular

interstitial nephritis] [Article in Chinese]| Hua Xi Yi Ke Da Xue Xue

Bao. 2000 Jun;31(2):211-3, 225. |Department of Nephrology, First

Affiliated Hospital, WCUMS, Chengdu 610041.|The objective of this

study was to determine the effect of Chinese herbs and immune

inhibitors on diffuse proliferative glomerulonephritis. The tubular-

interstitial infiltration of cell, TGF-beta expression and interstitial

fibrosis were investigated, and the relationship between clinical

data and pathological changes was analysed. The results showed

the infiltration of cells was inhibited in the " Chinese herbs

combined with prednisone " group, the infiltration of cells, TGF-beta

expression and interstitial fibrosis were all inhibited in the

cyclophosphamide and prednisone " group. But in the prednisone

group, interstitial fibrosis was not inhibited. These data suggest

that the combined use of Chinese herbs, immunosuppressant and

prednisone can inhibit the interstitial cell infiltration and prevent the

interstitial fibrosis in diffuse proliferative glomerulonephritis.|PMID:

12515139 [PubMed - indexed for MEDLINE]

 

Makino T, Ito M, Kiuchiu F, Ono T, Muso E, Honda G.|Inhibitory

effect of decoction of Perilla frutescens on cultured murine

mesangial cell proliferation and quantitative analysis of its active

constituents.| Planta Med. 2001 Feb;67(1):24-8. |Department of

Pharmacognosy, Graduate School of Pharmaceutical Sciences,

Kyoto University, Japan.|The leaves of Perilla frutescens (perilla)

are a common herb used in Japan for garnishing raw seafood.

Previously, we reported that a decoction of perilla leaves had

suppressive effects on the progression of glomerulonephritis in an

animal model of spontaneous IgA nephropathy. The objective of the

present study was to isolate anti-nephritic constituents in the

perilla decoction under the guidance of its in vitro anti-proliferative

activity on cultured murine mesangial cells, and to measure the

contents of the active constituents in decoctions prepared from

various perilla chemotypes, which differ in their composition of

essential oils and/or pigments. DNA synthesis of cultured

mesangial cells induced by 1% fetal calf serum was significantly

inhibited by the perilla decoction (IC50 values, 8.8 microg/ml).

Caffeic acid, luteolin 7-O-[beta-glucuronosyl(1-->2)beta-

glucuronide], apigenin 7-O-[beta-glucuronosyl(1-->2)beta-

glucuronide], scutellarin, and rosmarinic acid were isolated as

active constituents. The contents of these phenolic compounds

were not significantly different among chemotypes of P. frutescens.

Considering the relation between the contents in the perilla

decoction and the activities of these compounds, rosmarinic acid

represents the in vitro anti-proliferative effect of perilla

decoction.|PMID: 11270716 [PubMed - indexed for MEDLINE]

 

Makino T, Nakamura T, Ono T, Muso E, Honda G.|Suppressive

effects of Perilla frutescens on mesangioproliferative

glomerulonephritis in rats.| Biol Pharm Bull. 2001 Feb;24(2):172-5.

|Department of Pharmacognosy, Graduate School of

Pharmaceutical Sciences, Kyoto University, Japan.|Leaves of

Perilla frutescens var. crispa DECNE. (perilla, Labiatae) are used

as a garnishing vegetable in East Asian countries as well as an

herbal medicine prescribed in Kampo medicines such as Saiboku-

to. A previous in vitro study revealed that a decoction of perilla

leaves inhibits the proliferation of murine-cultured mesangial cells.

In the present study, we evaluated the in vivo anti-proliferative

effects of a perilla decoction using rat mesangio-proliferative

glomerulonephritis induced by an intravenous injection of rabbit anti-

rat thymocyte serum (ATS). Leaves of perilla were boiled, and the

decoction was orally administered to the rats as drinking water at

doses of 100 and 500 mg/kg/d from the day of ATS-injection (day

0) to day 8, when rats were sacrificed. In the histological

evaluation, the total number of glomerular cells, proliferating cell

nuclear antigen (PCNA) positive cells, and macrophage/monocyte

antigen-positive cells in the glomerulus, was significantly

decreased in perilla-treated rats. A significantly lower level of

proliferation was induced by the serum of the perilla-treated rats

than by that of the controls. These results suggest that the perilla

decoction suppresses the proliferation of mesangial cells in vivo by

an inhibition of the glomerular infiltration of macrophage/monocytes

and of the production of circulating growth factors.|PMID: 11217087

[PubMed - indexed for MEDLINE]

 

Makino T, Ono T, Liu N, Nakamura T, Muso E, Honda

G.|Suppressive effects of rosmarinic acid on mesangioproliferative

glomerulonephritis in rats.| Nephron. 2002 Dec;92(4):898-904.

|Department of Pharmacognosy, Graduate School of

Pharmaceutical Sciences, Kyoto University, Kyoto,

Japan.|BACKGROUND: Rosmarinic acid is known to be a natural

phenolic compound widely distributed in Labiatae herbs such as

rosemary, sweet basil, and perilla. In the present study, we

evaluated the suppressive effects of rosmarinic acid on

mesangioproliferative glomerulonephritis in vivo, which was induced

by intravenous injection of rabbit anti-rat thymocyte serum (ATS) to

rats. METHODS: Rosmarinic acid was orally administered to the

rats at a dose of 100 mg/kg/day from the day of ATS injection (day

0) to day 8 when rats were sacrificed. The degree of mesangial cell

proliferation and matrix accumulation were evaluated by trichrome

staining and by immunostaining for proliferating cell nuclear antigen

(PCNA), fibronectin, type IV collagen and fibrin. Superoxide

dismutase (SOD)-activity in the homogenate of renal cortex was

also evaluated. RESULTS: The number of PCNA-positive cells,

staining areas of trichrome, fibronectin, collagen IV and fibrin in the

glomerulus were significantly decreased, and SOD-activity of renal

cortex homogenate was significantly augmented in rosmarinic acid-

treated group. CONCLUSION: Rosmarinic acid would suppress the

proliferation of mesangial cells and glomerular matrix expansion in

vivo by its fibrinolytic and anti-oxidative activity. Copyright 2002 S.

Karger AG, Basel|PMID: 12399637 [PubMed - indexed for

MEDLINE]

 

Makino T, Ono T, Matsuyama K, Nogaki F, Miyawaki S, Honda G,

Muso E.|Suppressive effects of Perilla frutescens on IgA

nephropathy in HIGA mice.| Nephrol Dial Transplant. 2003

Mar;18(3):484-90. |Department of Pharmacognosy, Graduate

School of Pharmaceutical Sciences, Kyoto University,

Japan.|BACKGROUND: Perilla frutescens (perilla) is a herbal

medicine used in Japanese traditional Kampo medicine. The

present study was conducted to evaluate the anti-nephritic effects

of perilla in HIGA mice that spontaneously develop high levels of

serum immunoglobulin A (IgA) along with mesangial IgA

deposition. METHODS: A perilla decoction and its major active

constituent, rosmarinic acid (RsA), were orally administrated to 10-

week-old HIGA mice for 16 weeks. At study completion, we

measured proteinuria and serum IgA levels and generated

histological scores from kidney specimens. In addition, we

measured concentrations of IgA in culture media of intestinal

Peyer's patch cells and spleen cells obtained from the HIGA mice.

RESULTS: Perilla suppressed proteinuria, proliferation of

glomerular cells, serum levels of IgA, glomerular IgA and IgG

depositions in HIGA mice. Cultured Peyer's patch cells and spleen

cells from perilla-treated mice produced significantly less IgA than

controls. Rosmarinic acid, by itself, suppressed serum IgA levels

and glomerular IgA deposition in HIGA mice. Cultured spleen cells

from RsA-treated mice produced less IgA than controls.

CONCLUSIONS: The perilla decoction may suppress IgA

nephropathy, in part, through modulation of the intestinal mucosal

immune system. These effects were caused by RsA acting

synergistically with other constituents.|PMID: 12584268 [PubMed -

indexed for MEDLINE]

 

Makino T, Ono T, Muso E, Honda G, Sasayama S.|Suppressive

effects of Perilla frutescens on spontaneous IgA nephropathy in

ddY mice.| Nephron. 1999 Sep;83(1):40-6. |Department of

Pharmacognosy, Graduate School of Pharmaceutical Sciences,

Graduate School of Medicine, Kyoto University, Kyoto,

Japan.|Perilla frutescens (perilla) is a common herb used in Japan

for garnishing raw seafood to protect the alimentary tract from

inflammatory diseases. The present study was performed to

investigate whether or not perilla prevents the development of

lesions of IgA nephropathy in ddY mice which spontaneously

develop this disease. After orally administering perilla extract to

ddY mice from 8 to 42 weeks of age, the changes in urine, serum,

and kidneys were evaluated. Perilla extract significantly

suppressed proteinuria and glomerular IgA deposition (p < 0.01 and

p < 0.05, respectively). The decreased serum IgA concentration in

perilla-treated mice showed a significant correlation with glomerular

IgA deposition. Such findings suggest that perilla reduced

glomerular IgA deposition via suppression of IgA production in the

serum. On the other hand, the nitric oxide concentration in the

serum of perilla-treated mice was significantly higher than that

observed in the controls. The addition of the sera of perilla-treated

mice to quiescent cultured murine mesangial cells resulted in a

cell proliferation which was less than in controls, suggesting that

perilla might either directly prevent mesangial cell proliferation or

prevent proliferation by regulating circulating cytokines. Such

results indicate that perilla should prevent IgA nephropathy, thus

representing a promising herbal medicine for

glomerulonephritis.|PMID: 10461034 [PubMed - indexed for

MEDLINE]

 

Mitsuma T, Yokozawa T, Oura H, Terasawa K, Narita M.|[Clinical

evaluation of kampo medication, mainly with wen-pi-tang, on the

progression of chronic renal failure] [Article in Japanese]| Nippon

Jinzo Gakkai Shi. 1999 Dec;41(8):769-77. |Department of Japanese

Oriental (Kampo) Medicine, Iizuka Hospital, Fukuoka,

Japan.|Previous studies have shown that Kampo (traditional

Chinese) prescriptions, mainly Wen-Pi-Tang (Onpi-to, [symbol see:

text]), have a useful effect in patients with chronic renal failure

(CRF). We aimed to examine the long-term effect of Kampo

prescriptions on serum creatinine (Cr) among patients with CRF.

Patients with serum Cr levels of 2 mg/dl more were enrolled if they

had at least 4 recordings of serum Cr in the previous 6 months or

more, and were followed-up until the start of dialysis. Eight patients

aged 24-59 years with serum Cr 4.5 mg/dl were enrolled in the

study for 40 to 402 weeks (mean; 228.1 +/- 118.8 weeks). The

cause of CRF was chronic glomerulonephritis in 7 patients and

systemic lupus erythematosus in 1 patient. The end points of the

study were the slope of the reciprocal of the serum Cr

concentration plot against time using Mitch's method, and the

predicted period of pre-dialysis. The predicted pre-dialysis period

was defined as an increase in serum Cr by 10 mg/dl. As a result,

the individual slopes were improved in 6 of 8 cases, in particular, in

4 of 5 Wen-Pi Tang-treated cases. The average slope was improved

significantly (p < 0.01) in Wen-Pi-Tang-treated cases, although it

showed only a tendency to improve in all 8 cases. The predicted

pre-dialysis period was prolonged from 79.2 +/- 74.8 weeks to

389.5 +/- 355.4 weeks and 55.6 +/- 37.0 weeks to 262.4 +/- 145.8

weeks in all 8 cases and Wen-Pi-Tang-treated cases, respectively.

The observed pre-dialysis period was 228.1 +/- 118.8 weeks, which

showed that Kampo prescriptions prolonged the predicted period

for 186 additional weeks. In conclusion, this study demonstrated

that the Kampo prescriptions, consisting mainly of Wen-Pi-Tang,

retarded the progression of CRF.|Publication Types: Clinical Trial

PMID: 10655725 [PubMed - indexed for MEDLINE]

 

Mo R, Wei M, Xu WZ.|[Effects of shenyan yiqiye on experimental

membranous glomerulonephritis in rabbits] [Article in Chinese]|

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1994 May;14(5):295-7, 262.

|Beijing University of TCM.|The cationic bovine serum albumin (C-

BSA) was used for duplicating experimental animal model of

membranous glomerulonephritis with chronic renal failure. Shenyan

Yiqiye (SYYQY) was adopted for treatment. The results showed

that, in the therapeutic group, the urine protein and serum

creatinine were reduced as compared with those in pathological

group, P < 0.01. The parameter of morphometric analysis of

glomeruli such as mean diameter, mean perimeter, mean surface

area, mean volume, mean cross sectional area were all decreased,

P < 0.01, the number of glomerular proliferative cells and thickness

of glomerular capillary wall were all attenuated, P < 0.01, as

compared with those in the pathological group. It suggested that

SYYQY might alleviate the glomeruli lesions and benefit the renal

functions.|PMID: 7950217 [PubMed - indexed for MEDLINE]

 

Nagata M, Kawaguchi H, Komatsu Y, Hattori M, Itoh K.|[The

effects of sairei-to on nephrotoxic serum nephritis in rats--possible

effects on intraglomerular cell mediated immunity] [Article in

Japanese]| Nippon Jinzo Gakkai Shi. 1989 Jul;31(7):713-21. ||Sairei-

to, one of the herb drugs, has been demonstrated to have several

effects. Clinically, evidence have been accumulated showing that

sairei-to has been able to reduce the frequency of relapse in

minimal change nephrotic syndrome. It has also found that sairei-to

has improved proteinurial in minimal change nephrotic syndrome as

well as chronic glomerulonephritis in man. Although the

mechanism of such effects is still unclear, it is supposed that its

immune modulating actions that has been reported. In this study,

we quantitated the number of intrarenal Ia positive cells and T cells

in nephrotoxic nephritis in rats in order to clarify the intrarenal

immune actions of sairei-to on immune mediated

glomerulonephritis. Four groups of rats with nephrotoxic nephritis

were experimented on. The first group was the controlled group,

had no treatment whatsoever. The second group was administered

with MPSL (solu-medrol 20 mg/kg, alternate day). The fourth group

with both sairei-to and MPSL. The level of proteinuria in three

groups treated was almost the same, that is, less than that of

controlled group. On light microscopy, sairei-to suppressed

glomerular inflammation such as endocapillary proliferative lesions

and mesangial expansion, which were shown in controlled group.

The histological improvement was almost the found in rats treated

with MPSL and both. Sairei-to suppressed infiltrations of

intraglomerular Ia positive cells (P less than 0.01) and T cells (P

less than 0.01) on the 7th day and 14th day as well. Remarkable

suppression of T cells infiltration was noted in rats treated with

MPSL along with sairei-to on the 14th day (P less than

0.01).(ABSTRACT TRUNCATED AT 250 WORDS)|PMID: 2585824

[PubMed - indexed for MEDLINE]

 

Nakai S, Kawakita T, Himeno K, Nomoto K.|Combined treatments

with Ninjin-youei-to (Ren-shen-yang-rong-tang) plus a suboptimal

dose of prednisolone on autoimmune nephritis in MRL/lpr mice.| Int

J Immunopharmacol. 1998 Jun;20(6):275-84. |Kampo (Traditional

) Research Laboratories, Kanebo Ltd, Osaka,

Japan.|MRL/lpr mice suffer from a systemic lupus erythematosus-

like autoimmune disease. We studied the effects of oral treatments

with Ninjin-youei-to (NYT, Ren-shen-yang-rong-tang, 1000

mg/kg/day), a suboptimal dose (2 mg/kg/day) of prednisolone(PSL)

and their combination on nephritis in MRL/lpr mice. Treatments

with NYT or PSL alone inhibited the development of proteinuria and

prolonged survival. The combined treatment reduced the incidence

of proteinuria and prolonged survival. In histological analysis, NYT

treatments decreased the degree of mesangial proliferative

glomerulonephritis and infiltration of mononuclear cells in the

kidneys. PSL treatment was effective in reducing periglomerular

nephritis and vasculitis in addition to such effects as NYT and NYT

plus PSL treatment was more effective than PSL alone. The active

form of TGF-beta was reduced in NYT and PSL-treated mouse

serum, and the combined treatments further suppressed it.

However, the treatment with NYT alone did not induce a decrease

in the latent form of TGF-beta. The effect of NYT can be assumed

to be different from an immunosuppressive effect of PSL. Therefore,

the combined treatment with NYT and PSL can be expected to be

more useful for the therapy of autoimmune disease such as

nephritis, compared with NYT or PSL alone treatments.|PMID:

9754675 [PubMed - indexed for MEDLINE]

 

Nie L, Yu R, Lin X.|[Effect of Yiqi Zishen granule on ultrastructure of

glomeruli of IgA nephropathy in mice] [Article in Chinese]|

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999 Dec;19(12):737-9.

|Xiyuan Hospital, China Academy of TCM, Beijing

(100091).|OBJECTIVE: To study the effect and therapeutical

mechanism of Yiqi Zishen granule (YQZSG) in treating IgA

nephropathy. METHODS: One hundred and fifty mice were divided

into 5 groups randomly, in every treatment group, the relevant

drugs were given. Their kidney tissues were observed with light

microscope and electron microscope in batches at the 3rd, 6th, 9th

and 12th week. RESULTS: The glomerular mesangial cells and

mesangial matrix were proliferative in the model group at the 6th,

9th and 12th week. The light density of glomeruli, the mesangial

area, the numeral density of mesangial cells and the light density

of mesangial matrix in the model group were obviously higher, the

change of large and small dosage YQZSG group and positive

Chinese drug group were similar, but milder in pathological degree.

The light density of glomerulus area, the mesangial area, the

numeral density of mesangial cells and the light density of

mesangial matrix in large dosage YQZSG group were significantly

lower than those in the model group (P < 0.05 or P < 0.01).

CONCLUSION: YQZSG could inhibit the proliferation of mesangial

cells and the mesangial matrix in IgA nephropathy.|PMID:

11783147 [PubMed - indexed for MEDLINE]

 

Nykuda TD, Voznesens'kyi SO.|[An informational and statistical

validation of plant compounds for the treatment of patients with

chronic glomerulonephritis] [Article in Ukrainian]| Lik Sprava. 1994

Feb;(2):35-9. ||Chronic glomerulonephritis (ChGN) is a grave poorly

controlled disease for which no efficient method of pathogenetic

therapy is available. In looking for efficient methods of treatment

plants were of traditional (folk) medicine. The present investigation

involves an approach based on the concepts of informational

content of complicated prescriptions which form the basis of

traditional medicine. Methods have been worked out of

informational screening of structure of composite multicomponent

herbal remedies, on the basis of the information theory using

statistical methods. Computer the analysis has been performed of

176 phytotherapeutic formulae for the treatment of ChGN, based on

the folk medicine experience. Phytocompositions have been

selected to be used for a target-oriented action on human organism

in ChGN, being characterized by duplication of components of

unidirectional action. Herbs plants were singled out, incompatible

in the treatment of ChGN.|PMID: 8073716 [PubMed - indexed for

MEDLINE]

 

Sharma M, Li JZ, Sharma R, Artero M, Ge X, McCarthy ET, Wang

HY, Savin V.|Inhibitory effect of Tripterygium wilfordii multiglycoside

on increased glomerular albumin permeability in vitro.| Nephrol Dial

Transplant. 1997 Oct;12(10):2064-8. |Department of Medicine,

Medical College of Wisconsin, Milwaukee, USA.|BACKGROUND:

Tripterygium wilfordii Hook F is a medicinal plant used for the

treatment of glomerulonephritis in China. We studied the effect of

Tripterygium wilfordii multiglycoside (TWG) on glomerular albumin

permeability (Palbumin) in vitro. METHODS: Isolated rat glomeruli

were incubated with protamine (600 micrograms/ml) for 30 min, or

with human recombinant tumour necrosis factor (TNF-alpha 0.4

ng/ml), superoxide (10 units/ml), or serum from a focal segmental

glomerular sclerosis (FSGS) patient for 10 min at 37 degrees C.

TWG, 1 mg/ml, was added in parallel tubes to study the effect on

Palbumin. Control glomeruli were incubated under identical

conditions. The albumin reflection coefficient (sigma albumin) was

calculated from the change in glomerular volume in response to an

applied oncotic gradient. Convectional permeability (Palbumin) was

calculated as (1 - sigma albumin). RESULTS: Compared with

controls, protamine increased the Palbumin of glomeruli (0.83 +/-

0.05, n = 25, vs 0.18 +/- 0.03, n = 20); pretreatment with TWG

blocked this effect (0.13 +/- 0.04, n = 25). TNF-alpha also

increased the Palbumin (0.79 +/- 0.04, n = 24 vs 0.04 +/- 0.07, n =

19); preincubation with TWG blocked this effect (0.03 +/- 0.09, n =

24). Palbumin of glomeruli incubated with xanthine and xanthine

oxidase, resulting in the production of superoxide, also increased

as compared to controls (0.85 +/- 0.04, n = 15 vs 0.08 +/- 0.05, n =

14); TWG blocked this effect as well (0.21 +/- 0.08, n = 14). FSGS

serum also increased Palbumin of glomeruli significantly (0.88 +/-

0.02, n = 49 vs 0.00 +/- 0.02, n = 49); preincubation with TWG

blocked this effect (0.05 +/- 0.07, n = 30). TWG by itself had no

effect on Palbumin (0.19 +/- 0.10, n = 15). CONCLUSIONS: Our

results show that TWG blocks protamine, TNF-alpha, superoxide,

and FSGS serum-mediated increase in glomerular albumin

permeability in vitro. We conclude that reduction of proteinuria by

Tripterygium wilfordii multiglycoside in various kinds of glomerular

diseases in vivo might be due to protection of the glomerular

filtration barrier.|PMID: 9351066 [PubMed - indexed for MEDLINE]

 

Song Y, Ma J, Li CL.|[Mechanical research on effects of yishenqing

on membranous nephropathy] [Article in Chinese]| Zhongguo Zhong

Yao Za Zhi. 2002 Jul;27(7):537-40. |Department of Molecular and

Cellular Pharmacology, School of Pharmaceutical Science, Peking

University 100083, Beijing, China.|OBJECTIVE: To investigate the

therapeutic effect and mechanism of Yishenqing on rabbit

membranous nephropathy. METHOD: The rabbit membranous

nephropathy model was induced by cationic bovine serum albumin,

and the immunity of mice together with urine volume and

haemorheological property of rats were also estimated. RESULT:

Yishenqing could significantly reduce the urinary protein content,

preserve the renal function and pathologically restore the glomeruli.

Moreover, its effects also include immunity enhancement, diuretic

property and blood stasis amelioration. CONCLUSION: Yishenqing

has good effects on the rabbit membranous nephropathy, which is

probably due to the effects of diuretic property, immunity

enhancement and blood stasis amelioration.|PMID: 12776520

[PubMed - indexed for MEDLINE]

 

Sugimoto K, Fujise Y, Shibata K, Komori Y, Nikai T, Sugihara H,

Sakurai N.|Effects of a prescription of Chinese herbal medicine on

snake venom-induced nephropathy in mice.| Biol Pharm Bull. 1996

Apr;19(4):587-92. |Department of Hygiene, Hamamatsu University

School of Medicine, Japan.|A prescription of Chinese herbal

medicine, tentatively named P-19, was examined for its inhibitory

effect and its mechanism using an experimental model of

nephropathy induced by purified snake venom proteinase, Ac(1)-

proteinase (Ac(1)-P). The treated mice were injected with 0.1 ml of

crude extract of P-19 intraperitoneally every other day beginning 2

d before to 1 week after the injection of Ac(1)-P. The non-treated

mice were injected with saline instead of the medicine P-19. The

physiological condition and histopathological observation of the

mice at one week after Ac(1)-P injection were better in the treated

group than in the non-treated group. This indicates that P-19

inhibited the production of glomerular lesions induced in mice by

Ac(1)-P. The physiological condition and histopathological changes

in the mice were better with P-19 treatment than with P-3

treatment. Differences in the mechanism of action between the

crude extract of P-3 and P-19 are not only in diuretic action but

also in the changes in the glomerular basement membrane. On the

basis of spectrophotometric studies, phenolic carboxylates were

confirmed to be contained in the crude extract of P-19, having a

different chemical structure of caffeic acid, which is the effective

component in P-3. Immunohistochemical observation revealed a

difference between the groups. In the non-treated mice, deposits of

the venom were clearly observed in the glomerular tuft and

Bowman's capsule, corresponding to the histopathological

changes, within 2.5 min after the injection of Ac(1)-P. In the treated

mice, the deposits were indistinct in the Bowman's capsule. The

difference was considered to be caused by changes in the

glomerular basement membrane after P-19 treatment.|PMID:

8860964 [PubMed - indexed for MEDLINE]

 

Sun SL, Yi HP, Wang QL, Huang SZ, Liu XC.|Experimental studies

on immune-complex in situ type glomerulonephritis in rabbits

treated with mai-luo-tong and natural indigo.| J Tongji Med Univ.

1994;14(3):153-7. |Department of Nephrology, Tongji Hospital,

Tongji Medical University, Wuhan.|By injection of C-BSA, immune-

complex in situ type glomerulonephritis was duplicated in rabbits

and treated with Mai-Luo-Tong and natural Indigo. The results

showed that proteinuria in the treated groups M and Q was

decreased. The difference between group M and control group is

statistically significant (P < 0.05). Under light and electron

microscope, although glomerular basement membrane was

irregularly thickened and subepithelial dense electron deposited in

the treated group, but microthrombus, erythrocytes and platelets

aggregation and leukocytes impaction were not seen within

glomerular capillaries. Also in groups C, Q, M, mesenteric cell

count was 99.40 +/- 18.53, 92.87 +/- 17.89, 66.55 +/- 7.75

respectively, the M. Q groups are compared with group C, the

result is of statistical significance (P < 0.05) and there is no

apparent glomerular fibrosis in the treated groups.|PMID: 7807600

[PubMed - indexed for MEDLINE]

 

Sun Y, Chen B, Jia Q.|[Clinical effect of Xinqingning combined low

dose continuous gastrointestinal dialysis in treating uremia] [Article

in Chinese]| Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000

Sep;20(9):660-3. |Department of Nephrology, Xuanwu Hospital,

Capital University of Medical Sciences, Beijing

(100053).|OBJECTIVE: To investigate the clinical effect of

Xinqingning (XQN), a preparation of rhubarb, combined with low

dose continuous gastrointestinal dialysis in treating uremia.

METHODS: Patients of uremia were divided into three groups at

random, eighteen patients in the group A were treated with 1000 ml

gastrointestinal dialysate (non-absorbed mannitol solution) orally 2-

3 times a day, twenty patients in the group B treated with the

same therapy as that in the group A, but combined with XQN 5-10

tablets 3 times per day and 19 patients in the group C treated by

orally taken coated aldehyde oxystarch 5-10 g, 3 times a day. The

therapeutic course for the three groups were 11 months. The

changes in clinical manifestation, renal function, nutritional

condition, and electrolytes before and after treatment were

observed. RESULTS: After treatment, significant improvement was

revealed in aspects of uremic symptoms, quality of life, nutritional

condition, serum creatinine, urea nitrogen, serum phosphate, uric

acid, CO2 combining power, creatine clearance, body weight and

arm muscular circumference in the group A and B, as compared

with those in the group C. In comparison of the group A and B, the

group B showed a lower serum triglyceride and slower progression

of chronic renal failure (CRF). All the criteria were not improved in

the group C and with serum creatinine raised significantly.

CONCLUSION: XQN combined low dose continuous

gastrointestinal dialysis therapy was effective in definitely treating

uremia, it provides a new therapeutic means of non-replacement

therapy for CRF with uremia.|Publication Types: Clinical Trial

Randomized Controlled Trial PMID: 11789169 [PubMed - indexed

for MEDLINE]

 

Wang G, Li C, Jin L.|[Experimental study on treatment of chronic

renal failure with yishen qudu capsule] [Article in Chinese]|

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Oct;20(10):761-3.

|Postgraduate School of China Academy of TCM, Beijing

100700.|OBJECTIVE: To study the mechanism of action of Yishen

Qudu capsule (YSQDC) in experimental rat model of chronic renal

failure (CRF). METHODS: Membranous nephropathy model was

induced by cationized bovine serum albumin intravenous

administration in rats for 7 weeks and developed to CRF. The

model was then treated with YSQDC of large or small dose by

gastrogavage for 5 weeks. Oxidated starch was used in the control

group. RESULTS: YSQDC could reduce proteinuria, serum

creatinine, blood urea nitrogen, total cholesterol, triglyceride and

serum circulating immune complex (P < 0.01 or P < 0.05), it also

reduced the kidney coefficient, glomerular cells and tubular protein

cast significantly (all P < 0.01). The strength of immune

fluorescence weakened remarkably (P < 0.01). The pathological

lesions improved significantly after treatment under light and

electron-microscopic examination. CONCLUSION: YSQDC could

improve renal function significantly and inhibit the progression of

CRF.|PMID: 11938814 [PubMed - indexed for MEDLINE]

 

Wang QL, Huang SZ, Sun SL.|[Research on immune complex in

situ type glomerulonephritis treated with mai-luo-tong in rabbits]

[Article in Chinese]| Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993

Jan;13(1):30-2, 5-6. |Tongji Hospital, Tongji Medical University,

Wuhan.|Applying c-BSA to duplicate immune complex in situ type

glomerulonephritis in rabbits and treating it with Blood Circulation

Promoting and Stasis-Removing Drugs Mai-Luo-Tong, the results

showed that proteinuria in the treated group was decreased

significantly, as compared to the control group (P < 0.01). Under

light and electron microscope, although glomerular basement

membrane was irregularly thickened and subepithelial dense

electron deposits were found in both groups, but histopathologic

damage in the treated group less than that of control one. In the

treated group micro-thrombus, erythrocytes and platelets

aggregation, leukocytes impaction were not seen within glomerular

capillary. Also in the treated group mesangial cell proliferation and

granulocyte infiltration were decreased significantly (P < 0.01) and

there was no apparent glomerular fibrosis in former group.|PMID:

8499732 [PubMed - indexed for MEDLINE]

 

Wang SQ, Du XR, Lu HW, Wang TL, Li H.|Experimental and

clinical studies of " Shen Yan Ling " in treatment of chronic

glomerulonephritis.| J Tradit Chin Med. 1989 Jun;9(2):132-4. || " Shen

Yan Ling " (SYL) is a compound herbal preparation consisting of 16

ingredients: Herba Ecliptae, Radix Rhemanniae, Rhizoma Cibotii,

Radix Angelica Sinensis, Rhizoma Ligustici Chuanxiong, Radix

Paeoniae Rubra, Rhizoma Diosocoreae, Poria, Radix

Sanguisorbae, Radix Rubiae, Herba Portulacae, Fructus

Gardeniae, Herba Cirsii Japonici, Herba Cephalanoploris, etc. In

animal experiments, SYL was shown to have therapeutic effect for

Masugi's nephritis models. It has also been used with satisfactory

results in the treatment of 314 cases of chronic glomerulonephritis

of the common type with manifestations of Yin deficiency and

endogenous heat.|PMID: 2779276 [PubMed - indexed for MEDLINE]

 

Watanabe H, Takahashi Y, Fujioka T, Kanmatsuse K.|Effect of

Saireitoh on rabbit smooth muscle cell proliferation and

experimental atherosclerosis.| J Atheroscler Thromb. 2000;6(2):33-

41. |Second Department of Internal Medicine, Nihon University

School of Medicine, Tokyo, Japan.|Saireitoh is a traditional

Chinese medicine that is often given to patients with nephrotic

syndrome or glomerulonephritis. Studies have reported that

Saireitoh stimulates intrinsic steroid secretion in rats and

suppresses the proliferation of fibroblasts in vitro. We examined the

effects of Saireitoh on vascular smooth muscle cell proliferation and

migration in vitro and experimental atherosclerosis in vivo. Saireitoh

rabbit serum obtained from New Zealand White rabbits which were

given a diet containing 2% Saireitoh for 3 days significantly

inhibited [3H]-thymidine incorporation by smooth muscle cells,

which were isolated from thoracic aorta explants of rabbits. The

addition of 10% Saireitoh rabbit serum to a culture medium

containing smooth muscle cells inhibited DNA synthesis by 50%

as compared with a control culture to which 10% normal rabbit

serum was added. We also found that the number of smooth

muscle cells in the culture containing Saireitoh rabbit serum was

decreased. When PDGF was used as a chemoattractant, we

demonstrated that Saireitoh rabbit serum slightly inhibits the

migration of smooth muscle cells. In in vivo experiments, Saireitoh

did not suppress the development of atherosclerosis but tended to

reduce the damage. We concluded that although Saireitoh inhibited

the proliferation of smooth muscle cells, the effect of prevention on

the development of atherosclerosis is weak in the in vivo

condition.|PMID: 10872612 [PubMed - indexed for MEDLINE]

 

Wei BH.|[Clinical and experimental study on the prescription of

jianpi yipi] [Article in Chinese]| Zhong Xi Yi Jie He Za Zhi. 1989

Sep;9(9):537-9, 516. ||According to " Spleen-Stomach " theory, the

effect of Jianpi Yiqi prescription (JPYQ) was observed clinically and

studied experimentally. 168 cases manifested as Spleen-Qi

deficiency including chronic gastritis and peptic ulcer (84 cases),

chronic glomerulonephritis (44 cases) and vomitus gravidarum-

edema of pregnancy (40 cases) were treated with JPYQ.

Estimation were made based on their clinical conditions. Serum

gastrin, serum cholyglycine, blood acetylcholine and

cholinesterase, blood 5-HT and histamine were measured before

and after treatment. The overall effective rate was 92.9% in gastritis

and peptic ulcer group, 86.3% in nephritis group and 100% in

pregnancy group respectively. A marked increase of serum

glycocholic acid level was shown in gastritis and peptic ulcer and

vomitus gravidarum groups. That was considered as the result of

the secretion of cholic acid by this prescription. Clinical

improvement was also obtained in nephritis group accompanying

disappearance of albuminuria in 36.4%. Blood level of 5-HT and

histamine lowered to some extent and tended to be normal.

Besides, this prescription markedly inhibited electric stimulated

excitement on isolated longitudinal muscle strip of guinea pig's

ileum. The mechanism could be the inhibition of release of

acetylcholine from Auerbach's plexus by this prescription.|PMID:

2598359 [PubMed - indexed for MEDLINE]

 

Wei CY, Chen XM, Zhang YP.|[Clinical observation on effect of

shenle capsule in treating mesangial proliferating

glomerulonephritis] [Article in Chinese]| Zhongguo Zhong Xi Yi Jie

He Za Zhi. 2002 May;22(5):341-5. |Department of Nephrology,

General Hospital of PLA, Beijing 100853.|OBJECTIVE: To study

the therapeutic effect of Shenle capsule (SLC) in treating

mesangial proliferating glomerulonephritis (MsPGN) and to explore

its therapeutic mechanism and clinical indication. METHODS:

Adopting case control method, taking angiotensin-converting

enzyme inhibitor (benazepril) as control agent, the 142 cases of

MsPGN were randomly divided into 3 groups, treated with SLC

(Group A, n = 36), SLC plus benazepril (Group B, n = 68) and

benazepril alone (Group C, n = 38) respectively. Changes of

fibrinogen, lipids, renal function and urinary protein were observed.

RESULTS: The total effective rate in Group A was higher than that

in Group C, but with insignificant difference. The total effective rate

in Group B after 3 courses of treatment was 89.74%, which was

higher than that in Group C and Group A (P < 0.05). Levels of

cholesterol (CH), triglyceride (TG), serum creatinine, fibrinogen and

urinary protein (UP) were significantly lowered in Group A after

treatment, with the levels of CH, TG and UP lower than those in

Group C, while CH, TG and fibrinogen were unchanged in Group C

after treatment. CONCLUSION: SLC is superior in higher efficacy

and less side-effects in treating MsPGN, its effect is related with

the degree of kidney pathological changes, it is more effective in

treating patients with mild pathological change than in those with

severe change. The outcome of combined use of SLC and

angiotensin-converting enzyme inhibitor would be

better.|Publication Types: Clinical Trial Randomized Controlled Trial

PMID: 12584830 [PubMed - indexed for MEDLINE]

 

Wei J, Ni L, Yao J.|[Experimental treatment of rhubarb on

mesangio-proliferative glomerulonephritis in rats] [Article in

Chinese]| Zhonghua Nei Ke Za Zhi. 1997;36(2):87-9. |Department of

Nephrology, Drum Tower Hospital, Nanjing.|Accumulation of

extracellular matrix is a prominent feature of progressive

glomerulonephritis (GN). Previously, we have shown that Emodin,

an important component of Rhubarb, inhibits the fibronectin (FN)

production of cultured mesangial cells. We now provide evidence of

the same effect of Rhubarb in immune complex GN induced in rats

by injection of anti-thymocyte serum (ATS). Rhubarb ameliorated

mesangial matrix expansion on day 7 after ATS administration.

Decreased FN level and IL-1 activity were found in the supernatant

of cultured glomeruli from Rhubarb-treated animal at the 7th day.

Glomerular tissue FN fluorescence staining was also much weaker

than that of the untreated rats. These studies demonstrated that

Rhubarb-treated anti-Thy-1 animal model should develop

significantly less matrix expansion. Rhubarb also inhibited

synthesis and secretion of fibronectin, an important component of

mesangial extracellular matrix. Decreased IL-1 activity might be

involved in the therapeutic effect of Rhubarb on

mesangioproliferative glomerulonephritis.|PMID: 9812565 [PubMed -

indexed for MEDLINE]

 

Wei J, Yan XC, Wang JA.|[Clinical and experimental study on

effects of ji shen mixture for infantile acute glomerulonephritis]

[Article in Chinese]| Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993

Dec;13(12):733-5, 709. |First Affiliated Hospital, Xi'an Medical

University.|33 cases of acute glomerulonephritis treated with Ji

Shen Mixture (JSM) were studied with 31 cases treated with

Western medical therapy (WM) for comparison and 34 healthy

subjects as controls. The levels of lipo-peroxide (LPO), glutathione

peroxidase (GSH-Px), superoxide dismutase (SOD), theromboxane

B2 (TXB2), 6-keto-PGF1 alpha and TXB2/6-keto-PGF1 alpha ratio

were examined before and after treatment. Compared with healthy

controls, the levels of LPO, TXB2, TXB2/6-keto-PGF1 alpha of

patients increased and that of GSH-Px, 6-keto-PGF1 alpha

decreased significantly, whereas SOD activity had no significant

difference. After treatment, the level of LPO reduced and GSH-Px

activities raised significantly, but the effect of JSM group was better

than that of WM group. It indicated that JSM was more effective in

clearing the free radicals. The TXB2, TXB2/6-keto-PGF1 alpha

dropped and 6-keto-PGF1 alpha elevated significantly after

treatment, the effects of JSM were markedly better than those of

WM. Furthermore, JSM was more potent in raising the clearing

rate of hematuria and proteinuria.|PMID: 8136648 [PubMed -

indexed for MEDLINE]

 

Wu X, Li J, Liu B.|[Clinical study on dan shao tang in treating IgA

nephropathy of deficiency of yin with damp-heat symptom] [Article

in Chinese]| Zhong Yao Cai. 2003 Nov;26(11):844-6. |First Affiliated

Hospital of Sun Yat-sen University, Guangzhou

510080.|OBJECTIVE: To explore the effect of Dan Shao Tang(DST)

in treating IgA nephropathy(IgAN) of deficiency of Yin with damp-

heat symptom. METHODS: 90 patients with IgAN of deficiency of

Yin with damp-heat symptom were randomly divided into two

groups. 50 patients in treatment group were treated with DST and

western medicine and 40 patients in control group were treated

only with western medicine. The effects and changes of the

indexes including renal function, hematuria, proteinuria, blood IgA

before and after treatment were observed. RESULTS: After six

months treatment, the general effective rate in treatment group was

70.00%, which was markedly higher than that in control

group(37.50%, P < 0.01). Treatment group is obviously better than

control group on decreasing hematuria, proteinuria, blood IgA and

improving renal function(P < 0.05). CONCLUSION: DST is effective

on IgAN of deficiency of Yin with damp-heat symptom.|Publication

Types: Clinical Trial Randomized Controlled Trial PMID: 14989068

[PubMed - indexed for MEDLINE]

 

Wu X, Li J, Mo S, Zhou Y, Shen W.|[Clinical study on treatment 82

cases of chronic primary glomerulopathy with deficiency of yin with

damp-heat symptom with dan shao tang] [Article in Chinese]|

Zhong Yao Cai. 2001 Jun;24(6):465-7. |First Affiliated Hospital, Sun

Yat-sen University of Medical Sciences, Guangzhou

510080.|OBJECTIVE: To investigate the treatment effect of Dan

Shao Tang on chronic primary glomerulopathy with deficiency of

Yin with damp-heat symptom. METHODS: 132 cases of chronic

glomerulopathy with deficiency of Yin with damp-heat symptom,

which divided into two groups at random, the 82 cases which were

the therapy group using Dan Shao Tang and west medicine, and

the other 50 cases which treated only by west medicine. We

observed the effect and indexes change including renal function,

proteinuria, hematuria. RESULTS: The effective rate of the therapy

group is 90.24%, and the effective rate of the control group is 66%

(P < 0.05), The therapy group is superior to the control group in

improving renal function, decreasing proteinuria and hematuria in

evidence(P < 0.05). CONCLUSION: Dan Shao Tang is effective to

treatment on chronic primary glomerulopathy with deficiency of Yin

with damp-heat symptom.|Publication Types: Clinical Trial

Randomized Controlled Trial PMID: 11563193 [PubMed - indexed

for MEDLINE]

 

Xie T, Zhang L.|TCM differential treatment of 30 cases of IgA

nephropathy.| J Tradit Chin Med. 1997 Dec;17(4):243-6.

|Department of TCM, Chinese PLA General Hospital, Beijing.|Thirty

cases of IgA nephropathy having been diagnosed by biopsy with

kidney puncture were selected. The treatment was based on the

differentiation of syndromes in traditional Chinese medicine (TCM).

The disease was divided into 4 stages: the initial stage with the

lesion in the lung and kidney, the stable stage with the lesion in

the spleen and kidney, the late stage with the lesion in the liver and

kidney, and the recurrent stage. They were treated by TCM. Of

them, 10 cases were completely alleviated, 13 markedly alleviated,

4 improved, and 3 ineffective, the total effective rate being

90%.|PMID: 10437203 [PubMed - indexed for MEDLINE]

 

Xiong YL, Wang JH, Zong GZ, Tu GR, Feng QR, He W, Cai HB, Yu

JG, Hui LQ.|[Effects of guifu dihuang pills extract on rabbit IgG

accelerated mouse nephritis induced by nephrotoxic serum]

[Article in Chinese]| Zhongguo Zhong Yao Za Zhi. 1994

May;19(5):302-4, inside backcover. |Institute of Chinese Materia

Medica, China Academy of Traditional ,

Beijing.|The effects of Guifu Dihuang Pills extract were observed in

rabbit IgG accelerated mouse nephritis model induced by

nephrotoxic serum. The results showed that this preparation could

increase serum albumin, reduce urine protein, serum urea nitrogen

and total cholesterol in serum, and improve the histological lesions

in kidneys. The effects of Guifu Dihuang Pills extract in dosages of

0.3g/kg and 1.2g/kg were similar to those of cyclophosphamide

0.015g/kg.|PMID: 7945874 [PubMed - indexed for MEDLINE]

 

Ye RG.|[Treatment of IgA nephropathy by integrated traditional and

Western medicine] [Article in Chinese]| Zhongguo Zhong Xi Yi Jie

He Za Zhi. 1992 Jan;12(1):17-9, 4. |Renal Institute, Sun Yat-Sen

University of Medical Sciences, Guangzhou.|45 cases of IgA

nephropathy were confirmed by renal biopsy and were divided into

2 groups, the integrated traditional and western medicine (TCM-

WM) therapeutic group and the western medicine (WM) therapeutic

group. The WM group was treated by conventional western

medicine (persantin, vitamin B co.), and the TCM-WM group was

treated by the same western medicine plus differential

symptomatic treatment with decoction of Chinese crude herbs. In

this paper, most patients (30 cases) were present as deficiency of

Yin of the Liver and Kidney type, and were treated by Qiju Dihuang

pill plus Erzhi pill. All types in TCM-WM group were also used

herbs of promoting blood circulation and remove blood stasis in

almost every case. After 6 months of such treatment, the total

effective rate of TCM-WM group and the WM group were 86.4%

and 13.0% respectively. There was very significant difference (P

less than 0.01) between them. The results showed that the curative

effect of the TCM-WM group was much superior than WM alone for

the treatment of IgA nephropathy.|PMID: 1627942 [PubMed -

indexed for MEDLINE]

 

Yoshikawa N, Ito H, Sakai T, Takekoshi Y, Honda M, Awazu M, Ito

K, Iitaka K, Koitabashi Y, Yamaoka K, Nakagawa K, Nakamura H,

Matsuyama S, Seino Y, Takeda N, Hattori S, Ninomiya M.|[A

prospective controlled study of sairei-to in childhood IgA

nephropathy with focal/minimal mesangial proliferation. Japanese

Pediatric IgA Nephropathy Treatment Study Group] [Article in

Japanese]| Nippon Jinzo Gakkai Shi. 1997 Jul;39(5):503-6. |Faculty

of Health Science, Kobe University School of Medicine.|To

determine the effect of the Chinese herbal medicine, Sairei-to (TJ-

114) in children with newly diagnosed IgA nephropathy showing

focal/minimal mesangial proliferation, we undertook a prospective

controlled study. One hundred and one patients were randomly

assigned to receive Sairei-to for 2 years (group 1) or no drug for 2

years (group 2). Forty-six of the 50 patients in group 1 and 48 of

the 51 patients in group 2 completed their trial. At entry, the two

groups of patients did not differ in the clinical, laboratory and

pathologic findings. At the end of the trial, urinary protein excretion

and hematuria were significantly reduced in group 1, but were

unchanged in group 2. Twenty-one group 1 patients (46%) had

normal urine, but only 5 group 2 patients (10%) had normal urine at

the end of the trial (p < 0.001). Blood pressure and creatinine

clearance were normal at the end of the trial in all but one group 2

patient, who developed chronic renal failure. The present study

demonstrates that 2-year Sairei-to treatment early in the course of

disease is effective in children with IgA nephropathy showing

focal/minimal mesangial proliferation.|Publication Types: Clinical

Trial Multicenter Study Randomized Controlled Trial PMID:

9283216 [PubMed - indexed for MEDLINE]

 

Yu EK.|[Anti-free radical damage of chronic glomerulonephritis with

febrifugal and diuretic medicinal herbs] [Article in Chinese]|

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Aug;13(8):464-6, 452.

|Heilongjiang Institute of TCM, Harbin.|A clinical trial to evaluate the

method of removing Heat and eliminating Dampness (RHED) with

febrifugal and diuretic medicinal herbs in treating chronic

glomerulonephritis (CGN) patients was conducted. 45 cases of

CGN were compared with 42 cases of healthy persons as control.

The results showed that CGN patient's serum levels of lipid

peroxide (LPO) increased, superoxide dismutase (SOD) and trace

elements such as Zn, Cu, Se dropped down. After treatment with

RHED the activity of LPO, SOD, catalase (CAT) revealed

significant improvement. Serum levels of Zn, Cu, Se increased. It

was considered that free radical damage was a general

mechanisms of CGN and anti-free radical damage with RHED

might play an important role in treatment.|Publication Types:

Clinical Trial PMID: 8111197 [PubMed - indexed for MEDLINE]

 

Yu JY, Xiong NN.|[Pathogenic factor (Dampness-heat) of

glomerulopathy] [Article in Chinese]| Zhongguo Zhong Xi Yi Jie He

Za Zhi. 1992 Aug;12(8):458-60, 451. |Affiliated Hospital of Nanjing

College of TCM.|Mesangial proliferative glomerulonephritis

(MsPGN) induced by chronic serum sickness in rabbits coincide

with the human chronic progressive glomerulonephritis resulted

from repeated infection, which is similar to pathologic changes of

Dampness-Heat Syndrome. The experimental model of MsPGN

was treated by Abelmoschus manihot. which could remove the

Dampness-Heat. The amount of proteinuria in treating and

control group were 62.68mg/24hr and 121.94mg/24hr respectively (P < 0.05), the

number of cells in glomeruli were 61.54 and 80.39 respectively (P < 0.01), and

diameters of glomeruli were 102.43 microns and 121.13 microns respectively (P <

0.01). It suggested that the drug could alleviate circulating immune complex

(CIC) mediated renal injury.|PMID: 1477499 [PubMed - indexed for MEDLINE]

 

Yu Y, Cui J, Zhang F.|[Chinese drugs for invigorating spleen to remove

dampness, activating blood circulation to eliminate turbid in retarding

progression of chronic renal failure] [Article in Chinese]| Zhongguo Zhong Xi

Yi Jie He Za Zhi. 2000 Oct;20(10):727-8. |Department of Nephrology, General

Hospital of Chengdu Military Region, Chengdu 610083.|OBJECTIVE: To investigate

the effect of Chinese drugs (CD) for invigorating Spleen to remove dampness,

activating blood circulation to eliminate Turbid in retarding progression of

chronic renal failure (CRF). METHODS: Thirty-nine patients with CRF were

divided into two groups randomly, 18 patients in the control group were treated

with low protein diet and controlling blood pressure and 21 patients in the CD

group were treated similarly with that of the control group but with additional

CD. Levels of serum creatinine (SCr), blood urea nitrogen (BUN), blood albumin

(Alb), cholesterol (CH), triglyceride (TG), high-density lipoprotein (HDL) and

hemoglobin (Hb) were checked every 2 months, and the rate of progression of CRF

was estimated by slope of the creatinine reciprocal (1/SCr) with time (month).

RESULTS: Levels of SCr and BUN in the CD group were significantly lower and HDL

markedly higher than those in the control group, P < 0.05. Mean slopes of the

creatinine reciprocal with time in the two groups was significantly different,

P < 0.01. CONCLUSION: Additional CD treatment based upon the protein diet and

controlling blood pressure could retard the progression process of CRF

evidently.|Publication Types: Clinical Trial Randomized Controlled Trial PMID:

11938803 [PubMed - indexed for MEDLINE]

 

Yuan W.|[Changes in renal cortical thromboxane A2, prostaglandin F1 alpha and

effects of dazoxiben, chuan xiong on in situ immune complex glomerulonephritis

in rats] [Article in Chinese]| Zhonghua Yi Xue Za Zhi. 1993 Sep;73(9):528-31,

574. |Department of Nephrology, Changhai Hospital, Second Military Medical

University, Shanghai.|We investigated the relation between the changes of

TXA2-PG1 alpha balance and glomerular injury, and the effects of Dazoxiben,

Chuan Xiong on in situ immune complex glomerulonephritis (ISICGN) produecd by

C-BSA in rats. After two weeks of immunization, the level of renal cortical

TXB2 and urine protein was increased, while that of 6-keto-PGF1 alpha was

decreased. Four weeks later, the changes as mentioned above were more

significant, and platelet aggregation revealed an increase of maximal

aggregation. Positive correlation was seen between urine protein and renal

cortical TXA2, and negative correlation between urine protein and 6-keto-PGF1

alpha. Histological examination showed morphological changes. Two

treated-groups showed significant reduction of urine protein and renal cortical

TXB2, but increase of 6-keto-PGF1 alpha. Besides the changes like worm-eaten in

electron-dense deposits, foot process fusion disappeared. The thickened GBM and

mesangial proliferation were lessened, especially in Dazoxiben group. These

results suggests that there is a TXA2-PG1 alpha imbalance in ISICGN, and TXA2

plays an important pathogenetic role in the onset and progression of

glomerulonephritis. Dazoxiben and Chuan Xiong might improve TXA2-PG1 alpha

imbalance and attenuate glomerular injury to some extent in ISICGN.|PMID:

8313194 [PubMed - indexed for MEDLINE]

 

Zhang W, Li J.|[Clinical study of treating infantile acute nephritis with

antipyretic and detoxication, cooling blood and diuretic principle] [Article in

Chinese]| Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999 Mar;19(3):141-3. |Nanjing

Municipal Hospital of Children, Nanjing (210008).|OBJECTIVE: To find out the

relationship between nitric oxide and onset of infantile acute nephritis, and

the effect of traditional Chinese medicine (TCM) and Western medicine (WM)

combination therapy. METHODS: Dividing 44 infantile acute nephritis patients

into two groups. Group 1 was treated with cooling blood and diuretic principle,

together with WM, Group 2 was treated with antipyretic and detoxication,

cooling blood and diuretic principle, together with WM. The content of

nitrite/nitrate iron (Fe NO2/NO3) in blood before and after treatment were

determined through Griess nitrate reduction method, then compared with that of

28 healthy children. RESULTS: The content of Fe NO2/NO3 being in acute

nephritis period was obvious higher than that of control group and

reconvalecent period, P < 0.01. The macroscopic hematuria was higher than that

of microscopic hematuria, P < 0.01. Urinary alexin third element (C3) and alpha

2-macroglobulin (alpha 2-M) positive patients Fe NO2/NO3 was higher than that

of negative ones, P < 0.01. Those complicated with infection Fe NO2/NO3 was

higher than that without infection P < 0.01. Short term cure rate of group 2

was higher than that of group 1, P < 0.05. Nitric oxide may participate the

onset and pathogenesis of infantile acute nephritis. CONCLUSION: TCM-WM

combination therapy, especially antipyretic and detoxication, cooling blood and

diuretic principle, could restrain nitric oxide from damaging tissue and

remitting disease.|PMID: 11783279 [PubMed - indexed for MEDLINE]

 

Zheng JF, Chen SY.|Observations on therapeutic effects of huangdan decoction

and Tripterygium Wilfordii compound tablet on membranous glomerulonephritis in

rats.| J Tongji Med Univ. 1995;15(1):31-4. |Department of Traditional Chinese

Medicine, Xiehe Hospital, Tongji Medical University, Wuhan.|The model of

membranous glomerulonephritis (MGN) in rats was successfully established using

self-made cationic bovine serum albumin (C-BSA) and treated with Huangdan

Decoction (HDD) and Tripterygium Wilfordii Co. tablet (TW). Results indicated

that the levels of urinary protein, blood urea nitrogen (BUN) and serum

creatinine (Scr) in treated groups (groups A, B and C) were significantly

decreased as compared with the control group (group D) (P < 0.01). By light and

electron microscope and immunofluorescent technique, the damage to kidney in

groups A, B and C was found much milder than that in group D with lesion in

group A being slightest. These findings suggest that HDD and TW may alleviate

the pathological lesions of MGN, prevent or retard its progression, and have

remarkable therapeutic effects on MGN.|PMID: 7783260 [PubMed - indexed for

MEDLINE]

 

Zhu P, Wei X, Zhao W.|[Effect of Baoyuan Qiangshen capsule no. II on tubular

interstitial injury in chronic renal failure patients] [Article in Chinese]|

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999 Dec;19(12):721-4. |Jiangsu Provincial

TCM-WM Center of Nephropathy, Zhenjiang, Jiangsu (212002).|OBJECTIVE: To

investigate the protective effect and mechanism of Baoyuan Qiangshen Capsule

No. II (BYQS) in treating chronic renal failure (CRF). METHODS: Sixty patients

of CRF were divided into 2 groups randomly, the tested group treated with BYQS

combined with Lotensin and the control group treated with essential amino acid

combined with Lotensin. Changes of renal function and tubular marked proteins

were observed. RESULTS: The markedly effective rate and total effective rate of

the tested group were 63.3% and 93.3% respectively and those of the control

group were 30.0% and 56.7% respectively, the effect of the tested group was

markedly better than that of the control group (P < 0.01). In the tested group

after treatment, BUN, SCr and CCr were improved significantly, urine retinol

binding protein and beta 2-microglobulin and N-acetyl-beta-D-glucosamindase

decreased significantly (P < 0.01), while Tamm-Horfau protein increased

significantly (P < 0.05). CONCLUSION: BYQS could alleviate tubular interstitial

injury significantly so as to improve the renal function and enhance the

effective rate in treating CRF.|Publication Types: Clinical Trial Randomized

Controlled Trial PMID: 11783142 [PubMed - indexed for MEDLINE]

 

Zou Y.|[Effect of baoshen wan on serum lipid peroxide levels in nephritis

treated based on the differentiation-syndromes] [Article in Chinese]| Zhong Xi

Yi Jie He Za Zhi. 1990 Jul;10(7):404-5, 388. |Affiliated Hospital of Nanjing

College of TCM.|This paper deals with the treatment of 22 cases of chronic

nephritis with Baoshen Wan (protecting kidney pills) according to the

differentiation of syndromes; the results showed that 3 cases had got perfect

remission, 6 cases fundamental remission, and 10 cases partial remission; thus

its effective rate reached to 86.4%. Before treatment, the mean value of serum

LPO of the 22 patients was 4.44 +/- 0.099 (means +/- S means, mumol/L), which

compare with the normal value (3.69 +/- 0.075), P less than 0.05. After

treatment, the serum LPO level was lowered to 3.95 +/- 0.11, P less than 0.05.

It suggested that Baoshen Wan could disperse the free radical and lower the

serum LPO level in the patients with chronic nephritis.|PMID: 2208418 [PubMed -

indexed for MEDLINE]

 

SEE ALSO:

 

Bi ZQ, Zheng FL, Kang ZQ.|Treatment of chronic renal failure by retention-enema

with rhizoma rhei compound decoction.| J Tradit Chin Med. 1982 Sep;2(3):211-4.

|||Publication Types: Case Reports PMID: 6765716 [PubMed - indexed for MEDLINE]

 

Chu W.|[summary on the clinical uses and study of Tripterygium wilfordii]

[Article in Chinese]| Zhong Xi Yi Jie He Za Zhi. 1988 Jul;8(7):443-5.

|||Publication Types: Review Review, Tutorial PMID: 3061673 [PubMed - indexed

for MEDLINE]

 

Dong DC, Zhou LF, Chen JX.|[Changes in proteinuria, renal function and immunity

after treatment with injections of a solution of Astragalus membranaceus]

[Article in Chinese]| Zhong Xi Yi Jie He Za Zhi. 1987 Jul;7(7):403-4, 388.

|||PMID: 3690764 [PubMed - indexed for MEDLINE]

 

Guo L, Liu Y, Wang H.|Prof. Ye Chuanhui's experience in treating nephritic

proteinuria.| J Tradit Chin Med. 2002 Sep;22(3):163-9. |Nanjing University of

Traditional , Nanjing 210029.||Publication Types: Case Reports

PMID: 12400416 [PubMed - indexed for MEDLINE]

 

Hammerschmidt DE.|Xanthium strumarium.| J Lab Clin Med. 1998 Jul;132(1):86.

|||PMID: 9665377 [PubMed - indexed for MEDLINE]

 

He XP, Gu GL, Zhu QX.|[Effect of compound xiancao capsule on serum transforming

growth factor beta 1 level in patients with primary chronic glomerulonephritis]

[Article in Chinese]| Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Feb;24(2):156-7.

|hexpin||Publication Types: Clinical Trial Randomized Controlled Trial

PMID: 15015455 [PubMed - indexed for MEDLINE]

 

Ju J, Lian Y, Bo S.|Differential treatment for membranoproliferative

glomerulonephritis with TCM prescriptions plus triptoryph tablets--a report of

30 cases.| J Tradit Chin Med. 2003 Sep;23(3):177-9. |Yuhuangding Hospital,

Yanta, 264000, Shandong Province.||PMID: 14535177 [PubMed - indexed for MEDLINE]

 

Li RL.|[summary of second national symposium of Tripterygium wilfordii]

[Article in Chinese]| Zhong Xi Yi Jie He Za Zhi. 1991 Dec;11(12):758-60, 732.

|||Publication Types: Congresses PMID: 1687966 [PubMed - indexed for MEDLINE]

 

Lin CY.|Treatment of IgA nephropathy.| Springer Semin Immunopathol.

1994;16(1):121-7. |Department of Medical Research and Pediatrics, Veterans

General Hospital-Taipei, Taiwan, Republic of China.||Publication Types: Review

Review, Tutorial PMID: 7997942 [PubMed - indexed for MEDLINE]

 

Lin S.|Nephrological research.| Chin Med J (Engl). 1996 Jan;109(1):37-9.

|Huashan Hospital, Shanghai Medical University.||Publication Types: Review

Review, Tutorial PMID: 8758360 [PubMed - indexed for MEDLINE]

 

Shi SZ.|[Progress in research on urologic diseases with traditional Chinese

medicine and traditional Chinese medicine and Western medicine treatment]

[Article in Chinese]| Zhong Xi Yi Jie He Za Zhi. 1989 Sep;9(9):571-3.

|||Publication Types: Review Review, Tutorial PMID: 2688941 [PubMed - indexed

for MEDLINE]

 

Wang J, Zhang DS.|[Effect of shenqiwan on immunological function in the

nephrotic syndrome of chronic glomerulonephritis patients] [Article in

Chinese]| Zhong Xi Yi Jie He Za Zhi. 1987 Dec;7(12):731-3, 709. |||PMID:

3502398 [PubMed - indexed for MEDLINE]

 

Wei M, Huang QF, Zeng SP, Lang ZW.|Studies on treatment of glomerulonephritis

by TCM yi-qi huo-xue (Nourish Qi Move Blood) methods.| J Tradit Chin Med. 1988

Mar;8(1):55-60. |||PMID: 3393020 [PubMed - indexed for MEDLINE]

 

Wei M, Zhu L, Huang Q, Xu W, Li B.|Study on the therapeutic effects of

traditional Chinese drugs in experimental glomerulonephritis.| J Tradit Chin

Med. 1993 Dec;13(4):287-93. |Department of Pathology, Beijing College of

TCM.||PMID: 8139280 [PubMed - indexed for MEDLINE]

 

Xiong NN, Zou YQ, Huang XW, Gong LJ, Yu CH, Zou YX.|Effects of TCM therapy on

the progression of chronic renal failure caused by primary glomerulonephritis.|

J Tradit Chin Med. 1988 Jun;8(2):107-11. |||PMID: 3412003 [PubMed - indexed for

MEDLINE]

 

Ye L.|[Experiences of Doctor Ye Shaoli in the treatment of children's diseases]

[Article in Chinese]| Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000

Nov;20(11):856-7. |||PMID: 11938836 [PubMed - indexed for MEDLINE]

 

Zhao GH.|Modified five herb decoction [?Modified Wu Wu Tang] in treating

infantile acute nephritis.| J Tradit Chin Med. 1988 Sep;8(3):216. |||PMID:

3216668 [PubMed - indexed for MEDLINE]

 

Zhou E.|Professor Wang Gang's experience in treating chronic

glomerulonephritis.| J Tradit Chin Med. 2003 Jun;23(2):90-5.

|National Center of Nephroses, Jiangsu Provincial Hospital of

Taditional , Nanjing 210029.||PMID: 12875061

[PubMed - indexed for MEDLINE]

 

 

 

 

 

Best regards,

 

Email: <

 

WORK : Teagasc Research Management, Sandymount Ave., Dublin 4, Ireland

Mobile: 353-; [in the Republic: 0]

 

HOME : 1 Esker Lawns, Lucan, Dublin, Ireland

Tel : 353-; [in the Republic: 0]

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Chinese Proverb: " Man who says it can't be done, should not interrupt man doing

it "

[Guest guest]

A very good and safe choice used in mainland China is dong chong xia

cao/cordyceps.

 

 

On Aug 4, 2004, at 9:27 PM, xyberdoc wrote:

 

> Hello

>

> Does anyone have an idea what chinese herb we can use for

> glomerulonephritis? I have a patient with the said condition and

> despire being on steroid, his condition is deteriorating

>

> Thanks a lot. This group has helped me a lot

>

>

>

>