Guest guest Posted May 17, 2003 Report Share Posted May 17, 2003 J Agric Food Chem 2002 Jul 3;50(14):3999-4002 (ISSN: 0021-8561) Wild D; Toth G; Humpf HU Federal Center for Meat Research, Institute of Microbiology and Toxicology, E. C. Baumann Strasse 20, D-95326 Kulmbach, Germany. D.Wild. Red yeast rice (angkak, red koji) obtained as cultures of Monascus purpureus on rice was extracted and analyzed by HPLC. In addition to the known red, orange, and yellow pigments and the mycotoxin citrinin, a new Monascus metabolite was detected. It is present in the original red yeast rice and formed in higher amounts when red yeast rice is heated. High-resolution mass spectrometry indicated the molecular formula C(15)H(12)O(4). The chemical structure was elucidated by analysis of NMR data. The new compound, named monascodilone, is characterized by a propenyl group on a pyrone ring, an aromatic ring, and a gamma-lactone group. Alon Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 17, 2003 Report Share Posted May 17, 2003 J Altern Complement Med 2001 Apr;7(2):133-9 (ISSN: 1075-5535) Heber D; Lembertas A; Lu QY; Bowerman S; Go VL UCLA Center for Human Nutrition, UCLA School of Medicine, Los Angeles, California 90095-1742, USA. dheber. OBJECTIVES: Some strains of Chinese red yeast rice, when prepared by solid fermentation, produce compounds called monacolins that inhibit cholesterol production. When used as a dietary supplement to achieve and maintain healthy cholesterol levels, Chinese red yeast rice has significant potential to reduce health care costs and contribute to public health by reducing heart disease risk in individuals with moderate elevations of circulating cholesterol levels. Whereas one proprietary strain of Chinese red yeast rice has been demonstrated to lower cholesterol levels significantly in clinical trials, other strains being sold as Chinese red yeast rice dietary supplements have not undergone similar evaluation. In order to determine whether the results of a clinical trial conducted with one strain of Chinese red yeast rice could be generalized to other preparations of Chinese red yeast rice, nine different commercially available dietary supplements were purchased tested for chemical constituents. DESIGN: Monacolins were measured by high performance liquid chromatography (HPLC) that separates the various monacolins in Chinese red yeast rice. Citrinin concentration, a toxic fermentation byproduct, was measured by radioimmunoassay. RESULTS: Total monacolin content varied from 0% to 0.58% w/w and only 1 of 9 preparations had the full complement of 10 monacolin compounds. Citrinin was found at measurable concentrations in 7 of the 9 preparations. CONCLUSIONS: The findings from clinical trials demonstrating significant and clinically relevant cholesterol reduction using a defined Chinese red yeast rice preparation containing 10 different monacolins cannot be generalized to preparations that do not contain the same levels and profile of monacolins. Standardized manufacturing practices should be established for Chinese red yeast rice sold as a dietary supplement in order ensure equivalence of content of active ingredients in preparations being sold to the public and to limit the production of unwanted byproducts of fermentation such as citrinin. In common with other botanical dietary supplements, the full potential of this product will not be realized until standards for production and labeling of Chinese red yeast rice are further developed. >>>>As can be seen total statins in some of these were upto 0.58% Alon Major Subject Heading(s) Minor Subject Heading(s) CAS Registry / EC Numbers Anticholesteremic Agents [analysis] Citrinin [analysis] Dietary Supplements Fatty Acids Lovastatin [analysis] Naphthalenes [analysis] Phosphorus Proteins Starch Chromatography, High Pressure Liquid Drugs, Chinese Herbal [analysis] Human Radioimmunoassay 0 (Anticholesteremic Agents) 0 (Drugs, Chinese Herbal) 0 (Fatty Acids) 0 (Naphthalenes) 0 (Proteins) 0 (red yeast rice) 518-75-2 (Citrinin) 75330-75-5 (Lovastatin) 7723-14-0 (Phosphorus) 79394-47-1 (monacolin L) 9005-25-8 (Starch) Language: English MEDLINE Indexing 200108 Publication Type: Owner: NLM; Status: Completed Publication Type: Journal Article PreMedline Identifier: 0011327519 Unique NLM Identifier: 21224167 Journal Code: IM Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 17, 2003 Report Share Posted May 17, 2003 Anaphylaxis due to Monascus purpureus-fermented rice (red yeast rice). Allergy 1999 Dec;54(12):1330-1 (ISSN: 0105-4538) Wigger-Alberti W; Bauer A; Hipler UC; Elsner P Department of Dermatology, Friedrich-Schiller University, Jena, Germany. wigger. Major Subject Heading(s) Minor Subject Heading(s) CAS Registry / EC Numbers Anaphylaxis [etiology] Fatty Acids [adverse effects] Food Additives [adverse effects] Food Industry Naphthalenes [adverse effects] Occupational Exposure [adverse effects] Phosphorus [adverse effects] Proteins [adverse effects] Starch [adverse effects] Adult Case Report Food Hypersensitivity Human Immunoglobulin E [blood] Male 0 (Fatty Acids) 0 (Food Additives) 0 (Naphthalenes) 0 (Proteins) 0 (red yeast rice) 37341-29-0 (Immunoglobulin E) 7723-14-0 (Phosphorus) 9005-25-8 (Starch) Indexing Check Tags: Language: English MEDLINE Indexing 200003 Publication Type: Owner: NLM; Status: Completed Publication Type: Journal Article PreMedline Identifier: 0010688441 Unique NLM Identifier: 20151149 Journal Code: IM Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 9, 2008 Report Share Posted February 9, 2008 Hi, I've been a member of this group and have found all the advice helpful and informative. I was wondering if someone could educate me on red yeast. I have been told it is useful for improving blood circulation, but am at a loss as to what kind to buy. Nancy **************Biggest Grammy Award surprises of all time on AOL Music. (http://music.aol.com/grammys/pictures/never-won-a-grammy?NCID=aolcmp00300000002\ 5 48) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 10, 2008 Report Share Posted February 10, 2008 I am only familiar with red rice yeast as a cholesterol lowering agent. Its supposed to be pretty good stuff in that regard. If you want something for circulation, that's probably a different herb for you. http://heartdisease.about.com/cs/cholesterol/a/Nrxcol_rry.htm On Feb 9, 2008 3:15 PM, <Nancy5454 wrote: > Hi, > > I've been a member of this group and have found all the advice helpful and > > informative. I was wondering if someone could educate me on red yeast. I > have been told it is useful for improving blood circulation, but am at a > loss as > to what kind to buy. > -- , DAOM Pain is inevitable, suffering is optional. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 10, 2008 Report Share Posted February 10, 2008 I've used it in the past for that purpose (lowering cholesterol) and it works great. Unfortunately the FDA has made it so you can't get it anymore with the active ingredient, which was a naturally-occurring version of lovastatin. What you buy now has the cholesterol-lowering part removed. The FDA has become such a joke. Al Stone wrote: > > I am only familiar with red rice yeast as a cholesterol lowering > agent. Its > supposed to be pretty good stuff in that regard. If you want something for > circulation, that's probably a different herb for you. > > http://heartdisease.about.com/cs/cholesterol/a/Nrxcol_rry.htm > <http://heartdisease.about.com/cs/cholesterol/a/Nrxcol_rry.htm> > > On Feb 9, 2008 3:15 PM, <Nancy5454 > <Nancy5454%40aol.com>> wrote: > > > Hi, > > > > I've been a member of this group and have found all the advice > helpful and > > > > informative. I was wondering if someone could educate me on red yeast. I > > have been told it is useful for improving blood circulation, but am at a > > loss as > > to what kind to buy. > > > > -- > , DAOM > Pain is inevitable, suffering is optional. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2008 Report Share Posted February 15, 2008 I have to laugh - I feel the same way but what can we do really.... Nancy S+13 <nancy wrote: I've used it in the past for that purpose (lowering cholesterol) and it works great. Unfortunately the FDA has made it so you can't get it anymore with the active ingredient, which was a naturally-occurring version of lovastatin. What you buy now has the cholesterol-lowering part removed. The FDA has become such a joke. Looking for last minute shopping deals? Find them fast with Search. Quote Link to comment Share on other sites More sharing options...
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