sudden deafness antibiotic associated

[Guest guest]

hello everyone.

my name is Raffi G Shememian I am an MD / Acupuncturist recently I

have started treating a patient who himself is an MD who was

Hospitalized for cardiac and GI problems few months ago.the Intern who

was treating him under supervision of a Cardiologist gave him high

dosage of Amikacin/Lasix few days and my patient lost his hearing

almost 96-97 % .

after i started the treatment he gain back 8-10 % of 8000hz freq.

which he considers a miracle.in US Retinoic acid is the drug of choice

any idea any one? the points I have used so far are .hearing area on

the head,SJ 17-4. Gb 43, Gb 2. any suggestions regarding the points

too? i appreciate every help.thx in advance

[Guest guest]

Hi!

 

I don't know the effect of antibiotics. could you write your

differential diagnosis, that might be helpful for us to help you with

points. What was the symptoms if the cardiac and GI problems. If I'm

guessing a little bit from your information, he might have a stressful

job, which means the Liver is involved, this may be why he has GI

problems, the Liver gets overactive and invading and suppress the

function of the Stomach and Spleen, this may give symptoms of

constipation or diarrea depending on which of the two is more

affected, say it is the Spleen, then it would give diarrea since the

Liver suppress the function of the Spleens ability to transport and

transform. Leading to a deficient Spleen in the lon run. a deficient

Spleen often give rise to Damp. If the rising Yang from the Liver

elevates the turbid qi and damp from the Spleen this might get stuck

in the ear. If this is the cas, Gb-34 might be added to sooth the

Liver and clear Damp-heat in the Gb-channel

 

Reading the article:

http://acupuncturetoday.com/mpacms/at/article.php?id=30358

 

I can cite the effect of antibiotics in TCM.

" In TCM terms, antibiotics have a very cold property, which makes them

effective to clear heat and reduce inflammation. But the same cold

property also damages the spleen qi and the digestive function in

general. When applied to the intestines, the function of the spleen qi

to " separate clear from turbid " directly translates into modern

nutritional terms as the separation of nutrients from waste material.

When the spleen qi is damaged, its ability to separate clear from

turbid is impaired and " turbid " substances are allowed into

circulation, while nutritive substances (clear) manage to pass through

the stool. The spleen also plays a critical role in the production of

wei qi or " defensive qi, " which it produces through a transformation

process involving " clear " substances obtained from diet. Without

sufficient " clarity " in this raw material, the strength of the wei qi

is compromised, defense against external pathogens is diminished, and

chances for recurrent infection increase. "

 

 

Anyhow, try some distal points , for example Sj-3 might be good choice

because it is indicated in any kind of hearing problems. Or you might

try the coupled points on the extraordinary channels yin wei - dai mai

(Sj-5 - Gb-41), specielly since both of the channels the points are on

runs around the ears.

 

Just some ideas, pleas give some more information about the case if

you want, that might help us help you better

 

Kind Regards

Peter Johansson

 

Chinese Traditional Medicine , " doctorraffi " <doctorraffi

wrote:

>

> hello everyone.

> my name is Raffi G Shememian I am an MD / Acupuncturist recently I

> have started treating a patient who himself is an MD who was

> Hospitalized for cardiac and GI problems few months ago.the Intern who

> was treating him under supervision of a Cardiologist gave him high

> dosage of Amikacin/Lasix few days and my patient lost his hearing

> almost 96-97 % .

> after i started the treatment he gain back 8-10 % of 8000hz freq.

> which he considers a miracle.in US Retinoic acid is the drug of choice

> any idea any one? the points I have used so far are .hearing area on

> the head,SJ 17-4. Gb 43, Gb 2. any suggestions regarding the points

> too? i appreciate every help.thx in advance

>

[Guest guest]

Hello Dr. Raffi, and welcome to Chinese Traditional Medicine.

 

Even though the following article is on preventing hearing loss with

the use of aspirin, the hospital in Xi'an, China where the trial was

held may have info on TCM treatments once the deafness has occured.

 

Victoria

 

http://www.hearingcenteronline.com/newsletter/july00b.shtml

 

Component of aspirin prevents antibiotic-induced deafness

Acitve component of aspirin prevents antibiotic-induced deafness, say

U-M scientists. Clinical trial under way in humans.

 

ANN ARBOR---University of Michigan scientists have found that

salicylate---the active component of ordinary aspirin---can prevent

deafness in guinea pigs exposed to a common class of antibiotics that

destroy delicate hair cells in the inner ear. Results of the study

are published in the July 1999 issue of the journal Laboratory

Investigation.

 

A clinical trial currently under way at a hospital in Xi'an, China,

will determine whether aspirin is as effective in people as it is in

guinea pigs, according to Jochen Schacht, Ph.D., a biochemist in the

otolaryngology department of the U-M Medical School and a consultant

on the clinical trial.

 

Discovered in the 1940s, aminoglycosides---which include

streptomycin, gentamicin, neomycin and others---are the most widely

used antibiotics in the world even though they are known to cause

hearing loss and balance disorders in a significant percentage of

individuals who take them.

 

" These drugs are a serious problem in rural areas of developing

countries, especially China and Southeast Asia, where they are widely

used because they are so effective and inexpensive, " Schacht

said. " All too frequently, they are the only affordable drugs

available. Studies of deaf-mutism in southeastern China showed that

two-thirds of the cases were caused by aminoglycosides. "

 

In the United States and other industrialized countries,

aminoglycosides are most often used to treat people with serious

infections who have not responded to other antibiotics. " The

increasing worldwide threat of antibiotic-resistant tuberculosis in

the wake of AIDS, however, makes it likely that their use will

increase in the future, " Schacht added.

 

After years of research, Schacht and his colleagues reported in 1995

that gentamicin combines with iron in the body to trigger production

of free radicals---unstable molecules that rip apart and damage

cells. Thousands of tiny hair cells in the inner ear are especially

vulnerable. Without functional hair cells, the inner ear is unable to

detect sounds or transmit signals to auditory neurons leading to the

brain. The result is irreversible hearing loss.

 

In 1997, Schacht published the results of experiments showing that

iron chelators---medications used to " soak up " excess iron in the

bloodstream---protected guinea pigs from gentamicin's ototoxic

effects. One of the chelators tested was 2,3-dihydroxybenzoate or DHB.

 

In an effort to develop a simple and clinically feasible way to

prevent hair cell damage, Schacht and Su-Hua Sha, M.D., a research

associate in the U-M Medical School, modified the experiment using a

related compound called 2-hydroxybenzoate or salicylate. " Aspirin

breaks down to salicylate in the body within 15 to 20 minutes, "

Schacht said.

 

In the current study, one group of guinea pigs received injections of

gentamicin. Another group received gentamicin and salicylate. A

control group received saline solution. All animals were given

hearing tests before, during and after treatment. The quantity and

physical condition of hair cells in the cochlea or inner ear of the

animals were examined at the conclusion of the experiment.

 

Guinea pigs receiving gentamicin alone had profound hearing loss, up

to 70 decibels at some wavelengths, and almost complete destruction

of the outer hair cells in the cochlea. Animals receiving gentamicin

and salicylate had minor hearing impairment of less than 20 decibels

and minimal hair cell damage. The low salicylate doses used in the

experiment had no effect on guinea pig auditory thresholds. Use of

salicylate did not lower the blood serum levels of gentamicin, nor

did it affect the antibiotic's ability to kill E. coli bacteria.

 

" Salicylate levels providing protection in guinea pigs fall into the

lower range recommended for anti-inflammatory therapy in humans, "

Shacht added. " The required serum levels could easily be achieved

with moderate doses of aspirin. "

 

 

----

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The research was funded by the National Institute on Deafness & Other

Communication Disorders, National Institutes of Health. The

experiments were conducted at the U-M's Kresge Hearing Research

Institute.

 

The University of Michigan

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Ann Arbor, MI 48109-1399