Oleander, glioblastoma and other brain cancers

April 29, 2009

Hi folks -

Since oleander and brain cancer have been a fairly hot topic in recent posts, I thought I would pass along a few tidbits about oleander - which crosses the blood-brain barrier and has had considerable success against brain cancers (some of the earliest reported successes for oleander were against childhood brain cancers from what I have been told):

Case report from the mideast:

A 49 years old right-handed man, presented with a right homonomous hemianopia. A CT-scan of the head revealed a mass lesion in the left parietal-occipital region. There was a significant surrounding edema. The patient reported visual changes occurring over a several week interval prior to his evaluation at the hospital. His wife noted increasing difficulty with confusion. The patient revealed on examination a dense right homonomous hemianopia as well as evidence of a parietal-lobe syndrome. The patient was admitted to the hospital to undergo craniotomy with tumor debulking of the brain tumor and biopsy. The results of the fresh frozen section obtained at the time of craniotomy showed glioblastoma multiforma belonging to high grade astrocytoma. In addition to craniotomy and radiation therapy, the patient also was treated with chemotherapy. However, the condition of the patient deteriorated and the hospital discharged him. He and his wife decided to take nerium oleander extract as the last choice. He started the treatment with nerium oleander extract. However, he was in a very poor medical condition. He was being carried on a stretcher and unable to stand up due to the feebleness occurring in his legs and arms. Two months after treatment with nerium oleander extract using both routes, the patient was doing well. The feebleness in his legs and arms as well as his uncomfortable and agitated appearance had almost disappeared. Five months after the treatment with nerium oleander extract the patient could walk without any help and a brain CT-scan demonstrated considerable regression of the mass. Another brain CT-scan performed after 10 months revealed "no relapse of the tumor lesion" and the patient was feeling well. Another brain CT-scan performed after 18 months revealed no change with respect to the previous CT-scan. The patient was advised to start a maintenance therapy for another 18 months. Later on, the patient lived normally and he was free from any symptoms.

Excerpt from Phoenix Biotech Newsletter:

"We know that the active ingredients get across into the brain, so tumors such as glioblastoma, certain prostate tumors and breast tumors have responded, as has colon cancer," says Robert Newman, Ph.D. (and noted M. D. Anderson research scientist)

In the lab the drug is selective for tumor cells leaving, normal cells intact.

Grady Cage, who has prostate cancer that has spread to his hip bone, tested the drug. He found it especially helpful in tolerating the side effects of chemotherapy.

"In the last three cycles I was sick maybe once," he says.

Dr. Newman says studies in his lab show the oleander-based drug is especially effective against tumors that are resistant to chemotherapy. He thinks the drug will be taken with chemotherapy.

"We think this is a novel therapy with a novel target," he says.

"This is truly beyond a field of dreams. It is truly a field of life," says oleander field owner Curtis.

Researchers at M.D. Anderson Hospital are hopeful that these natural compounds will help change cancer from an acute disease to a chronic one, and enable a person to live a full and productive life.

Case Report from Dr. H. Z. Ozel (who re-discovered the age old oleander remedy and later made his own patented version Anvirzel):

Diagnosis: Brain Tumor

A 19-year-old man presented to a physician in the spring of 1991 when he experienced continuous headaches and weakness. He was given some analgesics that provided no improvement. After losing consciousness, he was taken to the emergency room of Social Security's Goztepe Hospital (S.S.K. Goztepe Hastanesi). He was transferred to the neurosurgery clinic. The computed tomography (CT) scan performed on 21 May 1991 with and without contrast revealed a large enhancing mass in the left parietal region with large amount of surrounding edema with mass effect shifting the midline structures to the right. There was a second enhancing lesion in the right cerebellum ( Appendix AS1 ). Magnetic resonance imaging (MRI) documented the same tumors on 31 May 1991 ( Appendix AS2 ). Although the possibility that the lesions might be due to an infectious disease was considered, the general impression was that they were metastases ( Appendix AS3 ). Anti edema treatment was applied and the patient gained partial consciousness. The patient was discharged with a recommendation of anti edema therapy and high dose of third generation sephalosporin ( Appendix AS3 and Appendix AS4 )

The patient was taken to Dr. Ozel on 26 August 1991. He could not feel nor move his right arm and leg. He had speech (diffuculty in finding and pronouncing words) and visual (he saw things in doubles) disorders, and sharp, continuous headache. Arterial blood pressure was 120/80 mm Hg. He had been taking Delta Kortril pills (four times daily), and Fomadin. Since the patient was using cortisone, no rise in fever was expected after N.O.I. injections. He was placed on a regiment with 1cc dose of N.O.I. to be given daily six times per week, and 3x0.5 cc of N.O.O. to be administered three times every day.

The relatives reported on 15 November 1991 that the patient's general condition had improved, that the paralysis of the right arm and leg had partially resolved.

An MR image obtained on 4 December 1991 ( Appendix AS5 ) demonstrated that the lesions in the left parietal site and right cerebellum continued to exist, but the mass effect and the shift had improved from 31 May 1991 with less mass effect.

The patient presented to Dr. Ozel on 24 June 1992 with an MRI image obtained on 27 May 1992. His consciousness was back to normal; he had no visual disturbance. He had traveled without company, and this was a good sign of his recovery. The paralysis in the right arm and leg had resolved by 75%. The MR image ( Appendix AS6 ) showed that the tumor in the left parietal regressed, and its pressure lessened. The tumor in the right cerebellum had decreased in size as well. The patient was recommended to carry on N.O. treatment as previously recommended.

MR images obtained on 13 November 1992 demonstrated remarkable regression of the tumor in the left parietal region, and no significant mass effect ( Appendix AS7 ). The tumor in the right cerebellum had disappeared almost completely. The patient's regimen was changed to one 1cc dose of N.O.I. to be given every two days, 0.5cc dose of N.O.O. to be administered three times daily.

Medical counsel of Social Security's Goztepe Hospital issued a statement on 18 December 1992 allowing the patient to go back to work ( Appendix AS8 ).

Another MRI scan performed on 27 May 1993 revealed continued improvement in the left parietal mass with no mass effect or compression of the underlying ventricle ( Appendix AS9 ). The right cerebellar lesion was no longer identified.

Electroencephalography performed on 15 September 1993 demonstrated no finding that might be related to a cortical lesion or epileptiform. Bioelectrical activity of the brain was found to be sufficient [ Appendix AS10 ]

CT scan performed on 18 October 1993 showed only a small area of encephalomalacia in the left parietal region ( Appendix AS11 ). The patient was recommended to stop N.O. treatment.

A follow up MR image obtained on 10 October 1996 demonstrated no lesion in left parietal region and in the right cerebellum. ( Appendix AS12 ).

He last visited Dr. Ozel in February 2007; he was in remission.

Case Report Number Two from Dr. H. Z. Ozel

Diagnosis: Brain Tumor (ependymoma)

A 19-year-old woman was diagnosed in 1979 as having ependymoma at the Neurosugery Clinic of Istanbul University Medical Faculty (NCIUMF); the brain tumor was surgically removed. Relapse occurred in 1981, and the patient presented to the same clinic for another surgical removal of the tumor.

In November 1984, the patient experienced headache, forgetfulness, and vomiting. Tomography demonstrated relapse tumor, and the patient was again hosptilized at NCIUMF on 29 November 1984. Relapse tumor was removed once more, histopathologic examination of the tumor corroborated the previous ependymoma diagnosis. The patient was discharged from the clinic on 10 December 1984 ( Appendix SD0 ).

In June 1985, the patient experienced a general feebleness as well as poor memory, and she presented again to the NCIUMF.

A brain CAT scan was performed on 10 July 1985 ( Appendix SD1 ); it showed relapse of the tumor again, and the patient was recommended radiotherapy. However, not only radiotherapy provided no benefit and her symptoms persisted, but also right hemiparesis (4/5), which included the face, occurred. Another brain CAT scan performed on 2 September 1985 demonstrated enlargement of the relapse ependymoma tumor at the left rear ventricle, infiltration to the right site, and hydrocephalus ( Appendix SD2 ). The tumor was considered to be inoperable. A ventriculo-peritoneal shunt was placed to provide relief from hydrocephalus; this provided some improvement in the right hemiparesis. The patient was discharged from NCIUMF on 18 September 1985 ( Appendix SD3 ).

The patient was taken to Dr. Ozel on 10 October 1985. She was in a very poor medical condition. She was being carried in a stretcher. She was unable to stand up due to the weakness of her arms and legs. Although she was awake, she had no awareness of her surrounding and she was unable to answer any question. She appeared to be uncomfortable and agitated. Her blood pressure was 80/55 mm Hg, her pulse was weak and 140/min. Her body temperature was 36.1o C. 0.3 cc test dose of NOI caused her body temperature to rise to 38.4o C. She was placed on a regular daily regimen of 0.3 cc dose of NOI to be given six times per week. It was advised to adjust the dosage according to the maximum fever occurring after NOI injections.

A home visit to the patient's hause on 5 January 1986 revealed: The feebleness in her legs and arms as well as her uncomfortable and agitated appearance had completely disappeared. She was aware of the events around her. She could walk with the help of others; she was able to take care of her body's natural needs. She was recommended to continue N.O. treatment as previously described.

On 10 April 1986, she visited Dr. Ozel at his office. She could walk on her own. Her talk and communication were normal. She could not remember the office and her previous visit there in October 1985. She had a brain CAT scan performed on 5 April 1986 that showed remarkable regression of the tumor ( Appendix SD4 ). However, 0.3cc dose of NOI was still causing a fever of about 37.5o C, and the patient was recommended to continue the regular regimen as previously described.

The patient started to experience no rise in body temperature after NOI injections. A maintenance regimen of 0.3 cc dose of NOI started on May 2, 1986. The regimen was first given every other day for three months and then, once every three days for another three months.

The brain CAT scan performed on 13 December 1986 demonstrated "no relapse tumoral lesion" ( Appendix SD5 ).

Another brain CAT scan, of which a copy is unawailable, was performed on 22 May 1987. It revealed "no medical change with respect to the previous CAT scan performed on 13 December 1986.

Further follow up MR images were obtained on 24 May 1998; they demonstrated cerebellar and cerebral atrophy, and no sign of any relapse ependymoma tumor ( Appendix SD6 ).

As in 2006, the patient has been in remission and living her normal daily life.

April 30, 2009

Thanks for this info Tony. I will pass this on to one of my friends in the US who is being treated homeopathically for a brain tumor. I am sure she will appreciate this.Blessings, Eva.--- On Wed, 4/29/09, Tony wrote:Tony Oleander, glioblastoma and other brain cancersoleander soup Date: Wednesday, April 29, 2009, 6:30 PM

Hi folks -

Since oleander and brain cancer have been a fairly hot topic in recent posts, I thought I would pass along a few tidbits about oleander - which crosses the blood-brain barrier and has had considerable success against brain cancers (some of the earliest reported successes for oleander were against childhood brain cancers from what I have been told):

Case report from the mideast:

A 49 years old right-handed man, presented with a right homonomous hemianopia. A CT-scan of the head revealed a mass lesion in the left parietal-occipital region. There was a significant surrounding edema. The patient reported visual changes occurring over a several week interval prior to his evaluation at the hospital. His wife noted increasing difficulty with confusion. The patient revealed on examination a dense right homonomous hemianopia as well as evidence of a parietal-lobe syndrome. The patient was admitted to the hospital to undergo craniotomy with tumor debulking of the brain tumor and biopsy. The results of the fresh frozen section obtained at the time of craniotomy showed glioblastoma multiforma belonging to high grade astrocytoma. In addition to craniotomy and radiation therapy, the patient also was treated with chemotherapy. However, the condition of the patient deteriorated and the hospital discharged him. He

and his wife decided to take nerium oleander extract as the last choice. He started the treatment with nerium oleander extract. However, he was in a very poor medical condition. He was being carried on a stretcher and unable to stand up due to the feebleness occurring in his legs and arms. Two months after treatment with nerium oleander extract using both routes, the patient was doing well. The feebleness in his legs and arms as well as his uncomfortable and agitated appearance had almost disappeared. Five months after the treatment with nerium oleander extract the patient could walk without any help and a brain CT-scan demonstrated considerable regression of the mass. Another brain CT-scan performed after 10 months revealed "no relapse of the tumor lesion" and the patient was feeling well. Another brain CT-scan performed after 18 months revealed no change with respect to the previous CT-scan. The patient was advised to start a maintenance therapy for

another 18 months. Later on, the patient lived normally and he was free from any symptoms.

Excerpt from Phoenix Biotech Newsletter:

"We know that the active ingredients get across into the brain, so tumors such as glioblastoma, certain prostate tumors and breast tumors have responded, as has colon cancer," says Robert Newman, Ph.D. (and noted M. D. Anderson research scientist)

In the lab the drug is selective for tumor cells leaving, normal cells intact.

Grady Cage, who has prostate cancer that has spread to his hip bone, tested the drug. He found it especially helpful in tolerating the side effects of chemotherapy.

"In the last three cycles I was sick maybe once," he says.

Dr. Newman says studies in his lab show the oleander-based drug is especially effective against tumors that are resistant to chemotherapy. He thinks the drug will be taken with chemotherapy.

"We think this is a novel therapy with a novel target," he says.

"This is truly beyond a field of dreams. It is truly a field of life," says oleander field owner Curtis.

Researchers at M.D. Anderson Hospital are hopeful that these natural compounds will help change cancer from an acute disease to a chronic one, and enable a person to live a full and productive life.

Case Report from Dr. H. Z. Ozel (who re-discovered the age old oleander remedy and later made his own patented version Anvirzel):

Diagnosis: Brain Tumor

A 19-year-old man presented to a physician in the spring of 1991 when he experienced continuous headaches and weakness. He was given some analgesics that provided no improvement. After losing consciousness, he was taken to the emergency room of Social Security's Goztepe Hospital (S.S.K. Goztepe Hastanesi). He was transferred to the neurosurgery clinic. The computed tomography (CT) scan performed on 21 May 1991 with and without contrast revealed a large enhancing mass in the left parietal region with large amount of surrounding edema with mass effect shifting the midline structures to the right. There was a second enhancing lesion in the right cerebellum ( Appendix AS1 ). Magnetic resonance imaging (MRI) documented the same tumors on 31 May 1991 ( Appendix AS2 ). Although the possibility that the lesions might be due to an infectious disease was considered, the general impression was that they were metastases ( Appendix AS3

). Anti edema treatment was applied and the patient gained partial consciousness. The patient was discharged with a recommendation of anti edema therapy and high dose of third generation sephalosporin ( Appendix AS3 and Appendix AS4 )

The patient was taken to Dr. Ozel on 26 August 1991. He could not feel nor move his right arm and leg. He had speech (diffuculty in finding and pronouncing words) and visual (he saw things in doubles) disorders, and sharp, continuous headache. Arterial blood pressure was 120/80 mm Hg. He had been taking Delta Kortril pills (four times daily), and Fomadin. Since the patient was using cortisone, no rise in fever was expected after N.O.I. injections. He was placed on a regiment with 1cc dose of N.O.I. to be given daily six times per week, and 3x0.5 cc of N.O.O. to be administered three times every day.

The relatives reported on 15 November 1991 that the patient's general condition had improved, that the paralysis of the right arm and leg had partially resolved.

An MR image obtained on 4 December 1991 ( Appendix AS5 ) demonstrated that the lesions in the left parietal site and right cerebellum continued to exist, but the mass effect and the shift had improved from 31 May 1991 with less mass effect.

The patient presented to Dr. Ozel on 24 June 1992 with an MRI image obtained on 27 May 1992. His consciousness was back to normal; he had no visual disturbance. He had traveled without company, and this was a good sign of his recovery. The paralysis in the right arm and leg had resolved by 75%. The MR image ( Appendix AS6 ) showed that the tumor in the left parietal regressed, and its pressure lessened. The tumor in the right cerebellum had decreased in size as well. The patient was recommended to carry on N.O. treatment as previously recommended.

MR images obtained on 13 November 1992 demonstrated remarkable regression of the tumor in the left parietal region, and no significant mass effect ( Appendix AS7 ). The tumor in the right cerebellum had disappeared almost completely. The patient's regimen was changed to one 1cc dose of N.O.I. to be given every two days, 0.5cc dose of N.O.O. to be administered three times daily.

Medical counsel of Social Security's Goztepe Hospital issued a statement on 18 December 1992 allowing the patient to go back to work ( Appendix AS8 ).

Another MRI scan performed on 27 May 1993 revealed continued improvement in the left parietal mass with no mass effect or compression of the underlying ventricle ( Appendix AS9 ). The right cerebellar lesion was no longer identified.

Electroencephalogra phy performed on 15 September 1993 demonstrated no finding that might be related to a cortical lesion or epileptiform. Bioelectrical activity of the brain was found to be sufficient [ Appendix AS10 ]

CT scan performed on 18 October 1993 showed only a small area of encephalomalacia in the left parietal region ( Appendix AS11 ). The patient was recommended to stop N.O. treatment.

A follow up MR image obtained on 10 October 1996 demonstrated no lesion in left parietal region and in the right cerebellum. ( Appendix AS12 ).

He last visited Dr. Ozel in February 2007; he was in remission.

Case Report Number Two from Dr. H. Z. Ozel

Diagnosis: Brain Tumor (ependymoma)

A 19-year-old woman was diagnosed in 1979 as having ependymoma at the Neurosugery Clinic of Istanbul University Medical Faculty (NCIUMF); the brain tumor was surgically removed. Relapse occurred in 1981, and the patient presented to the same clinic for another surgical removal of the tumor.

In November 1984, the patient experienced headache, forgetfulness, and vomiting. Tomography demonstrated relapse tumor, and the patient was again hosptilized at NCIUMF on 29 November 1984. Relapse tumor was removed once more, histopathologic examination of the tumor corroborated the previous ependymoma diagnosis. The patient was discharged from the clinic on 10 December 1984 ( Appendix SD0 ).

In June 1985, the patient experienced a general feebleness as well as poor memory, and she presented again to the NCIUMF.

A brain CAT scan was performed on 10 July 1985 ( Appendix SD1 ); it showed relapse of the tumor again, and the patient was recommended radiotherapy. However, not only radiotherapy provided no benefit and her symptoms persisted, but also right hemiparesis (4/5), which included the face, occurred. Another brain CAT scan performed on 2 September 1985 demonstrated enlargement of the relapse ependymoma tumor at the left rear ventricle, infiltration to the right site, and hydrocephalus ( Appendix SD2 ). The tumor was considered to be inoperable. A ventriculo-peritone al shunt was placed to provide relief from hydrocephalus; this provided some improvement in the right hemiparesis. The patient was discharged from NCIUMF on 18 September 1985 ( Appendix SD3 ).

The patient was taken to Dr. Ozel on 10 October 1985. She was in a very poor medical condition. She was being carried in a stretcher. She was unable to stand up due to the weakness of her arms and legs. Although she was awake, she had no awareness of her surrounding and she was unable to answer any question. She appeared to be uncomfortable and agitated. Her blood pressure was 80/55 mm Hg, her pulse was weak and 140/min. Her body temperature was 36.1o C. 0.3 cc test dose of NOI caused her body temperature to rise to 38.4o C. She was placed on a regular daily regimen of 0.3 cc dose of NOI to be given six times per week. It was advised to adjust the dosage according to the maximum fever occurring after NOI injections.

A home visit to the patient's hause on 5 January 1986 revealed: The feebleness in her legs and arms as well as her uncomfortable and agitated appearance had completely disappeared. She was aware of the events around her. She could walk with the help of others; she was able to take care of her body's natural needs. She was recommended to continue N.O. treatment as previously described.

On 10 April 1986, she visited Dr.. Ozel at his office. She could walk on her own. Her talk and communication were normal. She could not remember the office and her previous visit there in October 1985. She had a brain CAT scan performed on 5 April 1986 that showed remarkable regression of the tumor ( Appendix SD4 ). However, 0.3cc dose of NOI was still causing a fever of about 37.5o C, and the patient was recommended to continue the regular regimen as previously described.

The patient started to experience no rise in body temperature after NOI injections. A maintenance regimen of 0.3 cc dose of NOI started on May 2, 1986. The regimen was first given every other day for three months and then, once every three days for another three months.

The brain CAT scan performed on 13 December 1986 demonstrated "no relapse tumoral lesion" ( Appendix SD5 ).

Another brain CAT scan, of which a copy is unawailable, was performed on 22 May 1987. It revealed "no medical change with respect to the previous CAT scan performed on 13 December 1986.

Further follow up MR images were obtained on 24 May 1998; they demonstrated cerebellar and cerebral atrophy, and no sign of any relapse ependymoma tumor ( Appendix SD6 ).

As in 2006, the patient has been in remission and living her normal daily life.

May 1, 2009

Tony what is the protocol for Interveinous nerium oleander? Where can the IV N O

be purchased?--

- In oleander soup , " Tony " wrote:

>

> Hi folks -

>

> Since oleander and brain cancer have been a fairly hot topic in recent

> posts, I thought I would pass along a few tidbits about oleander - which

> crosses the blood-brain barrier and has had considerable success against

> brain cancers (some of the earliest reported successes for oleander were

> against childhood brain cancers from what I have been told):

>

> Case report from the mideast:

>

> A 49 years old right-handed man, presented with a right homonomous

> hemianopia. A CT-scan of the head revealed a mass lesion in the left

> parietal-occipital region. There was a significant surrounding edema.

> The patient reported visual changes occurring over a several week

> interval prior to his evaluation at the hospital. His wife noted

> increasing difficulty with confusion. The patient revealed on

> examination a dense right homonomous hemianopia as well as evidence of a

> parietal-lobe syndrome. The patient was admitted to the hospital to

> undergo craniotomy with tumor debulking of the brain tumor and biopsy.

> The results of the fresh frozen section obtained at the time of

> craniotomy showed glioblastoma multiforma belonging to high grade

> astrocytoma. In addition to craniotomy and radiation therapy, the

> patient also was treated with chemotherapy. However, the condition of

> the patient deteriorated and the hospital discharged him. He and his

> wife decided to take nerium oleander extract as the last choice. He

> started the treatment with nerium oleander extract. However, he was in a

> very poor medical condition. He was being carried on a stretcher and

> unable to stand up due to the feebleness occurring in his legs and arms.

> Two months after treatment with nerium oleander extract using both

> routes, the patient was doing well. The feebleness in his legs and arms

> as well as his uncomfortable and agitated appearance had almost

> disappeared. Five months after the treatment with nerium oleander

> extract the patient could walk without any help and a brain CT-scan

> demonstrated considerable regression of the mass. Another brain CT-scan

> performed after 10 months revealed " no relapse of the tumor lesion " and

> the patient was feeling well. Another brain CT-scan performed after 18

> months revealed no change with respect to the previous CT-scan. The

> patient was advised to start a maintenance therapy for another 18

> months. Later on, the patient lived normally and he was free from any

> symptoms.

>

> Excerpt from Phoenix Biotech Newsletter:

>

> " We know that the active ingredients get across into the brain, so

> tumors such as glioblastoma, certain prostate tumors and breast tumors

> have responded, as has colon cancer, " says Robert Newman, Ph.D. (and

> noted M. D. Anderson research scientist)

>

> In the lab the drug is selective for tumor cells leaving, normal cells

> intact.

>

> Grady Cage, who has prostate cancer that has spread to his hip bone,

> tested the drug. He found it especially helpful in tolerating the side

> effects of chemotherapy.

>

> " In the last three cycles I was sick maybe once, " he says.

>

> Dr. Newman says studies in his lab show the oleander-based drug is

> especially effective against tumors that are resistant to chemotherapy.

> He thinks the drug will be taken with chemotherapy.

>

> " We think this is a novel therapy with a novel target, " he says.

>

> " This is truly beyond a field of dreams. It is truly a field of life, "

> says oleander field owner Curtis.

>

> Researchers at M.D. Anderson Hospital are hopeful that these natural

> compounds will help change cancer from an acute disease to a chronic

> one, and enable a person to live a full and productive life.

>

> Case Report from Dr. H. Z. Ozel (who re-discovered the age old oleander

> remedy and later made his own patented version Anvirzel):

>

> Diagnosis: Brain Tumor

>

> A 19-year-old man presented to a physician in the spring of 1991 when he

> experienced continuous headaches and weakness. He was given some

> analgesics that provided no improvement. After losing consciousness, he

> was taken to the emergency room of Social Security's Goztepe Hospital

> (S.S.K. Goztepe Hastanesi). He was transferred to the neurosurgery

> clinic. The computed tomography (CT) scan performed on 21 May 1991 with

> and without contrast revealed a large enhancing mass in the left

> parietal region with large amount of surrounding edema with mass effect

> shifting the midline structures to the right. There was a second

> enhancing lesion in the right cerebellum ( Appendix AS1 ). Magnetic

> resonance imaging (MRI) documented the same tumors on 31 May 1991 (

> Appendix AS2 ). Although the possibility that the lesions might be due

> to an infectious disease was considered, the general impression was that

> they were metastases ( Appendix AS3 ). Anti edema treatment was applied

> and the patient gained partial consciousness. The patient was discharged

> with a recommendation of anti edema therapy and high dose of third

> generation sephalosporin ( Appendix AS3 and Appendix AS4 )

>

> The patient was taken to Dr. Ozel on 26 August 1991. He could not feel

> nor move his right arm and leg. He had speech (diffuculty in finding and

> pronouncing words) and visual (he saw things in doubles) disorders, and

> sharp, continuous headache. Arterial blood pressure was 120/80 mm Hg. He

> had been taking Delta Kortril pills (four times daily), and Fomadin.

> Since the patient was using cortisone, no rise in fever was expected

> after N.O.I. injections. He was placed on a regiment with 1cc dose of

> N.O.I. to be given daily six times per week, and 3x0.5 cc of N.O.O. to

> be administered three times every day.

>

> The relatives reported on 15 November 1991 that the patient's general

> condition had improved, that the paralysis of the right arm and leg had

> partially resolved.

>

> An MR image obtained on 4 December 1991 ( Appendix AS5 ) demonstrated

> that the lesions in the left parietal site and right cerebellum

> continued to exist, but the mass effect and the shift had improved from

> 31 May 1991 with less mass effect.

>

> The patient presented to Dr. Ozel on 24 June 1992 with an MRI image

> obtained on 27 May 1992. His consciousness was back to normal; he had no

> visual disturbance. He had traveled without company, and this was a good

> sign of his recovery. The paralysis in the right arm and leg had

> resolved by 75%. The MR image ( Appendix AS6 ) showed that the tumor in

> the left parietal regressed, and its pressure lessened. The tumor in the

> right cerebellum had decreased in size as well. The patient was

> recommended to carry on N.O. treatment as previously recommended.

>

> MR images obtained on 13 November 1992 demonstrated remarkable

> regression of the tumor in the left parietal region, and no significant

> mass effect ( Appendix AS7 ). The tumor in the right cerebellum had

> disappeared almost completely. The patient's regimen was changed to one

> 1cc dose of N.O.I. to be given every two days, 0.5cc dose of N.O.O. to

> be administered three times daily.

>

> Medical counsel of Social Security's Goztepe Hospital issued a statement

> on 18 December 1992 allowing the patient to go back to work ( Appendix

> AS8 ).

>

> Another MRI scan performed on 27 May 1993 revealed continued improvement

> in the left parietal mass with no mass effect or compression of the

> underlying ventricle ( Appendix AS9 ). The right cerebellar lesion was

> no longer identified.

>

> Electroencephalography performed on 15 September 1993 demonstrated no

> finding that might be related to a cortical lesion or epileptiform.

> Bioelectrical activity of the brain was found to be sufficient [

> Appendix AS10 ]

>

> CT scan performed on 18 October 1993 showed only a small area of

> encephalomalacia in the left parietal region ( Appendix AS11 ). The

> patient was recommended to stop N.O. treatment.

>

> A follow up MR image obtained on 10 October 1996 demonstrated no lesion

> in left parietal region and in the right cerebellum. ( Appendix AS12 ).

>

> He last visited Dr. Ozel in February 2007; he was in remission.

>

> Case Report Number Two from Dr. H. Z. Ozel

>

> Diagnosis: Brain Tumor (ependymoma)

>

> A 19-year-old woman was diagnosed in 1979 as having ependymoma at the

> Neurosugery Clinic of Istanbul University Medical Faculty (NCIUMF); the

> brain tumor was surgically removed. Relapse occurred in 1981, and the

> patient presented to the same clinic for another surgical removal of the

> tumor.

>

> In November 1984, the patient experienced headache, forgetfulness, and

> vomiting. Tomography demonstrated relapse tumor, and the patient was

> again hosptilized at NCIUMF on 29 November 1984. Relapse tumor was

> removed once more, histopathologic examination of the tumor corroborated

> the previous ependymoma diagnosis. The patient was discharged from the

> clinic on 10 December 1984 ( Appendix SD0 ).

>

> In June 1985, the patient experienced a general feebleness as well as

> poor memory, and she presented again to the NCIUMF.

>

> A brain CAT scan was performed on 10 July 1985 ( Appendix SD1 ); it

> showed relapse of the tumor again, and the patient was recommended

> radiotherapy. However, not only radiotherapy provided no benefit and her

> symptoms persisted, but also right hemiparesis (4/5), which included the

> face, occurred. Another brain CAT scan performed on 2 September 1985

> demonstrated enlargement of the relapse ependymoma tumor at the left

> rear ventricle, infiltration to the right site, and hydrocephalus (

> Appendix SD2 ). The tumor was considered to be inoperable. A

> ventriculo-peritoneal shunt was placed to provide relief from

> hydrocephalus; this provided some improvement in the right hemiparesis.

> The patient was discharged from NCIUMF on

> 18 September 1985 ( Appendix SD3 ).

>

> The patient was taken to Dr. Ozel on 10 October 1985. She was in a very

> poor medical condition. She was being carried in a stretcher. She was

> unable to stand up due to the weakness of her arms and legs. Although

> she was awake, she had no awareness of her surrounding and she was

> unable to answer any question. She appeared to be uncomfortable and

> agitated. Her blood pressure was 80/55 mm Hg, her pulse was weak and

> 140/min. Her body temperature was 36.1o C. 0.3 cc test dose of NOI

> caused her body temperature to rise to 38.4o C. She was placed on a

> regular daily regimen of 0.3 cc dose of NOI to be given six times per

> week. It was advised to adjust the dosage according to the maximum fever

> occurring after NOI injections.

>

> A home visit to the patient's hause on 5 January 1986 revealed: The

> feebleness in her legs and arms as well as her uncomfortable and

> agitated appearance had completely disappeared. She was aware of the

> events around her. She could walk with the help of others; she was able

> to take care of her body's natural needs. She was recommended to

> continue N.O. treatment as previously described.

>

> On 10 April 1986, she visited Dr. Ozel at his office. She could walk on

> her own. Her talk and communication were normal. She could not remember

> the office and her previous visit there in October 1985. She had a brain

> CAT scan performed on 5 April 1986 that showed remarkable regression of

> the tumor ( Appendix SD4 ). However, 0.3cc dose of NOI was still causing

> a fever of about 37.5o C, and the patient was recommended to continue

> the regular regimen as previously described.

>

> The patient started to experience no rise in body temperature after NOI

> injections. A maintenance regimen of 0.3 cc dose of NOI started on May

> 2, 1986. The regimen was first given every other day for three months

> and then, once every three days

> for another three months.

>

> The brain CAT scan performed on 13 December 1986 demonstrated " no

> relapse tumoral lesion " ( Appendix SD5 ).

>

> Another brain CAT scan, of which a copy is unawailable, was performed on

> 22 May 1987. It revealed " no medical change with respect to the previous

> CAT scan performed on 13 December 1986.

>

> Further follow up MR images were obtained on 24 May 1998; they

> demonstrated cerebellar and cerebral atrophy, and no sign of any relapse

> ependymoma tumor ( Appendix SD6 ).

>

> As in 2006, the patient has been in remission and living her normal

> daily life.

>

May 1, 2009

It is the patented drug Anvirzel which is injectible but NOT intravenously (that could be extremely dangerous due to the extract's cardiac glycosides)

http://www.saludintegral.hn

You have to qualify and send your medical records to them. It costs about $2700 for a three month supply (though they might give you a 10% discount if you mention this group and my book)

I am not aware of any benefit of taking oleander via injection versus extract or capsule.

oleander soup , "Mary" <maihards wrote:>> Tony what is the protocol for Interveinous nerium oleander? Where can the IV N O be purchased?--> > > > - In oleander soup , "Tony" @ wrote:> >> > > > Hi folks -> > > > Since oleander and brain cancer have been a fairly hot topic in recent> > posts, I thought I would pass along a few tidbits about oleander - which> > crosses the blood-brain barrier and has had considerable success against> > brain cancers (some of the earliest reported successes for oleander were> > against childhood brain cancers from what I have been told):> > > > Case report from the mideast:> > > > A 49 years old right-handed man, presented with a right homonomous> > hemianopia. A CT-scan of the head revealed a mass lesion in the left> > parietal-occipital region. There was a significant surrounding edema.> > The patient reported visual changes occurring over a several week> > interval prior to his evaluation at the hospital. His wife noted> > increasing difficulty with confusion. The patient revealed on> > examination a dense right homonomous hemianopia as well as evidence of a> > parietal-lobe syndrome. The patient was admitted to the hospital to> > undergo craniotomy with tumor debulking of the brain tumor and biopsy.> > The results of the fresh frozen section obtained at the time of> > craniotomy showed glioblastoma multiforma belonging to high grade> > astrocytoma. In addition to craniotomy and radiation therapy, the> > patient also was treated with chemotherapy. However, the condition of> > the patient deteriorated and the hospital discharged him. He and his> > wife decided to take nerium oleander extract as the last choice. He> > started the treatment with nerium oleander extract. However, he was in a> > very poor medical condition. He was being carried on a stretcher and> > unable to stand up due to the feebleness occurring in his legs and arms.> > Two months after treatment with nerium oleander extract using both> > routes, the patient was doing well. The feebleness in his legs and arms> > as well as his uncomfortable and agitated appearance had almost> > disappeared. Five months after the treatment with nerium oleander> > extract the patient could walk without any help and a brain CT-scan> > demonstrated considerable regression of the mass. Another brain CT-scan> > performed after 10 months revealed "no relapse of the tumor lesion" and> > the patient was feeling well. Another brain CT-scan performed after 18> > months revealed no change with respect to the previous CT-scan. The> > patient was advised to start a maintenance therapy for another 18> > months. Later on, the patient lived normally and he was free from any> > symptoms.> > > > Excerpt from Phoenix Biotech Newsletter:> > > > "We know that the active ingredients get across into the brain, so> > tumors such as glioblastoma, certain prostate tumors and breast tumors> > have responded, as has colon cancer," says Robert Newman, Ph.D. (and> > noted M. D. Anderson research scientist)> > > > In the lab the drug is selective for tumor cells leaving, normal cells> > intact.> > > > Grady Cage, who has prostate cancer that has spread to his hip bone,> > tested the drug. He found it especially helpful in tolerating the side> > effects of chemotherapy.> > > > "In the last three cycles I was sick maybe once," he says.> > > > Dr. Newman says studies in his lab show the oleander-based drug is> > especially effective against tumors that are resistant to chemotherapy.> > He thinks the drug will be taken with chemotherapy.> > > > "We think this is a novel therapy with a novel target," he says.> > > > "This is truly beyond a field of dreams. It is truly a field of life,"> > says oleander field owner Curtis.> > > > Researchers at M.D. Anderson Hospital are hopeful that these natural> > compounds will help change cancer from an acute disease to a chronic> > one, and enable a person to live a full and productive life.> > > > Case Report from Dr. H. Z. Ozel (who re-discovered the age old oleander> > remedy and later made his own patented version Anvirzel):> > > > Diagnosis: Brain Tumor> > > > A 19-year-old man presented to a physician in the spring of 1991 when he> > experienced continuous headaches and weakness. He was given some> > analgesics that provided no improvement. After losing consciousness, he> > was taken to the emergency room of Social Security's Goztepe Hospital> > (S.S.K. Goztepe Hastanesi). He was transferred to the neurosurgery> > clinic. The computed tomography (CT) scan performed on 21 May 1991 with> > and without contrast revealed a large enhancing mass in the left> > parietal region with large amount of surrounding edema with mass effect> > shifting the midline structures to the right. There was a second> > enhancing lesion in the right cerebellum ( Appendix AS1 ). Magnetic> > resonance imaging (MRI) documented the same tumors on 31 May 1991 (> > Appendix AS2 ). Although the possibility that the lesions might be due> > to an infectious disease was considered, the general impression was that> > they were metastases ( Appendix AS3 ). Anti edema treatment was applied> > and the patient gained partial consciousness. The patient was discharged> > with a recommendation of anti edema therapy and high dose of third> > generation sephalosporin ( Appendix AS3 and Appendix AS4 )> > > > The patient was taken to Dr. Ozel on 26 August 1991. He could not feel> > nor move his right arm and leg. He had speech (diffuculty in finding and> > pronouncing words) and visual (he saw things in doubles) disorders, and> > sharp, continuous headache. Arterial blood pressure was 120/80 mm Hg. He> > had been taking Delta Kortril pills (four times daily), and Fomadin.> > Since the patient was using cortisone, no rise in fever was expected> > after N.O.I. injections. He was placed on a regiment with 1cc dose of> > N.O.I. to be given daily six times per week, and 3x0.5 cc of N.O.O. to> > be administered three times every day.> > > > The relatives reported on 15 November 1991 that the patient's general> > condition had improved, that the paralysis of the right arm and leg had> > partially resolved.> > > > An MR image obtained on 4 December 1991 ( Appendix AS5 ) demonstrated> > that the lesions in the left parietal site and right cerebellum> > continued to exist, but the mass effect and the shift had improved from> > 31 May 1991 with less mass effect.> > > > The patient presented to Dr. Ozel on 24 June 1992 with an MRI image> > obtained on 27 May 1992. His consciousness was back to normal; he had no> > visual disturbance. He had traveled without company, and this was a good> > sign of his recovery. The paralysis in the right arm and leg had> > resolved by 75%. The MR image ( Appendix AS6 ) showed that the tumor in> > the left parietal regressed, and its pressure lessened. The tumor in the> > right cerebellum had decreased in size as well. The patient was> > recommended to carry on N.O. treatment as previously recommended.> > > > MR images obtained on 13 November 1992 demonstrated remarkable> > regression of the tumor in the left parietal region, and no significant> > mass effect ( Appendix AS7 ). The tumor in the right cerebellum had> > disappeared almost completely. The patient's regimen was changed to one> > 1cc dose of N.O.I. to be given every two days, 0.5cc dose of N.O.O. to> > be administered three times daily.> > > > Medical counsel of Social Security's Goztepe Hospital issued a statement> > on 18 December 1992 allowing the patient to go back to work ( Appendix> > AS8 ).> > > > Another MRI scan performed on 27 May 1993 revealed continued improvement> > in the left parietal mass with no mass effect or compression of the> > underlying ventricle ( Appendix AS9 ). The right cerebellar lesion was> > no longer identified.> > > > Electroencephalography performed on 15 September 1993 demonstrated no> > finding that might be related to a cortical lesion or epileptiform.> > Bioelectrical activity of the brain was found to be sufficient [> > Appendix AS10 ]> > > > CT scan performed on 18 October 1993 showed only a small area of> > encephalomalacia in the left parietal region ( Appendix AS11 ). The> > patient was recommended to stop N.O. treatment.> > > > A follow up MR image obtained on 10 October 1996 demonstrated no lesion> > in left parietal region and in the right cerebellum. ( Appendix AS12 ).> > > > He last visited Dr. Ozel in February 2007; he was in remission.> > > > Case Report Number Two from Dr. H. Z. Ozel> > > > Diagnosis: Brain Tumor (ependymoma)> > > > A 19-year-old woman was diagnosed in 1979 as having ependymoma at the> > Neurosugery Clinic of Istanbul University Medical Faculty (NCIUMF); the> > brain tumor was surgically removed. Relapse occurred in 1981, and the> > patient presented to the same clinic for another surgical removal of the> > tumor.> > > > In November 1984, the patient experienced headache, forgetfulness, and> > vomiting. Tomography demonstrated relapse tumor, and the patient was> > again hosptilized at NCIUMF on 29 November 1984. Relapse tumor was> > removed once more, histopathologic examination of the tumor corroborated> > the previous ependymoma diagnosis. The patient was discharged from the> > clinic on 10 December 1984 ( Appendix SD0 ).> > > > In June 1985, the patient experienced a general feebleness as well as> > poor memory, and she presented again to the NCIUMF.> > > > A brain CAT scan was performed on 10 July 1985 ( Appendix SD1 ); it> > showed relapse of the tumor again, and the patient was recommended> > radiotherapy. However, not only radiotherapy provided no benefit and her> > symptoms persisted, but also right hemiparesis (4/5), which included the> > face, occurred. Another brain CAT scan performed on 2 September 1985> > demonstrated enlargement of the relapse ependymoma tumor at the left> > rear ventricle, infiltration to the right site, and hydrocephalus (> > Appendix SD2 ). The tumor was considered to be inoperable. A> > ventriculo-peritoneal shunt was placed to provide relief from> > hydrocephalus; this provided some improvement in the right hemiparesis.> > The patient was discharged from NCIUMF on> > 18 September 1985 ( Appendix SD3 ).> > > > The patient was taken to Dr. Ozel on 10 October 1985. She was in a very> > poor medical condition. She was being carried in a stretcher. She was> > unable to stand up due to the weakness of her arms and legs. Although> > she was awake, she had no awareness of her surrounding and she was> > unable to answer any question. She appeared to be uncomfortable and> > agitated. Her blood pressure was 80/55 mm Hg, her pulse was weak and> > 140/min. Her body temperature was 36.1o C. 0.3 cc test dose of NOI> > caused her body temperature to rise to 38.4o C. She was placed on a> > regular daily regimen of 0.3 cc dose of NOI to be given six times per> > week. It was advised to adjust the dosage according to the maximum fever> > occurring after NOI injections.> > > > A home visit to the patient's hause on 5 January 1986 revealed: The> > feebleness in her legs and arms as well as her uncomfortable and> > agitated appearance had completely disappeared. She was aware of the> > events around her. She could walk with the help of others; she was able> > to take care of her body's natural needs. She was recommended to> > continue N.O. treatment as previously described.> > > > On 10 April 1986, she visited Dr. Ozel at his office. She could walk on> > her own. Her talk and communication were normal. She could not remember> > the office and her previous visit there in October 1985. She had a brain> > CAT scan performed on 5 April 1986 that showed remarkable regression of> > the tumor ( Appendix SD4 ). However, 0.3cc dose of NOI was still causing> > a fever of about 37.5o C, and the patient was recommended to continue> > the regular regimen as previously described.> > > > The patient started to experience no rise in body temperature after NOI> > injections. A maintenance regimen of 0.3 cc dose of NOI started on May> > 2, 1986. The regimen was first given every other day for three months> > and then, once every three days> > for another three months.> > > > The brain CAT scan performed on 13 December 1986 demonstrated "no> > relapse tumoral lesion" ( Appendix SD5 ).> > > > Another brain CAT scan, of which a copy is unawailable, was performed on> > 22 May 1987. It revealed "no medical change with respect to the previous> > CAT scan performed on 13 December 1986.> > > > Further follow up MR images were obtained on 24 May 1998; they> > demonstrated cerebellar and cerebral atrophy, and no sign of any relapse> > ependymoma tumor ( Appendix SD6 ).> > > > As in 2006, the patient has been in remission and living her normal> > daily life.> >>

May 1, 2009

Dear TOny,2 questions. fierst is .. sometimes my sister is to weak to eat drugs.. so what i did was.. i was open capsule, and i put this green powder to the water , and then i mix it and i gave to drink,,do you think i did well??????????????????other is ......ip6 make iron low. if my sister taking iron low.. then should she use this ip6???mala--- On Fri, 5/1/09, Tony wrote:Tony Re: Oleander, glioblastoma and other brain cancersoleander soup Date: Friday, May 1, 2009, 3:42 AM

It is the patented drug Anvirzel which is injectible but NOT intravenously (that could be extremely dangerous due to the extract's cardiac glycosides)

http://www.saludint egral.hn

You have to qualify and send your medical records to them. It costs about $2700 for a three month supply (though they might give you a 10% discount if you mention this group and my book)

I am not aware of any benefit of taking oleander via injection versus extract or capsule.

oleander soup, "Mary" <maihards wrote:>> Tony what is the protocol for Interveinous nerium oleander? Where can the IV N O be purchased?--> > > > - In oleander soup, "Tony" @ wrote:> >> > > > Hi folks -> > > > Since oleander and brain cancer have been a fairly hot topic in recent> > posts, I thought I would pass along a few tidbits about oleander - which> > crosses the blood-brain barrier and has had considerable success against> > brain cancers (some of the earliest reported successes for oleander were> > against childhood brain cancers from what I have been told):> > > > Case report from the mideast:> > > > A 49 years old right-handed man, presented with a right homonomous> > hemianopia. A CT-scan of the

head revealed a mass lesion in the left> > parietal-occipital region. There was a significant surrounding edema.> > The patient reported visual changes occurring over a several week> > interval prior to his evaluation at the hospital. His wife noted> > increasing difficulty with confusion. The patient revealed on> > examination a dense right homonomous hemianopia as well as evidence of a> > parietal-lobe syndrome. The patient was admitted to the hospital to> > undergo craniotomy with tumor debulking of the brain tumor and biopsy.> > The results of the fresh frozen section obtained at the time of> > craniotomy showed glioblastoma multiforma belonging to high grade> > astrocytoma. In addition to craniotomy and radiation therapy, the> > patient also was treated with chemotherapy. However, the condition of> > the patient deteriorated and

the hospital discharged him. He and his> > wife decided to take nerium oleander extract as the last choice. He> > started the treatment with nerium oleander extract. However, he was in a> > very poor medical condition. He was being carried on a stretcher and> > unable to stand up due to the feebleness occurring in his legs and arms.> > Two months after treatment with nerium oleander extract using both> > routes, the patient was doing well. The feebleness in his legs and arms> > as well as his uncomfortable and agitated appearance had almost> > disappeared. Five months after the treatment with nerium oleander> > extract the patient could walk without any help and a brain CT-scan> > demonstrated considerable regression of the mass. Another brain CT-scan> > performed after 10 months revealed "no relapse of the tumor lesion" and> > the

patient was feeling well. Another brain CT-scan performed after 18> > months revealed no change with respect to the previous CT-scan. The> > patient was advised to start a maintenance therapy for another 18> > months. Later on, the patient lived normally and he was free from any> > symptoms.> > > > Excerpt from Phoenix Biotech Newsletter:> > > > "We know that the active ingredients get across into the brain, so> > tumors such as glioblastoma, certain prostate tumors and breast tumors> > have responded, as has colon cancer," says Robert Newman, Ph.D. (and> > noted M. D. Anderson research scientist)> > > > In the lab the drug is selective for tumor cells leaving, normal cells> > intact.> > > > Grady Cage, who has prostate cancer that has spread to his hip bone,> > tested the drug. He

found it especially helpful in tolerating the side> > effects of chemotherapy.> > > > "In the last three cycles I was sick maybe once," he says.> > > > Dr. Newman says studies in his lab show the oleander-based drug is> > especially effective against tumors that are resistant to chemotherapy.> > He thinks the drug will be taken with chemotherapy.> > > > "We think this is a novel therapy with a novel target," he says.> > > > "This is truly beyond a field of dreams. It is truly a field of life,"> > says oleander field owner Curtis.> > > > Researchers at M.D. Anderson Hospital are hopeful that these natural> > compounds will help change cancer from an acute disease to a chronic> > one, and enable a person to live a full and productive life.> > > > Case Report from Dr. H. Z. Ozel

(who re-discovered the age old oleander> > remedy and later made his own patented version Anvirzel):> > > > Diagnosis: Brain Tumor> > > > A 19-year-old man presented to a physician in the spring of 1991 when he> > experienced continuous headaches and weakness. He was given some> > analgesics that provided no improvement. After losing consciousness, he> > was taken to the emergency room of Social Security's Goztepe Hospital> > (S.S..K. Goztepe Hastanesi). He was transferred to the neurosurgery> > clinic. The computed tomography (CT) scan performed on 21 May 1991 with> > and without contrast revealed a large enhancing mass in the left> > parietal region with large amount of surrounding edema with mass effect> > shifting the midline structures to the right. There was a second> > enhancing lesion in the right cerebellum

( Appendix AS1 ). Magnetic> > resonance imaging (MRI) documented the same tumors on 31 May 1991 (> > Appendix AS2 ). Although the possibility that the lesions might be due> > to an infectious disease was considered, the general impression was that> > they were metastases ( Appendix AS3 ). Anti edema treatment was applied> > and the patient gained partial consciousness. The patient was discharged> > with a recommendation of anti edema therapy and high dose of third> > generation sephalosporin ( Appendix AS3 and Appendix AS4 )> > > > The patient was taken to Dr. Ozel on 26 August 1991. He could not feel> > nor move his right arm and leg. He had speech (diffuculty in finding and> > pronouncing words) and visual (he saw things in doubles) disorders, and> > sharp, continuous headache. Arterial blood pressure was 120/80 mm Hg. He>

> had been taking Delta Kortril pills (four times daily), and Fomadin.> > Since the patient was using cortisone, no rise in fever was expected> > after N.O.I. injections. He was placed on a regiment with 1cc dose of> > N.O.I. to be given daily six times per week, and 3x0.5 cc of N.O.O. to> > be administered three times every day.> > > > The relatives reported on 15 November 1991 that the patient's general> > condition had improved, that the paralysis of the right arm and leg had> > partially resolved.> > > > An MR image obtained on 4 December 1991 ( Appendix AS5 ) demonstrated> > that the lesions in the left parietal site and right cerebellum> > continued to exist, but the mass effect and the shift had improved from> > 31 May 1991 with less mass effect.> > > > The patient presented to Dr. Ozel on 24

June 1992 with an MRI image> > obtained on 27 May 1992. His consciousness was back to normal; he had no> > visual disturbance. He had traveled without company, and this was a good> > sign of his recovery. The paralysis in the right arm and leg had> > resolved by 75%. The MR image ( Appendix AS6 ) showed that the tumor in> > the left parietal regressed, and its pressure lessened. The tumor in the> > right cerebellum had decreased in size as well. The patient was> > recommended to carry on N.O. treatment as previously recommended.> > > > MR images obtained on 13 November 1992 demonstrated remarkable> > regression of the tumor in the left parietal region, and no significant> > mass effect ( Appendix AS7 ). The tumor in the right cerebellum had> > disappeared almost completely. The patient's regimen was changed to one> > 1cc dose

of N.O.I. to be given every two days, 0.5cc dose of N.O.O. to> > be administered three times daily.> > > > Medical counsel of Social Security's Goztepe Hospital issued a statement> > on 18 December 1992 allowing the patient to go back to work ( Appendix> > AS8 ).> > > > Another MRI scan performed on 27 May 1993 revealed continued improvement> > in the left parietal mass with no mass effect or compression of the> > underlying ventricle ( Appendix AS9 ). The right cerebellar lesion was> > no longer identified.> > > > Electroencephalogra phy performed on 15 September 1993 demonstrated no> > finding that might be related to a cortical lesion or epileptiform.> > Bioelectrical activity of the brain was found to be sufficient [> > Appendix AS10 ]> > > > CT scan performed on 18 October 1993

showed only a small area of> > encephalomalacia in the left parietal region ( Appendix AS11 ). The> > patient was recommended to stop N.O. treatment.> > > > A follow up MR image obtained on 10 October 1996 demonstrated no lesion> > in left parietal region and in the right cerebellum. ( Appendix AS12 ).> > > > He last visited Dr. Ozel in February 2007; he was in remission.> > > > Case Report Number Two from Dr. H. Z. Ozel> > > > Diagnosis: Brain Tumor (ependymoma)> > > > A 19-year-old woman was diagnosed in 1979 as having ependymoma at the> > Neurosugery Clinic of Istanbul University Medical Faculty (NCIUMF); the> > brain tumor was surgically removed. Relapse occurred in 1981, and the> > patient presented to the same clinic for another surgical removal of the> > tumor.> >

> > In November 1984, the patient experienced headache, forgetfulness, and> > vomiting. Tomography demonstrated relapse tumor, and the patient was> > again hosptilized at NCIUMF on 29 November 1984. Relapse tumor was> > removed once more, histopathologic examination of the tumor corroborated> > the previous ependymoma diagnosis. The patient was discharged from the> > clinic on 10 December 1984 ( Appendix SD0 ).> > > > In June 1985, the patient experienced a general feebleness as well as> > poor memory, and she presented again to the NCIUMF.> > > > A brain CAT scan was performed on 10 July 1985 ( Appendix SD1 ); it> > showed relapse of the tumor again, and the patient was recommended> > radiotherapy. However, not only radiotherapy provided no benefit and her> > symptoms persisted, but also right hemiparesis (4/5),

which included the> > face, occurred. Another brain CAT scan performed on 2 September 1985> > demonstrated enlargement of the relapse ependymoma tumor at the left> > rear ventricle, infiltration to the right site, and hydrocephalus (> > Appendix SD2 ). The tumor was considered to be inoperable. A> > ventriculo-peritone al shunt was placed to provide relief from> > hydrocephalus; this provided some improvement in the right hemiparesis.> > The patient was discharged from NCIUMF on> > 18 September 1985 ( Appendix SD3 ).> > > > The patient was taken to Dr. Ozel on 10 October 1985. She was in a very> > poor medical condition. She was being carried in a stretcher. She was> > unable to stand up due to the weakness of her arms and legs. Although> > she was awake, she had no awareness of her surrounding and she was> > unable

to answer any question. She appeared to be uncomfortable and> > agitated. Her blood pressure was 80/55 mm Hg, her pulse was weak and> > 140/min. Her body temperature was 36.1o C. 0.3 cc test dose of NOI> > caused her body temperature to rise to 38.4o C. She was placed on a> > regular daily regimen of 0.3 cc dose of NOI to be given six times per> > week. It was advised to adjust the dosage according to the maximum fever> > occurring after NOI injections.> > > > A home visit to the patient's hause on 5 January 1986 revealed: The> > feebleness in her legs and arms as well as her uncomfortable and> > agitated appearance had completely disappeared. She was aware of the> > events around her. She could walk with the help of others; she was able> > to take care of her body's natural needs. She was recommended to> > continue N.O.

treatment as previously described.> > > > On 10 April 1986, she visited Dr. Ozel at his office. She could walk on> > her own. Her talk and communication were normal. She could not remember> > the office and her previous visit there in October 1985. She had a brain> > CAT scan performed on 5 April 1986 that showed remarkable regression of> > the tumor ( Appendix SD4 ). However, 0.3cc dose of NOI was still causing> > a fever of about 37.5o C, and the patient was recommended to continue> > the regular regimen as previously described.> > > > The patient started to experience no rise in body temperature after NOI> > injections. A maintenance regimen of 0.3 cc dose of NOI started on May> > 2, 1986. The regimen was first given every other day for three months> > and then, once every three days> > for another three

months.> > > > The brain CAT scan performed on 13 December 1986 demonstrated "no> > relapse tumoral lesion" ( Appendix SD5 ).> > > > Another brain CAT scan, of which a copy is unawailable, was performed on> > 22 May 1987. It revealed "no medical change with respect to the previous> > CAT scan performed on 13 December 1986.> > > > Further follow up MR images were obtained on 24 May 1998; they> > demonstrated cerebellar and cerebral atrophy, and no sign of any relapse> > ependymoma tumor ( Appendix SD6 ).> > > > As in 2006, the patient has been in remission and living her normal> > daily life.> >>