UPDATE resveratrol and cancer

[Guest guest]

When mega-dose resveratrol was put to the test in the first study involving

warm-blooded animals, the animals fed mega-dose resveratrol did not live as long

as animals placed on a normal-calorie diet. Many resveratrol pills sold online

and in retail stores suggest mega-doses of resveratrol (360 mg and 1565 mg) on

their label, doses that shortened the lives of lab animals. Lower doses, like

those found in 3-5 glasses of red wine, or in Longevinex® (100 mg

resveratrol), appear to be more efficacious

JMB.

[Guest guest]

Yeah - I noticed that study, which was released by Longinex and quotes their spokesman Bill Sardi. I am always a bit suspicious of people who sell their own version of a supplement, such as Sardi and Longinex, quoting mainstream studies to put down other competitive products.

I also am more than a little bit wary of mainstream studies that report negative results on natural supplements after numerous previous studies have indicated benefits. The negative studies seem to follow like clockwork, and when you get to the heart of the funding you almost invariable find either direct or indirect funding and connections to the pharmaceutical companies whose products and profits the natural supplements might compete against.

I wonder who funded the studies Longinex refers to while they are promoting their own products? That is always important information to know, given that studies are up to 8 times more likely to return results favorable to the funders than are studies funded independently.

I note that the main study referred to by Longinex was conducted on mice and not humans and that the mice were given the human equivalent of 4200 to 7700 milligrams of reseratrol per day - a dose so large that it would likely cause problems in a great number of supplements. Also, while the study may have found dose dependent negative effects on longevity at mega-dose levels, it also found other "profound health benefits" for the mice.

I agree that it may not be a good idea to take huge doses of resveratrol but I also think that it is likely that a person could safely take more than the 100 mg of resveratrol in the Longinex product safely. Other recent studies have indicated that a dosage of approximately 4.9 mg per kilogram of body weight is effective in reproducing effects similar to a healthy calorie restricted diet. So, for a 150 pound person, this would equal an approximate recommendation of a 334 mg dosage of resveratrol.

oleander soup , shaman urban <shaman_urban wrote:>> > When mega-dose resveratrol was put to the test in the first study involving warm-blooded animals, the animals fed mega-dose resveratrol did not live as long as animals placed on a normal-calorie diet. Many resveratrol pills sold online and in retail stores suggest mega-doses of resveratrol (360 mg and 1565 mg) on their label, doses that shortened the lives of lab animals. Lower doses, like those found in 3-5 glasses of red wine, or in Longevinex® (100 mg resveratrol), appear to be more efficacious> JMB.>