mouse studies again

[Guest guest]

The big question in my mind is whether it translates to humans.So many studies don't. RhodaTocotrienol Build-Up in Tumors Is Critical for Anti-Cancer Benefits

April 2009 A new study from Japan reports that tocotrienols, members of the

vitamin E family, may exert their anti-cancer benefits by accumulating

in cancer cells and delaying tumor growth. Both gamma- and

delta-tocotrienols may accumulate in cancer cells and promote the death

of the tumors, according to data from in vitro and in vivo studies by

researchers from Kyushu University in Japan.

The potential anti-cancer benefits of tocotrienols are not new, but

the Japanese researchers claim that their study is the first to show

accumulation of the compounds in cancer cells. " These results, to our

knowledge, are the first demonstration of specific accumulation of

gamma-tocotrienols and delta-tocotrienols in tumors and suggest that

tocotrienol accumulation is critical for the anti-tumor activities of

tocotrienols, " wrote lead author Yuhei Hiura in The Journal of Nutritional Biochemistry.

There are eight forms of vitamin E: four tocopherols (alpha, beta,

gamma, delta) and four tocotrienols (alpha, beta, gamma, delta).

Alpha-tocopherol is the main source found in supplements and in the

European diet, while gamma-tocopherol is the most common form in the

American diet.

The Japanese researchers studied the effects of gamma- and

delta-tocotrienol on mouse cancer cells (murine hepatoma MH134) both in

vitro and in vivo. For the cell study, the tumor cells were cultured in

the tocotrienols, and they found that the delta-version inhibited cell

growth more than the gamma-type. This was related to an induction of

apoptosis (programmed cell death).

For the animal studies, the researchers used C3H/HeN mice and

implanted the tumor cells. The animals were then fed a normal diet, or

the diet supplemented with 0.1 percent gamma-tocotrienol or 0.1 percent

delta-tocopherol for four weeks.

At the end of the study, a significant delay in tumor growth was

observed for both groups supplemented with the tocotrienols. No effects

on body weight were recorded. " In conclusion, our results suggested

that accumulation is critical for the anti-tumor activity of

tocotrienols, " researchers said.

The Journal of Nutritional Biochemistry Published online ahead of print.

[Guest guest]

Rhoda:

This is all about feeding and housing University Wonks and their professors, administrator, administrative assistance, lab techs, university janitors, university recruiters, contractors that bid on university jobs, lab equipment sales, people, lab equipment manufacturers, book publishers, grant procuring departments and the list goes on . It is just like the car business and the medical business, and government,

 

The whole thing is about jobs and sheep herding. Just be smart enough to not be sucked in or you will not get to pass GO and collect $200.00

 

Hope your day is going well.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Duke

Most health problems are related to fungus in our bodies and the chemically treated rotting garbage we are offered at the Super Markets. dukestone

--- On Fri, 4/24/09, Rhoda Mead <hummingbird541 wrote:

Rhoda Mead <hummingbird541 mouse studies againfirefly541Date: Friday, April 24, 2009, 10:33 PM

 

 

 

The big question in my mind is whether it translates to humans.So many studies don't. Rhoda

Tocotrienol Build-Up in Tumors Is Critical for Anti-Cancer Benefits

April 2009

A new study from Japan reports that tocotrienols, members of the vitamin E family, may exert their anti-cancer benefits by accumulating in cancer cells and delaying tumor growth. Both gamma- and delta-tocotrienols may accumulate in cancer cells and promote the death of the tumors, according to data from in vitro and in vivo studies by researchers from Kyushu University in Japan.

The potential anti-cancer benefits of tocotrienols are not new, but the Japanese researchers claim that their study is the first to show accumulation of the compounds in cancer cells. "These results, to our knowledge, are the first demonstration of specific accumulation of gamma-tocotrienols and delta-tocotrienols in tumors and suggest that tocotrienol accumulation is critical for the anti-tumor activities of tocotrienols," wrote lead author Yuhei Hiura in The Journal of Nutritional Biochemistry.

There are eight forms of vitamin E: four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta). Alpha-tocopherol is the main source found in supplements and in the European diet, while gamma-tocopherol is the most common form in the American diet.

The Japanese researchers studied the effects of gamma- and delta-tocotrienol on mouse cancer cells (murine hepatoma MH134) both in vitro and in vivo. For the cell study, the tumor cells were cultured in the tocotrienols, and they found that the delta-version inhibited cell growth more than the gamma-type. This was related to an induction of apoptosis (programmed cell death).

For the animal studies, the researchers used C3H/HeN mice and implanted the tumor cells. The animals were then fed a normal diet, or the diet supplemented with 0.1 percent gamma-tocotrienol or 0.1 percent delta-tocopherol for four weeks.

At the end of the study, a significant delay in tumor growth was observed for both groups supplemented with the tocotrienols. No effects on body weight were recorded. "In conclusion, our results suggested that accumulation is critical for the anti-tumor activity of tocotrienols," researchers said.

The Journal of Nutritional Biochemistry Published online ahead of print.