Guest guest Posted October 1, 2006 Report Share Posted October 1, 2006 Thanks JoAnn, your post snipped below reflects the research that shows oral glutathione doesn't increase glutathione levels in humans, so glutathione precursors are required to increase glutathione in cells. Duncan > The authors of the study concluded " it is not feasible to increase > circulating glutathione to a clinically beneficial extent by the oral > administrating of a single application of 3,000 mg of glutathione. " > Absorption of glutathione may be better in rats because unlike the > gastrointestinal tract of rats, the human gastrointestinal tract > contains significant amounts of an enzyme (gamma- > glutamyltranspeptidase) that breaks down glutathione. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 1, 2006 Report Share Posted October 1, 2006 I am a clinical Nutritionist. I have been using high dose oral Glutathione for ten years, The results have been outstanding. This often quoted study is part of a big lie. It was one study done on 7 people. A single dose of 3 grams of Glutathione was given orally.Blood test measurements did not show an incease in Glutathione. Lots of things wrong with this study and the conclusion. Very small sample, Glutathione can be distributed throughout the body, leaving less in the blood. The arguement that Glutathione is broken down is also not true, The enzymes that break down Glutathione are found in the kidney and the last part of the small intestine, It is not broken down by stomach acids. Anyone who has used high dose Glutathione powder orally will despute the absortion conclusion. Lets not base an entire theory on " one small study " , Duncan Crow <duncancrow wrote: > > Thanks JoAnn, your post snipped below reflects the research that > shows oral glutathione doesn't increase glutathione levels in > humans, so glutathione precursors are required to increase > glutathione in cells. > > Duncan > > > The authors of the study concluded " it is not feasible to increase > > circulating glutathione to a clinically beneficial extent by the oral > > administrating of a single application of 3,000 mg of glutathione. " > > Absorption of glutathione may be better in rats because unlike the > > gastrointestinal tract of rats, the human gastrointestinal tract > > contains significant amounts of an enzyme (gamma- > > glutamyltranspeptidase) that breaks down glutathione. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 1, 2006 Report Share Posted October 1, 2006 --- In The pharmacokinetics of oral glutathionine in humans are not well understood. It appears that in some animals (mice, rats, guinea pigs), serum glutathione levels do increase following its oral administration. Most human studies of glutathione have not found this to be the case. It appears that oral glutathione is hydrolyzed in the intestine via the intestinal gamma-glutamyl transferase enzyme. A small amount of orally administered glutathione may reach the portal circulation, but apparently this is also rapidly metabolized by hepatic gamma-glutamyltransferase. Thus, most studies have not observed a significant increase in circulating glutathione following its oral administration. However, there is an occasional study that does show an increase in circulating glutathione after oral administration. Further, there is some evidence that glutathione may be absorbed into the enterocytes following ingestion, but may not be released by these cells into the circulation. Research is needed to resolve the issue of glutathione absorption. , Duncan Crow <duncancrow wrote: > > Thanks JoAnn, your post snipped below reflects the research that > shows oral glutathione doesn't increase glutathione levels in > humans, so glutathione precursors are required to increase > glutathione in cells. > > Duncan > > > The authors of the study concluded " it is not feasible to increase > > circulating glutathione to a clinically beneficial extent by the oral > > administrating of a single application of 3,000 mg of glutathione. " > > Absorption of glutathione may be better in rats because unlike the > > gastrointestinal tract of rats, the human gastrointestinal tract > > contains significant amounts of an enzyme (gamma- > > glutamyltranspeptidase) that breaks down glutathione. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 2, 2006 Report Share Posted October 2, 2006 First of all, certainly I recognize that professional observation and repetition of positive outcome is as valid as lab measurements. I commend your persistance in trying high-dose glutathione despite the research showing negative results with its absorption into the blood serum. What promoted your intuition to do it in the first place would be a good question. Also, given the potency of glutathione, I would have considered the 3 gram dose that failed to increase circulating glutathione in humans in the lab to be a moderately high dose anyway. So, this leads to the obvious question -- What range of dose have you been using in your high-dose regime? I can imagine it might relate to body weight and disease condition but if you could give us a ballpark figure it would help. Would it be safe to say that perhaps circulating glutathione is increased provided you first saturate the local cells of the bowel lining that are known to absorb gutathione locally according to studies? Also, do you kow the source of the GSH; I mean can you satisfy the vegans too? I don't believe veganism is practical but that would be useful to a minority of clients who disagree. Studies also indicate that most cell types do not absorb glutathione directly, so when circulating glutathione is increased the measured elevation in these cells is the result of cellular glutathione-sparing rather than providing the neccesary precursors to the cells so they can produce their own. Other studies indicate that about 90% of the glutathione in the body is used within the cells, not only for mitochondrial protection but for energy production. So, I'd appeciate your thoughts on high-dose glutathione PLUS precursors to address the amount that has to be manufactured and used in the cells, or good reason to say that generally these cells might absorb GSH if the dose was high enough. And if there's anything else you could add on this topic please do, such as addessing the concern of a pro-oxidant effect of excess antioxidant. Again, I appeciate the dissemination of your field experience. This is indeed useful. Duncan Crow ,> > Posted by: " greenteasupreme " greenteasupreme > greenteasupreme Sun Oct 1, 2006 4:29 am (PDT) > > > > I am a clinical Nutritionist. I have been using high dose oral > Glutathione for ten years, The results have been outstanding. This > often quoted study is part of a big lie. It was one study done on 7 > people. A single dose of 3 grams of Glutathione was given orally.Blood Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 13, 2009 Report Share Posted April 13, 2009 This group is a fabulous source of knowledge! NAC is certainly much less expensive than the liposomal G I'm taking right now. When my carton is gone, I'll switch. Rhoda Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 14, 2009 Report Share Posted April 14, 2009 N-Acetyl Cysteine Powerful Antioxidant Amino Acid In a message dated 4/13/2009 9:52:29 P.M. Pacific Daylight Time, pgriff writes: what is NAC ? thanks Pam - Rhoda Mead oleander soup Tuesday, April 14, 2009 7:55 AM glutathione This group is a fabulous source of knowledge! NAC is certainly much less expensive than the liposomal G I'm taking right now. When my carton is gone, I'll switch. Rhoda Checked by AVG. Version: 7.5.557 / Virus Database: 270.11.47/2047 - Release 4/8/2009 5:53 AM Access 350+ FREE radio stations anytime from anywhere on the web. Get the Radio Toolbar! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 14, 2009 Report Share Posted April 14, 2009 what is NAC ? thanks Pam - Rhoda Mead oleander soup Tuesday, April 14, 2009 7:55 AM glutathione This group is a fabulous source of knowledge! NAC is certainly much less expensive than the liposomal G I'm taking right now. When my carton is gone, I'll switch. Rhoda Checked by AVG. Version: 7.5.557 / Virus Database: 270.11.47/2047 - Release 4/8/2009 5:53 AM Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 14, 2009 Report Share Posted April 14, 2009 NAC stands for N-Acetyl Cysteine. One's body requires the Cysteine to make its own Glutathione which, in turn, is the master oxidant in all living things. Although one can take Glutathione directly, the digestive juices destroy most of it. NAC is probably the best way to increase Glutathione levels in body cells. Marc Swanepoel - Pam Griffin oleander soup Tuesday, April 14, 2009 6:51 AM Re: glutathione what is NAC ? thanks Pam - Rhoda Mead oleander soup Tuesday, April 14, 2009 7:55 AM glutathione This group is a fabulous source of knowledge! NAC is certainly much less expensive than the liposomal G I'm taking right now. When my carton is gone, I'll switch. Rhoda Checked by AVG. Version: 7.5.557 / Virus Database: 270.11.47/2047 - Release 4/8/2009 5:53 AM Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 14, 2009 Report Share Posted April 14, 2009 Marc: What about whey isolate which has high levels of cysteine? oleander soup , " Marc Swanepoel - PhD " <marcswan wrote: > > NAC stands for N-Acetyl Cysteine. One's body requires the Cysteine to make its own Glutathione which, in turn, is the master oxidant in all living things. Although one can take Glutathione directly, the digestive juices destroy most of it. NAC is probably the best way to increase Glutathione levels in body cells. > > Marc Swanepoel > > - > Pam Griffin > oleander soup > Tuesday, April 14, 2009 6:51 AM > Re: glutathione what is NAC ? thanks Pam > > - > Rhoda Mead > oleander soup > Tuesday, April 14, 2009 7:55 AM > glutathione > > > This group is a fabulous source of knowledge! NAC is certainly much less expensive than the liposomal G I'm taking right now. When my carton is gone, I'll switch. Rhoda > > > > > ---------- > > > > Checked by AVG. > Version: 7.5.557 / Virus Database: 270.11.47/2047 - Release 4/8/2009 5:53 AM > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 14, 2009 Report Share Posted April 14, 2009 what is NAC?--- On Tue, 4/14/09, jrrjim <jim.mcelroy10 wrote: jrrjim <jim.mcelroy10 Re: glutathioneoleander soup Date: Tuesday, April 14, 2009, 8:41 AM Marc:What about whey isolate which has high levels of cysteine?oleander soup, "Marc Swanepoel - PhD" <marcswan@.. .> wrote:>> NAC stands for N-Acetyl Cysteine. One's body requires the Cysteine to make its own Glutathione which, in turn, is the master oxidant in all living things. Although one can take Glutathione directly, the digestive juices destroy most of it. NAC is probably the best way to increase Glutathione levels in body cells.> > Marc Swanepoel> > - > Pam Griffin > oleander soup@ . com > Tuesday, April 14, 2009 6:51 AM> Re: glutathione> > > > > > > what is NAC ? thanks Pam> > - > Rhoda Mead > oleander soup > Tuesday, April 14, 2009 7:55 AM> glutathione> > > This group is a fabulous source of knowledge! NAC is certainly much less expensive than the liposomal G I'm taking right now. When my carton is gone, I'll switch. Rhoda> > > > > ------------ --------- --------- --------- --------- --------- -> > > > Checked by AVG. > Version: 7.5.557 / Virus Database: 270.11.47/2047 - Release 4/8/2009 5:53 AM> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 14, 2009 Report Share Posted April 14, 2009 Read down: NAC stands for N-Acytl Cysteine. It is a vital precurser for the body to make glutathione, which is the body's master anti-oxidant. (I believe Marc had a bit of a typo when he said " master oxidant " ). This anti-oxidant works at the intra-cellular level, and, among other things, helps to recycle vitamins C and e, greatly reducing the need for higher doses of these. oleander soup , Lisa Tovar <tov_legsec wrote: > > what is NAC? > > --- On Tue, 4/14/09, jrrjim <jim.mcelroy10 wrote: > > > jrrjim <jim.mcelroy10 > Re: glutathione > oleander soup > Tuesday, April 14, 2009, 8:41 AM > > Marc: > > What about whey isolate which has high levels of cysteine? > > oleander soup, " Marc Swanepoel - PhD " <marcswan@ .> wrote: > > > > NAC stands for N-Acetyl Cysteine. One's body requires the Cysteine to make its own Glutathione which, in turn, is the master oxidant in all living things. Although one can take Glutathione directly, the digestive juices destroy most of it. NAC is probably the best way to increase Glutathione levels in body cells. > > > > Marc Swanepoel > > > > - > > Pam Griffin > > oleander soup > > Tuesday, April 14, 2009 6:51 AM > > Re: glutathione > > > > > > > > > > > > > > what is NAC ? thanks Pam > > > > - > > Rhoda Mead > > oleander soup > > Tuesday, April 14, 2009 7:55 AM > > glutathione > > > > > > This group is a fabulous source of knowledge! NAC is certainly much less expensive than the liposomal G I'm taking right now. When my carton is gone, I'll switch. Rhoda > > > > > > > > > > ------------ --------- --------- --------- --------- --------- - > > > > > > > > Checked by AVG. > > Version: 7.5.557 / Virus Database: 270.11.47/2047 - Release 4/8/2009 5:53 AM > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 15, 2009 Report Share Posted April 15, 2009 Undenatured whey isolate is also suitable to increase glutathione in the body. It is especially good for people with cancer who show signs of rapid weight loss (cachexia). And, as you have pointed out with my typo, it is an ANTI-OXIDANT and not an oxidant. Marc Swanepoel - jrrjim oleander soup Tuesday, April 14, 2009 5:41 PM Re: glutathione Marc:What about whey isolate which has high levels of cysteine?oleander soup , "Marc Swanepoel - PhD" <marcswan wrote:>> NAC stands for N-Acetyl Cysteine. One's body requires the Cysteine to make its own Glutathione which, in turn, is the master oxidant in all living things. Although one can take Glutathione directly, the digestive juices destroy most of it. NAC is probably the best way to increase Glutathione levels in body cells.> > Marc Swanepoel> > - > Pam Griffin > oleander soup > Tuesday, April 14, 2009 6:51 AM> Re: glutathione> > > > > > > what is NAC ? thanks Pam> > - > Rhoda Mead > oleander soup > Tuesday, April 14, 2009 7:55 AM> glutathione> > > This group is a fabulous source of knowledge! NAC is certainly much less expensive than the liposomal G I'm taking right now. When my carton is gone, I'll switch. Rhoda> > > > > -------------------------> > > > Checked by AVG. > Version: 7.5.557 / Virus Database: 270.11.47/2047 - Release 4/8/2009 5:53 AM> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 15, 2009 Report Share Posted April 15, 2009 What is the best brand of NAC and dosage pls? Thanks. Melly Quote Link to comment Share on other sites More sharing options...
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