Guest guest Posted January 24, 2009 Report Share Posted January 24, 2009 We are having discussions are about precursors to glutathione, such as NAC. Livon Labs just introduced liposomal glutathione, which has never been available before. Here's what Dr. Levy, probably the main expert on using and outcomes with liposomals has to say in a forwarded email. Rhoda Dr. Levy's E-Mail *********************************************************************** I recently submitted some info on a vitamin C forum about liposome encapsulation that should answer your questions and give you even a little more info: 1. Absorption/bioavailability. Liposomes are changing the definition of the word bioavailable. Percent absorption into the blood, always erroneously in my opinion, has long been equated to bioavailability. If something is 100% absorbed (or given IV), it is by " definition " 100% bioavailable. Not true, however, not even close. Because of this, however, IV administration of anything has long been and continues to be the " gold standard " of drug, vitamin, or nutrient administration. Intracellular delivery is now the " new " definition of bioavailability. This is accomplished by nontargeted, unmodified liposomes. Except for very, very few substances, IV delivery does not really even come close to what these liposomes can do. Oral ascorbic acid is poorly absorbed. The 1 to 5 ratio is a fair approximation for just its absorption into the blood versus liposome encapsulation absorption, without addressing intracellular uptake. My actual " estimation " is that for many conditions the oral liposome encapsulated vitamin C is 10 times as effective as intravenous vitamin C. And, believe me, I have always loved (and still do) intravenous vitamin C. And for those who can have it, there is a synergism between the oral liposome encapsulated vitamin C and the intravenous vitamin C. I fought this conclusion for a very long time as I continued to witness what were inexplicable clinical responses at the time to the oral liposome encapsulated vitamin C. 2. Liposomes have been well-documented to deliver their encapsulated substances directly into the cytoplasm, mitochondria, endoplasmic reticula, and even the nucleus. These cellular compartments are rarely approached efficiently to even a minimal degree with any other form of delivery. 3. Many substances, including reduced vitamin C, once effectively delivered into the blood, require the consumption of energy to be taken up into the cell. This is very counterproductive to the goal of net electron donation, especially when you are trying to deliver energy-delivering substances such as antioxidants inside the cell. Liposomes, in many cases, are energy-sparing (or non-energy-consuming) vehicles for intracellular delivery of their contents. 4. Macrophages and monocytes take up many of the liposomes. This, if you will, helps to " supercharge " these important components of the immune system. 5. The liposome itself (largely phosphatidylcholine) is a very good supplement, having anti-atherosclerotic and cell wall-repairing qualities independently. 6. Blood levels, except acutely, mean little with the liposome encapsulated vitamin C. As blood levels drop, this means much more that the liposomes and vitamin C are going inside the cells, not being excreted into the urine as with regular vitamin C. 7. There is now a liposome encapsulated glutathione, and its clinical effectiveness is surpassing that of the lipsome encapsulated vitamin C, not surprising, when you appreciate how important glutathione is as an intracellular antioxidant and how much energy needs to be expended to increase its intracellular levels, even after IV administration of the glutathione. 8. My prediction is that orally ingested liposomes will eventually be the administration of choice for a majority of drugs and nutrients, clearly outstripping IV administration for very many clinical applications. Also, intravenous administration of liposome encapsulated substances in some circumstances will have its own distinct advantages over the oral administration of liposome products. Dr. Levy Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 25, 2009 Report Share Posted January 25, 2009 In the last few days, I've become very confused on the whole issue of glutathione and cancer. I used to think that raising glutathione levels was the do-all end-all of cancer cures. Now I am finding out that cancer cells are chock full of glutatione! They love the stuff and it protects them from destruction. How? Why? Because it is probably the most powerful antioxidant there is in the body. Oddly, normal cells in cancer patients are depleted in glutathione, while cancer cells are loaded with the stuff. Interestingly, whey isolate seems to raise glutathione levels in normal cells while stripping it from cancer cells. Why? I have no idea. But what about all the glutathione precursors? They are all powerful antioxidants too, and glutathione makes sure that they are all recycled in the body -- these precursors are vitamins C, E, selenium, zinc, and alpha lipoic acid. So are antioxidants actually BAD for cancer patients? Gee, the Budwig people seem to think so. This guy also seems to think so (Dr. Steve): http://grouppekurosawa.com/blog/2006_03_29_ This runs contrary to so much that I have read about alternative cancer cures to date. I am completely confused. oleander soup , Rhoda Mead <hummingbird541 wrote: > > *We are having discussions are about precursors to glutathione*, *such as > NAC. Livon Labs just introduced liposomal glutathione, which has never been > available before. Here's what Dr. Levy, probably the main expert on using > and outcomes with liposomals has to say in a forwarded email. Rhoda* > > Dr. Levy's E-Mail ****************************** > ***************************************** > > I recently submitted some info on a vitamin C forum about > liposome encapsulation that should answer your questions > and give you even a little more info: > > 1. Absorption/bioavailability. Liposomes are changing the definition of the > word bioavailable. Percent absorption into the blood, always erroneously in > my opinion, has long been equated to bioavailability. If something is 100% > absorbed (or given IV), it is by " definition " 100% bioavailable. Not true, > however, not even close. Because of this, however, IV administration of > anything has long been and continues to be the " gold standard " of drug, > vitamin, or nutrient administration. Intracellular delivery is now the " new " > definition of bioavailability. This is accomplished by nontargeted, > unmodified liposomes. Except for very, very few substances, IV delivery does > not really even come close to what these liposomes can do. > Oral ascorbic acid is poorly absorbed. The 1 to 5 ratio is a fair > approximation for just its absorption into the blood versus liposome > encapsulation absorption, without addressing intracellular uptake. My actual > " estimation " is that for many conditions the oral liposome encapsulated > vitamin C is 10 times as effective as intravenous vitamin C. And, believe > me, I have always loved (and still do) intravenous vitamin C. And for those > who can have it, there is a synergism between the oral liposome encapsulated > vitamin C and the intravenous vitamin C. I fought this conclusion for a very > long time as I continued to witness what were inexplicable clinical > responses at the time to the oral liposome encapsulated vitamin C. > > 2. Liposomes have been well-documented to deliver their encapsulated > substances directly into the cytoplasm, mitochondria, endoplasmic reticula, > and even the nucleus. These cellular compartments are rarely approached > efficiently to even a minimal degree with any other form of delivery. > > 3. Many substances, including reduced vitamin C, once effectively delivered > into the blood, require the consumption of energy to be taken up into the > cell. This is very counterproductive to the goal of net electron donation, > especially when you are trying to deliver energy-delivering substances such > as antioxidants inside the cell. Liposomes, in many cases, are > energy-sparing (or non-energy-consuming) vehicles for intracellular delivery > of their contents. > > 4. Macrophages and monocytes take up many of the liposomes. This, if you > will, helps to " supercharge " these important components of the immune > system. > > 5. The liposome itself (largely phosphatidylcholine) is a very good > supplement, having anti-atherosclerotic and cell wall-repairing qualities > independently. > > 6. Blood levels, except acutely, mean little with the liposome encapsulated > vitamin C. As blood levels drop, this means much more that the liposomes and > vitamin C are going inside the cells, not being excreted into the urine as > with regular vitamin C. > > 7. There is now a liposome encapsulated glutathione, and its clinical > effectiveness is surpassing that of the lipsome encapsulated vitamin C, not > surprising, when you appreciate how important glutathione is as an > intracellular antioxidant and how much energy needs to be expended to > increase its intracellular levels, even after IV administration of the > glutathione. > > 8. My prediction is that orally ingested liposomes will eventually be the > administration of choice for a majority of drugs and nutrients, clearly > outstripping IV administration for very many clinical applications. Also, > intravenous administration of liposome encapsulated substances in some > circumstances will have its own distinct advantages over the oral > administration of liposome products. > Dr. Levy > Quote Link to comment Share on other sites More sharing options...
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