Sainsbury's supermarket chain in UK to ban aspartame, sodium benzoate, and artificial flavourings and colours

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Sainsbury's supermarket chain in UK details its bans of aspartame, sodium benzoate, and artificial flavourings and colours: Carol Key, Customer Manager: Murray 2007.11.09aspartameNM/message/1487aspartame/ 1051 membershttp://health.aspartame/message/218182007.11.08 6:43 AMHi AllI have been writing to supermarkets to thank them for organic ranges and to encourage them to increase chemical free ranges etc...here is reply from sainsburys, might be of some interest...maybe others could write to supermarkets too, one way to make positive changes.I have replied regarding the sucralose to suggest natural alternatives

ie stevia or brazzein.Karen ginghamcrossCustomer.ServiceThank you for your email and your positive comments about Sainsbury’sincreasing the range of organic products in our stores.I can see from your email that you would also like to see more foods without aspartame and msg.I understand you would like us to produce more preservative free body and home cleaning products.In April 2007 Sainsbury’s became the first UK retailer to announce itsintention to remove all artificial colours and flavourings from its range of over 120 own-brand soft drinks including fizzy drinks, squash, cordials and mixers.The reformulation, which took place from June 2007, will bring Sainsbury’s ambient soft drinks in line with the supermarket’s market-leading ingredient standards.Research has shown that customers will welcome the move.In addition, Sainsbury’s

is replacing Aspartame amongst other sweeteners in low calorie drinks with Sucralose, a sweetener made from sugar that tastes like sugar.Standard drinks will now contain full sugar and no sweeteners.The move, which sees Sainsbury’s innovating quicker than many manufacturers, and sees Sainsbury’s as the first in the industry to remove Sulphite Ammonia Caramel (E150d) from its cola drinks.The removal of artificial colours means that Sainsbury’s will be looking to use natural colours and fruit and vegetable extracts as colouring agents in the drinks.Where flavorings are used, these will be from the named fruits and from other natural sources.Sainsbury’s are also the first major food retailer to remove artificialcolouring, flavour enhancers and benzoate preservatives from virtually all our 12,000-plus own brand food and soft drinks including fizzy drinks.Our entire 'Kids' range is free from

artificial flavourings, colours and preservative sodium benzoate.The only exceptions are canned strawberries, raspberries, glace cherries, processed peas and angel cake, where we are actively sourcing natural alternatives.In the meantime they are clearly labelled so that they can be easilyidentified for customers to make an informed choice.Thank you once again for taking the time to contact us.I hope you will continue to enjoy shopping with us in the future.Kind regards,Carol Key Customer Manager [THREAD ID:1-334SNR]ginghamcrossSent: 06.11.2007 06:30:21 PM"Customer.Service" Other QuestionsCHECK OUT OUR WEBSITE!! http://presidiotex.com/aspartame"They come after rival food chain Sainsbury's last month pledged to remove artificial colours and flavours from its 120 own-label soft

drinks."aspartameNM/message/1426ASDA (unit of Wal-Mart Stores WMT.N) and Marks & Spencerwill join Tesco and also Sainsbury to ban and limitaspartame, MSG, artificial flavors dyes preservatives additives,trans fats, salt "nasties" to protect kids from ADHD:leading UK media: Murray 2007.05.15aspartameNM/message/1427more from The Independent, UK, Martin Hickman, re ASDA(unit of Wal-Mart Stores) and Marks & Spencer ban ofaspartame, MSG, artificial chemical additives and dyesto prevent ADHD in kids: Murray 2007.05.16http://news.independent.co.uk/uk/health_medical/article2548747.eceaspartameNMmessage/1437stevia to be approved and cyclamates limited byFood Standards Australia New Zealand:JMC Geuns critiques of two recent stevia studies by Nunes:Murray

2007.05.29aspartameNM/message/1438Coca-Cola and Cargill Inc., after years of development,with 24 patents, will soon sell rebiana (stevia)in drinks and foods: Murray 2007.05.31aspartameNMmessage/1451Artificial sweeteners (aspartame, sucralose) and coloringagents will be banned from use in newly-born and baby foods,the European Parliament decided: Latvia ban in schools 2006:Murray 2007.07.12////////////////////////////////////////////////////////////"Of course, everyone chooses, as a natural priority, to enjoy peace, joy, and love by helping to find, quickly share, and positively act upon evidence about healthy and safe food, drink, and environment."Rich Murray, MA Room For All rmforall505-501-2298 1943 Otowi Road, Santa Fe, New Mexico 87505http://RMForAll.blogspot.com new primary

archiveaspartameNM/messagesgroup with 111 members, 1,487 posts in a public,searchable archivehttp://rmforall.blogspot.com/2007_09_01_archive.htmSaturday, September 15, 2007aspartameNM/message/1472bias, omissions, incuriosity = opportunity, aspartame safety evaluation, Magnuson BA, Burdock GA, Williams GM, 7 more, 2007 Sept, Ajinomoto funded 98 pages html [$ 32 781888262_content.pdf]: Murray 2007.09.15////////////////////////////////////////////////////////////13 mainstream research studies in 24 months showing aspartame toxicity, also 3 relevant studies on methanol and formaldehyde: Murray 2007.11.09aspartameNM/message/1464Aspartame toxicity was shown in thirteen detailed mainstream researchstudies in 24 months in work by expert teams in USA, South Africa, England, Italy, Greece, Hungary, and

Mexico.Very little has been publicized in mass print and broadcast media.Also highly relevant are a study in South Korea that finds levels ofmethanol similar to those from aspartame drinks cause the hangoversfrom alcohol drinks, a study in China on Alzheimer's type damage innerve cells from low dose formaldehyde, and an IARC review by 25experts that determines formaldehyde to be a human carcinogen.////////////////////////////////////////////////////////////http://RMForAll.blogspot.com October 12, 2007aspartameNM/message/147913,620 seniors using more than 1 can/week artificially sweetened[aspartame] soft drinks had 8 % higher death risk, 1981-2004, Paganini-Hill A, Kawas CH, Corrada MM, U. Southern Cal., Prev. Med. 2007 April44(4) 305-10: Murray 2007.10.12aspartameNM/message/147519,000 people, the 4 % of users of aspartame who drink

average 5 cansdaily, have more problems in NIH AARP study of 474,000 people: Murray2007.09.21http://RMForAll.blogspot.com September 21, 2007Table 1. NIH-AARP Diet and Health Study aspartame intake levels frombeverages, 1995-2000 (N = 473,984)[ adapted from article -- a 12-oz can diet soda has 200 mg aspartame ]0 - under 100 - 100-200 - 200-400 - 400-600 - 600-1200 - over 1200 mg/dcohort %46 ------- 25 ------ 13 ------ 7 -------- 5 -- about 3 --- under 1This is the first good data about the percentage of aspartame userswho use over 3 cans daily, averaging 5 cans daily at 200 mg per 12 ozcan diet soda.About 4 % of 473,984 is 19,000 people, with a peak intake of 17 cansdaily, and average 5 cans daily.It would be worthwhile to investigate a wide variety of symptoms forthe 0.1 % of highest level users, about 500 people.For about 200 million USA aspartame users, this would be

200,000people.Table 1 reveals consistent increase in problems from--------------------- zero to (400-600) to (over 600) mg/daspartame intake:% of cohort ---------- 46 -------- 5 -------- 4 %mean aspartame mg/d --- 0 -------441 ------ 98616+ education -------- 37 ------- 40 ------- 34 %diabetes history ------ 3 ------- 22 ------- 26 %alcohol g/d ---------- 14 ------- 11 ------- 13never smoke ---------- 36 ------- 31 ------- 29 %Body Mass Index ------ 26 ------- 29 ------- 2918.5 - 25 ------------ 42 ------- 21 ------- 19 %30 - 35 -------------- 13 ------- 23 ------- 26 %over 35 -------------- 4 ------- 10 ------- 13 %Physical activity %:under 3-4/mo --------- 32 ------- 32 ------- 37 %under 1-2/wk --------- 22 ------- 21 ------- 19 %over 3-4/wk ---------- 45 ------- 45 ------- 43 %Calories kcal ----- 1,919 ---- 1,855 ---- 2,044

%Caffeine mg/d ------ 393 ------ 364 ------ 424There do seem to be many increases of problemsfrom the second to third row, as mean aspartame use doubles.Granted, this is cherry picking the data, selecting interestingpatterns.Correlations alone do not prove any direction of causation.Nevertheless, it may be of value to study the correlations forincreasing aspartame intake among the 4 % using over 600 mg, theequivalent of 3 cans 12-oz cans diet soda daily. The average use forthis group is 5 cans daily.For instance, are a minority of these heavy users displaying the greatmajority of the problems that are reflected in the mean for each levelof use, with most users only having little or no increase in problems?This is a group of about 20,000 people.aspartameNM/message/1141Nurses Health Study can quickly reveal the extent of aspartame(methanol,

formaldehyde, formic acid) toxicity: Murray 2004.11.21The Nurses Health Study is a bonanza of information about the healthof probably hundreds of nurses who use 6 or more cans daily of diet softdrinks -- they have also stored blood and tissue samples from theirimmense pool of subjects, over 100,000 for decades.Cancer Epidemiol Biomarkers Prev. 2006 Sep; 15(9): 1654-9.Comment in:Cancer Epidemiol Biomarkers Prev. 2007 Jul; 16(7): 1527-8;author reply 1528-9.Consumption of aspartame-containing beverages and incidence ofhematopoietic and brain malignancies.Lim U, Subar AF, Mouw T, Hartge P, Morton LM, Stolzenberg-Solomon R,Campbell D, Hollenbeck AR, Schatzkin A.Division of Cancer Control and Population Sciences,National Cancer Institute, 6130 Executive Boulevard, EPN 4005,Rockville, MD 20852-7344, USA. PMID: 16985027Unhee Lim 1,Amy F. Subar 2, subara,Traci Mouw 1,Patricia

Hartge 1,Lindsay M. Morton 1,Rachael Stolzenberg-Solomon 1,David Campbell 3,Albert R. Hollenbeck 4and Arthur Schatzkin 11 Division of Cancer Epidemiology and Genetics,2 Division of Cancer Control and Population Sciences, National CancerInstitute, NIH, Department of Health and Human Services;3 Information Management Services, Inc., Rockville, Maryland; and4 AARP, Washington, District of ColumbiaRequests for reprints: Amy Subar,Division of Cancer Control and Population Sciences,National Cancer Institute,6130 Executive Boulevard, EPN 4005, Rockville, MD 20852-7344.Phone: 301-594-0831; Fax: 301-435-3710. E-mail: subarahttp://cebp.aacrjournals.org/cgi/content/full/15/9/1654 free fulltextBACKGROUND:In a few animal experiments, aspartame has been linked tohematopoietic and brain cancers.Most animal studies have found no increase in the risk of these

orother cancers.Data on humans are sparse for either cancer.Concern lingers regarding this widely used artificial sweetener.OBJECTIVE:We investigated prospectively whether aspartame consumption isassociated with the risk of hematopoietic cancers or gliomas(malignant brain cancer).METHODS:We examined 285,079 men and 188,905 women ages 50 to 71 years in theNIH-AARP Diet and Health Study cohortDaily aspartame intake was derived from responses to a baseline self-administered food frequency questionnaire that queried consumption offour aspartame-containing beverages (soda, fruit drinks, sweetenediced tea, and aspartame added to hot coffee and tea) during the pastyear.Histologically confirmed incident cancers were identified from eightstate cancer registries.Multivariable-adjusted relative risks (RR) and 95% confidenceintervals (CI) were estimated using Cox proportional

hazardsregression that adjusted for age, sex, ethnicity, body mass index, andhistory of diabetes.RESULTS:During over 5 years of follow-up (1995-2000), 1,888 hematopoieticcancers and 315 malignant gliomas were ascertained.Higher levels of aspartame intake were not associated with the risk ofoverall hematopoietic cancer(RR for over 600 mg/d, 0.98; 95 % CI, 0.76-1.27),glioma (RR for over 400 mg/d, 0.73; 95 % CI, 0.46-1.15;P for inverse linear trend = 0.05),or their subtypes in men and women.CONCLUSIONS:Our findings do not support the hypothesis that aspartame increaseshematopoietic or brain cancer risk. PMID: 16985027"We cannot exclude the possibility that higher aspartame consumptionthan that observed in this study may be associated with an elevatedrisk of hematopoietic or brain cancers.In the laboratory study with positive findings, animals were fed dosesstarting from 4 mg up to

5,000 mg per kg body weight.Significantly elevated lymphomas and leukemias were observed in femalerats fed 20 mg of aspartame and higher (e.g., 1,200 mg for humansweighing 60 kg or 132 lb; refs. 13, 14).The reported aspartame intake in our data ranged from 0 to 3,400 mg/dwith sparse numbers in the upper intake categories (under 1 %consuming over 1,200 mg/d).However, we did not detect any increase in risk estimates in thehighest categories (over 1,200 or 2,000 mg/d, which is equivalent toabout 7 to 11 cans of soft drinks daily) compared with the lowestcategories,and the associations were similarly null in both men and women."////////////////////////////////////////////////////////////aspartameNM/message/1472bias, omissions, incuriosity, opportunity, aspartame safetyevaluation, Magnuson BA, Burdock GA, Williams GM, 7 more, 2007 Sept,Ajinomoto funded 98 pages html

[$ 32 781888262_content.pdf]: Murray2007.09.14Eur J Clin Nutr. 2007 Aug 8; [Epub ahead of print]Direct and indirect cellular effects of aspartame on the brain.Humphries P,Pretorius E, resia.pretorius,Naudé H.[1] Department of Anatomy, University of Pretoria, Pretoria, Gauteng,South Africa[2] Department of Anatomy, University of the Limpopo, South Africa.aspartameNM/message/1463Ultrastruct Pathol. 2007 Mar-Apr; 31(2): 77-83.Ultrastructural changes to rabbit fibrin and platelets due toaspartame.Pretorius E,Humphries P.Department of Anatomy, Faculty of Medicine,University of Pretoria, South Africa.[ Humphries P also atDepartment of Anatomy, University of Limpopo.Medunsa Campus, Garankuwa. South Africa ]*Correspondence to E. Pretorius,BMW Building, PO Box 2034,Faculty of Health Sciences,University of Pretoria, Pretoria 0001,

South AfricaaspartameNM/message/1452aspartame decreases evoked extracellular dopamine levels in the rat brain, Brian P Bergstrom, Muskingum College, Neuropharmacology 2007.09.29: Murray 2007.11.06"These findings suggest that APM has a relatively potent effect ofdecreasing evoked extracellular DA levels when administered systemicallyunder the conditions specified. "Neuropharmacology. 2007 Sep 29; [Epub ahead of print]Aspartame decreases evoked extracellular dopamine levels in the rat brain: An in vivo voltammetry study.Bergstrom BP, brianb,[ (2001), Associate Professor of Biology, B.S., Ph.D., Illinois StateUniversityBrian Bergstrom studies neurochemical changes in synaptic function ofdopamine neurons in response to neurodegenerative disease, drugs ofabuse, and pharmacological regulation.He is Assistant Professor of Biology and teaches Intro to

Cell andMolecular Biology, Cell Physiology, and Advanced Neuroscience.]Cummings DR, bynehill,Skaggs TA.Department of Biology, Neuroscience Program,Muskingum College, New Concord, OH 43762, USA.aspartameNM/message/1485[ not about aspartame, but highly suggestive... ]aspartameNM/message/1471Food additives and hyperactive behaviour in kids, McCann D, GrimshawK, Sonuga-Barke, Warner JO, Stevenson J, et al, The Lancet 2007.09.06pdf 454 KB: Murray 2007.09.06www.dailymail.co.uk/pages/live/articles/health/womenfamily.html?in_article_id=45\3431 & in_page_id=1799By UK Daily Mail NewspaperThe proof food additives ARE as bad as we fearedBy SEAN POULTER Last updated at 09:53am on 18th May 2007[ This team will publish their confirming study later in 2007. ]http://adc.bmj.com/cgi/content/full/89/6/506Archives of Disease in

Childhood 2004; 89(6): 506-511Erratum in: Arch Dis Child. 2005 Aug; 90(8): 875.© 2004 BMJ Publishing Group & Royal College of Paediatrics and ChildHealthThe effects of a double blind, placebo controlled, artificial foodcolourings and benzoate preservative challenge on hyperactivity in ageneral population sample of preschool childrenB Bateman 1,J O Warner 1, j.o.warner,E Hutchinson 3,T Dean 5, tara.dean,P Rowlandson 4, Dr. Piers Rolandson, Paediatric TutorC Gant 5,J Grundy 5,C Fitzgerald 3and J Stevenson 2 jsteven,1 Infection, Inflammation and Repair Division, University ofSouthampton, Southampton, UK2 Department of Psychology, University of Southampton, Southampton, UK3 Department of Clinical Psychology, St Mary's Hospital, Isle ofWight, UK4 Department of Paediatrics, St Mary's Hospital, Isle of Wight, UK5 David Hide Asthma and Allergy Research

Centre, St Mary's Hospital,Isle of Wight, UKaspartameNM/message/1461www.ehponline.org/members/2007/10271/10271.pdf free full text 24 pagesNational Institutes of HealthU.S. Department of Health and Human ServicesENVIRONMENTAL HEALTH PERSPECTIVESLifespan Exposure to Low Doses of Aspartame Beginning During PrenatalLife Increases Cancer Effects in Ratsdoi:10.1289/ehp.10271 (available at http://dx.doi.org/)Online 13 June 2007Morando Soffritti 1,Fiorella Belpoggi 1,Eva Tibaldi 1,Davide Degli Esposti 1,Michela Lauriola 11 Cesare Maltoni Cancer Research Center, European Ramazzini Foundationof Oncology and Environmental Sciences, Bologna ItalyAddress of the institution: Cesare Maltoni Cancer Research Center,European Ramazzini Foundation of Oncology and Environmental SciencesCastello di Bentivoglio, Via Saliceto, 3, 40010 Bentivoglio, Bologna,Italy +39 051

6640460 fax +39 051 6640223crcfr, www.ramazzini.itAddress correspondence to: M. SoffrittiAcknowledgements:This research was supported entirely by the European RamazziniFoundation Environmental Sciences.The authors declare that they have no competing financial interests.aspartameNM/message/1441http://www.ramazzini.it/fondazione/docs/NYAS_Aspartame_Ramazzini.pdfResults of Long-Term Carcinogenicity Bioassay on Sprague-Dawley RatsExposed to Aspartame Administered in FeedAnn. N.Y. Acad. Sci. 2006 Sep; 1076: 559-577.Fiorella Belpoggi,Morando Soffritti,Michela Padovani,Davide Degli Esposti,Michelina Lauriola, andFranco Minardi.The end judges everything -- HERODOTUS (480-425 B.C.) The HistoryCesare Maltoni Cancer Research Center,European Foundation of Oncology and Environmental Sciences'B. Ramazzini', 40010 Bentivoglio, Bologna,

ItalyaspartameNM/message/1382[ and, previously ]First experimental demonstration of the multipotentialcarcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats.Environ. Health Perspect. 2006 Mar; 114: 379-385. PMID: 16507461Soffritti M, Belpoggi F, Degli Esposti D, Lambertini L, Tibaldi E,Rigano A.Environmental Health Perspectives Volume 113, Number 11November 2005 Current print issueThe full version of this article is available for free in PDF format.http://ehp.niehs.nih.gov/members/2005/8711/8711.pdf 35 pagesFirst Experimental Demonstration of theMultipotential Carcinogenic Effects of AspartameAdministered in the Feed to Sprague-Dawley Rats.Morando Soffritti, Fiorella Belpoggi, Davide Degli Esposti,Luca Lambertini, Eva Tibaldi, and Anna Rigano.doi:10.1289/ehp.8711 (available at http://dx.doi.org/)Online 17 November 2005The National

Institute of Environmental Health SciencesNational Institutes of HealthU.S. Department of Health and Human Serviceshttp://www.ehponline.org/Cesare Maltoni Cancer Research Center,European Ramazzini Foundation of Oncology andEnvironmental SciencesSofritti, M. et al. 2005.Aspartame induces lymphomas and leukaemias in rats.Eur. J. Oncol. 2005; 10: 107-116.aspartameNM/message/1250Food Chem Toxicol. 2007 Jun 16;[Epub ahead of print]The effect of aspartame metabolites on the suckling ratfrontal cortex acetylcholinesterase. An in vitro study.Simintzi I,Schulpis KH, inchildh,Angelogianni P,Liapi C,Tsakiris S. stsakir,Department of Experimental Physiology, Medical School,University of Athens,P.O. Box 65257, GR 15401 Athens, Greece.aspartameNM/message/1459Toxicology. 2007 May 18; [Epub ahead of

print]l-Cysteine and glutathione restore the reduction of rat hippocampalNa(+),K(+)-ATPase activity induced by aspartame metabolites.Simintzi I,Schulpis KH,Angelogianni P,Liapi C,Tsakiris S.Department of Experimental Physiology,Medical School, Athens University,P.O. Box 65257, GR-15401 Athens, Greece.aspartameNM/message/1447Pharmacol Res. 2007 May 13; [Epub ahead of print]The effect of aspartame on acetylcholinesterase activity inhippocampal homogenates of suckling rats.Simintzi I,Schulpis KH,Angelogianni P,Liapi C,Tsakiris S.Department of Experimental Physiology,Medical School, University of Athens,P.O. Box 65257, GR-15401 Athens, Greece.aspartameNM/message/1444Eur J Clin Nutr. 2005 Dec 14; [Epub ahead of print]The effect of L-cysteine and glutathione on inhibition ofNa(+), K(+)-ATPase activity

by aspartame metabolitesin human erythrocyte [red blood cell] membrane.Schulpis KH, Kleopatra H. Schulpis, MD, PhD.Institute of Child Health, Aghia Sophia Children's Hospital,GR-11527 Athens (Greece) +30 1 7708291, Fax +30 1 7700111inchildhPapassotiriou I, biochem,Tsakiris T,Tsakiris S. Stylianos Tsakiris. stsakir,1 Institute of Child Health, Research Center,'Aghia Sophia' Children's Hospital, Athens, Greece.ggbriass ersi_voskaridoummoschov siahanidouaspartameNM/message/1279Pharmacol Res. 2005 Aug 26; [Epub ahead of print]The effect of aspartame metabolites on human [red blood cell]erythrocyte membrane acetylcholinesterase activity.Tsakiris S,Giannoulia-Karantana A,Simintzi I,Schulpis KH.Department of Experimental Physiology, Medical School,University of Athens, P.O.

Box 65257, GR-154 01 Athens, Greece.Stylianos Tsakiris. stsakir,Giannoulia-Karantana A. First Department of Pediatrics,Aghia Sophia Children's Hospital, University of Athens, Greece.Kleopatra H. Schulpis, MD, PhD. Institute of Child Health,Aghia Sophia Children's Hospital, GR-11527 Athens (Greece)Tel. +30 1 7708291, Fax +30 1 7700111 inchildh[ Papoutsakis T. tina.papoutsakis,Papadopoulos G. Department of Biochemistry and Biotechnology,University of Thessaly, Ploutonos 26, 41221 Larisa, Greecepapg, ]aspartameNM/message/1213In Vivo. 2007 Jan-Feb; 21(1): 89-92.The effect of aspartame administration on oncogene and suppressor geneexpressions.Gombos K, katalin_gombos,Varjas T,Orsos Z,Polyak E,Peredi J,Varga Z,Nowrasteh G,Tettinger A,Mucsi G,Ember I.Faculty of Medicine, Institute of Public

Health University of Pecs,Pecs, Hungary.aspartameNM/message/1414Hum Exp Toxicol. 2006 Aug; 25(8): 453-9.The effect of aspartame on rat brain xenobiotic-metabolizing enzymes.Vences-Mejia A 1,Labra-Ruiz N 1,Hernandez-Martinez N 1,Dorado-Gonzalez V 1,Gomez-Garduno J 1,Perez-Lopez I 1,Nosti-Palacios R 1,Camacho Carranza R 2,Espinosa-Aguirre JJ 2.Laboratorio de Toxicologia Genetica,1: Instituto Nacional de Pediatria, Insurgentes Sur, 3700-C,04530 Mexico, DF Mexico.2: Instituto de Investigaciones Biomédicas, UNAM, Apartado postal70228,Ciudad Universitaria 04510 México, D.F., Méxicohttp://www.biomedicas.unam.mx/index.asp*Correspondence: JJ Espinosa-Aguirre, Instituto de InvestigacionesBiome´dicas, UNAM, Apartado postal 70228, CiudadUniversitaria 04510 Me´xico, D.F., Me´xicoHuman & Experimental Toxicology (2006) 25(8): 453 -

459.www.sagepublications.comc 2006 SAGE Publications 10.1191/0960327106het646oa[ Dra. Araceli Vences MJefa de Laboratorio de Toxicologia Genetica6° P de Hospital Laboratorios10 84 09 00 Ext.1410 -1448 aritaven, ]aspartameNM/message/1373Toxicol Sci. 2006 Mar;90(1):178-87.Synergistic interactions between commonly used food additives in adevelopmental neurotoxicity test.Lau K, McLean WG, Williams DP, Howard CV.Developmental Toxicopathology Unit,Department of Human Anatomy & Cell Biology,University of Liverpool, Sherrington Buildings, Liverpool L69 3GE, UK;Department of Pharmacology & Therapeutics,University of Liverpool, Sherrington Buildings, Liverpool L69 3GE, UK.W. Graham McLean w.g.mclean,C. V. Howard c.v.howard,D. P. Williams dom, 0151 794 5791 http://www.liv.ac.uk/Miss. Karen Lau

karenlau, 0151 795 4223aspartameNM/message/1271http://www.biomedcentral.com/content/pdf/1471-2202-8-9.pdffree full text 28 pagesThis Provisional PDF corresponds to the article as it appeared uponacceptance.Copyedited and fully formatted PDF and full text (HTML) versions willbe made available soon.Amyloid-like aggregates of neuronal tau induced by formaldehydepromoteapoptosis of neuronal cellsBMC Neuroscience 2007 Jan 23, 8(1): 9 doi: 10.1186/1471-2202-8-9Chunlai Nie niecl1022,Xing sheng Wang step,Ying Liu liuy,Sarah Perrett sperrett,Rongqiao He herq,ISSN 1471-2202Article type Research articleSubmission date 15 August 2006Acceptance date 23 January 2007Publication date 23 January 2007Article URL http://www.biomedcentral.com/1471-2202/8/9Chun Lai Nie 1,3,Xing Sheng Wang

1,3,Ying Liu 1,Sarah Perrett 2 andRong Qiao He 1,3*1 State Key Laboratory of Brain and Cognitive Science,Institute of Biophysics, 15 Datun Rd, Chaoyang District, Beijing100101, China2 National Laboratory of Biomacromolecules,Institute of Biophysics, 15 Datun Rd, Chaoyang District, Beijing100101, China3 Graduate School, Chinese Academy of Sciences, 19 Yuquan Rd,ShijingshanDistrict, Beijing 100049, China*Corresponding authoraspartameNM/message/1406Addict Biol. 2005 Dec;10(4): 351-5.Concentration changes of methanol in blood samples duringan experimentally induced alcohol hangover state.Woo YS, Yoon SJ, Lee HK, Lee CU, Chae JH, Lee CT, Kim DJ.Chuncheon National Hospital, Department of Psychiatry,The Catholic University of Korea, Seoul, Korea.http://www.cuk.ac.kr/eng/ sysopSongsin Campus: 02-740-9714 Songsim Campus:

02-2164-4116Songeui Campus: 02-2164-4114http://www.cuk.ac.kr/eng/sub055.htm eight hospitalsaspartameNM/message/1394" Absorbed formaldehyde can be oxidized to formate and carbon dioxideor can be incorporated into biologic macromolecules. "[ References include: Soffritti M, Belpoggi F, Lambertini L, LauriolaM,Padovani M, Maltoni C. 2002. Results of long-term experimental studieson the carcinogenicity of formaldehyde and acetaldehyde in rats. AnnNY Acad Sci 982: 87-105.Soffritti M, Maltoni C, Maffei F, Biagi R. 1989. Formaldehyde: anexperimental multipotential carcinogen. Toxicol Ind Health 5:699-730."Morando Soffritti is a member of the Working Group. ]http://www.ehponline.org/members/2005/7542/7542.html free full textAfter a thorough discussion of the epidemiologic, experimental, andother relevant data, the working group concluded that formaldehyde

iscarcinogenic to humans, based on sufficient evidence in humans and inexperimental animals.In the epidemiologic studies, there was sufficient evidence thatformaldehyde causes nasopharyngeal cancer, "strong but not sufficient"evidence of leukemia, and limited evidence of sinonasal cancer.The working group also concluded that 2-butoxyethanol and1-tert-butoxy-2-propanol are not classifiable as to theircarcinogenicity to humans, each having limited evidence inexperimental animals and inadequate evidence in humans.These three evaluations and the supporting data will be published asVolume 88 of the IARC Monographs. PMID: 16140628Environ Health Perspect. 2005 Sep; 113(9): 1205-8.Meeting report: summary of IARC monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol.Cogliano VJ, Vincent James Cogliano cogliano,Grosse Y, Yann Grosse grosse,Baan RA, Robert A. Baan

baan,Straif K, Kurt straif,Secretan MB, Marie Béatrice Secretan secretan,El Ghissassi F, Fatiha El Ghissassi elghissassi,Working Group for Volume 88.IARC, 150 Cours Albert Thomas, 69372 Lyon CEDEX 08, FranceTel: +33 (0)4 72 73 84 85 - Fax: +33 (0)4 72 73 85 75© IARC 2004 - http://monographs.iarc.fr cie,Monographs Recently PublishedIARC Monographs Vol 88Formaldehyde, 2-Butoxyethanol and 1-tert-Butoxypropan-2-olDecember 2006478 pagesISBN 92 832 1288 6US$ 40This volume re-evaluates the available evidence on the carcinogenicpotential of formaldehyde, a substance that is found in the workplaceand in the environment.Formaldehyde is widely used in resins that bind wood products, pulpand paper; in glasswool and rockwool insulation; in plastics andcoatings, textile finishing, chemical manufacture; and as adisinfectant and

preservative.Also evaluated are two glycol ethers, 2-butoxyethanol and 1-tert-butoxypropan-2-ol,which are widely used as solvents in paints and paint thinners,coatings, glass and surface cleaners, inks, adhesives, personal-careproducts, and as chemical intermediates.As for formaldehyde, there is sufficient evidence in epidemiologicalstudies for nasopharyngeal cancer, strong but not sufficient evidencefor leukaemia, and limited evidence for sinonasal cancer.The extensive scientific database on the mechanisms by whichformaldehyde can induce nasal-tract cancer in humans is considered.These data provide strong support for the empirical observation ofnasopharyngeal cancer in humans.In contrast, the lack of information on possible mechanisms by whichformaldehyde might increase the risk for leukaemia in humans temperedthe interpretation of the epidemiological data on that cancer.Although this volume focuses on a

qualitative assessment of thecarcinogenic potential of formaldehyde, subsequent predictions of therisks for nasopharyngeal cancer should consider pertinent informationon mechanisms of carcinogenesis, including genotoxicity and dose-dependent cytoxicity.A theme common to the three evaluations is the consideration ofmechanistic information to develop and evaluate hypotheses on thesequence of steps that lead to the induction of tumours inexperimental animals.The hypothesized mechanisms described provide an interesting set ofcases that range from a vast literature on respiratory tract tumoursin rats induced by the inhalation of formaldehyde to some moretentative hypotheses on the various tumours observed in animalsfollowing exposure to both glycol ethers.Recurring issues were the criteria that characterize a rare tumour orhow to introduce additional information to resolve difficultquestions; for example, how to

consider the results of historicalcontrols.International Agency for Research on Cancer, Lyon, France.An international, interdisciplinary working group of expert scientistsmet in June 2004 to develop IARC Monographs on the Evaluation of theCarcinogenic Risk of Chemicals to Humans (IARC Monographs) onformaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol.Each IARC Monograph includes a critical review of the pertinentscientific literature and an evaluation of an agent's potential tocause cancer in humans.Key words: 1-tert-butoxy-2-propanol, 2-butoxyethanol, carcinogen,formaldehyde, glycol ethers, hazard identification, IARC Monographs,leukemia, nasopharyngeal cancer, sinonasal cancer. Environ HealthPerspect 113: 1205-1208 (2005) .doi:10.1289/ehp.7542 available via http://dx.doi.org/ [Online 12 May2005]Address correspondence to V.J. Cogliano, Carcinogen Identification andEvaluation,

International Agency for Research on Cancer, 150 coursAlbert Thomas, 69372 Lyon cedex 08, France.33-4-72-73-84-76. fax 33-4-72-73-83-19 cogliano,The Working Group for Volume 88 of the IARC Monographs includes:Ulrich Andrae (Germany) , andrae, Dr. Ulrich Andrae, GSF-Institut für Toxikologie,. Postfach 1129, D-85758 Neuherberg, GermanyFax: 149-089-3187-3449 Sherwood Burge (UK),Rajendra S Chhabra (USA) , http://dir.niehs.nih.gov/dirtob/chhabra.htmchhabrar@..., General Toxicology Group, TOB, ETP, DIRJohn Cocker (UK) , Health and Safety Laboratory, Buxton, UKjohn.cocker,David N Coggon (UK) , MRC Environmental Epidemiology Unit at theUniversity of Southampton, UK dnc,Rory Conolly (USA) , Rconolly, Senior Research Biologist,National Center for Computational Toxicology, Office of Research andDevelopment, U.S. Environmental Protection

AgencyPaul Demers (Canada) , pdemers, Occupational HygieneInstitute, University of British ColumbiaDavid A Eastmond (USA) , david.eastmond, EnviromentalToxicologyGraduate Program, University of California Riverside, CA 92521 (951)827-4497 (Voice) (951) 827-3087 (Fax)Elaine Faustman (USA) , faustman, Professor, Env. andOcc. Health Sciences, Adjunct Professor, Evans School 206-685-2269Victor J Feron (the Netherlands) , TNO Nutrition and Food Research(retired), The Netherlands TNO-CIVO TOXICOLOGY AND NUTRITION INSTITUTEUtrechtseweg 48 3704 HE Zeist The Netherlands (31)-3404 44 144Michel Gérin (Canada, Chair) , gerinm, Departement demedecine du travail et d'hygiene du milieu, Universite de Montreal,Quebec, Canada.Marcel Goldberg (France) , marcel.goldberg,France -- National Institute of Health and Medical Research

INSERMUnite 88, HNSM 14 Rue de Val d'Osne F-94410 St. Maurice France [33]1-451-83859 [33] 1-451-83889 Departement Sante Travail, Institut deVeille Sanitaire, 12, rue du Val d'Osne, 94410 Saint Maurice, FranceBernard D Goldstein (USA) , bdgold, Director of theEnvironmental and Occupational Health Sciences Institute and Professorand Chair of the Department of Environmental and Community Medicine atUMDNJ - Robert Wood Johnson Medical School. Dean's Office, Universityof Pittsburgh Graduate School of Public Health, A624 Crabtree Hall,130 DeSoto St., Pittsburgh, PA 15261, USA.Roland C Grafström (Sweden) , roland.grafstrom, Roland CGrafström, Institute of Environmental Medicine, Karolinska Institutet,Box 210, S−17177 Stockholm, Sweden Telefax: +46-8−329402Johnni Hansen (Denmark) , johnni, PhD, Senior researcher,Danish Cancer Registry , Institute of Cancer Epidemiology,

DanishCancer Society, Strandboulevarden 49, DK-2100, Copenhagen, Denmark.Michael Hauptmann (USA) , The National Cancer InstituteKathy Hughes (Canada) , Head, Existing Substances Section 1, HealthCanada,Ted Junghans (USA) , tjunghans, Technical ResourcesInternational, Inc., 6500 Rock Spring Drive, Suite 650, Bethesda, MD20817, USA.Dan Krewski (Canada) , MHA, MSc, PhD dkrewski, ProfessorDirector, R. Samuel McLaughlin Centre for Population Health RiskAssessment, Institute of Population Healt, 1 Stewart Street, Room 320,Phone: (613) 562-5381 Fax: (613)562-5380Steve Olin (USA) , solin, ILSI International Life SciencesInstituteMartine Reynier (France) , martine.reynier, Mme MartineREYNIER,Institut National de Recherche et de Sécurité (INRS), 30, rue OlivierNoyer, 75680 Paris Cedex 14 (France) Tel : +33 (0)1 40 44 30 81 Fax :+33 (0)1 40 44 30

54Judith Shaham (Israel) , yshaham, Occupational CancerDepartment, National Institute of Occupational and EnvironmentalHealth,Raanana, Israel. MD, Occupational Cancer Unit, Occupational Health & Rehabilitation Institute, P.O. Box 3, Raanana 43100, ISRAELMorando Soffritti (Italy) , crcfr, European Foundation ofOncology and Environmental Sciences "B. Ramazzini", Cesare MaltoniCancer Research Center, Bologna, ItalyLeslie Stayner (USA) , lstayner, Division of Epidemiology andBiostatistics, University of Illinois at Chicago School of PublicHealth (M/C 923), 1603 West Taylor Street, Room 971, Chicago, IL60612. E-mail:Patricia Stewart (USA) , National Food Safety and Toxicology Center,165 Food Safety and Toxicology Building, Michigan State University,East Lansing, MI 48824; fax (517) 432-2310Douglas Wolf (USA) , wolf.doug, DVM, PhD, USEPA,

(Toxicology)We gratefully acknowledge the important contributions of theadministrative staff of the IARC Monographs: S. Egraz, M. Lézère, J.Mitchell, and E. Perez.The IARC Monographs are supported, in part, by grants from the U.S.National Cancer Institute, the European Commission, the U.S. NationalInstitute of Environmental Health Sciences, and the U.S. EnvironmentalProtection Agency.The authors declare they have no competing financial interests.Received 31 August 2004 ; accepted 12 May 2005.aspartameNM/message/1417////////////////////////////////////////////////////////////aspartameNM/message/14674 cases of aspartame-induced thrombocytopenia [ very low platelets inblood ], HJ Roberts MD, Letter in Southern Medical Journal 2007 May:100(5); 543: Murray 2007.08.25aspartameNM/message/1468Formaldehyde

induced urticarial vasculitis in male medical student,age 40, Michael Pellizzari, Gillian Marshman, Flinders U.,Australasian J. Dermatol. 2007 Aug: Murray 2007.08.29aspartameNM/message/1469highly toxic formaldehyde, the cause of alcohol hangovers, is made bythe body from 100 mg doses of methanol from dark wines and liquors,dimethyl dicarbonate, and aspartame: Murray 2007.08.31aspartameNM/message/1470new details on how formaldehyde and formic acid from methanol areneurotoxic: Chun Lai Nie, Rong Giao He, et al, PLoS ONE 2(7): e6292007.07.18 Chinese Academy of Sciences, Beijing: Murray 20097.09.01////////////////////////////////////////////////////////////aspartameNM/message/1457aspartame bans, tis more an avalanche than a trend...: Rich Murray2007.08.17[ see

also:aspartameNM/message/1458ASDA, Wal-Mart's UK supermarket chain, bans artificial colors, transfats, MSG and aspartame, Marguerite Kelly, The Washington Post: Murray2007.08.03 ]So far, USA print and broadcast media are deaf, blind, and dumb,regarding recent major bans of aspartame and MSG in the UK and EU.The EU Parliament voted July 12 to ban artificial sweetenersin newly born and infant foods.On May 15 four huge UK supermarket chains announced bansof aspartame and MSG, food dyes, and many additivesto protect kids from ADHD --Sainsbury, Tesco, Marks & Spencer, and ASDA, a unit of WalMart.May 31: Coca-Cola and the much larger Cargill Inc.,after years of secret development, with 24 patents,will soon sell rebiana (stevia) in drinks and foodin the many nations where it is approved as a sweetener --for decades a major sweetener in Japan, China, Korea,

Taiwan,Thailand, Malasia, Saint Kitts, Nevis,Brazil, Peru, Paraguay, Uruguay, and Israel,and an approved supplement in USA, Australia, and Canada,according to Wikipedia.aspartameNM/message/1454recent research and news re aspartame and stevia: Murray 2007.08.16aspartameNM/message/1395Aspartame Controversy, in Wikipedia democraticencyclopedia, 72 references (including AspartameNM # 864and 1173 by Murray, brief fair summary of much more research:Murray 2007.01.01aspartameNM/message/1453Souring on fake sugar (aspartame), Jennifer Couzin,Science 2007.07.06: 4 page letter to FDA from 12 eminentUSA toxicologists re two Ramazzini Foundationcancer studies 2007.06.25: Murray 2007.07.18aspartameNMmessage/1451Artificial sweeteners (aspartame, sucralose) and coloringagents

will be banned from use in newly-born and baby foods,the European Parliament decided: Latvia ban in schools 2006:Murray 2007.07.12aspartameNMmessage/1437stevia to be approved and cyclamates limited byFood Standards Australia New Zealand:JMC Geuns critiques of two recent stevia studies by Nunes:Murray 2007.05.29aspartameNM/message/1427more from The Independent, UK, Martin Hickman, re ASDA(unit of Wal-Mart Stores) and Marks & Spencer ban ofaspartame, MSG, artificial chemical additives and dyesto prevent ADHD in kids: Murray 2007.05.16http://news.independent.co.uk/uk/health_medical/article2548747.eceaspartameNM/message/1426ASDA (unit of Wal-Mart Stores WMT.N) and Marks & Spencerwill join Tesco and also Sainsbury to ban and limitaspartame, MSG, artificial flavors dyes preservatives additives,trans

fats, salt "nasties" to protect kids from ADHD:leading UK media: Murray 2007.05.15aspartameNM/message/1438Coca-Cola and Cargill Inc., after years of development,with 24 patents, will soon sell rebiana (stevia)in drinks and foods: Murray 2007.05.31http://RMForAll.blogspot.com October 17, 2007aspartameNM/message/1480the tobacco industry violated the Racketeer Influenced CorruptOrganizations Act RICO law to "defraud the public." with huge amountsof false research to mislead people about its addictive toxin, Elisa KTong, Stanton A Glantz, Circulation 2007 Oct. 16: Murray 2007.10.17www.ncbi.nlm.nih.gov/sites/entrez?db=PubMed search PubMed////////////////////////////////////////////////////////////Post message: aspartameNM Subscribe: aspartameNM- Unsubscribe:

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