Marijuana Extract Shrinks Brain Tumors

[Guest guest]

http://www.primidi.com/2004/09/05.html Marijuana Extract Shrinks Brain TumorsA team of Spanish researchers has discovered that cannabinoids, the active ingredients in marijuana, make brain tumors shrink by halting the growth of blood vessels that feed the tumors, reports New Scientist. The researchers have successfully tested the effect of this cannabis extract on thirty mice which were given a cancer similar to the human brain cancer (glioblastoma multiforme). More importantly, they also successfully tested the procedure on two human patients who had glioblastoma multiforme and had not responded to chemotherapy, radiotherapy or surgery. Of course, these results are encouraging, even if larger studies need to be done to be sure that these cannabinoids are really effective on human brain cancers, and possibly other forms of cancers. Read more...Here is the introduction of the New Scientist article.Cannabis extracts may shrink brain tumours and other cancers by blocking the growth of the blood vessels which feed them, suggests a new study.An active component of the street drug has previously been shown to improve brain tumours in rats. But now Manuel Guzmán at Complutense University, Spain, and colleagues have demonstrated how the cannabis extracts block a key chemical needed for tumours to sprout blood vessels -- a process called angiogenesis.Will this turn on a new weapon against cancer?Cristina Blázquez at Complutense University, and one of the team, stresses the results are preliminary. "But it’s a good point to start and continue.""The cannabinoid inhibits the angiogenesis response - if a tumour doesn’t do angiogenesis, it doesn’t grow," she explains. "So if you can improve angiogenesis on one side and kill the tumour cells on the other side, you can try for a therapy for cancer."What kind of tests were done?The team tested the effects of delta-9-tetrahydrocannabinol in 30 mice. They found the marijuana extract inhibited the expression of several genes related to the production of a chemical called vascular endothelial growth factor (VEGF).VEGF is critical for angiogenesis, which allows tumours to grow a network of blood vessels to supply their growth. The cannabinoid significantly lowered the activity of VEGF in the mice and two human brain cancer patients, the study showed.In "Cannabis extract makes brain tumors shrink, halts growth of blood vessels," Medical News Today gives other details about the tests done on human patients.[The researchers] selected two patients who had glioblastoma multiforme and had not responded to chemotherapy, radiotherapy or surgery. The scientists took samples from them before and after treating them with a cannabinoids solution -- this was administered directly into the tumor.Amazingly, both patients experienced reduced VEGF levels in the tumor as a result of treatment with cannabinoids.The researchers said that the results were encouraging. In order to be sure about their findings they need to carry out a larger study, they said.Here you can see the effect of the treatment on the two patients with brain cancers. VEGFR-2 activation is shown in green and its expression in red. Cell nuclei are stained in blue. Relative values of activated-VEGFR-2 pixels are displayed in parentheses and total-VEGFR-2 pixels in square brackets are given for the two patients per cell nucleus. (Credit: Cancer Research).For more information, you also can read this news release from the American Association for Cancer Research, "Marijuana ingredient inhibits VEGF pathway required for brain tumor blood vessels."The research work has been published by the Cancer Research journal under the title "Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas." Here are two links to the abstract and to the full paper (PDF format, 7 pages, 732 KB). The above illustration comes from this paper.Sources: Shaoni Bhattacharya, New Scientist, August 15, 2004; Medical News Today, August 15, 2004; American Association for Cancer Research news release, via EurekAlert!, August 15, 2004; Cancer Research, Vol. 64, Num. 16, Pages 5617-5623, August 15, 20041:36:45 PM Permalink

[Guest guest]

But this doesn't mean that patients with brain tumor

should start eating and drinking and smoking

marijuana. This wouldn't work in many patients because

of two reasons:

#1. Some patients may give a brain-allergic reaction

to marijuana mimicing schizo'.

#2. Ham/Marijuana plant today is not the original

crop. Its contaminated with insecticides, pesticides.

 

I say so because I have had a case in the family and

we all suffered due to the psychosis of that family

member, induced in him by over one year history of

smoking pot.

Ratan.

--- Raven <NWRaven wrote:

 

> http://www.primidi.com/2004/09/05.html

>

>

>

> Marijuana Extract Shrinks Brain Tumors

> A team of Spanish researchers has discovered that

> cannabinoids, the active ingredients in marijuana,

> make brain tumors shrink by halting the growth of

> blood vessels that feed the tumors, reports New

> Scientist. The researchers have successfully tested

> the effect of this cannabis extract on thirty mice

> which were given a cancer similar to the human brain

> cancer (glioblastoma multiforme). More importantly,

> they also successfully tested the procedure on two

> human patients who had glioblastoma multiforme and

> had not responded to chemotherapy, radiotherapy or

> surgery. Of course, these results are encouraging,

> even if larger studies need to be done to be sure

> that these cannabinoids are really effective on

> human brain cancers, and possibly other forms of

> cancers. Read more...

> Here is the introduction of the New Scientist

> article.

> Cannabis extracts may shrink brain tumours and other

> cancers by blocking the growth of the blood vessels

> which feed them, suggests a new study.

> An active component of the street drug has

> previously been shown to improve brain tumours in

> rats. But now Manuel Guzmán at Complutense

> University, Spain, and colleagues have demonstrated

> how the cannabis extracts block a key chemical

> needed for tumours to sprout blood vessels -- a

> process called angiogenesis.

> Will this turn on a new weapon against cancer?

> Cristina Blázquez at Complutense University, and one

> of the team, stresses the results are preliminary.

> " But it’s a good point to start and continue. "

> " The cannabinoid inhibits the angiogenesis response

> - if a tumour doesn’t do angiogenesis, it doesn’t

> grow, " she explains. " So if you can improve

> angiogenesis on one side and kill the tumour cells

> on the other side, you can try for a therapy for

> cancer. "

> What kind of tests were done?

> The team tested the effects of

> delta-9-tetrahydrocannabinol in 30 mice. They found

> the marijuana extract inhibited the expression of

> several genes related to the production of a

> chemical called vascular endothelial growth factor

> (VEGF).

> VEGF is critical for angiogenesis, which allows

> tumours to grow a network of blood vessels to supply

> their growth. The cannabinoid significantly lowered

> the activity of VEGF in the mice and two human brain

> cancer patients, the study showed.

> In " Cannabis extract makes brain tumors shrink,

> halts growth of blood vessels, " Medical News Today

> gives other details about the tests done on human

> patients.

> [The researchers] selected two patients who had

> glioblastoma multiforme and had not responded to

> chemotherapy, radiotherapy or surgery. The

> scientists took samples from them before and after

> treating them with a cannabinoids solution -- this

> was administered directly into the tumor.

> Amazingly, both patients experienced reduced VEGF

> levels in the tumor as a result of treatment with

> cannabinoids.

> The researchers said that the results were

> encouraging. In order to be sure about their

> findings they need to carry out a larger study, they

> said.

> Here you can see the effect of the treatment on the

> two patients with brain cancers. VEGFR-2 activation

> is shown in green and its expression in red. Cell

> nuclei are stained in blue. Relative values of

> activated-VEGFR-2 pixels are displayed in

> parentheses and total-VEGFR-2 pixels in square

> brackets are given for the two patients per cell

> nucleus. (Credit: Cancer Research).

>

> For more information, you also can read this news

> release from the American Association for Cancer

> Research, " Marijuana ingredient inhibits VEGF

> pathway required for brain tumor blood vessels. "

> The research work has been published by the Cancer

> Research journal under the title " Cannabinoids

> Inhibit the Vascular Endothelial Growth Factor

> Pathway in Gliomas. " Here are two links to the

> abstract and to the full paper (PDF format, 7 pages,

> 732 KB). The above illustration comes from this

> paper.

> Sources: Shaoni Bhattacharya, New Scientist, August

> 15, 2004; Medical News Today, August 15, 2004;

> American Association for Cancer Research news

> release, via EurekAlert!, August 15, 2004; Cancer

> Research, Vol. 64, Num. 16, Pages 5617-5623, August

> 15, 2004

>

> 1:36:45 PM Permalink

>

 

 

Ratan Singh

Phone: 91 141 2652561

Address: 7- NA- 16

Jawahar Nagar

Jaipur- 302004 INDIA

----------

- Certificate in Food & Nutrition;

- Author of " Nutrition & Supplements in Major Mental Illnesses " ;

- M.A. (Psychol), Postgraduate Diploma in Medical & Social Psychology, Ph.D.;

- Certified Behavior Therapist (from late Prof. J. Wolpe's Unit, Temple

University Medical School, Philadelphia, USA);

- Hypnotist, Biofeedback and Meditation Therapist.

- Family, Marital and Sex Therapist.

->Consultant Nutritional & Clinical Psychologist in Jaipur Hospital, India.

psych_58,

www.jaipurmart.com/trade/meditationandhealth,

meditationandcancer-

 

 

______________________________\

____

Shape in your own image. Join our Network Research Panel today!

http://surveylink./gmrs/_panel_invite.asp?a=7

[Guest guest]

I just had my 69th birthday. I long ago stopped smoking pot. I live in L.A., and have known literally thousands of pot smokers, with all of whom I long ago lost contact. In all those years, I have absoutely "never" ever met, or known a single individual that had the absolutely tiniest problem, mental or physical, with pot; not even if they smoked it for 50 years. By the way: "...drinking" marijuana? That's a new one for me, unless you're talking about hemp milk, which is devoid of THC, and is actually a very healthful beverage.

jp

 

 

-

psych doc

Friday, August 24, 2007 12:35 AM

Re: Marijuana Extract Shrinks Brain Tumors

 

 

But this doesn't mean that patients with brain tumorshould start eating and drinking and smokingmarijuana. This wouldn't work in many patients becauseof two reasons:#1. Some patients may give a brain-allergic reactionto marijuana mimicing schizo'.#2. Ham/Marijuana plant today is not the originalcrop. Its contaminated with insecticides, pesticides.I say so because I have had a case in the family andwe all suffered due to the psychosis of that familymember, induced in him by over one year history ofsmoking pot.Ratan.--- Raven <NWRaven > wrote:> http://www.primidi.com/2004/09/05.html> > > > Marijuana Extract Shrinks Brain Tumors> A team of Spanish researchers has discovered that> cannabinoids, the active ingredients in marijuana,> make brain tumors shrink by halting the growth of> blood vessels that feed the tumors, reports New> Scientist. The researchers have successfully tested> the effect of this cannabis extract on thirty mice> which were given a cancer similar to the human brain> cancer (glioblastoma multiforme). More importantly,> they also successfully tested the procedure on two> human patients who had glioblastoma multiforme and> had not responded to chemotherapy, radiotherapy or> surgery. Of course, these results are encouraging,> even if larger studies need to be done to be sure> that these cannabinoids are really effective on> human brain cancers, and possibly other forms of> cancers. Read more...> Here is the introduction of the New Scientist> article.> Cannabis extracts may shrink brain tumours and other> cancers by blocking the growth of the blood vessels> which feed them, suggests a new study.> An active component of the street drug has> previously been shown to improve brain tumours in> rats. But now Manuel Guzmán at Complutense> University, Spain, and colleagues have demonstrated> how the cannabis extracts block a key chemical> needed for tumours to sprout blood vessels -- a> process called angiogenesis.> Will this turn on a new weapon against cancer?> Cristina Blázquez at Complutense University, and one> of the team, stresses the results are preliminary.> "But it’s a good point to start and continue."> "The cannabinoid inhibits the angiogenesis response> - if a tumour doesn’t do angiogenesis, it doesn’t> grow," she explains. "So if you can improve> angiogenesis on one side and kill the tumour cells> on the other side, you can try for a therapy for> cancer."> What kind of tests were done?> The team tested the effects of> delta-9-tetrahydrocannabinol in 30 mice. They found> the marijuana extract inhibited the expression of> several genes related to the production of a> chemical called vascular endothelial growth factor> (VEGF).> VEGF is critical for angiogenesis, which allows> tumours to grow a network of blood vessels to supply> their growth. The cannabinoid significantly lowered> the activity of VEGF in the mice and two human brain> cancer patients, the study showed.> In "Cannabis extract makes brain tumors shrink,> halts growth of blood vessels," Medical News Today> gives other details about the tests done on human> patients.> [The researchers] selected two patients who had> glioblastoma multiforme and had not responded to> chemotherapy, radiotherapy or surgery. The> scientists took samples from them before and after> treating them with a cannabinoids solution -- this> was administered directly into the tumor.> Amazingly, both patients experienced reduced VEGF> levels in the tumor as a result of treatment with> cannabinoids.> The researchers said that the results were> encouraging. In order to be sure about their> findings they need to carry out a larger study, they> said.> Here you can see the effect of the treatment on the> two patients with brain cancers. VEGFR-2 activation> is shown in green and its expression in red. Cell> nuclei are stained in blue. Relative values of> activated-VEGFR-2 pixels are displayed in> parentheses and total-VEGFR-2 pixels in square> brackets are given for the two patients per cell> nucleus. (Credit: Cancer Research).> > For more information, you also can read this news> release from the American Association for Cancer> Research, "Marijuana ingredient inhibits VEGF> pathway required for brain tumor blood vessels."> The research work has been published by the Cancer> Research journal under the title "Cannabinoids> Inhibit the Vascular Endothelial Growth Factor> Pathway in Gliomas." Here are two links to the> abstract and to the full paper (PDF format, 7 pages,> 732 KB). The above illustration comes from this> paper.> Sources: Shaoni Bhattacharya, New Scientist, August> 15, 2004; Medical News Today, August 15, 2004;> American Association for Cancer Research news> release, via EurekAlert!, August 15, 2004; Cancer> Research, Vol. 64, Num. 16, Pages 5617-5623, August> 15, 2004> > 1:36:45 PM Permalink > Ratan SinghPhone: 91 141 2652561Address: 7- NA- 16Jawahar NagarJaipur- 302004 INDIA----------- Certificate in Food & Nutrition;- Author of "Nutrition & Supplements in Major Mental Illnesses";- M.A. (Psychol), Postgraduate Diploma in Medical & Social Psychology, Ph.D.;- Certified Behavior Therapist (from late Prof. J. Wolpe's Unit, Temple University Medical School, Philadelphia, USA);- Hypnotist, Biofeedback and Meditation Therapist.- Family, Marital and Sex Therapist.->Consultant Nutritional & Clinical Psychologist in Jaipur Hospital, India.psych_58 , www.jaipurmart.com/trade/meditationandhealth,meditationandcancer-________Shape in your own image. Join our Network Research Panel today! http://surveylink./gmrs/_panel_invite.asp?a=7