hepatoma and interesting studies

[Guest guest]

I wanted to show everyone something. I was watching a program about

a specific herb and wanted to get more information I googled it the

herb by the way was vinca Major. I got not much information at all

if anyone knows where to get good info let me know by the way. I

heard on the program that it is good to help raise dopamine levels.

 

To get some information went to WWW.pubmed.com and searched it. I

then because I wanted to see what would happen I put in the word

Ginger. Got 1003 abtracts on the that word. The 4th one down was an

abstract on its effect with cancer a common liver cancer. Well here

is the abstract for those interested it is studied only in rats right

now.

 

Title of abstract

Inhibitory effect of gingerol on the proliferation and invasion of

hepatoma cells in culture.

 

Authors

Yagihashi S, Miura Y, Yagasaki K.

 

Department of Applied Biological Science, Tokyo Noko University,

Saiwai-cho 3-5-8, Fuchu, Tokyo, 183-8509, Japan.

 

Effect of [6]-gingerol, a major pungent component in ginger, on the

proliferation of a rat ascites hepatoma AH109A cells was investigated

by measuring [(3)H]thymidine incorporation into acid-insoluble

fraction of the cultured cells and that on the invasion by co-

culturing the hepatoma cells with rat mesentery-derived mesothelial

cells. [6]-Gingerol inhibited both the proliferation and invasion of

hepatoma cells in a dose-dependent manner at concentrations of 6.25-

200 muM (proliferation) and 50-200 muM (invasion). [6]-Gingerol

accumulated cells in S phase and elongated doubling time of hepatoma

cells, and increased the rate of apoptosis. Hepatoma cells previously

cultured with hypoxanthine (HX) and xanthine oxidase (XO) or with

hydrogen peroxide showed increased invasive activities. [6]-Gingerol

suppressed the reactive oxygen species-potentiated invasive capacity

by simultaneously treating AH109A cells with [6]-gingerol, HX and XO

or with [6]-gingerol and hydrogen peroxide. Furthermore, [6]-gingerol

reduced the intracellular peroxide levels in AH109A cells. These

results suggest that the suppression of hepatoma cell proliferation

by [6]-gingerol may be due to cell cycle arrest and apoptosis

induction. They also suggest that the anti-oxidative property of [6]-

gingerol may be involved in its anti-invasive activity of hepatoma

cells.