Propolis Component Boosts Brain Cells

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Propolis Component Boosts Brain Cells

 

 

 

(Taiwan) NatureWise Announces Updates on Cancer Drug Candidate,

Neurotrophic Factors for Neurodegenerative Disorders

 

 

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(Press release, NatureWise Biotech & Medicals Corp.)

 

 

 

Botanically-derived drug discovery and development firm NatureWise

Biotech & Medicals Corp. (TPO:4732) announced this week two major

updates to its drug discovery and development pipeline, with research

results to be presented at the BIO 2008 conference and exhibition in San

Diego 17-19 June, 2008.

 

 

 

The first is a drug candidate for targeted cancer therapy and spinal

muscular atrophy (SMA), a genetic disorder. The second relates to the

company's breakthrough neurotrophic factors derived from prenylflavanone

agents (PPLs), which, unlike conventional neurotrophic factors, can pass

the blood-brain barrier and reach neurons in the brain. This has

exciting implications for the development of new drugs for

neurodegenerative diseases, such as Alzheimer's disease…

 

 

 

About neurotrophic agents from PPLs for neurodegenerative disease

therapy:

 

 

Several prenylflavanone compounds of small molecular weight--abbreviated

as PPLs--were isolated from Taiwanese bee propolis. At low

concentrations (as low as 150 ng/mL), these PPLs increased both the

survival of cortical neurons and the proliferation of neural stem cells,

and induced differentiation of neural stem cells into large number of

neuronal cells.