Please No Tylenol ( stops GSH) for children use Motrin or homeopathic

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Please for anyone that is ill or has a child with illness avoid Tylenol.

If needed Motrin short term unless GI distress would be a better

choice. I know that is not what we have all been taught but one dose

of Tylenol stops Glutathione production in the body for approx. 22

days. Glutathione(GSH) is very important for everyone when dealing

with any illness, adults and children. References are below.

DM

Patient Resource

 

Tylenol depletes GSH

 

Slattery JT et al. Dose-dependent pharmacokinetics of acetaminophen:

evidence of glutathione depletion in humans. Clin Pharmacol Ther 1987

41(4):413-8 PMID 3829578

 

Lauterburg BH, Mitchell JR. Therapeutic doses of acetaminophen

stimulate the turnover of cysteine and glutathione in man. J Hepatol.

1987 Apr;4(2):206-11. PMID 3584929

 

" The data indicate that therapeutic doses of acetaminophen markedly

stimulate the rate of turnover of the pool of cysteine available for

the synthesis of GSH, most likely due to an increased rate of

synthesis of GSH which is required to detoxify the toxic metabolite of

acetaminophen. Patients who are not able to respond to a similar

demand on their stores of GSH by increasing the synthesis of GSH may

be at higher risk of developing hepatic injury from drugs that require

GSH for their detoxification. "

 

Spielberg SP. Acetaminophen toxicity in lymphocytes heterozygous for

glutathione synthetase deficiency. Can J Physiol Pharmacol 1985

63(5):468-71 PMID 4041989

 

Heterozygous cells failed to use N-acetylcysteine as efficiently to

resynthesize glutathione, and the cells were not protected from

acetaminophen toxicity. Heterozygotes may be at increased risk of

toxicity from drugs whose metabolites are detoxified by glutathione

conjugation. "

 

Depletion of hepatic glutathione in rats impairs phagocytosis in

vivo. Arch Toxicol Suppl 1989;13:326-9 PMID 2774956