Vaccines: 6 years production for 20% population coverage

[Guest guest]

Sat, 15 Apr 2006 16:03:03 +0200

" Sepp Hasslberger " <sepp

Fwd: Re: Vaccines: 6 years production for 20% population coverage

 

 

F Y I

 

Sepp

 

 

 

> Sat, 15 Apr 2006 14:58:02 +0200

 

> jp

 

> Sepp Hasslberger

 

> Re: FW: Vaccines: 6 years production for 20% population

coverage

 

>

> " The key to our survival in the next two or three years is good

surveillance "

 

>

> It would appear to me that the key to our survival is staying

healthy in general, and specifically having a high enough intake of

both selenium and vitamin C, not whether we find a dead duck here or

there.

>

> Probably birds have always had the flu, we only now notice it - as

every dead bird found is tested. In the past, no one ever looked. So

the apparent increase of bird flu may be entirely due to our new

passion for finding it.

>

> Also, it appears that someone is getting ready to spring a vaccine

on the US population, and my pessimistic view is that THAT will be the

start of an epidemic, if there ever is to be one. The virus is being

created in US laboratories. See article following here.

 

>

> Kind regards

 

> Sepp

 

>

>

> http://washingtontimes.com/upi-breaking/20050324-030452-8400r.htm

 

>

> U.S. to create a bird flu virus mutation

 

> Atlanta, GA, Mar. 24 (UPI) -- The U.S. Centers for Disease Control

and Prevention has begun a series of experiments to see how likely the

bird flu virus could result in a human pandemic.

>

> The six-month series of experiments seeks to simulate the mixing and

matching of genes from the H5N1 avian flu virus that has plagued Asia

and a common human flu virus that public-health experts fear could

turn avian flu into a pandemic, the Wall Street Journal reported Thursday.

 

> CDC scientists inside an ultra-secure laboratory have started

swapping the genes of the H5N1 avian virus with the genes of an H3N2

virus, the strain behind most recent human flu outbreaks.

 

> The goal is to substitute the eight genes of each virus, one by one,

with the eight genes from the other virus to see which of more than

250 possible combinations create flu viruses that could spread easily

among humans.

 

> The work responds to fears by global public health experts that the

bird flu virus could mutate to form one that could spawn a global

outbreak of the disease.

 

 

>>

>

>> FYI

>

>> See end statements, as well as useful info on the vaccines (or lack

of them) prospects

 

>

>> http://www.twincities.com/mld/twinc...on/14347296.htm

>

>>

>> Posted on Sat, Apr. 15, 2006

>> Scientists go beyond eggs to make bird flu vaccine

>> But big supplies won't be ready anytime soon

>> BY ROBERT S. BOYD

 

>> Washington Bureau

 

>> CLEVELAND - Health scientists and engineers are racing to find new

ways to produce a vaccine that will protect people from the threat of

a worldwide bird-flu pandemic.

>>

>> They're working with plants, insects and bacteria that they hope

can churn out huge quantities of vaccine more efficiently than the

present, agonizingly slow system of using millions of chicken eggs.

>>

>> An adequate supply of vaccine for the lethal H5N1 flu virus won't

be available for years, experts from seven countries, 44 universities

and 60 biotechnology companies agreed at a conference this week in

Cleveland sponsored by the National Academy of Sciences.

>>

>> " We're not ready, " said Bruce Gellin, the director of the National

Vaccine Program Office at the Department of Health and Human Services.

" If it happens tomorrow or next year, we're in trouble. It's a

sobering picture. "

>>

>> Klaus Stohr, the head of the World Health Organization Influenza

Team, said that one dose of a safe, effective vaccine for H5N1 was

" going to be much more valuable than diamonds. "

>>

>> In the past three years, bird flu - also known as avian flu - has

killed millions of birds, a small number of mammals and 109 humans in

Asia, Europe and Africa. So far, it's overwhelmingly a bird disease,

but it's mutating rapidly and might change into a form that could pass

among humans.

>>

>> The 2006 spring bird-migration season is just beginning, raising

fears that the virus could reach the Western Hemisphere this year.

>>

>> " It's routine for a virus to cross hemispheres from Russia to

Canada via the Arctic, " said Michael Callahan, the manager of avian

influenza surveillance for the Department of State.

>>

>> Ducks and other wild birds can carry a virus along an established

" flyway " through Alaska to Washington state, Oregon, California,

Arizona and Mexico. A sick or dead duck could be a warning signal.

>>

>> About 30 potential vaccines are being tested for safety and

effectiveness in the United States and Europe, but the results have

been disappointing, Stohr said.

>>

>> The tests show that very high doses of vaccine - and at least two

shots - are needed to prevent infection, which means much greater

quantities will be necessary, far more than can be produced by current

technology.

>>

>> There will be no breakthrough this year, Stohr said. " It will take

six years to have enough vaccine for 20 percent of the world's

population. It may take eight to 10 years to solve the problem. "

>>

>> Furthermore, the virus keeps changing, so a vaccine developed for

one type of flu may not work against another variant. The H5N1 type

that began in Asia already has split into two main branches.

>>

>> " They are different enough that we may need two stockpiles of

vaccine, " said James Matthews, the senior science-policy director at

Sanofi Pasteur, a vaccine manufacturer in Swiftwater, Pa.

>>

>> To meet the challenge, scientists are trying to grow vaccines in

various kinds of cells, which they multiply in giant vats, instead of

in eggs. Yeast, tobacco leaf, soybeans and duckweed cell cultures

avoid many of the problems encountered with eggs, but that still

doesn't speed up the process much.

>>

>> " You can't make cells divide any faster, " said Patrick Scannon, the

chief scientist at Xoma Ltd., a biotechnology firm in Berkeley, Calif.

>>

>> Researchers also are seeking novel methods to deliver vaccine to

patients without the necessity of refrigeration and sterile needles,

which can pose obstacles in many parts of the world.

>>

>> " Theoretically you could have a vaccine in a tomato, " said Alan

Shaw, the president of VacInnate, a biotechnology company in New

Haven, Conn. Eating the tomato would provide additional protection

after the first inoculation, like a booster shot, he said.

>>

>> Another idea is to insert the genes for the virus in the DNA of a

bacterial cell and then inject it into a human cell. Once there, the

DNA generates the proteins that block infection.

>

>>

>> " You make the vaccine all by yourself, " Shaw said.

>

>>

>> Given the lack of an adequate vaccine, experts at the conference

stressed the importance of a strong surveillance system to detect a

local flu outbreak promptly, before it can spread into a pandemic.

Such a system helped limit the SARS epidemic, which killed 774 people

in Canada and Asia in 2003.

>>

>> " We need a computerized system to collect events and spot

clusters, " said Roy Anderson, an epidemiologist at London's Imperial

College. " Two days is the critical threshold for a quarantine to

control H5N1. "

>

>> " The key to our survival in the next two or three years is good

surveillance, " Shaw said.

>>

>> " We need to be on a wartime footing, " Gellin said. " Innovation

comes out of crisis. "

>

>>

>

>

>

> --

--

 

 

 

The individual is supreme and finds its way through intuition.

 

Sepp Hasslberger

 

 

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