Wine Flavonoids Protect against LDL Oxidation and Atherosclerosis

[Guest guest]

Wine Flavonoids Protect against LDL Oxidation and Atherosclerosis

MICHAEL AVIRAM and BIANCA FUHRMAN

http://www.annalsnyas.org/cgi/content/abstract/957/1/146

 

The Lipid Research Laboratory, Technion Faculty of Medicine, The

Rappaport Family Institute for Research in the Medical Sciences and

Rambam Medical Center, Haifa, Israel

 

Address for correspondence: Prof. Michael Aviram, D.Sc., The Lipid

Research Laboratory, Rambam Medical Center, Haifa, Israel, 31096.

Voice: 972-4-8542970; fax: 972-4-8542130.

aviram.

Ann. N.Y. Acad. Sci. 957: 146-161 (2002).

 

 

We have previously shown that consumption of red wine, but not of

white wine, by healthy volunteers, resulted in the enrichment of

their plasma LDL with flavonoid antioxidants such as quercetin, the

potent free radicals scavenger flavanol, which binds to the LDL via

a glycosidic ether bond. This phenomenon was associated with a

significant three-fold reduction in copper ion-induced LDL

oxidation. The ineffectiveness of flavonoid-poor white wine could be

overcome by grape's skin contact for 18 hours in the presence of

alcohol, which extracts grape's skin flavonoids. Recently, we

observed that the high antioxidant potency of Israeli red wine could

be related to an increased content of flavonols, which are very

potent antioxidants and their biosynthesis is stimulated by sunlight

exposure. To find out the effect (and mechanisms) of red wine

consumption on atherosclerosis, we used the apo E deficient (E0)

mice. In these mice, red wine consumption for two months resulted in

a 40% decrement in basal LDL oxidation, a similar decrement in LDL

oxidizability and aggregation, a 35% reduction in lesion size, and a

marked attenuation in the number and morphology of lesion's

macrophage foam cells. Red wine consumption resulted in accumulation

of flavonoids in the mouse macrophages and these cells oxidized LDL

and took up LDL about 40% less than macrophages from placebo-treated

mice. Finally, the activity of serum paraoxonase (which can

hydrolyze specific lipid peroxides in oxidized LDL and in

atherosclerotic lesions) was significantly increased following

consumption of red wine by E0 mice. Red wine consumption thus acts

against the accumulation of oxidized LDL in lesions as a first line

of defense (by a direct inhibition of LDL oxidation), and as a

second line of defense (by paraoxonase elevation and removal of

atherogenic lesion's and lipoprotein's oxidized lipids).

_________________

JoAnn Guest

mrsjoguest

www.geocities.com/mrsjoguest/Genes

[Guest guest]

Can you get some or all or even more of the same effect by eating

grapes??

 

On Sun, 06 Nov 2005 02:15:05 -0000 " JoAnn Guest "

<angelprincessjo writes:

Wine Flavonoids Protect against LDL Oxidation and Atherosclerosis

MICHAEL AVIRAM and BIANCA FUHRMAN

http://www.annalsnyas.org/cgi/content/abstract/957/1/146

 

The Lipid Research Laboratory, Technion Faculty of Medicine, The

Rappaport Family Institute for Research in the Medical Sciences and

Rambam Medical Center, Haifa, Israel

 

Address for correspondence: Prof. Michael Aviram, D.Sc., The Lipid

Research Laboratory, Rambam Medical Center, Haifa, Israel, 31096.

Voice: 972-4-8542970; fax: 972-4-8542130.

aviram.

Ann. N.Y. Acad. Sci. 957: 146-161 (2002).

 

 

We have previously shown that consumption of red wine, but not of

white wine, by healthy volunteers, resulted in the enrichment of

their plasma LDL with flavonoid antioxidants such as quercetin, the

potent free radicals scavenger flavanol, which binds to the LDL via

a glycosidic ether bond. This phenomenon was associated with a

significant three-fold reduction in copper ion-induced LDL

oxidation. The ineffectiveness of flavonoid-poor white wine could be

overcome by grape's skin contact for 18 hours in the presence of

alcohol, which extracts grape's skin flavonoids. Recently, we

observed that the high antioxidant potency of Israeli red wine could

be related to an increased content of flavonols, which are very

potent antioxidants and their biosynthesis is stimulated by sunlight

exposure. To find out the effect (and mechanisms) of red wine

consumption on atherosclerosis, we used the apo E deficient (E0)

mice. In these mice, red wine consumption for two months resulted in

a 40% decrement in basal LDL oxidation, a similar decrement in LDL

oxidizability and aggregation, a 35% reduction in lesion size, and a

marked attenuation in the number and morphology of lesion's

macrophage foam cells. Red wine consumption resulted in accumulation

of flavonoids in the mouse macrophages and these cells oxidized LDL

and took up LDL about 40% less than macrophages from placebo-treated

mice. Finally, the activity of serum paraoxonase (which can

hydrolyze specific lipid peroxides in oxidized LDL and in

atherosclerotic lesions) was significantly increased following

consumption of red wine by E0 mice. Red wine consumption thus acts

against the accumulation of oxidized LDL in lesions as a first line

of defense (by a direct inhibition of LDL oxidation), and as a

second line of defense (by paraoxonase elevation and removal of

atherogenic lesion's and lipoprotein's oxidized lipids).

_________________

JoAnn Guest

mrsjoguest

www.geocities.com/mrsjoguest/Genes

 

 

[Guest guest]

, Dave R Hermanson

<tumblweed4@j...> wrote:

>

> Can you get some or all or even more of the same effect by eating

> grapes??

>

 

Hi Dave!

Yes, as a matter of fact there are a lot of benefits to be

derived from eating grapes. Grapes with seeds are recommended.

It certainly would not hurt to eat a bunch of organic grapes

including chewing the seeds when these are seasonally available.

The restorative power of grapes is phenomenal, cleansing the liver

and removing uric acid from the body.

Grapes are an excellent source of potassium which encourage an

alkaline blood balance and also stimulate the kidneys and regulate

heart beat.

 

Try to find grapes at natural food stores that do not have additives

(since grapes are sprayed so heavily when they are not organic).

Grapes are the most over-sprayed of all fruits, therefore wash

thoroughly. Always look for a faint powdery appearance,indicating

blooming. A grape bunch should have a few grapes either falling off

or mushy. The stems should not be shriveled, but green-looking.

 

Concord grapes have cancer-fighting antioxidant power. The active

ingredients in purple grapes are called flavonoids and research has

discovered that one specific flavonoid - resveratrol - appears to be

most important. Grape " skins " contain " resveratrol " .

 

Resveratrol acts as a powerful antioxidant (more powerful than

either vitamins E or C) because it protects tissues from

damage by minimizing " ill effects " of free radicals.

It also may protect the body through other mechanisms of action. We

are just starting to scratch the surface on cancer-fighting

properties of antioxidants.

 

Pterostilbene, a powerful antioxidant compound found in grapes and

blueberries, activates a type of cell receptor involved in absorbing

lipids(cholesterol)into cells for use in energy production.

 

A study published in the July 2004 issue of the Journal of

Agricultural and Food Chemistry found that " pterostilbene " was as

effective as the lipid-lowering drug ciprofibrate in " activating "

this cell receptor, called PPAR-alpha.

 

They based their comparison on each compound's ability to activate

PPAR-alpha (short for peroxisome proliferator-activated receptor

alpha).

 

The PPARs are a family of receptors on cells all throughout the

body that are involved in the absorption of compounds into cells

for use in energy production. PPAR-alpha is crucial for

the " metabolism " of lipids, including cholesterol.

Pterostilbene outperformed resveratrol in activating PPAR-alpha.

 

Red grapes are antibacterial and antiviral in test tube studies.

 

Vitamins such as vitamin A, C and E are powerful free radical

scavengers. One of the most powerful, Pycnogenol, is present in pine

bark and grape seeds.

 

In France, people frequently go on a grape-fast during harvest

time. Studies have shown a lower incidence of cancer in the areas of

France where this grape-fast is practiced yearly.

Grapes make excellent juice. Although they make the juicer

sound like a miniature machine gun, the juicer will not be damaged.

Make sure you swirl the juice in your mouth before swallowing.

If you drink too quickly, there will not be enough saliva for

proper digestion, which may cause stomach cramping. If you find just

grape juice too sweet, add some lemon juice. It can also be mixed

half and half with pure water if the juice is too strong.

 

Stores like Whole Foods Market usually carry natural grapes.

 

Best Regards,

JoAnn

 

 

Interesting info:

 

Grape extract can inhibit cancer growth (in the test tube) and, for

some cancer cells, it is lethal.

 

Grape skins contain resveratrol, shown to inhibit blood-platelet

clumping (and consequently, blood clot formation) and boost good-

type HDL cholesterol.

 

 

> On Sun, 06 Nov 2005 02:15:05 -0000 " JoAnn Guest "

> <angelprincessjo> writes:

> Wine Flavonoids Protect against LDL Oxidation and Atherosclerosis

> MICHAEL AVIRAM and BIANCA FUHRMAN

> http://www.annalsnyas.org/cgi/content/abstract/957/1/146

>

> The Lipid Research Laboratory, Technion Faculty of Medicine, The

> Rappaport Family Institute for Research in the Medical Sciences

and

> Rambam Medical Center, Haifa, Israel

>

> Address for correspondence: Prof. Michael Aviram, D.Sc., The Lipid

> Research Laboratory, Rambam Medical Center, Haifa, Israel, 31096.

> Voice: 972-4-8542970; fax: 972-4-8542130.

> aviram@t...

> Ann. N.Y. Acad. Sci. 957: 146-161 (2002).

>

>

> We have previously shown that consumption of red wine, but not of

> white wine, by healthy volunteers, resulted in the enrichment of

> their plasma LDL with flavonoid antioxidants such as quercetin,

the

> potent free radicals scavenger flavanol, which binds to the LDL

via

> a glycosidic ether bond. This phenomenon was associated with a

> significant three-fold reduction in copper ion-induced LDL

> oxidation. The ineffectiveness of flavonoid-poor white wine could

be

> overcome by grape's skin contact for 18 hours in the presence of

> alcohol, which extracts grape's skin flavonoids. Recently, we

> observed that the high antioxidant potency of Israeli red wine

could

> be related to an increased content of flavonols, which are very

> potent antioxidants and their biosynthesis is stimulated by

sunlight

> exposure. To find out the effect (and mechanisms) of red wine

> consumption on atherosclerosis, we used the apo E deficient (E0)

> mice. In these mice, red wine consumption for two months resulted

in

> a 40% decrement in basal LDL oxidation, a similar decrement in LDL

> oxidizability and aggregation, a 35% reduction in lesion size, and

a

> marked attenuation in the number and morphology of lesion's

> macrophage foam cells. Red wine consumption resulted in

accumulation

> of flavonoids in the mouse macrophages and these cells oxidized

LDL

> and took up LDL about 40% less than macrophages from placebo-

treated

> mice. Finally, the activity of serum paraoxonase (which can

> hydrolyze specific lipid peroxides in oxidized LDL and in

> atherosclerotic lesions) was significantly increased following

> consumption of red wine by E0 mice. Red wine consumption thus acts

> against the accumulation of oxidized LDL in lesions as a first

line

> of defense (by a direct inhibition of LDL oxidation), and as a

> second line of defense (by paraoxonase elevation and removal of

> atherogenic lesion's and lipoprotein's oxidized lipids).

> _________________

> JoAnn Guest

> mrsjoguest@s...

> www.geocities.com/mrsjoguest/Genes

>

>