Arylamine exposure ( cigarettes) related to bladder cancer risk

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Arylamine exposure ( cigarettes) related to bladder cancer risk JoAnn Guest

Oct 22, 2005 15:01 PDT

 

Dec 22, 2004 17:26 PST

 

Public release date: 5-Oct-2004

 

 

Contact: Sarah L. Zielinski

jnc-

301-841-1287

 

Journal of the National Cancer Institute

 

Arylamine exposure related to bladder cancer risk

 

Exposure to a family of carcinogens called arylamines is associated with

 

bladder cancer risk in both smokers and nonsmokers, according to a new

study in the October 6 issue of the Journal of the National Cancer

Institute.

 

Arylamines are found in cigarette smoke, permanent hair dyes,

and other environmental sources.

 

Cigarette smoking is an established risk factor for bladder cancer and

suspected to play a role in at least half of all U.S. bladder cancer

cases.

 

Several arylamine compounds are found in cigarette smoke and are

believed to be the source of the risk. However, exposure to an arylamine

 

called 4-ABP is a risk factor for bladder cancer among nonsmokers.

 

To examine the possible relationship between bladder cancer risk and

nine other members of the arylamine family, Paul L. Skipper, Ph.D., of

the Massachusetts Institute of Technology in Cambridge, Mass., and

colleagues conducted a case–control study of about 300 bladder cancer

patients and about 300 control subjects.

 

They measured exposure to the

compounds by measuring the levels of arylamine–hemoglobin

adducts--reaction products that form in red blood cells after exposure

to the arylamine compounds.

 

Levels of all but one of the nine arylamine–hemoglobin adducts were

higher in smokers than in nonsmokers, and levels of all nine adducts

were higher in the cancer patients than in the control subjects.

 

In

addition, higher levels of three individual adducts were associated with

 

bladder cancer risk after adjusting for other potential risk factors,

including current cigarette smoking and lifetime smoking history.

 

Higher levels of adducts were also associated with bladder cancer risk

in

nonsmokers.

 

These results " implicate exposure to arylamines as the causal factor

responsible for most cases of bladder cancer in humans, " the authors

write.

 

" Tobacco smoke as a source of these carcinogenic arylamines is

already well known.

 

Therefore, identifying the non–smoking-related

sources of these carcinogenic arylamines should become a high scientific

 

priority. "

 

 

###

Contact: Elizabeth Thomson, MIT News Office, 617-258-5402,

tho-

 

Citation: Gan J, Skipper PL, Gago-Dominguez M, Arakawa K, Ross RK, Yu

MC, et al. Alkylaniline–Hemoglobin Adducts and Risk of

Non–Smoking-Related Bladder Cancer. J Natl Cancer Inst 2004;96:1425–31.

 

Note: The Journal of the National Cancer Institute is published by

Oxford University Press and is not affiliated with the National Cancer

Institute. Attribution to the Journal of the National Cancer Institute

is requested in all news coverage.

Visit the Journal online at http://jncicancerspectrum.oupjournals.org/.

 

 

 

 

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