Study Investigates Anti-Arthritic Effect of Bee Venom

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Study Investigates Anti-Arthritic Effect of Bee Venom

 

 

 

Effects of Melittin on the Production of Matrix Metalloproteinase-1 and

-3 in Rheumatoid Arthritic Fibroblast-Like Synoviocytes

 

Journal of Pharmacological Sciences, Vol. 106 (2008) , No. 1 pp.162-166

 

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Bee venom (BV) has been used in patients with arthritis, including

rheumatoid arthritis, to reduce pain and edema . In the arthritic rat

model, BV has been shown to act as an anti-inflammatory adjuvant and to

reduce LPS-induced inflammatory edema and polyarthritis . The

hydrophilic peptide melittin, the major active ingredient of BV, may

retain anti-RA activity in rabbit models of immune-mediated arthritis.

 

 

 

We have previously shown that melittin downregulates MMP-3 expression in

human osteoarthritic chondrocytes . Here, we examined the effects of

melittin on MMP1 and MMP3 production in human FLS obtained from RA

patients…