Guest guest Posted October 31, 2007 Report Share Posted October 31, 2007 Chili Peppers as an Anesthetic? L. Lewis October 4, 2007 Researchers have found that adding capsaicin to a lidocaine derivative called QX-314 it had the ability to enter nerve cells but only the pain-sensing nocieptors. So what is capsaicin? Simple, it's the potent ingredient in chili peppers. Seems QX-134 doesn't have the ability to get through the nerve cells and that's where the chili pepper come in. Pain sensing neurons have the TRPV1 receptor which only opens when stimulated by excessive heat or a spicy compound. So far this combination has only been tested on lab rats so more work has to be done to establish if it will work on humans. If so then a " cocktail " of anesthetic and capsaicin will have to be developed to mitigate the painful effects of the capsaicin. Eventually, this method could completely transform surgical and post-surgical analgesia, allowing patients to remain fully alert without experiencing pain or paralysis. Clifford Woolf, M.D., of Massachusetts General Hospital, the study's senior author. [source: WebMD] http://www.pharmagazette.com/2007/10/chili_peppers_as_an_anesthetic.html Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 31, 2007 Report Share Posted October 31, 2007 The use of capsaicin was also brought up in a recent diabetes breakthrough: http://www.canada.com/nationalpost/news/story.html?id=a042812e-492c-4f07-8245-8a\ 598ab5d1bf & k=63970 In a discovery that has stunned even those behind it, scientists at a Toronto hospital say they have proof the body's nervous system helps trigger diabetes, opening the door to a potential near-cure of the disease [...] Suspecting a link between the nerves and diabetes, he and Dr. Salter used an old experimental trick -- injecting capsaicin, the active ingredient in hot chili peppers, to kill the pancreatic sensory nerves in mice that had an equivalent of Type 1 diabetes. " Then we had the biggest shock of our lives, " Dr. Dosch said. Almost immediately, the islets began producing insulin normally " It was a shock " really out of left field, because nothing in the literature was saying anything about this. " It turns out the nerves secrete neuropeptides that are instrumental in the proper functioning of the islets. Further study by the team, which also involved the University of Calgary and the Jackson Laboratory in Maine, found that the nerves in diabetic mice were releasing too little of the neuropeptides, resulting in a " vicious cycle " of stress on the islets. So next they injected the neuropeptide " substance P " in the pancreases of diabetic mice, a demanding task given the tiny size of the rodent organs. The results were dramatic. The islet inflammation cleared up and the diabetes was gone. Some have remained in that state for as long as four months, with just one injection. They also discovered that their treatments curbed the insulin resistance that is the hallmark of Type 2 diabetes, and that insulin resistance is a major factor in Type 1 diabetes, suggesting the two illnesses are quite similar.[end quote] Gaby , " Pratham " <pratham wrote: > > > Chili Peppers as an Anesthetic? > L. Lewis October 4, 2007 > > Researchers have found that adding capsaicin to a lidocaine derivative called QX-314 it had the ability to enter nerve cells but only the pain-sensing nocieptors. > > So what is capsaicin? > Simple, it's the potent ingredient in chili peppers. Seems QX-134 > doesn't have the ability to get through the nerve cells and that's > where the chili pepper come in. Pain sensing neurons have the TRPV1 > receptor which only opens when stimulated by excessive heat or a spicy > compound. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 1, 2007 Report Share Posted November 1, 2007 In use is Cayenne pepper, the hotter the better, 130,000 h.u. I recently purchased a 5lb. supply. Great supplement.. available at: http://www.herbalcom.com -- In , " navigante1978 " <navegante1978 wrote: > > The use of capsaicin was also brought up in a recent diabetes > breakthrough: > > http://www.canada.com/nationalpost/news/story.html?id=a042812e- 492c-4f07-8245-8a598ab5d1bf & k=63970 > > In a discovery that has stunned even those behind it, scientists at a > Toronto hospital say they have proof the body's nervous system helps > trigger diabetes, opening the door to a potential near-cure of the > disease [...] > > Suspecting a link between the nerves and diabetes, he and Dr. Salter > used an old experimental trick -- injecting capsaicin, the active > ingredient in hot chili peppers, to kill the pancreatic sensory nerves > in mice that had an equivalent of Type 1 diabetes. > > " Then we had the biggest shock of our lives, " Dr. Dosch said. Almost > immediately, the islets began producing insulin normally " It was a > shock " really out of left field, because nothing in the literature was > saying anything about this. " > > It turns out the nerves secrete neuropeptides that are instrumental in > the proper functioning of the islets. Further study by the team, which > also involved the University of Calgary and the Jackson Laboratory in > Maine, found that the nerves in diabetic mice were releasing too > little of the neuropeptides, resulting in a " vicious cycle " of stress > on the islets. > > So next they injected the neuropeptide " substance P " in the pancreases > of diabetic mice, a demanding task given the tiny size of the rodent > organs. The results were dramatic. > > The islet inflammation cleared up and the diabetes was gone. Some have > remained in that state for as long as four months, with just one > injection. > > They also discovered that their treatments curbed the insulin > resistance that is the hallmark of Type 2 diabetes, and that insulin > resistance is a major factor in Type 1 diabetes, suggesting the two > illnesses are quite similar.[end quote] > > Gaby > > , " Pratham " <pratham@> wrote: > > > > > > Chili Peppers as an Anesthetic? > > L. Lewis October 4, 2007 > > > > Researchers have found that adding capsaicin to a lidocaine > derivative called QX-314 it had the ability to enter nerve cells but > only the pain-sensing nocieptors. > > > > So what is capsaicin? > > Simple, it's the potent ingredient in chili peppers. Seems QX-134 > > doesn't have the ability to get through the nerve cells and that's > > where the chili pepper come in. Pain sensing neurons have the TRPV1 > > receptor which only opens when stimulated by excessive heat or a spicy > > compound. > Quote Link to comment Share on other sites More sharing options...
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