Thimerosal causes Fragmented DNA

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Effects of thimerosal on NGF signal transduction and cell death in

neuroblastoma cells.

 

 

Control levels of fragmented DNA were similar in both the presence

and absence of NGF. With and without NGF, thimerosal caused elevated

levels of fragmented DNA appearing at 0.01 microM (apoptosis) to

decrease at concentrations >1 microM (necrosis). These data

demonstrate that thimerosal could alter NGF-induced signaling in

neurotrophin-treated cells at concentrations lower than those

responsible for cell death.

 

 

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=15843506 & query_hl=1

 

 

Donna