Fish intake and risk of incident heart failure.

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Fish intake and risk of incident heart failure. JoAnn Guest Jun 29, 2005

10:02 PDT

 

Mozaffarian D, Bryson CL, Lemaitre RN, Burke GL, Siscovick DS.

 

Channing Laboratory, Department of Medicine, Brigham and Women's

Hospital and Harvard Medical School, Harvard School of Public Health,

665 Huntington Avenue, Boston, MA 02115, USA. smoz-

 

OBJECTIVES: Our aim was to investigate the relation between fish

consumption and incidence of congestive heart failure (CHF). BACKGROUND:

The incidence and health burden of CHF are rising, particularly in older

persons. Although n-3 fatty acids have effects that could favorably

influence risk of CHF, the relation between fish intake and CHF

incidence is unknown.

 

METHODS: Among 4,738 adults age > or =65 years and free of CHF at

baseline in 1989-90, usual dietary intake was assessed using a food

frequency questionnaire.

 

In a participant subsample, consumption of tuna or other broiled or

baked fish, but not fried fish, correlated with plasma phospholipid n-3

fatty acids. Incidence of CHF was prospectively adjudicated.

 

RESULTS: During 12 years' follow-up, 955 participants developed CHF. In

multivariate-adjusted analyses, tuna/other fish consumption was

inversely associated with incident CHF, with 20% lower risk with intake

1 to 2 times/week (hazard ratio

---

= 0.80, 95% confidence interval

[CI] = 0.64 to 0.99), 31% lower risk with intake 3 to 4 times/week (HR =

0.69, 95% CI = 0.52 to 0.91), and 32% lower risk with intake > or =5

times/week (HR = 0.68, 95% CI = 0.45 to 1.03), compared with intake <1

time/month (p trend = 0.009).

 

In similar analyses, fried fish consumption was positively associated

with incident CHF (p trend = 0.01). Dietary long-chain n-3 fatty acid

intake was also inversely associated with CHF (p trend = 0.009), with

37% lower risk in the highest quintile of intake (HR = 0.73, 95% CI =

0.57 to 0.94) compared with the lowest.

 

CONCLUSIONS: Among older adults, consumption of tuna or other broiled or

baked fish, but not fried fish, is associated with lower incidence of

CHF. Confirmation in additional studies and evaluation of potential

mechanisms is warranted.

 

PMID: 15963403 [PubMed - in process]

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JoAnn Guest

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