Guest guest Posted September 2, 2003 Report Share Posted September 2, 2003 This one from your list is cool Phil - don't suppose anyone has access to the full paper?? Jackie 1: Clin Exp Pharmacol Physiol. 2003 Sep;30(9):605-15. Related Articles, Links Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway. Achike FI, Kwan CY. Clinical Sciences Section, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia and Department of Medicine and Smooth Muscle Research Program, McMaster University, Hamilton, Ontario, Canada. 1. Nitric oxide (NO) is formed enzymatically from l-arginine in the presence of nitric oxide synthase (NOS). Nitric oxide is generated constitutively in endothelial cells via sheer stress and blood-borne substances. Nitric oxide is also generated constitutively in neuronal cells and serves as a neurotransmitter and neuromodulator in non-adrenergic, non-cholinergic nerve endings. Furthermore, NO can also be formed via enzyme induction in many tissues in the presence of cytokines. 2. The ubiquitous presence of NO in the living body suggests that NO plays an important role in the maintenance of health. Being a free radical with vasodilatory properties, NO exerts dual effects on tissues and cells in various biological systems. At low concentrations, NO can dilate the blood vessels and improve the circulation, but at high concentrations it can cause circulatory shock and induce cell death. Thus, diseases can arise in the presence of the extreme ends of the physiological concentrations of NO. 3. The NO signalling pathway has, in recent years, become a target for new drug development. The high level of flavonoids, catechins, tannins and other polyphenolic compounds present in vegetables, fruits, soy, tea and even red wine (from grapes) is believed to contribute to their beneficial health effects. Some of these compounds induce NO formation from the endothelial cells to improve circulation and some suppress the induction of inducible NOS in inflammation and infection. 4. Many botanical medicinal herbs and drugs derived from these herbs have been shown to have effects on the NO signalling pathway. For example, the saponins from ginseng, ginsenosides, have been shown to relax blood vessels (probably contributing to the antifatigue and blood pressure-lowering effects of ginseng) and corpus cavernosum (thus, for the treatment of men suffering from erectile dysfunction; however, the legendary aphrodisiac effect of ginseng may be an overstatement). Many plant extracts or purified drugs derived from Chinese medicinal herbs with proposed actions on NO pathways are also reviewed. PMID: 12940876 [PubMed - in process] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 2, 2003 Report Share Posted September 2, 2003 Hi All, See below: Biomail Search Profile: herb? OR herbal* OR phytother* OR kampo OR Ayurvedic [The Links, below, return the relevant Abstracts] Baumgertel A, Grimm R, Eisenbeiss W, Kreis W Purification and characterization of a flavonol 3-O-beta- heterodisaccharidase from the dried herb of Fagopyrum esculentum Moench. Phytochemistry 2004 Jan;64(2):411-418. PMID: 12943757 [PubMed - pubmed-not-medline] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12943757 & dopt=Abstract Hinoshita F, Ogura Y, Suzuki Y, Hara S, Yamada A, Tanaka N, Yamashita A, Marumo F Effect of orally administered shao-yao-gan-cao-tang (Shakuyaku- kanzo-to) on muscle cramps in maintenance hemodialysis patients: a preliminary study. Am J Chin Med 2003;31(3):445-53. PMID: 12943175 [PubMed - in-process] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12943175 & dopt=Abstract Ushiroyama T, Sakuma K, Souen H, Nakai G, Morishima S, Yasuda K, Orino I, Ueki M Therapeutic effects of Kyuki-chouketsu-in in restoring postpartum physical condition. Am J Chin Med 2003;31(3):437-44. PMID: 12943174 [PubMed - in-process] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12943174 & dopt=Abstract Isobe H, Yamamoto K, Cyong JC Effects of hachimi-jio-gan (ba-wei-di-huang-wan) on blood flow in the human central retinal artery. Am J Chin Med 2003;31(3):425-35. PMID: 12943173 [PubMed - in-process] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12943173 & dopt=Abstract Liu J, Zhu M, Shi R, Yang M Radix Sophorae flavescentis for chronic hepatitis B: a systematic review of randomized trials. Am J Chin Med 2003;31(3):337-54. PMID: 12943166 [PubMed - in-process] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12943166 & dopt=Abstract Lu Y Herb use in critical care: what to watch for. Crit Care Nurs Clin North Am 2003 Sep;15(3):313-9, viii. PMID: 12943137 [PubMed - in-process] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12943137 & dopt=Abstract Aung HH, Dey L, Mehendale S, Xie JT, Wu JA, Yuan CS Scutellaria baicalensis extract decreases cisplatin-induced pica in rats. Cancer Chemother Pharmacol 2003 Aug 27;. PMID: 12942313 [PubMed - pubmed-not-medline] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12942313 & dopt=Abstract Cheng YL, Chang WL, Lee SC, Liu YG, Lin HC, Chen CJ, Yen CY, Yu DS, Lin SZ, Harn HJ Acetone extract of Bupleurum scorzonerifolium inhibits proliferation of A549 human lung cancer cells via inducing apoptosis and suppressing telomerase activity. Life Sci 2003 Sep 19;73(18):2383-2394. PMID: 12941440 [PubMed - pubmed-not-medline] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12941440 & dopt=Abstract Rosenberg Z Integrative tumor board: recently diagnosed prostate cancer: traditional chinese medicine. Integr Cancer Ther 2003 Mar;2(1):83-5. PMID: 12941173 [PubMed - in-process] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12941173 & dopt=Abstract Chang YS, Seo EK, Gyllenhaal C, Block KI Panax ginseng: A Role in Cancer Therapy? Integr Cancer Ther 2003 Mar;2(1):13-33. PMID: 12941165 [PubMed - in-process] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12941165 & dopt=Abstract Achike FI, Kwan CY Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway. Clin Exp Pharmacol Physiol 2003 Sep;30(9):605-15. PMID: 12940876 [PubMed - in-process] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12940876 & dopt=Abstract Walton R, Manos GH Psychosis related to ephedra-containing herbal supplement use. South Med J 2003 Jul;96(7):718-20. PMID: 12940331 [PubMed - in-process] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12940331 & dopt=Abstract Keung WM Anti-dipsotropic isoflavones: The potential therapeutic agents for alcohol dependence. Med Res Rev 2003 Nov;23(6):669-96. PMID: 12939789 [PubMed - in-process] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12939789 & dopt=Abstract Liang SX, Sun HW [Determination of six nutritional elements in Chinese herbal medicines by graphite furnace atomic absorption spectrometry] Guang Pu Xue Yu Guang Pu Fen Xi 2002 Oct;22(5):847-9. PMID: 12938448 [PubMed - in-process] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12938448 & dopt=Abstract Song YR, Wang SZ, Xu JP, Wang DF, Shi Y [study on the determination of manganese in the polgonum multiflorum by flame atomic absorption spectrometry] Guang Pu Xue Yu Guang Pu Fen Xi 2002 Jun;22(3):483-4. PMID: 12938342 [PubMed - in-process] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12938342 & dopt=Abstract Cherdshewasart W, Nimsakul N Clinical trial of Butea superba, an alternative herbal treatment for erectile dysfunction. Asian J Androl 2003 Sep;5(3):243-6. PMID: 12937809 [PubMed - in-process] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12937809 & dopt=Abstract Inoue M Shosaikoto as a potential antiatherosclerotic agent. Drug News Perspect 2000 Sep;13(7):407-12. PMID: 12937613 [PubMed - in-process] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12937613 & dopt=Abstract Chen X, Yang L, Zhang N, Turpin JA, Buckheit RW, Osterling C, Oppenheim JJ, Howard OM Shikonin, a Component of Chinese Herbal Medicine, Inhibits Chemokine Receptor Function and Suppresses Human Immunodeficiency Virus Type 1. Antimicrob Agents Chemother 2003 Sep;47(9):2810-2816. PMID: 12936978 [PubMed - pubmed-not-medline] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12936978 & dopt=Abstract Elinav E, Chajek-Shaul T Licorice consumption causing severe hypokalemic paralysis. Mayo Clin Proc 2003 Jun;78(6):767-8. PMID: 12934789 [PubMed - completed] http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db =PubMed & list_uids=12934789 & dopt=Abstract Best regards, WORK : Teagasc Staff Development Unit, Sandymount Ave., Dublin 4, Ireland WWW : Email: < Tel : 353-; [in the Republic: 0] HOME : 1 Esker Lawns, Lucan, Dublin, Ireland WWW : http://homepage.eircom.net/~progers/searchap.htm Email: < Tel : 353-; [in the Republic: 0] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 2, 2003 Report Share Posted September 2, 2003 This one from your list is cool Phil - don't suppose anyone has access to the full paper?? Jackie 1: Clin Exp Pharmacol Physiol. 2003 Sep;30(9):605-15. Related Articles, Links Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway. Achike FI, Kwan CY. Clinical Sciences Section, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia and Department of Medicine and Smooth Muscle Research Program, McMaster University, Hamilton, Ontario, Canada. 1. Nitric oxide (NO) is formed enzymatically from l-arginine in the presence of nitric oxide synthase (NOS). Nitric oxide is generated constitutively in endothelial cells via sheer stress and blood-borne substances. Nitric oxide is also generated constitutively in neuronal cells and serves as a neurotransmitter and neuromodulator in non-adrenergic, non-cholinergic nerve endings. Furthermore, NO can also be formed via enzyme induction in many tissues in the presence of cytokines. 2. The ubiquitous presence of NO in the living body suggests that NO plays an important role in the maintenance of health. Being a free radical with vasodilatory properties, NO exerts dual effects on tissues and cells in various biological systems. At low concentrations, NO can dilate the blood vessels and improve the circulation, but at high concentrations it can cause circulatory shock and induce cell death. Thus, diseases can arise in the presence of the extreme ends of the physiological concentrations of NO. 3. The NO signalling pathway has, in recent years, become a target for new drug development. The high level of flavonoids, catechins, tannins and other polyphenolic compounds present in vegetables, fruits, soy, tea and even red wine (from grapes) is believed to contribute to their beneficial health effects. Some of these compounds induce NO formation from the endothelial cells to improve circulation and some suppress the induction of inducible NOS in inflammation and infection. 4. Many botanical medicinal herbs and drugs derived from these herbs have been shown to have effects on the NO signalling pathway. For example, the saponins from ginseng, ginsenosides, have been shown to relax blood vessels (probably contributing to the antifatigue and blood pressure-lowering effects of ginseng) and corpus cavernosum (thus, for the treatment of men suffering from erectile dysfunction; however, the legendary aphrodisiac effect of ginseng may be an overstatement). Many plant extracts or purified drugs derived from Chinese medicinal herbs with proposed actions on NO pathways are also reviewed. PMID: 12940876 [PubMed - in process] Quote Link to comment Share on other sites More sharing options...
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