Guest guest Posted June 24, 2003 Report Share Posted June 24, 2003 Victoria, I found this when I was hunting for the garlic stuff...just in case anyone is interested. All done with this topic. Michelle Drug Handling in the Cat The cat has several metabolic idiosyncrasies which make medicating this species a slightly riskier proposition 3: 1. Delayed biotransformation of many exogenous substances due to decreased UDP-glucuronyl transferase activity. Glucuronic acid conjugation is probably the most important process for activating and increasing water solubility of xenobiotics 4 . The cat, therefore, does not process compounds such as coumarin, morphine, certain sulfonamides and salicylic acid. 2. Feline hemoglobin has an enhanced susceptibility to oxidation, producing methemoglobinemia and Heinz body anemia. Cats are susceptible to fatal anemias produced by acetominophen and by onions. 3. Cat receptors react to certain drugs in anomalous ways; or instance, morphine causes excitation, as opposed to sedation, in cats 4. Feline liver transaminase and deaminase activities are higher than in most species 5 . 5. Cats are uniquely sensitive to phenolic compounds, and other compounds containing benzene rings. Compounds preserved with benzyl alcohol are toxic to cats. Caution should be taken with essential oils containing phenols, such as, potentially, thyme, cinnamon, tea tree and many others 6. The examples given above are by no means all-encompassing -- they were simply all I could think of when I wrote the article. I think they give us reason to be concerned about ANY herb,nutraceutical, EO, etc that we give a cat for the first time. Susan G. Wynn, DVM Greater Atlanta Veterinary Medical Group Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 24, 2003 Report Share Posted June 24, 2003 Hi, I agree to all this we need to learn about our cat and his problems and what he can take and not take. Remember what is good for one may not be good for another just like humans...Amazing isn't it. Ray michellec <michellec wrote: Victoria, I found this when I was hunting for the garlic stuff...just in case anyone is interested. All done with this topic. Michelle Drug Handling in the Cat The cat has several metabolic idiosyncrasies which make medicating this species a slightly riskier proposition 3: 1. Delayed biotransformation of many exogenous substances due to decreased UDP-glucuronyl transferase activity. Glucuronic acid conjugation is probably the most important process for activating and increasing water solubility of xenobiotics 4 . The cat, therefore, does not process compounds such as coumarin, morphine, certain sulfonamides and salicylic acid. 2. Feline hemoglobin has an enhanced susceptibility to oxidation, producing methemoglobinemia and Heinz body anemia. Cats are susceptible to fatal anemias produced by acetominophen and by onions. 3. Cat receptors react to certain drugs in anomalous ways; or instance, morphine causes excitation, as opposed to sedation, in cats 4. Feline liver transaminase and deaminase activities are higher than in most species 5 . 5. Cats are uniquely sensitive to phenolic compounds, and other compounds containing benzene rings. Compounds preserved with benzyl alcohol are toxic to cats. Caution should be taken with essential oils containing phenols, such as, potentially, thyme, cinnamon, tea tree and many others 6. The examples given above are by no means all-encompassing -- they were simply all I could think of when I wrote the article. I think they give us reason to be concerned about ANY herb,nutraceutical, EO, etc that we give a cat for the first time. Susan G. Wynn, DVM Greater Atlanta Veterinary Medical Group Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 29, 2003 Report Share Posted June 29, 2003 Thanks, Michelle. This is something for those interested in TCM applied to animals to keep in mind. Bensky and Gamble's Chinese Herbal Medicine Materia Medica lists the major compounds present in herbs in addition to their TCM properties and uses. Knowing which compounds specific species (or subgroups) can't metabolize is a start to knowing which not to give. > Drug Handling in the Cat > > The cat has several metabolic idiosyncrasies which make medicating this species a slightly riskier proposition 3: > > 1. Delayed biotransformation of many exogenous substances due to decreased UDP-glucuronyl transferase activity. Glucuronic acid conjugation is probably the most important process for activating and increasing water solubility of xenobiotics 4 . The cat, therefore, does not process compounds such as coumarin, morphine, certain sulfonamides and salicylic acid. > > 2. Feline hemoglobin has an enhanced susceptibility to oxidation, producing methemoglobinemia and Heinz body anemia. Cats are susceptible to fatal anemias produced by acetominophen and by onions. > > 3. Cat receptors react to certain drugs in anomalous ways; or instance, morphine causes excitation, as opposed to sedation, in cats > > 4. Feline liver transaminase and deaminase activities are higher than in most species 5 . > > 5. Cats are uniquely sensitive to phenolic compounds, and other compounds containing benzene rings. Compounds preserved with benzyl alcohol are toxic to cats. Caution should be taken with essential oils containing phenols, such as, potentially, thyme, cinnamon, tea tree and many others > > 6. The examples given above are by no means all-encompassing -- they were simply all I could think of when I wrote the article. I think they give us reason to be concerned about ANY herb,nutraceutical, EO, etc that we give a cat for the first time. > > Susan G. Wynn, DVM > Greater Atlanta Veterinary Medical Group Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 30, 2003 Report Share Posted June 30, 2003 You're welcome. Michelle - victoria_dragon Chinese Traditional Medicine Sunday, June 29, 2003 2:15 PM [Chinese Traditional Medicine] Re: cats and drugs/oils, etc. Thanks, Michelle. This is something for those interested in TCM applied to animals to keep in mind. Bensky and Gamble's Chinese Herbal Medicine Materia Medica lists the major compounds present in herbs in addition to their TCM properties and uses. Knowing which compounds specific species (or subgroups) can't metabolize is a start to knowing which not to give. > Drug Handling in the Cat > > The cat has several metabolic idiosyncrasies which make medicating this species a slightly riskier proposition 3: > > 1. Delayed biotransformation of many exogenous substances due to decreased UDP-glucuronyl transferase activity. Glucuronic acid conjugation is probably the most important process for activating and increasing water solubility of xenobiotics 4 . The cat, therefore, does not process compounds such as coumarin, morphine, certain sulfonamides and salicylic acid. > > 2. Feline hemoglobin has an enhanced susceptibility to oxidation, producing methemoglobinemia and Heinz body anemia. Cats are susceptible to fatal anemias produced by acetominophen and by onions. > > 3. Cat receptors react to certain drugs in anomalous ways; or instance, morphine causes excitation, as opposed to sedation, in cats > > 4. Feline liver transaminase and deaminase activities are higher than in most species 5 . > > 5. Cats are uniquely sensitive to phenolic compounds, and other compounds containing benzene rings. Compounds preserved with benzyl alcohol are toxic to cats. Caution should be taken with essential oils containing phenols, such as, potentially, thyme, cinnamon, tea tree and many others > > 6. The examples given above are by no means all-encompassing -- they were simply all I could think of when I wrote the article. I think they give us reason to be concerned about ANY herb,nutraceutical, EO, etc that we give a cat for the first time. > > Susan G. Wynn, DVM > Greater Atlanta Veterinary Medical Group Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.