FW: [iodine] New Study: Pathways in Antiprolif. Effect of Iodine in Breast Cancer Cells

[Guest guest]

More food for thought. This was sent to the Iodine group. I have permission to cross post.Nonie

 

Cited below is the abstract for the new Aceves Group study, "Signalling Pathways Involved in the Antiproliferative effect of Molecular Iodine in Normal and Tumoral Breast Cells: Evidence that 6-Iodolactone Mediates Apoptotic Cells."

 

SUMMARY: Iodine exerts its cancer-killing capability in breast cancer cells by binding with high concentrations of polyunsaturated fats found in breast tumors.

 

Sally

Breast Cancer Choices

www.breastcancerchoices.org

 

 

 

 

1: Endocr Relat Cancer. 2008 Sep 30. [Epub ahead of print] Links

 

 

Signalling pathways involved in the antiproliferative effect of molecular iodine in normal and tumoral breast cells: evidence that 6-iodolactone mediates apoptotic effects.

Arroyo-Helguera O, Rojas E, Delgado G, Aceves C.

O Arroyo-Helguera, Instituto de Neurobiologia, UNAM-Juriquilla, Universidad Nacional Autonoma de Mexico, Juriquilla, Mexico.

Previous reports have documented the antiproliferative properties of molecular iodine (I2) and the arachidonic acid (AA) derivative 6-iodolactone (6-IL) in both thyroid and mammary gland. In this study, we characterized the cellular pathways activated by these molecules and their effects on cell cycle arrest and apoptosis in normal (MCF-12F) and cancerous (MCF-7) breast cells. Low to moderate concentrations of I2 (10-20 muM) cause G1 and G2/M phase arrest in MCF-12F, and caspase-dependent apoptosis in MCF-7 cells. In normal cells, only high doses of I2 (40 muM) induced apoptosis, and this effect was mediated by poly (ADP-ribose) polymerase-1 (PARP-1) and the apoptosis-induced factor (AIF), suggesting an oxidative influence of iodine at high concentrations. Our data indicate that both I2 and 6-IL trigger the same intracellular pathways and suggest that the antineoplasic effect of I2 in mammary cancer involves the intracellular formation of 6-IL. Mammary cancer cells are known to contain high concentrations of arachidonic acid, which might explain why I2 exerts apoptotic effects at lower concentrations only in tumoral cells.

PMID: 18827038 [PubMed - as supplied by publisher]

[Guest guest]

Nonie,

What do they mean by high doses? It isn't clear. Thank you.

 

 

Tammatha

 

-

Nonie

oleander soup

Monday, October 27, 2008 12:23 AM

FW: [iodine] New Study: Pathways in Antiprolif. Effect of Iodine in Breast Cancer Cells

 

 

More food for thought. This was sent to the Iodine group. I have permission to cross post.Nonie

 

Cited below is the abstract for the new Aceves Group study, "Signalling Pathways Involved in the Antiproliferative effect of Molecular Iodine in Normal and Tumoral Breast Cells: Evidence that 6-Iodolactone Mediates Apoptotic Cells."

 

SUMMARY: Iodine exerts its cancer-killing capability in breast cancer cells by binding with high concentrations of polyunsaturated fats found in breast tumors.

 

Sally

Breast Cancer Choices

www.breastcancerchoices.org

 

 

 

 

1: Endocr Relat Cancer. 2008 Sep 30. [Epub ahead of print] Links

 

 

Signalling pathways involved in the antiproliferative effect of molecular iodine in normal and tumoral breast cells: evidence that 6-iodolactone mediates apoptotic effects.

Arroyo-Helguera O, Rojas E, Delgado G, Aceves C.

O Arroyo-Helguera, Instituto de Neurobiologia, UNAM-Juriquilla, Universidad Nacional Autonoma de Mexico, Juriquilla, Mexico.

Previous reports have documented the antiproliferative properties of molecular iodine (I2) and the arachidonic acid (AA) derivative 6-iodolactone (6-IL) in both thyroid and mammary gland. In this study, we characterized the cellular pathways activated by these molecules and their effects on cell cycle arrest and apoptosis in normal (MCF-12F) and cancerous (MCF-7) breast cells. Low to moderate concentrations of I2 (10-20 muM) cause G1 and G2/M phase arrest in MCF-12F, and caspase-dependent apoptosis in MCF-7 cells. In normal cells, only high doses of I2 (40 muM) induced apoptosis, and this effect was mediated by poly (ADP-ribose) polymerase-1 (PARP-1) and the apoptosis-induced factor (AIF), suggesting an oxidative influence of iodine at high concentrations. Our data indicate that both I2 and 6-IL trigger the same intracellular pathways and suggest that the antineoplasic effect of I2 in mammary cancer involves the intracellular formation of 6-IL. Mammary! cancer cells are known to contain high concentrations of arachidonic acid, which might explain why I2 exerts apoptotic effects at lower concentrations only in tumoral cells.

PMID: 18827038 [PubMed - as supplied by publisher]

[Guest guest]

I think this is getting right to the point. Not sure that a sick person really needs all the science but it of course doesn't hurt.

 

It appears that I am back where I was two months ago with lots of energy and ambition and may have found the cause of all my distress. The ninety year old house is full of mold and the hydroxyl producing light bulb and the use of six or eight different methods of cleaning up the air and junk that has accumulated is making a big differents. Yesterday I discovered how infested the under side of the surface of the coils in the Central air conditioner were and spent about six hour with various organic cleaners plus direct ozone to the area and wow what a difference.

 

Plus upping my Lugal's to 40 drops a day and using Betadine directly on the tumor. Which has begun to look very different and last night I was actually able to eat -- not much but it did go down.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Duke Stone ----- Dallas, Texas

info

--- On Mon, 10/27/08, Nonie <nmsammy wrote:

Nonie <nmsammy FW: [iodine] New Study: Pathways in Antiprolif. Effect of Iodine in Breast Cancer Cellsoleander soup Date: Monday, October 27, 2008, 2:23 AM

 

 

More food for thought. This was sent to the Iodine group. I have permission to cross post.Nonie

 

Cited below is the abstract for the new Aceves Group study, "Signalling Pathways Involved in the Antiproliferative effect of Molecular Iodine in Normal and Tumoral Breast Cells: Evidence that 6-Iodolactone Mediates Apoptotic Cells."

 

SUMMARY: Iodine exerts its cancer-killing capability in breast cancer cells by binding with high concentrations of polyunsaturated fats found in breast tumors.

 

Sally

Breast Cancer Choices

www.breastcancercho ices.org

 

 

 

 

1: Endocr Relat Cancer. 2008 Sep 30. [Epub ahead of print] Links

 

 

Signalling pathways involved in the antiproliferative effect of molecular iodine in normal and tumoral breast cells: evidence that 6-iodolactone mediates apoptotic effects.

Arroyo-Helguera O, Rojas E, Delgado G, Aceves C.

O Arroyo-Helguera, Instituto de Neurobiologia, UNAM-Juriquilla, Universidad Nacional Autonoma de Mexico, Juriquilla, Mexico.

Previous reports have documented the antiproliferative properties of molecular iodine (I2) and the arachidonic acid (AA) derivative 6-iodolactone (6-IL) in both thyroid and mammary gland. In this study, we characterized the cellular pathways activated by these molecules and their effects on cell cycle arrest and apoptosis in normal (MCF-12F) and cancerous (MCF-7) breast cells. Low to moderate concentrations of I2 (10-20 muM) cause G1 and G2/M phase arrest in MCF-12F, and caspase-dependent apoptosis in MCF-7 cells. In normal cells, only high doses of I2 (40 muM) induced apoptosis, and this effect was mediated by poly (ADP-ribose) polymerase-1 (PARP-1) and the apoptosis-induced factor (AIF), suggesting an oxidative influence of iodine at high concentrations. Our data indicate that both I2 and 6-IL trigger the same intracellular pathways and suggest that the antineoplasic effect of I2 in mammary cancer involves the intracellular

formation of 6-IL. Mammary cancer cells are known to contain high concentrations of arachidonic acid, which might explain why I2 exerts apoptotic effects at lower concentrations only in tumoral cells.

PMID: 18827038 [PubMed - as supplied by publisher]