Vitamin B6 Reduces Colon Cancer

[Guest guest]

FOR

IMMEDIATE RELEASE

Orthomolecular Medicine News Service, October

21, 2008

Vitamin

B6 Reduces Colon Cancer

Intake is Often

" Inadequate " Even When it Exceeds the RDA

(OMNS, October 21,

2008) A study of almost 5,000 persons has shown that consuming more vitamin B6

means less colon cancer. (1) The researchers described the connection as

" moderately strong. " Any nutrient that has a " moderately

strong " influence on reducing colon cancer risk is very important indeed.

Almost 150,000 Americans are annually diagnosed with colon cancer; nearly

55,000 die every single year. Other authors, reviewing previous studies, have

said the same thing: B6 substantially reduces colon cancer risk. (2,3)

Many of us are not

getting nearly enough B6 from our diets. The American Journal of Clinical

Nutrition (May, 2008) published a study of nearly 8,000 people showing that B6

inadequacy is common throughout the United States. " Across the study

population, " the authors said, " we noticed participants with

inadequate vitamin B6 status even though they reported consuming more than the

Recommended Daily Allowance of vitamin B6, which is less than 2 milligrams per

day. " Three out of four women using oral contraceptives are vitamin B6

deficient, unless they also take vitamin B6 supplements. Smokers and the

elderly are also especially likely to be at risk. Remarkably, even among people

who take B6 supplements, one in ten is still B6 deficient. (4)

This indicates that

we might better take more B6. But many won't. This is because the public has

been warned off of supplementing with this vitamin. So irrational is this fear

that, at one point, a so-called " Safe Upper Limit " for daily B6

intake was set at only 10 mg. (6) That was only about six times the US RDA/DRI.

Who set such a " limit " ? Not the voters, that's for sure. An unelected

committee did it, one created by the National Academy of Sciences, Institute of

Medicine's Food and Nutrition Board. (5) They have, in a manner of speaking,

recently admitted that they were wrong. The " Safe Upper Limit " is now

100 mg.

That is more like it,

but still too low. Alan Gaby, M.D., in reviewing B6 toxicity, wrote that

adverse effects from B6 (pyridoxine) were occurring in people taking

" 2,000 mg/day or more of pyridoxine, although some were taking only 500

mg/day. There is a single case report of a neuropathy occurring in a person

taking 200 mg/day of pyridoxine, but the reliability of that case report is

unclear. The individual in question was never examined, but was merely

interviewed by telephone after responding to a local television report that

publicized pyridoxine-induced neuropathy. " Dr Gaby adds that there have

been no reports of B6 side effects at under 200 mg/day. (6)

Modern processed,

low-nutrient diets are not providing anything close to 200 milligrams. In fact,

they typically provide less that 1% of that amount. You can get some B-6 from

food, if you really like to eat whole grains, seeds and organ meats. A goodly

slice of beef liver contains a whopping 1.2 mg of B-6. Chicken liver is only

0.6 mg per serving, and most other foods contain less. Avocados (0.5 mg each)

and bananas (0.7 mg each) lead the pyridoxine league for fruits. Potatoes (0.7

mg each) and nuts (especially filberts, peanuts and walnuts) are fairly good

vegetable sources.

But people are not

eating nuts, seeds, vegetables, and liver. What they are eating is way too many

nutrient-poor junk foods. Our diets are low in B6, yet B6 reduces risk of colon

cancer. Clearly supplementation is the way to go.

References:

(1) Theodoratou E,

Farrington SM, Tenesa A et al. Dietary vitamin B6 intake and the risk of

colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):171-82.

 

(2) Matsubara K, Komatsu S, Oka T, Kato N. Vitamin B6-mediated suppression of

colon tumorigenesis, cell proliferation, and angiogenesis (review). J Nutr

Biochem. 2003 May;14(5):246-50. See also: Komatsu S, Yanaka N, Matsubara K,

Kato N. Antitumor effect of vitamin B6 and its mechanisms. Biochim Biophys

Acta. 2003 Apr 11;1647(1-2):127-30. " Epidemiological studies have reported

an inverse association between vitamin B(6) intake and colon cancer risk. "

http://www.ncbi.nlm.nih.gov/pubmed/12686121

 

 

(3) Zhang SM et al. Folate, vitamin B6, multivitamin supplements, and

colorectal cancer risk in women. Am J Epidemiol. 2006 January 15; 163(2):

108-115. http://aje.oxfordjournals.org/cgi/content/full/163/2/108

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(4) Morris MS, Picciano MF, Jacques PF, Selhub J. Plasma pyridoxal 5'-phosphate

in the US population: the National Health and Nutrition Examination Survey,

2003-2004. Am J Clin Nutr. 2008 May;87(5):1446-54. See also: http://www.lef.org/whatshot/2008_05.htm#Vitamin-B6-RDA-questioned

 

 

(5) http://www.iom.edu/CMS/3788/3971.aspx

 

 

(6) Gaby AR. " Safe Upper Limits " for nutritional supplements: one

giant step backward. J Orthomolecular Med, 2003, Vol 18, No 3 & 4, p 126-130.

http://findarticles.com/p/articles/mi_m0ISW/is_243/ai_109946551

and http://www.iahf.com/20040127.html

 

 

Many full-text nutrition therapy papers are posted for free access at http://orthomolecular.org/library/jom

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