The Newman Studies on Oleander - The Oleander Series pt 8

[Guest guest]

As posted at

The Best Years in LifeThe Oleander and Related Studies of MD Anderson Researcher Dr. Robert Newman

Newman studies involving oleander extract and the patented oleander medicine Anvirzel

1: Newman RA, Kondo Y, Yokoyama T, Dixon S, Cartwright C, Chan D, Johansen M, Yang P.

Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.

Integr Cancer Ther. 2007 Dec;6(4):354-64.

PMID: 18048883 [PubMed - indexed for MEDLINE]

2: Ni D, Madden TL, Johansen M, Felix E, Ho DH, Newman RA.

Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander.

J Exp Ther Oncol. 2002 Sep-Oct;2(5):278-85.

PMID: 12416031 [PubMed - indexed for MEDLINE]

3: Smith JA, Madden T, Vijjeswarapu M, Newman RA.

Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin.

Biochem Pharmacol. 2001 Aug 15;62(4):469-72.

PMID: 11448457 [PubMed - indexed for MEDLINE]

4: Pathak S, Multani AS, Narayan S, Kumar V, Newman RA.

Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells.

Anticancer Drugs. 2000 Jul;11(6):455-63.

PMID: 11001386 [PubMed - indexed for MEDLINE]

5: Wang X, Plomley JB, Newman RA, Cisneros A.

LC/MS/MS analyses of an oleander extract for cancer treatment.

Anal Chem. 2000 Aug 1;72(15):3547-52.

PMID: 10952541 [PubMed - indexed for MEDLINE]

6: Manna SK, Sah NK, Newman RA, Cisneros A, Aggarwal BB.

Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.

Cancer Res. 2000 Jul 15;60(14):3838-47.

PMID: 10919658 [PubMed - indexed for MEDLINE]

Newman studies involving cardiac glycosides

1: Newman RA, Yang P, Pawlus AD, Block KI.

Cardiac glycosides as novel cancer therapeutic agents.

Mol Interv. 2008 Feb;8(1):36-49.

PMID: 18332483 [PubMed - in process]

2: Newman RA, Kondo Y, Yokoyama T, Dixon S, Cartwright C, Chan D, Johansen M, Yang P.

Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.

Integr Cancer Ther. 2007 Dec;6(4):354-64.

PMID: 18048883 [PubMed - indexed for MEDLINE]

3: Newman RA, Yang P, Hittelman WN, Lu T, Ho DH, Ni D, Chan D, Vijjeswarapu M, Cartwright C, Dixon S, Felix E, Addington C.

Oleandrin-mediated oxidative stress in human melanoma cells.

J Exp Ther Oncol. 2006;5(3):167-81.

PMID: 16528968 [PubMed - indexed for MEDLINE]

4: Newman LS, Feinberg MW, LeWine HE.

Clinical problem-solving. A bitter tale.

N Engl J Med. 2004 Aug 5;351(6):594-9. No abstract available.

PMID: 15295053 [PubMed - indexed for MEDLINE]

5: Pinter A, Dorian P, Paquette M, Ng A, Burns M, Spanu I, Freeman M, Korley V, Newman D.

Left ventricular performance during acute rate control in atrial fibrillation: the importance of heart rate and agent used.

J Cardiovasc Pharmacol Ther. 2003 Mar;8(1):17-24.

PMID: 12652326 [PubMed - indexed for MEDLINE]

6: Ni D, Madden TL, Johansen M, Felix E, Ho DH, Newman RA.

Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander.

J Exp Ther Oncol. 2002 Sep-Oct;2(5):278-85.

PMID: 12416031 [PubMed - indexed for MEDLINE]

7: Nasu S, Milas L, Kawabe S, Raju U, Newman R.

Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process.

Cancer Lett. 2002 Nov 28;185(2):145-51.

PMID: 12169388 [PubMed - indexed for MEDLINE]

8: Smith JA, Madden T, Vijjeswarapu M, Newman RA.

Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin.

Biochem Pharmacol. 2001 Aug 15;62(4):469-72.

PMID: 11448457 [PubMed - indexed for MEDLINE]

9: Harjai KJ, Nunez E, Stewart Humphrey J, Turgut T, Shah M, Newman J.

Does gender bias exist in the medical management of heart failure?

Int J Cardiol. 2000 Aug;75(1):65-9.

PMID: 11054508 [PubMed - indexed for MEDLINE]

10: Pathak S, Multani AS, Narayan S, Kumar V, Newman RA.

Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells.

Anticancer Drugs. 2000 Jul;11(6):455-63.

PMID: 11001386 [PubMed - indexed for MEDLINE]

11: Wang X, Plomley JB, Newman RA, Cisneros A.

LC/MS/MS analyses of an oleander extract for cancer treatment.

Anal Chem. 2000 Aug 1;72(15):3547-52.

PMID: 10952541 [PubMed - indexed for MEDLINE]

12: Manna SK, Sah NK, Newman RA, Cisneros A, Aggarwal BB.

Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.

Cancer Res. 2000 Jul 15;60(14):3838-47.

PMID: 10919658 [PubMed - indexed for MEDLINE]

13: McConkey DJ, Lin Y, Nutt LK, Ozel HZ, Newman RA.

Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells.

Cancer Res. 2000 Jul 15;60(14):3807-12.

PMID: 10919654 [PubMed - indexed for MEDLINE]

14: Weightman WM, Gibbs NM, Sheminant MR, Whitford EG, Mahon BD, Newman MA.

Drug therapy before coronary artery surgery: nitrates are independent predictors of mortality and beta-adrenergic blockers predict survival.

Anesth Analg. 1999 Feb;88(2):286-91.

PMID: 9972742 [PubMed - indexed for MEDLINE]

15: Davey CL, Thakkar H, Newman DJ, Price CP.

A simple, automated, nonextraction assay for serum digoxin using particle-enhanced immunoassay.

Ther Drug Monit. 1997 Feb;19(1):108-11.

PMID: 9029759 [PubMed - indexed for MEDLINE]

16: Rautaharju PM, Manolio TA, Furberg CD, Siscovick D, Newman AB, Borhani NO, Gardin JM.

Ischemic episodes in 24-h ambulatory electrocardiograms of elderly persons: the Cardiovascular Health Study.

Int J Cardiol. 1995 Sep;51(2):165-75.

PMID: 8522413 [PubMed - indexed for MEDLINE]

17: Fletcher SE, Fyfe DA, Case CL, Wiles HB, Upshur JK, Newman RB.

Myocardial necrosis in a newborn after long-term maternal subcutaneous terbutaline infusion for suppression of preterm labor.

Am J Obstet Gynecol. 1991 Nov;165(5 Pt 1):1401-4.

PMID: 1843619 [PubMed - indexed for MEDLINE]

18: Newman WH, Lee JT Jr, Webb JG.

Persistent desensitization of the heart to the inotropic action of isoproterenol by adenosine.

Res Commun Chem Pathol Pharmacol. 1989 Nov;66(2):233-54.

PMID: 2602656 [PubMed - indexed for MEDLINE]

19: Daut J, Mehrke G, Nees S, Newman WH.

Passive electrical properties and electrogenic sodium transport of cultured guinea-pig coronary endothelial cells.

J Physiol. 1988 Aug;402:237-54.

PMID: 2853223 [PubMed - indexed for MEDLINE]

20: Grupp G, Grupp IL, Newman G, Schwartz A.

Effects of a new positive inotropic agent, 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (OPC-8212) and its solvent sulfolane on isolated heart preparations of the rat, guinea pig, and dog.

Arzneimittelforschung. 1984;34(3A):359-63.

PMID: 6540089 [PubMed - indexed for MEDLINE]

21: Newman WH, Webb JG, Privitera PJ.

Persistence of myocardial failure following removal of chronic volume overload.

Am J Physiol. 1982 Dec;243(6):H876-83.

PMID: 6756171 [PubMed - indexed for MEDLINE]

22: Newman WH, Ellison DM.

A differential effect of ouabain and beta-agonists on contractility and lactic acid production in the hypertrophied heart.

Eur J Pharmacol. 1980 Dec 19;68(4):437-42.

PMID: 6110553 [PubMed - indexed for MEDLINE]

23: Newman WH, Webb JG.

A differential inotropic responsiveness to isoprenaline and ouabain in dogs with heart failure.

Cardiovasc Res. 1980 Sep;14(9):530-6.

PMID: 7214396 [PubMed - indexed for MEDLINE]

24: Newman WH, Webb JG.

Adaptation of left ventricle to chronic pressure overload: response to inotropic drugs.

Am J Physiol. 1980 Feb;238(2):H134-43.

PMID: 6444783 [PubMed - indexed for MEDLINE]

25: Newman PJ, Sherman LA.

Isolation and characterization of photosystem I and II membrane particles from the blue-green alga, Synechococcus cedrorum.

Biochim Biophys Acta. 1978 Aug 8;503(2):343-61.

PMID: 99171 [PubMed - indexed for MEDLINE]

26: Spector R, McGrath P, Uretsky N, Newman R, Cohen P.

Does intervention by a nurse improve medication compliance?

Arch Intern Med. 1978 Jan;138(1):36-40.

PMID: 619829 [PubMed - indexed for MEDLINE]

27: Bagwell EE, Custy J, Steen RG, Newman WH.

Beta receptor blocking and antiarrhythmic properties of tolamolol.

J Pharmacol Exp Ther. 1974 Dec;191(3):496-505. No abstract available.

PMID: 4154378 [PubMed - indexed for MEDLINE]

28: Reves JG, Newman WH.

Cardiovascular response to hemorrhage after alcohol in dogs.

Q J Stud Alcohol. 1972 Jun;33(2):464-75. No abstract available.

PMID: 5064203 [PubMed - indexed for MEDLINE]

29: Lasser R, Haft JI, Newman BJ, Allen DF, Ishigura J, Friedberg CK.

Chronic left heart failure--an experimental model in the dog.

Mt Sinai J Med. 1971 Sep-Oct;38(5):440-9. No abstract available.

PMID: 4255995 [PubMed - indexed for MEDLINE]

30: Hollister RM, Newman W.

The Wotman test for digitalis toxicity: a preliminary report.

J Tenn Med Assoc. 1971 Aug;64(8):679-80. No abstract available.

PMID: 5141165 [PubMed - indexed for MEDLINE]

31: Newman WH, Valicenti JF Jr.

Ventricular function following acute alcohol administration: a strain-gauge analysis of depressed ventricular dyamics.

Am Heart J. 1971 Jan;81(1):61-8. No abstract available.

PMID: 5099692 [PubMed - indexed for MEDLINE]