Results of Long-Term Carcinogenicity Bioassays on Coca-Cola

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For the complete astonishing 17 page report on CARCINOGENICITY BIOASSAYS ON COCA-COLAgo to: http://www.ramazzini.it/fondazione/docs/NYAS_Coca-Cola_Ramazzini.pdf Results of Long-Term CarcinogenicityBioassays on Coca-Cola Administeredto Sprague-Dawley RatsFIORELLA BELPOGGI, MORANDO SOFFRITTI, EVA TIBALDI,LAURA FALCIONI, LUCIANO BUA, AND FRANCESCA TRABUCCOCesare Maltoni Cancer Research Center, European Foundationfor Oncology and Environmental Sciences “B. Ramazzini,” 40010 Bentivoglio,Bologna, ItalyABSTRACT: Coca-Cola was invented in May 1886 in Atlanta, Georgia bya pharmacist who, by accident or design, mixed carbonated water withthe syrup of sugar, phosphoric acid, caffeine, and other natural flavorsto create what is known as “the world’s favorite soft drink.” Coca-Cola iscurrently sold in more than 200 countries and in early 2000, the companysold its 10 billionth unit case of Coca-Cola branded products. Given theworldwide consumption of Coca-Cola, a project of experimental bioassaysto study its long-term effects when administered as substitute fordrinking water on male and female Sprague-Dawley rats was plannedand executed. The objective of the project was to study whether and howlong-term consumption of Coca-Cola affects the basic tumorigram oftest animals. The bioassays were performed on rats beginning at differentages, namely: (a) on males and females exposed since embryonic lifeor from 7 weeks of age; and (b) on males and females exposed from 30,39, or 55 weeks of age. Overall, the project included 1999 rats. Duringthe biophase, data were collected on fluid and feed consumption, bodyweight, and survival. Animals were kept under observation until spontaneousdeath and underwent complete necropsy. The results indicate: (a)an increase in body weight in all treated animals; (b) a statistically significantincrease of the incidence in females, both breeders and offspring,bearing malignant mammary tumors; © a statistically significant increasein the incidence of exocrine ademonas of the pancreas in bothmale and female breeders and offspring; and (d) an increased incidence,albeit not statistically significant, of pancreatic islet cell carcinomas infemales, a malignant tumor which occurs very rarely in our historicalcontrols. On the basis of the results of this study, excessive consumptionAddress for correspondence: Morando Soffritti, M.D., Cesare Maltoni Cancer Research Center,European Ramazzini Foundation, Castello di Bentivoglio, 40010 Bentivoglio (BO), Italy. Voice: +39-051-6640460; fax: +39-051-6640223.e-mail: crcfr; www.ramazzini.itFunding for this research was provided entirely by the European Foundation on Oncology andEnvironmental Sciences “B. Ramazzini.”Ann. N.Y. Acad. Sci. 1076: 736–752 (2006). C 2006 New York Academy of Sciences.doi: 10.1196/annals.1371.078