Is your high-salt program slowly killing you?

[Guest guest]

High-salt is linked to kidney and brain damage through oxidative

stress.

 

In both human and experimental salt-sensitive hypertension,

superoxide production and renal damage are increased, antioxidant

capacity is decreased, and antioxidant therapy can be helpful,

note the researchers.

FULLTEXT:

http://members.shaw.ca/duncancrow/salt_hypertension_superoxide_ren

al.pdf (PDF)

-unbreakable URL:

http://tinyurl.com/yxqrzx

 

The study, " Oxidative Stress: The Curse That Underlies Cerebral

Vascular Dysfunction " , highlights the brain damage: " Oxidative

stress in the vasculature appears to be a common feature in

diverse models of cerebral vascular disease and injury. ...Many

of these same risk factors have also been linked with vascular

cognitive impairment and Alzheimer disease. ...Nitric oxide (NO),

a potent vasodilator, is a major mediator of endothelium-

dependent relaxation and thus regulator of tone in large arteries

and microvessels of the brain. NO reacts extremely efficiently

with superoxide, resulting in loss of NO bioavailability. "

FULLTEXT: http://members.shaw.ca/duncancrow/Oxidative-Stress-and-

Cerebral-Vascular-Dysfunction.pdf (PDF)

(Advances in Stroke 2004, Frank M. Faraci, PhD)

-unbreakable URL:

http://tinyurl.com/ycv5nx

 

In " Role of superoxide and angiotensin II suppression in salt-

induced changes in endothelial Ca2+ signaling and NO production

in rat aorta " , the researchers observed increased superoxide in

the high-salt group.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrie

ve & dopt=AbstractPlus & list_uids=16603691 & query_hl=1 & itool=pubmed_do

csum

-unbreakable URL:

http://tinyurl.com/ylnkkj

 

The increased oxidation is independent of a hypertension

reaction. The study, " Effect of high-salt diet on NO release and

superoxide production in rat aorta " , notes, " ...the present study

demonstrates that impaired endothelium-dependent relaxation,

reduced NO release, and increased superoxide production also may

occur during elevated salt intake in normotensive animals. "

FULLTEXT:

http://members.shaw.ca/duncancrow/salt_superoxide_low_nitric_oxide

..pdf

-unbreakable URL:

http://tinyurl.com/ufglm

 

In fact, superoxide helps to cause salt-sensitive hypertension;

the study " Superoxide contributes to development of salt

sensitivity and hypertension induced by nitric oxide deficiency "

points out that " The development of any imbalance between

oxidative and antioxidative processes in living tissues would

lead to derangements in organ function including the kidney. The

results of the present study, which demonstrate a close relation

between enhancement of superoxide and the development of salt

sensitivity during NOS inhibition, provide an important clue in

our quest in understanding the pathophysiology of salt-sensitive

hypertension. "

FULLTEXT:

http://members.shaw.ca/duncancrow/salt_hypertension_superoxide_low

_nitric_oxide.pdf

-unbreakable tinyurl:

http://tinyurl.com/yjpb97

 

Here we have validation for dietary prevention of disease using

antioxidants, with this April 2005 study, " Antioxidant treatment

prevents renal damage and dysfunction and reduces arterial

pressure in salt-sensitive hypertension " .

FULLTEXT:

http://members.shaw.ca/duncancrow/salt_antioxidants_prevent_damage

_hypertension.pdf

-unbreakable tinyurl:

http://tinyurl.com/ylqzlh

 

When excess salt results in the depletion of antioxidant and

nitric oxide it can aggravate many inflammatory and/or oxidative

disorders. In lung issues like asthma and COPD for example,

antioxidant glutathione and nitric oxide are known to be

depleted; this depletion leads to increased airway constriction

and superoxide, peroxide and other free radical damage, which is

accompanied by more irritation and mucous production, symptoms

that often go away when levels are replete. This review

" Oxidative stress and antioxidant deficiencies in asthma:

potential modification by diet " and several related articles

accessible from on this page make the point.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrie

ve & dopt=AbstractPlus & list_uids=16354413

-unbreakable tinyurl:

http://tinyurl.com/ybj7p9

 

Excess salt also depletes cellular potassium; potassium

supplements and high-potassium food may be needed to balance a

high-salt diet and avoid the cell death and tissue wasting

condition of rhabdomyolysis. One would avoid and reverse early

stages of kidney scarring and fibrosis, which is the biggest

cause of renal failure in the elderly, with oral fibrinolytic

enzymes.

 

Duncan

[Guest guest]

<begin forward>

High-salt is linked to kidney and brain damage through oxidative

stress.

 

In both human and experimental salt-sensitive hypertension,

superoxide production and renal damage are increased, antioxidant

capacity is decreased, and antioxidant therapy can be helpful, note

the researchers.

FULLTEXT:

http://members.shaw.ca/duncancrow/salt_hypertension_superoxide_ren

al.pdf (PDF)

-unbreakable URL:

http://tinyurl.com/yxqrzx

 

The study, " Oxidative Stress: The Curse That Underlies Cerebral

Vascular Dysfunction " , highlights the brain damage: " Oxidative

stress in the vasculature appears to be a common feature in

diverse models of cerebral vascular disease and injury. ...Many

of these same risk factors have also been linked with vascular

cognitive impairment and Alzheimer disease. ...Nitric oxide (NO), a

potent vasodilator, is a major mediator of endothelium- dependent

relaxation and thus regulator of tone in large arteries and

microvessels of the brain. NO reacts extremely efficiently with

superoxide, resulting in loss of NO bioavailability. "

FULLTEXT:

http://members.shaw.ca/duncancrow/Oxidative-Stress-and-

Cerebral-Vascular-Dysfunction.pdf (PDF)

(Advances in Stroke 2004,

Frank M. Faraci, PhD)

-unbreakable URL:

http://tinyurl.com/ycv5nx

 

 

In " Role of superoxide and angiotensin II suppression in salt-

induced changes in endothelial Ca2+ signaling and NO production

in rat aorta " , the researchers observed increased superoxide in

the high-salt group.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrie

ve & dopt=AbstractPlus & list_uids=16603691 & query_hl=1 & itool=pubmed_do

csum

-unbreakable URL:

http://tinyurl.com/ylnkkj

 

The increased oxidation is independent of a hypertension

reaction. The study, " Effect of high-salt diet on NO release and

superoxide production in rat aorta " , notes, " ...the present study

demonstrates that impaired endothelium-dependent relaxation, reduced

NO release, and increased superoxide production also may occur during

elevated salt intake in normotensive animals. "

FULLTEXT:

http://members.shaw.ca/duncancrow/salt_superoxide_low_nitric_oxide

..pdf

-unbreakable URL:

http://tinyurl.com/ufglm

 

In fact, superoxide helps to cause salt-sensitive hypertension;

the study " Superoxide contributes to development of salt

sensitivity and hypertension induced by nitric oxide deficiency "

points out that " The development of any imbalance between oxidative

and antioxidative processes in living tissues would lead to

derangements in organ function including the kidney. The results of

the present study, which demonstrate a close relation between

enhancement of superoxide and the development of salt sensitivity

during NOS inhibition, provide an important clue in our quest in

understanding the pathophysiology of salt-sensitive hypertension. "

FULLTEXT:

http://members.shaw.ca/duncancrow/salt_hypertension_superoxide_low

_nitric_oxide.pdf

-unbreakable tinyurl:

http://tinyurl.com/yjpb97

 

Here we have validation for dietary prevention of disease using

antioxidants, with this April 2005 study, " Antioxidant treatment

prevents renal damage and dysfunction and reduces arterial pressure in

salt-sensitive hypertension " .

FULLTEXT:

http://members.shaw.ca/duncancrow/salt_antioxidants_prevent_damage

_hypertension.pdf

-unbreakable tinyurl:

http://tinyurl.com/ylqzlh

 

When excess salt results in the depletion of antioxidant and

nitric oxide it can aggravate many inflammatory and/or oxidative

disorders. In lung issues like asthma and COPD for example,

antioxidant glutathione and nitric oxide are known to be depleted;

this depletion leads to increased airway constriction and superoxide,

peroxide and other free radical damage, which is accompanied by more

irritation and mucous production, symptoms that often go away when

levels are replete. This review " Oxidative stress and antioxidant

deficiencies in asthma: potential modification by diet " and several

related articles accessible from on this page make the point.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrie

ve & dopt=AbstractPlus & list_uids=16354413

-unbreakable tinyurl:

http://tinyurl.com/ybj7p9

 

Excess salt also depletes cellular potassium; potassium

supplements and high-potassium food may be needed to balance a

high-salt diet and avoid the cell death and tissue wasting

condition of rhabdomyolysis. One would avoid and reverse early

stages of kidney scarring and fibrosis, which is the biggest

cause of renal failure in the elderly, with oral fibrinolytic

enzymes.

 

Duncan

<end forward>

 

Bonnie