Vitamin B6 misinformation - Warning to Forum Assassins

[Guest guest]

In an attempt to rebuke the B6 disease, here is the

right information.

 

I am a biochemist by training and lately there is

certain parties trying to spread misinformation by

participating in various forum that B6 is not good for

you. Lately there has been several " forum assassins "

trying to spread misinformation that chelation of

mercury is dangerous, and will not work on autistics,

and other. Currently that i am aware of there is about

100,000 forum assassins who are quite active

throughout cyberspace trying to spread misinformation

in forums. The best way to handle this is go straight

to the horses' mouth: pubmed, real research abstracts

that you can check out yourself. Sometimes, when

research becomes conflicting I go directly through the

patent office where research are all compiled and

conducted there for you. You will find a near

unanimous research results that B6 increases

MELATONIN, not reduced!!!

 

The other thing is I studied biochemistry, B6 and

tryptophan is used for years to induce sleep and

regular circadium rhythms. Check out a good

biochemistry book in your nearest library!!

 

Ted

 

 

Now to dispel the myth that B6 can destroy your

melatonin, in biochemistry we used this to help with

your sleep. Even in Children. Feel free to check out

the following abstracts:

 

 

Summary: children have higher level of melatonin upon

B6 administration

J Neural Transm. 1996;103(7):833-42. Related

Articles, Links

 

Pineal response after pyridoxine test in children.

 

Munoz-Hoyos A, Amoros-Rodriguez I, Molina-Carballo A,

Uberos-Fernandez J, Acuna-Castroviejo D.

 

Departamento de Pediatria, Hospital Universitario,

Facultad de Medicina, Universidad de Granada, Spain.

 

To characterize the pineal response to pyridoxine,

plasma melatonin was measured in one hundred and

twenty children 3 hours after vitamin B6

administration. The children, aged between 1.5 and 8

years, were divided in four groups as follows: a)

control day group, grouping 27 children sampled at

9:00 and at 12:00; b) control night group, grouping 29

children sampled at 21:00 and at 24:00; c) pyridoxine

day group, grouping 30 children sampled at 9:00, then

intravenously (i.v.) injected with 3 mg/kg of

pyridoxine, and sampled at 12:00; and d) pyridoxine

night group, grouping 34 children sampled at 21:00,

i.v. injected with 3 mg/kg of pyridoxine, and sampled

at 24:00. Melatonin concentration was measured by

radioimmuno assay. The data obtained showed a

significant increase in melatonin levels after

pyridoxine administration in the pyridoxine night

group (39.87 +/- 8.02 pg/ml basal vs 88.45 +/- 9.21

pg/ml after pyridoxine, p < 0.001). The other groups

did not showed significant differences in melatonin

concentrations. Statistical analysis shows that the

administration of pyridoxine during the nocturnal

hours represents a stimulating factor to increase the

pineal production of melatonin in children.

 

PMID: 8872867 [PubMed - indexed for MEDLINE]

 

 

summary: B6 is helpful against drug induce Parkinson's

disease

 

Int J Neurosci. 1990 Jun;52(3-4):225-32. Related

Articles, Links

 

 

Melatonin deficiency is DUE TO VITAMIN B6 deficiency,

read this!!!

 

 

Sandyk R, Pardeshi R.

 

Department of Psychiatry College of Physicians and

Surgeons of Columbia University, New York State

Psychiatric Institute, NY 10032.

 

Drug-induced Parkinsonism is a common serious

side-effect of neuroleptic therapy. In cases of

irreversible drug-induced Parkinsonism,

pharmacological management is notoriously difficult. A

schizophrenic patient with severe neuroleptic-induced

Parkinsonism and Tardive Dyskinesia is presented in

whom administration of pyridoxine (vitamin B6) (100

mg/d) resulted in dramatic and persistent attenuation

of the movement disorders as well as reduction of

psychotic behavior. Since pyridoxine deficiency is

associated with marked reduction of cerebral serotonin

concentrations and pineal melatonin production in

rats, the effects of pyridoxine on the movement

disorder and psychosis may have been mediated largely

by enhancing serotonin and melatonin functions. An

additional effect of excess pyridoxine administration

on GABA and dopamine activity cannot be excluded.

Pyridoxine has been reported to attenuate the severity

of levodopa-induced dyskinesias in patients with

Parkinson's disease and it is suggested that

pyridoxine supplementation should be considered in

psychiatric patients with drug-induced movement

disorders including persistent Parkinsonism. An

underlying pyridoxine deficiency in these patients may

exacerbate the psychotic behavior and additionally,

potentially increase the risk of drug-induced movement

disorders.

 

Publication Types:

 

 

 

summary B6 results in higher melatonin production

 

 

Georgian Med News. 2006 Mar;(132):121-123. Links

 

[bIOCHEMICAL, PHARMACOLOGICAL AND CLINICAL ASPECTS OF

I NFLUENCING METHIONINC, TRYPLOPHAN, PYRIDOXINE

(VITAMIN B6), Ca(2+) AND HIGH-CALORIE FOOD ON THE

SYNTHESIS AND INTENSITY OF THE SECRETION OF

MELATONIN.]

 

[Article in Russian]

 

Tavartkiladze A, Simonia G, Kolbaia D, Shalashvili A,

Petriashvili T.

 

Acad. S. Durmishidze Institute of Biochemistry and

Biotechnology, Academy of Sciences of Georgia.

 

The goal of the investigation was the determination of

the influence of Ca(2+), vitamin B6 methionine,

tryptophan, the combination of the listed elements and

high-calorie food on the intensity of synthesis and

secretion of melatonin. The level of melatonin in the

blood serum was being determined through the method of

radio-immune (immune-enzyme) analysis. Based on the

results received it was found out that the influence

of the vitamin B6, tryptophan and their combination in

the organism of the tested objects - white rats)

resulted in the considerable increase of formation of

melatonin. In the conditions of feeding them with

high-calorie food - the value of melntonin in blood is

sharply reducing. Consequently we may conclude that

the vitamin B6 and tryptophan separately and in

combination, either directly or through some other

mechanism participate actively in biosynthesis and

secretion of melatonin. The high-calorie food through

unknown mechanism to us reduces the formation of the

melatonin in epiphysis. This might point to the

important role of the deficit of melatonin in

etiopathogenesis of the diseases, detected and

developed on the background of hypercholesterinemy.

 

PMID: 16636399 [PubMed - as supplied by publisher]

 

Other research abstract (and this) results saying

similar things:

 

 

1: Tavartkiladze A, Simonia G, Kolbaia D, Shalashvili

A, Petriashvili T. Links

[bIOCHEMICAL, PHARMACOLOGICAL AND CLINICAL ASPECTS OF

I NFLUENCING METHIONINC, TRYPLOPHAN, PYRIDOXINE

(VITAMIN B6), Ca(2+) AND HIGH-CALORIE FOOD ON THE

SYNTHESIS AND INTENSITY OF THE SECRETION OF

MELATONIN.]

Georgian Med News. 2006 Mar;(132):121-123. Russian.

PMID: 16636399 [PubMed - as supplied by publisher]

2: Sorouraddin MH, Rashidi MR, Ghorbani-Kalhor E,

Asadpour-Zeynali K. Related Articles, Links

Simultaneous spectrofluorimetric and

spectrophotometric determination of melatonin and

pyridoxine in pharmaceutical preparations by

multivariate calibration methods.

Farmaco. 2005 May;60(5):451-8.

PMID: 15885688 [PubMed - indexed for MEDLINE]

3: de Lima VR, Morfim MP, Teixeira A, Creczynski-Pasa

TB. Related Articles,Links

Relationship between the action of reactive oxygen

and nitrogen species on bilayer membranes and

antioxidants.

Chem Phys Lipids. 2004 Dec;132(2):197-208.

PMID: 15555605 [PubMed - indexed for MEDLINE]

4: Luboshitzky R, Ophir U, Nave R, Epstein R,

Shen-Orr Z, Herer P. Related Articles, Links

The effect of pyridoxine administration on melatonin

secretion in normal men.

Neuro Endocrinol Lett. 2002 Jun;23(3):213-7.

PMID: 12080281 [PubMed - indexed for MEDLINE]

5: Uslu B, Demircigil BT, Ozkan SA, Senturk Z,

Aboul-Enein HY. Related Articles, Links

Simultaneous determination of melatonin and

pyridoxine in tablet formulations by differential

pulse voltammetry.

Pharmazie. 2001 Dec;56(12):938-42.

PMID: 11802655 [PubMed - indexed for MEDLINE]

6: Nunez-Vergara LJ, Squella JA, Sturm JC, Baez H,

Camargo C. Related Articles, Links

Simultaneous determination of melatonin and

pyridoxine in tablets by gas chromatography-mass

spectrometry.

J Pharm Biomed Anal. 2001 Dec;26(5-6):929-38.

PMID: 11600305 [PubMed - indexed for MEDLINE]

7: Johnson S. Related Articles, Links

The possible role of gradual accumulation of copper,

cadmium, lead and iron and gradual depletion of zinc,

magnesium, selenium, vitamins B2, B6, D, and E and

essential fatty acids in multiple sclerosis.

Med Hypotheses. 2000 Sep;55(3):239-41.

PMID: 10985916 [PubMed - indexed for MEDLINE]

8: Mortani Barbosa EJ, Ferreira ZS, Markus RP.

Related Articles, Links

Purinergic and noradrenergic cotransmission in the

rat pineal gland.

Eur J Pharmacol. 2000 Jul 28;401(1):59-62.

PMID: 10915838 [PubMed - indexed for MEDLINE]

9: Abdine HH, Gazy AA, Abdel-Hay MH. Related

Articles, Links

Simultaneous determination of melatonin-pyridoxine

combination in tablets by zero-crossing derivative

spectrophotometry and spectrofluorimetry.

J Pharm Biomed Anal. 1998 Jul;17(3):379-86.

PMID: 9656147 [PubMed - indexed for MEDLINE]

10: Munoz-Hoyos A, Amoros-Rodriguez I,

Molina-Carballo A, Uberos-Fernandez J,

Acuna-Castroviejo D. Related Articles, Links

Pineal response after pyridoxine test in children.

J Neural Transm. 1996;103(7):833-42.

PMID: 8872867 [PubMed - indexed for MEDLINE]

11: Sandyk R, Pardeshi R. Related Articles, Links

Pyridoxine improves drug-induced parkinsonism and

psychosis in a schizophrenic patient.

Int J Neurosci. 1990 Jun;52(3-4):225-32.

PMID: 2269609 [PubMed - indexed for MEDLINE]

12: Dakshinamurti K, Paulose CS, Viswanathan M, Siow

YL, Sharma SK, Bolster B. Related Articles, Links

Neurobiology of pyridoxine.

Ann N Y Acad Sci. 1990;585:128-44. Review. No abstract

available.

PMID: 2192608 [PubMed - indexed for MEDLINE]

13: Gonnard P. Related Articles, Links

[Current data on the lateral biochemical effects of

dopa]

Pathol Biol (Paris). 1974 Mar;22(3):263-76. Review.

French. No abstract available.

PMID: 4152656 [PubMed - indexed for MEDLINE]

14: Anton-Tay F. Related Articles, Links

Melatonin: effects on brain function.

Adv Biochem Psychopharmacol. 1974;11(0):315-24.

Review. No abstract available.

PMID: 4367648 [PubMed - indexed for MEDLINE]

15: McCoy EE, Henn SW, Colombini CE. Related

Articles, Links

The effect of neuropharmacological agents on

metabolism in vitamin B6 in brain.

Adv Biochem Psychopharmacol. 1972;4:93-104. Review. No

abstract available.

PMID: 4557808 [PubMed - indexed for MEDLINE]

16: McCoy EE, Henn SW, Colombini CE. Related

Articles, Links

The effect of neuropharmacological agents on

metabolism of vitamin B 6 in brain.

Adv Biochem Psychopharmacol. 1972;4:93-104. Review. No

abstract available.

PMID: 4555933 [PubMed - indexed for MEDLINE]

17: Cotzias GC, Papavasiliou PS, Ginos J, Steck A,

Duby S. Related Articles, Links

Metabolic modification of Parkinson's disease and of

chronic manganese poisoning.

Annu Rev Med. 1971;22:305-26. Review. No abstract

available.

PMID: 4944422 [PubMed - indexed for MEDLINE]

 

 

 

 

 

 

[Guest guest]

Excellent Ted - thanks - a friend of mine - allopathic GP (deceased 1990) used to prescribe B6 1,000mg per day for carpal tunnel - have never found anyone else giving that much or any reference to its use at that level.

 

Jane

 

-

Parhatsathid Napatalung

Thursday, April 27, 2006 8:39 PM

Vitamin B6 misinformation - Warning to Forum Assassins

In an attempt to rebuke the B6 disease, here is theright information.I am a biochemist by training and lately there iscertain parties trying to spread misinformation byparticipating in various forum that B6 is not good foryou. Lately there has been several "forum assassins"trying to spread misinformation that chelation ofmercury is dangerous, and will not work on autistics,and other. Currently that i am aware of there is about100,000 forum assassins who are quite activethroughout cyberspace trying to spread misinformationin forums. The best way to handle this is go straightto the horses' mouth: pubmed, real research abstractsthat you can check out yourself. Sometimes, whenresearch becomes conflicting I go directly through thepatent office where research are all compiled andconducted there for you. You will find a nearunanimous research results that B6 increasesMELATONIN, not reduced!!!The other thing is I studied biochemistry, B6 andtryptophan is used for years to induce sleep andregular circadium rhythms. Check out a goodbiochemistry book in your nearest library!!TedNow to dispel the myth that B6 can destroy yourmelatonin, in biochemistry we used this to help withyour sleep. Even in Children. Feel free to check outthe following abstracts:Summary: children have higher level of melatonin uponB6 administrationJ Neural Transm. 1996;103(7):833-42. RelatedArticles, Links Pineal response after pyridoxine test in children.Munoz-Hoyos A, Amoros-Rodriguez I, Molina-Carballo A,Uberos-Fernandez J, Acuna-Castroviejo D.Departamento de Pediatria, Hospital Universitario,Facultad de Medicina, Universidad de Granada, Spain.To characterize the pineal response to pyridoxine,plasma melatonin was measured in one hundred andtwenty children 3 hours after vitamin B6administration. The children, aged between 1.5 and 8years, were divided in four groups as follows: a)control day group, grouping 27 children sampled at9:00 and at 12:00; b) control night group, grouping 29children sampled at 21:00 and at 24:00; c) pyridoxineday group, grouping 30 children sampled at 9:00, thenintravenously (i.v.) injected with 3 mg/kg ofpyridoxine, and sampled at 12:00; and d) pyridoxinenight group, grouping 34 children sampled at 21:00,i.v. injected with 3 mg/kg of pyridoxine, and sampledat 24:00. Melatonin concentration was measured byradioimmuno assay. The data obtained showed asignificant increase in melatonin levels afterpyridoxine administration in the pyridoxine nightgroup (39.87 +/- 8.02 pg/ml basal vs 88.45 +/- 9.21pg/ml after pyridoxine, p < 0.001). The other groupsdid not showed significant differences in melatoninconcentrations. Statistical analysis shows that theadministration of pyridoxine during the nocturnalhours represents a stimulating factor to increase thepineal production of melatonin in children.PMID: 8872867 [PubMed - indexed for MEDLINE]summary: B6 is helpful against drug induce Parkinson'sdiseaseInt J Neurosci. 1990 Jun;52(3-4):225-32. RelatedArticles, Links Melatonin deficiency is DUE TO VITAMIN B6 deficiency,read this!!!Sandyk R, Pardeshi R.Department of Psychiatry College of Physicians andSurgeons of Columbia University, New York StatePsychiatric Institute, NY 10032.Drug-induced Parkinsonism is a common seriousside-effect of neuroleptic therapy. In cases ofirreversible drug-induced Parkinsonism,pharmacological management is notoriously difficult. Aschizophrenic patient with severe neuroleptic-inducedParkinsonism and Tardive Dyskinesia is presented inwhom administration of pyridoxine (vitamin B6) (100mg/d) resulted in dramatic and persistent attenuationof the movement disorders as well as reduction ofpsychotic behavior. Since pyridoxine deficiency isassociated with marked reduction of cerebral serotoninconcentrations and pineal melatonin production inrats, the effects of pyridoxine on the movementdisorder and psychosis may have been mediated largelyby enhancing serotonin and melatonin functions. Anadditional effect of excess pyridoxine administrationon GABA and dopamine activity cannot be excluded.Pyridoxine has been reported to attenuate the severityof levodopa-induced dyskinesias in patients withParkinson's disease and it is suggested thatpyridoxine supplementation should be considered inpsychiatric patients with drug-induced movementdisorders including persistent Parkinsonism. Anunderlying pyridoxine deficiency in these patients mayexacerbate the psychotic behavior and additionally,potentially increase the risk of drug-induced movementdisorders.Publication Types:summary B6 results in higher melatonin productionGeorgian Med News. 2006 Mar;(132):121-123. Links [bIOCHEMICAL, PHARMACOLOGICAL AND CLINICAL ASPECTS OFI NFLUENCING METHIONINC, TRYPLOPHAN, PYRIDOXINE(VITAMIN B6), Ca(2+) AND HIGH-CALORIE FOOD ON THESYNTHESIS AND INTENSITY OF THE SECRETION OFMELATONIN.][Article in Russian]Tavartkiladze A, Simonia G, Kolbaia D, Shalashvili A,Petriashvili T.Acad. S. Durmishidze Institute of Biochemistry andBiotechnology, Academy of Sciences of Georgia.The goal of the investigation was the determination ofthe influence of Ca(2+), vitamin B6 methionine,tryptophan, the combination of the listed elements andhigh-calorie food on the intensity of synthesis andsecretion of melatonin. The level of melatonin in theblood serum was being determined through the method ofradio-immune (immune-enzyme) analysis. Based on theresults received it was found out that the influenceof the vitamin B6, tryptophan and their combination inthe organism of the tested objects - white rats)resulted in the considerable increase of formation ofmelatonin. In the conditions of feeding them withhigh-calorie food - the value of melntonin in blood issharply reducing. Consequently we may conclude thatthe vitamin B6 and tryptophan separately and incombination, either directly or through some othermechanism participate actively in biosynthesis andsecretion of melatonin. The high-calorie food throughunknown mechanism to us reduces the formation of themelatonin in epiphysis. This might point to theimportant role of the deficit of melatonin inetiopathogenesis of the diseases, detected anddeveloped on the background of hypercholesterinemy.PMID: 16636399 [PubMed - as supplied by publisher]Other research abstract (and this) results sayingsimilar things:1: Tavartkiladze A, Simonia G, Kolbaia D, ShalashviliA, Petriashvili T. Links [bIOCHEMICAL, PHARMACOLOGICAL AND CLINICAL ASPECTS OFI NFLUENCING METHIONINC, TRYPLOPHAN, PYRIDOXINE(VITAMIN B6), Ca(2+) AND HIGH-CALORIE FOOD ON THESYNTHESIS AND INTENSITY OF THE SECRETION OFMELATONIN.]Georgian Med News. 2006 Mar;(132):121-123. Russian. PMID: 16636399 [PubMed - as supplied by publisher] 2: Sorouraddin MH, Rashidi MR, Ghorbani-Kalhor E,Asadpour-Zeynali K. Related Articles, Links Simultaneous spectrofluorimetric andspectrophotometric determination of melatonin andpyridoxine in pharmaceutical preparations bymultivariate calibration methods.Farmaco. 2005 May;60(5):451-8. PMID: 15885688 [PubMed - indexed for MEDLINE] 3: de Lima VR, Morfim MP, Teixeira A, Creczynski-PasaTB. Related Articles,Links Relationship between the action of reactive oxygenand nitrogen species on bilayer membranes andantioxidants.Chem Phys Lipids. 2004 Dec;132(2):197-208. PMID: 15555605 [PubMed - indexed for MEDLINE] 4: Luboshitzky R, Ophir U, Nave R, Epstein R,Shen-Orr Z, Herer P. Related Articles, Links The effect of pyridoxine administration on melatoninsecretion in normal men.Neuro Endocrinol Lett. 2002 Jun;23(3):213-7. PMID: 12080281 [PubMed - indexed for MEDLINE] 5: Uslu B, Demircigil BT, Ozkan SA, Senturk Z,Aboul-Enein HY. Related Articles, Links Simultaneous determination of melatonin andpyridoxine in tablet formulations by differentialpulse voltammetry.Pharmazie. 2001 Dec;56(12):938-42. PMID: 11802655 [PubMed - indexed for MEDLINE] 6: Nunez-Vergara LJ, Squella JA, Sturm JC, Baez H,Camargo C. Related Articles, Links Simultaneous determination of melatonin andpyridoxine in tablets by gas chromatography-massspectrometry.J Pharm Biomed Anal. 2001 Dec;26(5-6):929-38. PMID: 11600305 [PubMed - indexed for MEDLINE] 7: Johnson S. Related Articles, Links The possible role of gradual accumulation of copper,cadmium, lead and iron and gradual depletion of zinc,magnesium, selenium, vitamins B2, B6, D, and E andessential fatty acids in multiple sclerosis.Med Hypotheses. 2000 Sep;55(3):239-41. PMID: 10985916 [PubMed - indexed for MEDLINE] 8: Mortani Barbosa EJ, Ferreira ZS, Markus RP.Related Articles, Links Purinergic and noradrenergic cotransmission in therat pineal gland.Eur J Pharmacol. 2000 Jul 28;401(1):59-62. PMID: 10915838 [PubMed - indexed for MEDLINE] 9: Abdine HH, Gazy AA, Abdel-Hay MH. RelatedArticles, Links Simultaneous determination of melatonin-pyridoxinecombination in tablets by zero-crossing derivativespectrophotometry and spectrofluorimetry.J Pharm Biomed Anal. 1998 Jul;17(3):379-86. PMID: 9656147 [PubMed - indexed for MEDLINE] 10: Munoz-Hoyos A, Amoros-Rodriguez I,Molina-Carballo A, Uberos-Fernandez J,Acuna-Castroviejo D. Related Articles, Links Pineal response after pyridoxine test in children.J Neural Transm. 1996;103(7):833-42. PMID: 8872867 [PubMed - indexed for MEDLINE] 11: Sandyk R, Pardeshi R. Related Articles, Links Pyridoxine improves drug-induced parkinsonism andpsychosis in a schizophrenic patient.Int J Neurosci. 1990 Jun;52(3-4):225-32. PMID: 2269609 [PubMed - indexed for MEDLINE] 12: Dakshinamurti K, Paulose CS, Viswanathan M, SiowYL, Sharma SK, Bolster B. Related Articles, Links Neurobiology of pyridoxine.Ann N Y Acad Sci. 1990;585:128-44. Review. No abstractavailable. PMID: 2192608 [PubMed - indexed for MEDLINE] 13: Gonnard P. Related Articles, Links [Current data on the lateral biochemical effects ofdopa]Pathol Biol (Paris). 1974 Mar;22(3):263-76. Review.French. No abstract available. PMID: 4152656 [PubMed - indexed for MEDLINE] 14: Anton-Tay F. Related Articles, Links Melatonin: effects on brain function.Adv Biochem Psychopharmacol. 1974;11(0):315-24.Review. No abstract available. PMID: 4367648 [PubMed - indexed for MEDLINE] 15: McCoy EE, Henn SW, Colombini CE. RelatedArticles, Links The effect of neuropharmacological agents onmetabolism in vitamin B6 in brain.Adv Biochem Psychopharmacol. 1972;4:93-104. Review. Noabstract available. PMID: 4557808 [PubMed - indexed for MEDLINE] 16: McCoy EE, Henn SW, Colombini CE. RelatedArticles, Links The effect of neuropharmacological agents onmetabolism of vitamin B 6 in brain.Adv Biochem Psychopharmacol. 1972;4:93-104. Review. Noabstract available. PMID: 4555933 [PubMed - indexed for MEDLINE] 17: Cotzias GC, Papavasiliou PS, Ginos J, Steck A,Duby S. Related Articles, Links Metabolic modification of Parkinson's disease and ofchronic manganese poisoning.Annu Rev Med. 1971;22:305-26. Review. No abstractavailable. PMID: 4944422 [PubMed - indexed for MEDLINE]